Gene Symbol: Il34
Description: interleukin 34
Alias: 2010004A03Rik, AI593503, interleukin-34
Species: mouse
Products:     Il34

Top Publications

  1. Baud huin M, Renault R, Charrier C, Riet A, Moreau A, Brion R, et al. Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis. J Pathol. 2010;221:77-86 pubmed publisher
    ..Overall, these data reveal that IL-34 can be entirely substituted for M-CSF in RANKL-induced osteoclastogenesis, thus identifying a new biological activity for this cytokine and a contribution to the pathogenesis of GCTs...
  2. Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science. 2008;320:807-11 pubmed publisher
    ..This systematic approach is thus useful for discovering new ligands and receptors and assessing the functional selectivity of extracellular regulatory proteins. ..
  3. Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M, Motoyoshi K, et al. IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. Cell Death Differ. 2010;17:1917-27 pubmed publisher
    ..Our findings indicate that macrophage phenotype and function are differentially regulated even at the level of the single receptor, Fms. ..
  4. Wang Y, Szretter K, Vermi W, Gilfillan S, Rossini C, Cella M, et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol. 2012;13:753-60 pubmed publisher
    ..Here we investigated whether an alternative CSF1R ligand, interleukin 34 (IL-34), is responsible for this discrepancy...
  5. Wei S, Nandi S, Chitu V, Yeung Y, Yu W, Huang M, et al. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol. 2010;88:495-505 pubmed publisher
    ..Whole-mount IL34 in situ hybridization and CSF-1 reporter expression revealed that IL34 mRNA was strongly expressed in the embryonic ..
  6. Nandi S, Gokhan S, Dai X, Wei S, Enikolopov G, Lin H, et al. The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol. 2012;367:100-13 pubmed publisher
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis. ..
  7. Chen Z, Buki K, Vääräniemi J, Gu G, Vaananen H. The critical role of IL-34 in osteoclastogenesis. PLoS ONE. 2011;6:e18689 pubmed publisher
    ..Our results strongly suggest the need to revisit these strategies as they may provide a new potential pharmaceutical target for the regulation of bone metabolism in addition to their role in the treatment of inflammatory diseases. ..
  8. Mizuno T, Doi Y, Mizoguchi H, Jin S, Noda M, Sonobe Y, et al. Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-? neurotoxicity. Am J Pathol. 2011;179:2016-27 pubmed publisher
    ..These findings support the idea that enhancement of the neuroprotective property of microglia by IL-34 may be an effective approach against oA? neurotoxicity in AD. ..
  9. Ma D, Doi Y, Jin S, Li E, Sonobe Y, Takeuchi H, et al. TGF-? induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid ? neurotoxicity. Neurosci Lett. 2012;529:86-91 pubmed publisher
    ..These findings suggest that TGF-? produced by IL-34-treated microglia is a negative regulator of microglial proliferation and enhances the neuroprotective property of microglia. ..

More Information


  1. Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, et al. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity. 2012;37:1050-1060 pubmed publisher
    ..In contrast, microglia and their yolk sac precursors develop independently of IL-34 but rely on it for their maintenance in the adult brain. ..
  2. Yu Y, Yang D, Qiu L, Okamura H, Guo J, Haneji T. Tumor necrosis factor-? induces interleukin-34 expression through nuclear factor??B activation in MC3T3-E1 osteoblastic cells. Mol Med Rep. 2014;10:1371-6 pubmed publisher
    ..Pretreatment with 100 µM CAPE, an inhibitor of NF-?B, significantly inhibited TNF-?-induced IL-34 expression. These results indicate that TNF-? induces IL-34 expression via NF-?B in osteoblasts. ..
  3. Jin S, Sonobe Y, Kawanokuchi J, Horiuchi H, Cheng Y, Wang Y, et al. Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. PLoS ONE. 2014;9:e115981 pubmed publisher
    ..The novel function of IL-34 on the blood-brain barrier may give us a clue for new therapeutic strategies in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. ..
  4. Xu R, Sun H, Williams D, Jones A, Al Hussaini A, Song B, et al. IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2. J Immunol Res. 2015;2015:328146 pubmed publisher
    ..The results of this study indicated that constitutive IL-34 expressed by skin keratinocytes might suppress resident macrophage responses to C. albicans colonisation by maintaining low levels TLR2 and Dectin-1 expression by macrophages. ..
  5. Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell A, Flórido M, et al. A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity. 2017;47:374-388.e6 pubmed publisher
    ..Thus, the liver contains two separate and non-overlapping niches occupied by distinct resident macrophage populations mediating immunosurveillance at these two pathogen entry points to the liver. ..
  6. Zhu C, Herrmann U, Falsig J, Abakumova I, Nuvolone M, Schwarz P, et al. A neuroprotective role for microglia in prion diseases. J Exp Med. 2016;213:1047-59 pubmed publisher
    ..Additionally, deficiency of microglia in interleukin 34 knockout (IL34(-/-)) mice again resulted in significantly augmented proteinase K-resistant prion protein ..
  7. Wang Y, Bugatti M, Ulland T, Vermi W, Gilfillan S, Colonna M. Nonredundant roles of keratinocyte-derived IL-34 and neutrophil-derived CSF1 in Langerhans cell renewal in the steady state and during inflammation. Eur J Immunol. 2016;46:552-9 pubmed publisher
    ..its impact on skin LCs in the developing embryo and adult mice in the steady state and during inflammation using Il34(LacZ) reporter mice and newly generated inducible Il34-knockout mice...
  8. Baek J, Zeng R, Weinmann Menke J, Valerius M, Wada Y, Ajay A, et al. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest. 2015;125:3198-214 pubmed publisher
    ..In conclusion, IL-34-dependent, Mø-mediated, CSF-1 nonredundant mechanisms promote persistent ischemia-incited AKI that worsens subsequent CKD. ..
  9. Zwicker S, Martinez G, Bosma M, Gerling M, Clark R, Majster M, et al. Interleukin 34: a new modulator of human and experimental inflammatory bowel disease. Clin Sci (Lond). 2015;129:281-90 pubmed publisher
    ..In the present paper, we investigated the expression of IL34, CSF1 and their shared receptor CSF1R in normal human ileum and colon, in inflamed and non-inflamed tissues of CD ..
  10. Ségaliny A, Mohamadi A, Dizier B, Lokajczyk A, Brion R, Lanel R, et al. Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment. Int J Cancer. 2015;137:73-85 pubmed publisher
    ..By promoting new vessel formation and extravasation of immune cells, IL-34 may play a key role in tumor development and inflammatory diseases. ..
  11. Liu H, Leo C, Chen X, Wong B, Williams L, Lin H, et al. The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta. 2012;1824:938-45 pubmed publisher
    ..negative cooperativity of CSF-1 at the receptor-recognition sites, in combination with the difference in hydrophobicity which dictates a more stable IL-34:CSF-1R complex compared to the CSF-1:CSF-1R complex. ..
  12. Nandi S, Cioce M, Yeung Y, Nieves E, Tesfa L, Lin H, et al. Receptor-type protein-tyrosine phosphatase ? is a functional receptor for interleukin-34. J Biol Chem. 2013;288:21972-86 pubmed publisher
    ..This study identifies an alternate receptor for IL-34 that may mediate its action on novel cellular targets. ..
  13. Chemel M, Brion R, Segaliny A, Lamora A, Charrier C, Brulin B, et al. Bone Morphogenetic Protein 2 and Transforming Growth Factor ?1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts. Am J Pathol. 2017;187:156-162 pubmed publisher
    ..This work identifies TGF-?1 and BMP-2 as potent inhibitors of IL-34 expression in RA synovial fibroblasts. These cytokines, as upstream inhibitors of IL-34, may thus contribute to antagonize inflammation and bone erosions in RA. ..