Gene Symbol: Il7
Description: interleukin 7
Alias: A630026I06Rik, Il-7, hlb368, interleukin-7
Species: mouse
Products:     Il7

Top Publications

  1. von Freeden Jeffry U, Vieira P, Lucian L, McNeil T, Burdach S, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med. 1995;181:1519-26 pubmed
    ..These data show that proper T and B cell development is dependent on IL-7. The IL-7-deficient mice are the first example of single cytokine-deficient mice that exhibit severe lymphoid abnormalities. ..
  2. Ranson T, Vosshenrich C, Corcuff E, Richard O, Muller W, Di Santo J. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood. 2003;101:4887-93 pubmed
    ..Using an adoptive transfer system, we have investigated the role of gammac-dependent cytokines, in particular interleukin 7 (IL-7) and IL-15, and major histocompatibility complex (MHC) class I molecules in peripheral NK-cell ..
  3. Vosshenrich C, Ranson T, Samson S, Corcuff E, Colucci F, Rosmaraki E, et al. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol. 2005;174:1213-21 pubmed
    ..Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity. ..
  4. Haks M, Oosterwegel M, Blom B, Spits H, Kruisbeek A. Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR. Semin Immunol. 1999;11:23-37 pubmed
  5. Meier D, Bornmann C, Chappaz S, Schmutz S, Otten L, Ceredig R, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007;26:643-54 pubmed
    ..Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs. ..
  6. Satoh Takayama N, Lesjean Pottier S, Vieira P, Sawa S, Eberl G, Vosshenrich C, et al. IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med. 2010;207:273-80 pubmed publisher
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
  7. Seet C, Brumbaugh R, Kee B. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med. 2004;199:1689-700 pubmed
    ..Remarkably, however, we find that E2A proteins are required for interleukin 7-dependent proliferation due, in part, to a role for E2A in optimal expression of N-myc...
  8. Vosshenrich C, Garcia Ojeda M, Samson Villéger S, Pasqualetto V, Enault L, Richard Le Goff O, et al. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol. 2006;7:1217-24 pubmed
    ..NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional ..
  9. von Freeden Jeffry U, Solvason N, Howard M, Murray R. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity. 1997;7:147-54 pubmed
    ..These data specify a T cell lineage developmental transition point, prior to T cell antigen receptor rearrangement, where IL-7 signal transduction is linked to an anti-apoptosis mechanism and the cell cycle. ..

More Information


  1. Murray A, Simm B, Beagley K. Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development. Cytokine. 1998;10:337-45 pubmed
    ..Stem cell factor (SCF) and interleukin 7 (IL-7) message was abundant in all three tissues during fetal development...
  2. Sawa S, Kamimura D, Jin G, Morikawa H, Kamon H, Nishihara M, et al. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med. 2006;203:1459-70 pubmed
  3. Moore T, von Freeden Jeffry U, Murray R, Zlotnik A. Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol. 1996;157:2366-73 pubmed
    ..Together, these data clarify the developmental abnormalities during T cell development due to the absence of IL-7. ..
  4. Weitzmann M, Roggia C, Toraldo G, Weitzmann L, Pacifici R. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest. 2002;110:1643-50 pubmed
    ..Thus, because it targets both the osteoclast and the osteoblast pathways, IL-7 is central to the altered bone turnover characteristic of estrogen deficiency. ..
  5. El Kassar N, Lucas P, Klug D, Zamisch M, Merchant M, Bare C, et al. A dose effect of IL-7 on thymocyte development. Blood. 2004;104:1419-27 pubmed
    ..These results show for the first time in vivo a dose effect of IL-7 on alphabeta T-cell development and have implications for IL-7 in the clinical setting. ..
  6. Mazzucchelli R, Hixon J, Spolski R, Chen X, Li W, Hall V, et al. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood. 2008;112:3283-92 pubmed publisher
  7. Tan J, Ernst B, Kieper W, LeRoy E, Sprent J, Surh C. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med. 2002;195:1523-32 pubmed
    ..Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct. ..
  8. Goldrath A, Sivakumar P, Glaccum M, Kennedy M, Bevan M, Benoist C, et al. Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med. 2002;195:1515-22 pubmed
    ..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments. ..
  9. Harnaha J, Machen J, Wright M, Lakomy R, Styche A, Trucco M, et al. Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes. 2006;55:158-70 pubmed
  10. Li W, Jiang Q, Aleem E, Kaldis P, Khaled A, Durum S. IL-7 promotes T cell proliferation through destabilization of p27Kip1. J Exp Med. 2006;203:573-82 pubmed
    ..Hence, IL-7 maintains T cell proliferation through a novel pathway of p27Kip1 regulation. ..
  11. Baccala R, Witherden D, Gonzalez Quintial R, Dummer W, Surh C, Havran W, et al. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol. 2005;174:4606-12 pubmed
    ..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors. ..
  12. Boyman O, Ramsey C, Kim D, Sprent J, Surh C. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol. 2008;180:7265-75 pubmed
    ..The strong stimulatory activity of IL-7/mAb complexes could be useful for treatment of immunodeficiency and cancer. ..
  13. Sawa Y, Arima Y, Ogura H, Kitabayashi C, Jiang J, Fukushima T, et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity. 2009;30:447-57 pubmed publisher
  14. Wei C, Zeff R, Goldschneider I. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. J Immunol. 2000;164:1961-70 pubmed
    ..These key events, in turn, appear to be prerequisite both for differentiation of pro-B cells to pre-B cells and for proliferation of these cell subsets upon continued stimulation with IL-7. ..
  15. Lenz D, Kurz S, Lemmens E, Schoenberger S, Sprent J, Oldstone M, et al. IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A. 2004;101:9357-62 pubmed
    ..We propose that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences. ..
  16. Peffault De Latour R, Dujardin H, Mishellany F, Burlen Defranoux O, Zuber J, Marques R, et al. Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood. 2006;108:2300-6 pubmed
    ..It also highlights the potential of the regulatory Foxp3-expressing CD4+CD25- T-cell population to restore a functional CD4+CD25+ T-cell compartment through an IL-7-independent pathway. ..
  17. Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N, et al. The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity. 2001;15:323-34 pubmed
    ..Moreover, SDF-1 exhibited specific biologic activities on the earliest B cell precursors. SDF-1 provides the first example of a cytokine responsible for the earliest B lineage stages. ..
  18. Venkitaraman A, Cowling R. Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor. Eur J Immunol. 1994;24:2168-74 pubmed
    ..PtdIns 3-kinase may, therefore, play a unique and important role in the biological response to IL-7. ..
  19. Stephan R, Reilly C, Witte P. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood. 1998;91:75-88 pubmed
    ..Therefore, we conclude that the age-related decrease in the function of bone marrow stromal cells is related to the impaired release of IL-7. ..
  20. Zamisch M, Moore Scott B, Su D, Lucas P, Manley N, Richie E. Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol. 2005;174:60-7 pubmed
  21. Schmutz S, Bosco N, Chappaz S, Boyman O, Acha Orbea H, Ceredig R, et al. Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells. J Immunol. 2009;183:2217-21 pubmed publisher
    ..Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool. ..
  22. Li W, Guszczynski T, Hixon J, Durum S. Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Mol Cell Biol. 2010;30:590-600 pubmed publisher
    ..Our findings suggest that the maintenance of peripheral T cells by IL-7 occurs partly through inhibition of Bim activity at the posttranslational level. ..
  23. Tsuda S, Rieke S, Hashimoto Y, Nakauchi H, Takahama Y. Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells. J Immunol. 1996;156:3233-42 pubmed
  24. Kasper L, Matsuura T, Khan I. IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii. J Immunol. 1995;155:4798-804 pubmed
    ..These observations indicate that exogenous administration of human rIL-7 is able to protect mice against acute parasite challenge by stimulating IFN-gamma production and augmenting the CD8+ T cell-mediated CTL response. ..
  25. Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med. 1998;187:389-402 pubmed
    We have demonstrated that intestinal epithelial cells produce interleukin 7 (IL-7), and IL-7 serves as a potent regulatory factor for proliferation of intestinal mucosal lymphocytes expressing functional IL-7 receptor...
  26. Candeias S, Peschon J, Muegge K, Durum S. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett. 1997;57:9-14 pubmed
    ..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus. ..
  27. Klonowski K, Williams K, Marzo A, Lefrancois L. Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development. J Immunol. 2006;177:4247-51 pubmed
    ..Thus, IL-7Ralpha regulation occurs independently of IL-7 in responding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7Ralpha interactions. ..
  28. Miller J, Izon D, DeMuth W, Gerstein R, Bhandoola A, Allman D. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med. 2002;196:705-11 pubmed
    ..These findings challenge previous notions regarding the point in B cell development affected by the loss of IL-7R signaling and suggest that IL-7 plays a key and requisite role during the earliest phases of B cell development. ..
  29. Rathmell J, Farkash E, Gao W, Thompson C. IL-7 enhances the survival and maintains the size of naive T cells. J Immunol. 2001;167:6869-76 pubmed
    ..These data demonstrate that T cells require the continuous presence of extrinsic signals not only to survive but also to maintain their size, metabolic activity, and the ability to respond rapidly to mitogenic signals. ..
  30. Laky K, Lefrancois L, von Freeden Jeffry U, Murray R, Puddington L. The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells. J Immunol. 1998;161:707-13 pubmed
    ..Thus, intrathymic IL-7 was required for development of thymic TCR gamma delta cells, while peripheral IL-7 was sufficient for development of extrathymic TCR gamma delta IEL. ..
  31. Winkler T, Melchers F, Rolink A. Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Blood. 1995;85:2045-51 pubmed
    ..Thus, IL-7 and IL-3 are alternative growth factors for the same pre-BI cell. ..
  32. Montgomery R, Dallman M. Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. Cytokine. 1997;9:717-26 pubmed
    ..The mRNA abundance and pattern of expression of each cytokine or cytokine receptor may indicate the relative contribution that it makes to different stages of fetal thymic ontogeny. ..
  33. Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 2010;11:171-9 pubmed publisher
    STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus...
  34. Park J, Yu Q, Erman B, Appelbaum J, Montoya Durango D, Grimes H, et al. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004;21:289-302 pubmed
    ..We suggest that this homeostatic regulatory mechanism promotes survival of the maximum possible number of T cells for the amount of IL-7 available. ..
  35. Chowdhury D, Sen R. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity. 2003;18:229-41 pubmed
    ..Thus, transient signals mediate V(H) gene activation and inactivation during development. ..
  36. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, et al. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol. 2008;180:383-90 pubmed
  37. Tan J, Dudl E, Leroy E, Murray R, Sprent J, Weinberg K, et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A. 2001;98:8732-7 pubmed
    ..Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation. ..
  38. Mertsching E, Burdet C, Ceredig R. IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro. Int Immunol. 1995;7:401-14 pubmed
    ..We conclude that IL-7 is probably not an important differentiation factor for immature mouse thymocytes. ..
  39. Kieper W, Burghardt J, Surh C. A role for TCR affinity in regulating naive T cell homeostasis. J Immunol. 2004;172:40-4 pubmed
    ..The results suggest that the strength of the TCR affinity determines the relative "fitness" of naive T cells to compete for factors that support cell survival and homeostatic proliferation. ..
  40. Buentke E, Mathiot A, Tolaini M, Di Santo J, Zamoyska R, Seddon B. Do CD8 effector cells need IL-7R expression to become resting memory cells?. Blood. 2006;108:1949-56 pubmed
  41. Lu L, Chaudhury P, Osmond D. Regulation of cell survival during B lymphopoiesis: apoptosis and Bcl-2/Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2. J Immunol. 1999;162:1931-40 pubmed
    ..The results demonstrate that IL-7 strongly promotes in vivo cell survival and maintains antiapoptotic Bcl-2/Bax ratios during the development of precursor B cells in mouse bone marrow. ..
  42. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, et al. IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol. 2007;178:4737-48 pubmed
  43. Park J, Adoro S, Lucas P, Sarafova S, Alag A, Doan L, et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol. 2007;8:1049-59 pubmed
    ..Coreceptor tuning' results from interplay between cytokine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 expression and thereby promote TCR ..
  44. Guimond M, Veenstra R, Grindler D, Zhang H, Cui Y, Murphy R, et al. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol. 2009;10:149-57 pubmed publisher
    b>Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation...
  45. Montgomery R, Dallman M. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol. 1991;147:554-60 pubmed
  46. Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol. 2003;4:680-6 pubmed
    ..We have shown here that interleukin 7 (IL-7) was an important survival factor for CD4 memory T cells that together with T cell receptor (TCR) ..
  47. Jin J, Goldschneider I, Lai L. In vivo administration of the recombinant IL-7/hepatocyte growth factor ? hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. J Immunol. 2011;186:1915-22 pubmed publisher
    ..It also supports the maturation and homeostatic expansion of peripheral T cells. Consequently, the in vivo administration of rIL-7/HGF? may offer a new approach to preventing and/or correcting post-BMT T cell immune deficiency. ..
  48. Kim G, Ligons D, Hong C, Luckey M, Keller H, Tai X, et al. An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis. J Immunol. 2012;188:5859-66 pubmed publisher
  49. Williams I, Rawson E, Manning L, Karaoli T, Rich B, Kupper T. IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. J Immunol. 1997;159:3044-56 pubmed
    ..Our results also suggest that features of the epidermal microenvironment besides keratinocyte-derived IL-7 account for the normal predominance of Vgamma5 Vdelta1 DETC in mouse epidermis. ..
  50. Unsinger J, McGlynn M, Kasten K, Hoekzema A, Watanabe E, Muenzer J, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol. 2010;184:3768-79 pubmed publisher
    ..If additional animal studies support its efficacy in sepsis and if current clinical trials continue to confirm its safety in diverse settings, rhIL-7 should be strongly considered for clinical trials in sepsis. ..
  51. Khaled A, Li W, Huang J, Fry T, Khaled A, Mackall C, et al. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity. 2002;17:561-73 pubmed
    ..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency. ..
  52. Salopek D, Grcevic D, Katavic V, Kovacic N, Lukic I, Marusic A. Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunol Lett. 2008;121:134-9 pubmed publisher
  53. Carvalho T, Mota Santos T, Cumano A, Demengeot J, Vieira P. Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)- mice. J Exp Med. 2001;194:1141-50 pubmed
    b>Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes...
  54. Schluns K, Kieper W, Jameson S, Lefrancois L. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol. 2000;1:426-32 pubmed
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis. ..
  55. Jacobs S, Michalek R, Rathmell J. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol. 2010;184:3461-9 pubmed publisher
  56. Namen A, Lupton S, Hjerrild K, Wignall J, Mochizuki D, Schmierer A, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988;333:571-3 pubmed
    ..Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7. ..
  57. Cho J, Kim H, Surh C, Sprent J. T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity. 2010;32:214-26 pubmed publisher
    ..Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells. ..
  58. Allman D, Sambandam A, Kim S, Miller J, Pagan A, Well D, et al. Thymopoiesis independent of common lymphoid progenitors. Nat Immunol. 2003;4:168-74 pubmed
    ..Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive ..
  59. Kieper W, Tan J, Bondi Boyd B, Gapin L, Sprent J, Ceredig R, et al. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med. 2002;195:1533-9 pubmed
    ..Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7. ..
  60. Malissen M, Pereira P, Gerber D, Malissen B, DiSanto J. The common cytokine receptor gamma chain controls survival of gamma/delta T cells. J Exp Med. 1997;186:1277-85 pubmed
  61. Alugupalli K, Gerstein R, Chen J, Szomolanyi Tsuda E, Woodland R, Leong J. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003;170:3819-27 pubmed
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis. ..
  62. Toraldo G, Roggia C, Qian W, Pacifici R, Weitzmann M. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A. 2003;100:125-30 pubmed
    ..Importantly, T cell adoptive transfer into nude mice restored IL-7-induced bone loss, and RANKL and TNF-alpha secretion, demonstrating that T cells are essential mediators of IL-7-induced bone loss in vivo. ..
  63. Vonarbourg C, Mortha A, Bui V, Hernandez P, Kiss E, Hoyler T, et al. Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor-expressing ROR?t(+) innate lymphocytes. Immunity. 2010;33:736-51 pubmed publisher
    ..Our data also define a previously unappreciated role of ROR?t? NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...