Gene Symbol: Il6st
Description: interleukin 6 signal transducer
Alias: 5133400A03Rik, AA389424, BB405851, CD130, D13Ertd699e, gp130, interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, membrane glycoprotein 130, oncostatin-M receptor subunit alpha
Species: mouse
Products:     Il6st

Top Publications

  1. Gearing D, Thut C, VandeBos T, Gimpel S, Delaney P, King J, et al. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991;10:2839-48 pubmed
    ..The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and ..
  2. Sawa S, Kamimura D, Jin G, Morikawa H, Kamon H, Nishihara M, et al. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med. 2006;203:1459-70 pubmed
    Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated ..
  3. Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, et al. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000;12:95-105 pubmed
    We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disrupted, by replacing the mouse gp130 gene with human gp130 mutant cDNAs...
  4. Silver J, Stumhofer J, Passos S, Ernst M, Hunter C. IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. J Immunol. 2011;187:350-60 pubmed publisher
    ..Paradoxically, these factors both signal through gp130, but little is known about how the signals downstream of gp130 are integrated to coordinate the immune response to ..
  5. Howlett M, Giraud A, Lescesen H, Jackson C, Kalantzis A, van Driel I, et al. The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology. 2009;136:967-77 pubmed publisher
    ..Gastric cancer is the second most common cause of cancer-related mortality worldwide, mainly as a result of late-stage detection. Interleukin (IL)-11 is a multifunctional cytokine reported to be up-regulated in human gastric cancer...
  6. Jenkins B, Quilici C, Roberts A, Grail D, Dunn A, Ernst M. Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling. Exp Hematol. 2002;30:1248-56 pubmed
    Studies on mice lacking the common receptor subunit gp130 reveal that activation of gp130-dependent signaling pathways is essential for normal fetal and adult hematopoiesis...
  7. Ernst M, Najdovska M, Grail D, Lundgren May T, Buchert M, Tye H, et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest. 2008;118:1727-38 pubmed publisher
    ..Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which carries a mutated gp130 cytokine receptor signaling subunit that ..
  8. Judd L, Bredin K, Kalantzis A, Jenkins B, Ernst M, Giraud A. STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology. 2006;131:1073-85 pubmed
    The gp130(757F/F) mouse is a well-characterized and robust model of distal gastric tumorigenesis displaying many of the characteristics of human intestinal type gastric cancer...
  9. Jenkins B, Grail D, Nheu T, Najdovska M, Wang B, Waring P, et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med. 2005;11:845-52 pubmed
    The latent transcription factor Stat3 is activated by gp130, the common receptor for the interleukin (IL)-6 cytokine family and other growth factor and cytokine receptors...

More Information


  1. Streetz K, Wüstefeld T, Klein C, Kallen K, Tronche F, Betz U, et al. Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology. 2003;125:532-43 pubmed
    Interleukin 6 (IL-6) contributes via its signal transducer gp130 to the acute phase response (APR) in hepatocytes. Recent studies indicated that IL-6 is involved in the regulation of different pathophysiologic conditions of the liver...
  2. Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med. 2002;196:979-90 pubmed
    ..a mouse line in which the src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-2 binding site of gp130, tyrosine 759, was mutated to phenylalanine (gp130(F759/F759))...
  3. Ernst M, Inglese M, Waring P, Campbell I, Bao S, Clay F, et al. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med. 2001;194:189-203 pubmed
    The receptor subunit gp130 transduces multiple cell type-specific activities of the leukemia inhibitory factor (LIF)/interleukin (IL)-6 family of cytokines through the signal transducer and activator of transcription (STAT) and src ..
  4. Sander L, Sackett S, Dierssen U, Beraza N, Linke R, Muller M, et al. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J Exp Med. 2010;207:1453-64 pubmed publisher
    ..Using a mouse model of polymicrobial sepsis, we show that abrogation of APP production by hepatocyte-specific gp130 deletion, the signaling receptor shared by IL-6 family cytokines, strongly increased mortality despite normal ..
  5. Kawasaki K, Gao Y, Yokose S, Kaji Y, Nakamura T, Suda T, et al. Osteoclasts are present in gp130-deficient mice. Endocrinology. 1997;138:4959-65 pubmed
    ..These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine...
  6. Plum W, Tschaharganeh D, Kroy D, Corsten E, Erschfeld S, Dierssen U, et al. Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis. Am J Pathol. 2010;176:2236-46 pubmed publisher
    ..The role of the interleukin-6/glycoprotein 130 (gp130) system in this context is still undefined...
  7. Gearing D, Comeau M, Friend D, Gimpel S, Thut C, McGourty J, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992;255:1434-7 pubmed
    ..with the low-affinity LIF receptor and is identical to the signal transducing subunit of the IL-6 receptor, gp130. The gp130 subunit alone confers low-affinity binding of OSM when expressed in COS-7 cells...
  8. Klein C, Wüstefeld T, Assmus U, Roskams T, Rose John S, Muller M, et al. The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest. 2005;115:860-9 pubmed
    ..IL-6 activates intracellular pathways via the gp130 receptor...
  9. Betz U, Bloch W, van Den Broek M, Yoshida K, Taga T, Kishimoto T, et al. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med. 1998;188:1955-65 pubmed
    ..oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1 are mediated by the cytokine receptor subunit gp130 as the common signal transducer...
  10. Yao L, Yokota T, Xia L, Kincade P, McEver R. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood. 2005;106:4093-101 pubmed
    ..We used a Cre/loxP-mediated recombination to produce mice that lacked the cytokine receptor subunit gp130 in hematopoietic and endothelial cells...
  11. Howlett M, Judd L, Jenkins B, La Gruta N, Grail D, Ernst M, et al. Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130. Gastroenterology. 2005;129:1005-18 pubmed
    We have shown that mice with a mutation in gp130 (gp130(757F/F)), the signal transducing receptor for interleukin (IL)-6 family cytokines, have chronic gastric inflammation and develop distal stomach tumors associated with deregulated ..
  12. Jenkins B, Roberts A, Najdovska M, Grail D, Ernst M. The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood. 2005;105:3512-20 pubmed
    ..homozygous for a knock-in mutation in the IL-6 cytokine family receptor signaling subunit glycoprotein (gp) 130 (gp130(Y757F/Y757F)) that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 ..
  13. Ishihara K, Sawa S, Ikushima H, Hirota S, Atsumi T, Kamimura D, et al. The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. Int Immunol. 2004;16:455-65 pubmed
    ..We generated a double-mutant mouse by crossing two murine models of RA, a gp130 mutant knock-in mouse (gp130F759/F759) and an HTLV-1 pX transgenic mouse (pX-Tg), in a C57BL/6 background, which ..
  14. Lang R, Pauleau A, Parganas E, Takahashi Y, Mages J, Ihle J, et al. SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol. 2003;4:546-50 pubmed
    ..with interleukin-6 (IL-6) but not IL-10, indicating that SOCS3 specifically affects signaling mediated by IL-6 and gp130. IL-6 induces a wider transcriptional response in Socs3-deficient macrophages than in wild-type cells; this ..
  15. Wuestefeld T, Klein C, Streetz K, Betz U, Lauber J, Buer J, et al. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem. 2003;278:11281-8 pubmed
    ..and its family members for liver regeneration after PH, we used conditional knockout mice for glycoprotein 130 (gp130), the common signal transducer of all IL6 family members...
  16. Kumanogoh A, Marukawa S, Kumanogoh T, Hirota H, Lee I, Yasui T, et al. Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130. Proc Natl Acad Sci U S A. 1997;94:2478-82 pubmed
    b>gp130 is a common signal-transducing receptor component for the interleukin 6 family of cytokines functioning in, for example, immune, hematopoietic, and nervous systems...
  17. Tebbutt N, Giraud A, Inglese M, Jenkins B, Waring P, Clay F, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002;8:1089-97 pubmed
    ..STAT1/3) and the Src-homology tyrosine phosphatase 2 (SHP2)-Ras-ERK, emanating from the common signal transducer, gp130, in the gastrointestinal tract...
  18. El Kasmi K, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, et al. General nature of the STAT3-activated anti-inflammatory response. J Immunol. 2006;177:7880-8 pubmed
    ..We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R. ..
  19. Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol. 1992;148:4066-71 pubmed
    ..different chains: a ligand binding-chain (IL-6R) and a non-ligand-binding but signal-transducing chain (gp130)...
  20. Jenkins B, Roberts A, Greenhill C, Najdovska M, Lundgren May T, Robb L, et al. Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. 2007;109:2380-8 pubmed
    We have previously demonstrated that STAT3 hyperactivation via the interleukin 6 (IL-6) cytokine family receptor gp130 in gp130 (Y757F/Y757F) mice leads to numerous hematopoietic and lymphoid pathologies, including neutrophilia, ..
  21. Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol. 2007;19:695-702 pubmed
    ..We reported that IL-6 transduces two signaling pathways via tyrosine redidues of the signal transducer gp130: one depends on signal transducers and activators of transcription (STAT)-3 activation and the other on Src ..
  22. Jia G, Gutierrez Ramos J. Analysis of interleukin receptor gene expression in mouse fetal liver by quantitative polymerase chain reaction. Eur J Immunol. 1995;25:2096-100 pubmed
    ..and abundant expression of the genes encoding the signal transducing subunits interleukin-2 receptor gamma and gp130. Their expression seems to precede that of the genes encoding the specific subunits of these interleukin receptor ..
  23. Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A. 1996;93:407-11 pubmed
    b>gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1...
  24. Streetz K, Tacke F, Leifeld L, Wüstefeld T, Graw A, Klein C, et al. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Hepatology. 2003;38:218-29 pubmed
    ..findings, we applied the tetrachlorcarbonide (CCl(4)) model to conditional knockout animals (Cre/loxP system) for gp130, the common signal transducer of IL-6 family cytokines...
  25. Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, et al. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity. 2008;29:628-36 pubmed publisher
    ..of suppressor of cytokine signaling 3 (SOCS3)-dependent negative regulation of the IL-6 signal transducer gp130 contributed to the development of arthritis...
  26. Robb L, Li R, Hartley L, Nandurkar H, Koentgen F, Begley C. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med. 1998;4:303-8 pubmed
    ..These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction. ..
  27. Bergamin E, Wu J, Hubbard S. Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure. 2006;14:1285-92 pubmed
    ..the N-terminally extended SH2 domain of SOCS3 in complex with its phosphopeptide target on the cytokine receptor gp130. The structure reveals that major insertions in the EF and BG loops of the SOCS3 SH2 domain are responsible for ..
  28. Luchtefeld M, Schunkert H, Stoll M, Selle T, Lorier R, Grote K, et al. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med. 2007;204:1935-44 pubmed
    ..We report that the gp130 receptor, which is a key component of the inflammatory signaling pathway within hepatocytes, influences the risk ..
  29. Hyatt Sachs H, Rohrer H, Zigmond R. The conditioning lesion effect on sympathetic neurite outgrowth is dependent on gp130 cytokines. Exp Neurol. 2010;223:516-22 pubmed publisher
    ..LIF and IL-6 belong to a family of cytokines known as the gp130 family because they act on receptors containing the subunit gp130...
  30. Greenhill C, Rose John S, Lissilaa R, Ferlin W, Ernst M, Hertzog P, et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol. 2011;186:1199-208 pubmed publisher
    ..of inflammatory mediators, especially IL-6, which signals via the shared IL-6 cytokine family receptor subunit gp130. However, the exact role of IL-6, which can elicit either proinflammatory or anti-inflammatory responses, in the ..
  31. Toledo Corral C, Banner L. Early changes of LIFR and gp130 in sciatic nerve and muscle of diabetic mice. Acta Histochem. 2012;114:159-65 pubmed publisher
    ..potential role in diabetic nerve and muscle, we studied the expression of the shared receptor subunits, LIFR and gp130 in a mouse model of streptozotocin (STZ)-induced diabetes...
  32. Haroon F, Drögemüller K, Händel U, Brunn A, Reinhold D, Nishanth G, et al. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J Immunol. 2011;186:6521-31 pubmed publisher
    ..To gain insight into the astrocyte-specific function of gp130 in EAE, we immunized mice lacking cell surface expression of gp130, the signal-transducing receptor for cytokines ..
  33. Melnick M, Chen H, Zhou Y, Jaskoll T. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001;168:233-45 pubmed
    ..Taken together, our experimental results indicate that IL-6 signaling is important to SMG developmental homeostasis. ..
  34. Uozumi H, Hiroi Y, Zou Y, Takimoto E, Toko H, Niu P, et al. gp130 plays a critical role in pressure overload-induced cardiac hypertrophy. J Biol Chem. 2001;276:23115-9 pubmed
    b>gp130, a common receptor for the interleukin 6 family, plays pivotal roles in growth and survival of cardiac myocytes...
  35. Suchorska W, Dams Kozlowska H, Kazimierczak U, Wysocki P, Mackiewicz A. Hyper-interleukin-11 novel designer molecular adjuvant targeting gp130 for whole cell cancer vaccines. Expert Opin Biol Ther. 2011;11:1555-67 pubmed publisher
    Hyper-IL-11 (H11) is a fusion protein comprising IL-11 and soluble IL-11 receptor directly targeting gp130. We evaluated efficacy of H11 as a molecular adjuvant in therapeutic whole tumor cell vaccine formulation...
  36. Davey R, Zandstra P. Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche. Stem Cells. 2006;24:2538-48 pubmed
    ..Endogenous self-renewal signaling resulted from autocrine non-LIF gp130 ligands, which buffered cells against differentiation upon exogenous LIF deprivation...
  37. Arulanandam R, Geletu M, Feracci H, Raptis L. Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration. Exp Cell Res. 2010;316:875-86 pubmed publisher
    ..Knockdown of gp130, the common subunit of this family reduced Stat3 activity, indicating that these cytokines may be responsible for ..
  38. Shin H, Divieti P, Sims N, Kobayashi T, Miao D, Karaplis A, et al. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004;145:1376-85 pubmed
    Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities...
  39. Lee J, Nakagiri T, Oto T, Harada M, Morii E, Shintani Y, et al. IL-6 amplifier, NF-?B-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses. J Immunol. 2012;189:1928-36 pubmed publisher
    ..From these results, we consider whether the IL-6 amplifier in grafts might be a valuable therapeutic target for the prevention of transplant rejection, including chronic rejection. ..
  40. Hsu M, Frausto R, Rose John S, Campbell I. Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M. Glia. 2015;63:132-41 pubmed publisher
    The interleukin (IL)-6/gp130 family of cytokines (e.g., IL-6, IL-11, leukemia inhibitory factor (LIF) and oncostatin M (OSM)) play important roles in the central nervous system (CNS) during neuroinflammation and neurodevelopment...
  41. Heath V, Suh H, Holman M, Renn K, Gooya J, Parkin S, et al. C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood. 2004;104:1639-47 pubmed
    ..These findings show that C/EBPalpha deficiency results in hyperproliferation of HPCs and a block in the ability of multipotential progenitors to differentiate into bipotential granulocyte/macrophage progenitors and their progeny. ..
  42. Carow B, Reuschl A, Gavier Widen D, Jenkins B, Ernst M, Yoshimura A, et al. Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. PLoS Pathog. 2013;9:e1003442 pubmed publisher
    ..signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens...
  43. Ueki Y, Ash J, Zhu M, Zheng L, Le Y. Expression of Cre recombinase in retinal Müller cells. Vision Res. 2009;49:615-21 pubmed publisher
    ..using a Cre-activatable lacZ reporter mouse line (R26R) and a floxed interleukin six signal transducing receptor (gp130) mouse line...
  44. Harker J, Dolgoter A, Zuniga E. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4? T cell responses and viral control during chronic infection. Immunity. 2013;39:548-59 pubmed publisher
    ..Here we showed that T cell-specific ablation of the common interleukin-6 (IL-6) family receptor, gp130, profoundly compromised virus-specific CD4? T cell survival, T follicular helper responses, and IL-21 production ..
  45. Taniguchi K, Wu L, Grivennikov S, de Jong P, Lian I, Yu F, et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015;519:57-62 pubmed publisher
    ..Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control ..
  46. Judd L, Ulaganathan M, Howlett M, Giraud A. Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression. J Pathol. 2009;217:552-62 pubmed publisher
    The cytokines IL-6 and IL-11, which signal via the receptor gp130, have been implicated in various gut pathologies, including inflammation and wound healing...
  47. Atsumi T, Sato M, Kamimura D, Moroi A, Iwakura Y, Betz U, et al. IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int Immunol. 2009;21:73-80 pubmed publisher
    ..T cell death increased in IL-6 knockout (KO) mice, whereas it decreased in mice characterized by enhanced IL-6-gp130-STAT3 signaling...
  48. Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong Z, et al. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation. 2011;124:2690-701 pubmed publisher
    Suppressor of cytokine signaling-3 (SOCS3) is a key negative-feedback regulator of the gp130 receptor that provides crucial signaling for cardiac hypertrophy and survival; however, an in vivo role of SOCS3 regulation on cardiac gp130 ..
  49. Obana M, Maeda M, Takeda K, Hayama A, Mohri T, Yamashita T, et al. Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation. 2010;121:684-91 pubmed publisher
    ..IL-11 attenuated cardiac fibrosis after MI through STAT3. Activation of the IL-11/glycoprotein 130/STAT3 axis may be a novel therapeutic strategy against cardiovascular diseases. ..
  50. Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, et al. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med. 1999;189:63-73 pubmed
    ..mostly mediates the rapid activation of the c-myc gene upon stimulation of the interleukin (IL)-6 receptor or gp130, a signal transducing subunit of the receptor complexes for the IL-6 cytokine family...
  51. Miller A, McLeod L, Alhayyani S, Szczepny A, Watkins D, Chen W, et al. Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma. Oncogene. 2017;36:3059-3066 pubmed publisher
    ..In this study, we report that the gp130F/F knock-in mouse model displaying hyperactivation of the latent transcription factor STAT3 via the ..
  52. Allen M, Fan Y, Monk J, Hou T, Barhoumi R, McMurray D, et al. n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4? T cells. J Nutr. 2014;144:1306-13 pubmed publisher
    ..cytokine that induces Th17 polarization via signaling through the membrane-bound transducer glycoprotein 130 (GP130)...
  53. Thiem S, Eissmann M, Elzer J, Jonas A, Putoczki T, Poh A, et al. Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. Cancer Res. 2016;76:2277-87 pubmed publisher
    ..developing gastric adenomas in gp130(F/F) mice, which carry a knockin mutation in the Il6 signal transducer (Il6st), we generated Tg(Tff1-CreERT2);Stat3(fl/fl);gp130(F/F) mice that also harbor a conditional Stat3 knockout allele ..
  54. Riordan J, Nadeau J. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mamm Genome. 2014;25:473-86 pubmed publisher
    ..Additionally, an overview of nutritional models of progressive NAFLD is provided. ..
  55. Zhao L, Hart S, Cheng J, Melenhorst J, Bierie B, Ernst M, et al. Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem. 2004;279:44093-100 pubmed
    The interleukin-6 (IL6) family of cytokines signals through the common receptor subunit gp130, and subsequently activates Stat3, MAPK, and PI3K...
  56. Putoczki T, Thiem S, Loving A, Busuttil R, Wilson N, Ziegler P, et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell. 2013;24:257-71 pubmed publisher
    ..cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway...
  57. Sun X, Bartos A, Whitsett J, Dey S. Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses. Mol Endocrinol. 2013;27:1492-501 pubmed publisher
    ..LIF function is thought to be mediated by its binding to LIF receptor (LIFR) and recruitment of coreceptor GP130 (glycoprotein 130), and this receptor complex then activates signal transducer and activator of transcription (..
  58. Yeoh G, Ernst M, Rose John S, Akhurst B, Payne C, Long S, et al. Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation. Hepatology. 2007;45:486-94 pubmed
    b>Gp130-mediated IL-6 signaling may play a role in oval cell proliferation in vivo...
  59. Chow S, Speck M, Yoganathan P, Nackiewicz D, Hansen A, Ladefoged M, et al. Glycoprotein 130 receptor signaling mediates ?-cell dysfunction in a rodent model of type 2 diabetes. Diabetes. 2014;63:2984-95 pubmed publisher
    ..IL-6 family cytokines require the glycoprotein 130 (gp130) receptor to signal...
  60. Phesse T, Buchert M, Stuart E, Flanagan D, Faux M, Afshar Sterle S, et al. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. Sci Signal. 2014;7:ra92 pubmed publisher
    ..We found that genetic activation of the cytokine-stimulated pathway mediated by the receptor gp130, the associated Jak (Janus kinase) kinases, and the transcription factor Stat3 (signal transducer and activator of ..
  61. Sonda N, Simonato F, Peranzoni E, Calì B, Bortoluzzi S, Bisognin A, et al. miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis. Immunity. 2013;38:1236-49 pubmed publisher
    ..Tumor-released cytokines signaling through gp130, the common subunit of the interleukin-6 cytokine receptor family, induced the LAP? isoform of C/EBP? ..
  62. Ruwanpura S, McLeod L, Miller A, Jones J, Vlahos R, Ramm G, et al. Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. Am J Physiol Lung Cell Mol Physiol. 2012;302:L627-39 pubmed publisher
    ..IL-6 signaling via the gp130 coreceptor is coupled to multiple signaling pathways, especially the latent transcription factor signal transducer ..
  63. Smith P, Sun F, Park K, Cai B, Wang C, Kuwako K, et al. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 2009;64:617-23 pubmed publisher
    ..This regeneration-promoting effect is efficiently blocked in SOCS3-gp130 double-knockout mice, suggesting that SOCS3 deletion promotes axon regeneration via a gp130-dependent pathway...
  64. Gregg C, Weiss S. CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development. 2005;132:565-78 pubmed
    ..In the present study, we asked whether ciliary neurotrophic factor (CNTF)/leukemia inhibitory factor (LIF)/gp130 signaling plays a role in the development of the germinal layers in the lateral ganglionic eminence...
  65. Park S, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol. 2004;173:3844-54 pubmed
    ..We examined this effect further in knockin mice expressing mutant versions of the IL-6 signal transducer gp130, with defective signaling through either Src homology region 2 domain-containing phosphatase 2/Gab/MAPK (gp130(..
  66. Sims N, Jenkins B, Quinn J, Nakamura A, Glatt M, Gillespie M, et al. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. J Clin Invest. 2004;113:379-89 pubmed
    The gp130-dependent cytokines, which signal through at least two intracellular pathways, regulate osteoclast and osteoblast formation...
  67. Nichols J, Chambers I, Taga T, Smith A. Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Development. 2001;128:2333-9 pubmed
    ..Their derivation and propagation are dependent upon cytokine-stimulated activation of gp130 signal transduction...
  68. Timper K, Denson J, Steculorum S, Heilinger C, Engström Ruud L, Wunderlich C, et al. IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Cell Rep. 2017;19:267-280 pubmed publisher
    ..Blocking IL-6 trans-signaling in the CNS abrogates the ability of IL-6 to suppress feeding. Furthermore, gp130 expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of ..
  69. Kershaw N, Murphy J, Liau N, Varghese L, Laktyushin A, Whitlock E, et al. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat Struct Mol Biol. 2013;20:469-76 pubmed publisher
    ..These studies reveal that SOCS3 targets specific JAK-cytokine receptor pairs and explains the mechanism and specificity of SOCS action. ..
  70. Garbers C, Spudy B, Aparicio Siegmund S, Waetzig G, Sommer J, Holscher C, et al. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J Biol Chem. 2013;288:4346-54 pubmed publisher
    ..act via the non-signaling membrane-bound IL-6 ?-receptor (IL-6R) as an agonistic cytokine but also as a gp130 ?-receptor antagonist, leading to inhibition of IL-6 signaling...
  71. Gresle M, Alexandrou E, Wu Q, Egan G, Jokubaitis V, Ayers M, et al. Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism. PLoS ONE. 2012;7:e47379 pubmed publisher
    ..and Ciliary Neurotrophic factor (CNTF) are members of the interleukin-6 family of cytokines, defined by use of the gp130 molecule as an obligate receptor...