Il2rg

Summary

Gene Symbol: Il2rg
Description: interleukin 2 receptor, gamma chain
Alias: CD132, gamma(c), p64, cytokine receptor common subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, common gamma chain, gamma C receptor, interleukin-2 receptor subunit gamma
Species: mouse
Products:     Il2rg

Top Publications

  1. Shultz L, Ishikawa F, Greiner D. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007;7:118-30 pubmed
  2. Kovacic B, Stoiber D, Moriggl R, Weisz E, Ott R, Kreibich R, et al. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell. 2006;10:77-87 pubmed
    ..Furthermore, we describe the upregulation of MHC class I expression as a general mechanism that allows for the escape of hematopoietic malignancies from immune surveillance. ..
  3. Boitano A, Wang J, Romeo R, Bouchez L, Parker A, Sutton S, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329:1345-8 pubmed publisher
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy. ..
  4. Brehm M, Racki W, Leif J, Burzenski L, Hosur V, Wetmore A, et al. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012;119:2778-88 pubmed publisher
    ..HSC engraftment are observed in immunodeficient mice expressing mutations in the IL2-receptor common ? chain (IL2rg) gene, including NOD-scid IL2r?(null) (NSG) mice...
  5. Sanos S, Bui V, Mortha A, Oberle K, Heners C, Johner C, et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol. 2009;10:83-91 pubmed publisher
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis. ..
  6. Simpson Abelson M, Sonnenberg G, Takita H, Yokota S, Conway T, Kelleher R, et al. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol. 2008;180:7009-18 pubmed
    ..We conclude that the NOD-scid IL2Rgamma(null) tumor xenograft model provides an opportunity to study tumor and tumor-stromal cell interactions in situ for prolonged periods. ..
  7. Klose C, Kiss E, Schwierzeck V, Ebert K, Hoyler T, d Hargues Y, et al. A T-bet gradient controls the fate and function of CCR6-ROR?t+ innate lymphoid cells. Nature. 2013;494:261-5 pubmed publisher
  8. Ranson T, Vosshenrich C, Corcuff E, Richard O, Muller W, Di Santo J. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood. 2003;101:4887-93 pubmed
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells. ..
  9. Rankin L, Groom J, Chopin M, Herold M, Walker J, Mielke L, et al. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol. 2013;14:389-95 pubmed publisher
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  10. Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100:3175-82 pubmed

Detail Information

Publications62

  1. Shultz L, Ishikawa F, Greiner D. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007;7:118-30 pubmed
  2. Kovacic B, Stoiber D, Moriggl R, Weisz E, Ott R, Kreibich R, et al. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell. 2006;10:77-87 pubmed
    ..Furthermore, we describe the upregulation of MHC class I expression as a general mechanism that allows for the escape of hematopoietic malignancies from immune surveillance. ..
  3. Boitano A, Wang J, Romeo R, Bouchez L, Parker A, Sutton S, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329:1345-8 pubmed publisher
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy. ..
  4. Brehm M, Racki W, Leif J, Burzenski L, Hosur V, Wetmore A, et al. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012;119:2778-88 pubmed publisher
    ..HSC engraftment are observed in immunodeficient mice expressing mutations in the IL2-receptor common ? chain (IL2rg) gene, including NOD-scid IL2r?(null) (NSG) mice...
  5. Sanos S, Bui V, Mortha A, Oberle K, Heners C, Johner C, et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol. 2009;10:83-91 pubmed publisher
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis. ..
  6. Simpson Abelson M, Sonnenberg G, Takita H, Yokota S, Conway T, Kelleher R, et al. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol. 2008;180:7009-18 pubmed
    ..We conclude that the NOD-scid IL2Rgamma(null) tumor xenograft model provides an opportunity to study tumor and tumor-stromal cell interactions in situ for prolonged periods. ..
  7. Klose C, Kiss E, Schwierzeck V, Ebert K, Hoyler T, d Hargues Y, et al. A T-bet gradient controls the fate and function of CCR6-ROR?t+ innate lymphoid cells. Nature. 2013;494:261-5 pubmed publisher
  8. Ranson T, Vosshenrich C, Corcuff E, Richard O, Muller W, Di Santo J. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood. 2003;101:4887-93 pubmed
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells. ..
  9. Rankin L, Groom J, Chopin M, Herold M, Walker J, Mielke L, et al. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol. 2013;14:389-95 pubmed publisher
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  10. Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100:3175-82 pubmed
  11. Billerbeck E, Barry W, Mu K, Dorner M, Rice C, Ploss A. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R?(null) humanized mice. Blood. 2011;117:3076-86 pubmed publisher
  12. Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti J, Lanzavecchia A, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004;304:104-7 pubmed
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo. ..
  13. Shultz L, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, et al. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A. 2010;107:13022-7 pubmed publisher
    ..To achieve HLA-restricted human immune response, we created an immune-compromised non-obese diabetic/SCID/IL2rg(null) strain (NSG) with homozygous expression of HLA class I heavy chain and light chain (NSG-HLA-A2/HHD)...
  14. Al Shami A, Spolski R, Kelly J, Fry T, Schwartzberg P, Pandey A, et al. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med. 2004;200:159-68 pubmed
    ..Thus, as compared with other known cytokines, TSLP is distinctive in exhibiting a lineage preference for the expansion and survival of CD4(+) T cells. ..
  15. Strowig T, Gurer C, Ploss A, Liu Y, Arrey F, Sashihara J, et al. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med. 2009;206:1423-34 pubmed publisher
    ..Both loss of CD4(+) and CD8(+) T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation. ..
  16. Guimond M, Veenstra R, Grindler D, Zhang H, Cui Y, Murphy R, et al. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol. 2009;10:149-57 pubmed publisher
    ..Our results indicate that IL-7Ralpha(+) DCs are regulators of the peripheral CD4(+) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4(+) T cell population expansion in vivo. ..
  17. Agliano A, Martin Padura I, Mancuso P, Marighetti P, Rabascio C, Pruneri G, et al. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer. 2008;123:2222-7 pubmed publisher
    ..Cg-Prkdc(scid)B2m(tm1Unc)/J, abbreviated NOD/scid/beta2 null, NSB; and NOD.Cg-Prkdc(scid)Il2rg(tm1Wjll)/SzJ, abbreviated NOD/scid/IL-2Rgamma null, NSG)...
  18. Kumar P, Ban H, Kim S, Wu H, Pearson T, Greiner D, et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008;134:577-86 pubmed publisher
    ..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model. ..
  19. O Leary J, Goodarzi M, Drayton D, von Andrian U. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol. 2006;7:507-16 pubmed
    ..These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells. ..
  20. Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty S, Teichmann L, et al. Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol. 2014;32:364-72 pubmed publisher
    ..This humanized mouse model may be used to model the human immune system in scenarios of health and pathology, and may enable evaluation of therapeutic candidates in an in vivo setting relevant to human physiology. ..
  21. Shultz L, Lyons B, Burzenski L, Gott B, Chen X, Chaleff S, et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005;174:6477-89 pubmed
    ..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment. ..
  22. Willinger T, Rongvaux A, Takizawa H, Yancopoulos G, Valenzuela D, Murphy A, et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A. 2011;108:2390-5 pubmed publisher
    ..The hIL-3/GM-CSF KI mice represent a unique mouse model that permits the study of human mucosal immune responses to lung pathogens. ..
  23. Miller J, Izon D, DeMuth W, Gerstein R, Bhandoola A, Allman D. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med. 2002;196:705-11 pubmed
    ..of CLPs and downstream pre-pro- and pro-B cells in adult mice lacking either the alpha chain or the common gamma chain (gamma(c)) of the IL-7R...
  24. Satoh Takayama N, Vosshenrich C, Lesjean Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29:958-70 pubmed publisher
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  25. McDermott S, Eppert K, Lechman E, Doedens M, Dick J. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood. 2010;116:193-200 pubmed publisher
  26. Cosgun K, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, et al. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014;15:227-38 pubmed publisher
    ..Thus, we have found that the capacity of this Kit mutation to open up stem cell niches across species barriers has significant potential and broad applicability in human HSC research. ..
  27. van Rijn R, Simonetti E, Hagenbeek A, Bonyhadi M, Storm G, Martens A, et al. Quantitative assessment of human T lymphocytes in RAG2(-/-)gammac(-/-) mice: the impact of ex vivo manipulation on in vivo functionality. Exp Hematol. 2007;35:117-27 pubmed
    ..The huPBMC-RAG2(-/-)gammac(-/-) xenogeneic transplant model is the most sensitive to date for in vivo functional evaluation of human T cells. ..
  28. Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K, et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood. 2003;102:873-80 pubmed
    ..NOD/SCID/ gammacnull mice provide a unique model to investigate human lymphopoiesis without the cotransplantation of human tissues. ..
  29. Garcia Ojeda M, Klein Wolterink R, Lemaitre F, Richard Le Goff O, Hasan M, Hendriks R, et al. GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice. Blood. 2013;121:1749-59 pubmed publisher
    ..As such, GATA-3 is essential to sealing in Notch-induced T-cell fate in early thymocyte precursors by promoting T-cell identity through the repression of alternative developmental options. ..
  30. Morris S, Orekhova T, Meadows M, Heidorn S, Yang J, Finkelman F. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol. 2006;176:5299-305 pubmed
    ..This explains how IL-4 can contribute to Th1 cytokine-associated immune effector functions and suggests how IL-13 can have stronger proallergic effects than IL-4. ..
  31. Kwant Mitchell A, Ashkar A, Rosenthal K. Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. J Virol. 2009;83:10664-76 pubmed publisher
    ..This approach provides a means for studying human immune responses in vivo using a small-animal model and may become an important preclinical tool. ..
  32. Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood. 2005;106:1565-73 pubmed
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system. ..
  33. Masse G, Corcuff E, Strick Marchand H, Guy Grand D, Tafuri Bladt A, Albert M, et al. Gamma c cytokines condition the progressive differentiation of CD4+ T cells. Proc Natl Acad Sci U S A. 2007;104:15442-7 pubmed
    ..These results define a late checkpoint in T cell differentiation in the tissues where gamma(c) cytokines, including IL-15, authenticate CD4(+) T cell effector functions. ..
  34. Schuster C, Berger A, Hoelzl M, Putz E, Frenzel A, Simma O, et al. The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas. Blood. 2011;118:4635-45 pubmed publisher
    ..Our findings provide first evidence that the nature of the second hit affects tumor immunosurveillance in c-MYC-driven lymphomas and define a potential shortcoming of antitumor therapies targeting BCL-2. ..
  35. Sun J, Ma A, Lanier L. Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection. J Immunol. 2009;183:2911-4 pubmed publisher
    ..Remarkably, even in Rag2(-/-) x Il2rg(-/-) mice, a widely used model of NK cell deficiency, we detected a significant number of NK cells 1 wk after ..
  36. Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N, et al. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol. 2002;169:204-9 pubmed
    ..This newly developed mouse model is expected to become a useful tool for the analysis of human T lymphopoiesis and immune response, and an animal model for studying T lymphotropic viral infections, such as HIV. ..
  37. Putz E, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, et al. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep. 2013;4:437-44 pubmed publisher
    ..Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8). Inhibition of CDK8-mediated STAT1-S727 phosphorylation may thus represent a therapeutic strategy for stimulating NK cell-mediated tumor surveillance. ..
  38. Rathinam C, Poueymirou W, Rojas J, Murphy A, Valenzuela D, Yancopoulos G, et al. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood. 2011;118:3119-28 pubmed publisher
    ..In addition, humanized CSF-1 mice will be a valuable experimental model to study human myeloid cell biology. ..
  39. Satoh Takayama N, Dumoutier L, Lesjean Pottier S, Ribeiro V, Mandelboim O, Renauld J, et al. The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium. J Immunol. 2009;183:6579-87 pubmed publisher
    ..Our results provide further evidence for functional heterogeneity in intestinal NKp46(+) cells that contrast with splenic NK cells. ..
  40. King M, Covassin L, Brehm M, Racki W, Pearson T, Leif J, et al. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol. 2009;157:104-18 pubmed publisher
    ..This model now provides the opportunity to investigate in vivo mechanisms of xenogeneic GVHD as well as to assess the efficacy of therapeutic agents rapidly. ..
  41. Burchill M, Yang J, Vogtenhuber C, Blazar B, Farrar M. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007;178:280-90 pubmed
    ..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3. ..
  42. Fontenot J, Rasmussen J, Gavin M, Rudensky A. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142-51 pubmed
    ..In contrast, Foxp3 was not expressed in thymocytes or peripheral T cells from Il2rg(-/-) mice...
  43. Paust S, Gill H, Wang B, Flynn M, Moseman E, Senman B, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010;11:1127-35 pubmed publisher
    ..Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6. ..
  44. Vosshenrich C, Cumano A, Muller W, Di Santo J, Vieira P. Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol. 2003;4:773-9 pubmed
    ..receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability ..
  45. Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature. 2010;463:540-4 pubmed publisher
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'. ..
  46. Jaiswal S, Pearson T, Friberg H, Shultz L, Greiner D, Rothman A, et al. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS ONE. 2009;4:e7251 pubmed publisher
    ..The lack of a suitable animal model to study viral and immunological mechanisms of human dengue disease has been a deterrent to dengue research...
  47. Lu L, Ikizawa K, Hu D, Werneck M, Wucherpfennig K, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007;26:593-604 pubmed
  48. Kelly J, Spolski R, Imada K, Bollenbacher J, Lee S, Leonard W. A role for Stat5 in CD8+ T cell homeostasis. J Immunol. 2003;170:210-7 pubmed
    ..Moreover, CD8+ memory T cells are substantially affected by Stat5 levels. These findings identify Stat5 proteins as critical signaling mediators used by cytokines to regulate CD8+ T cell homeostasis. ..
  49. Strowig T, Chijioke O, Carrega P, Arrey F, Meixlsperger S, Rämer P, et al. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood. 2010;116:4158-67 pubmed publisher
    ..These data suggest that a functional, but resting, NK-cell compartment can be established in immune-compromised mice after human hematopoietic progenitor cell transfer...
  50. Majeti R, Park C, Weissman I. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell. 2007;1:635-45 pubmed publisher
    ..Furthermore, we report the first prospective isolation of a population of candidate human multipotent progenitors, Lin-CD34+CD38-CD90-CD45RA- cord blood. ..
  51. Kassiotis G, Zamoyska R, Stockinger B. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med. 2003;197:1007-16 pubmed
    ..In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals. ..
  52. Taieb J, Chaput N, Menard C, Apetoh L, Ullrich E, Bonmort M, et al. A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med. 2006;12:214-9 pubmed
    ..Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not...
  53. Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28:839-47 pubmed publisher
    ..The demonstration that a minority of CCR5(-/-) HSPCs can populate an infected animal with HIV-1-resistant, CCR5(-/-) progeny supports the use of ZFN-modified autologous hematopoietic stem cells as a clinical approach to treating HIV-1. ..
  54. Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, et al. Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A. 2011;108:13218-23 pubmed publisher
    ..In summary, hSIRPa-transgenic Rag2(-/-)?(c)(-/-) mice represent a unique mouse strain supporting high levels of human cell engraftment, which can easily be genetically manipulated. ..
  55. Gallina G, Dolcetti L, Serafini P, De Santo C, Marigo I, Colombo M, et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest. 2006;116:2777-90 pubmed
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions. ..
  56. Vosshenrich C, Ranson T, Samson S, Corcuff E, Colucci F, Rosmaraki E, et al. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol. 2005;174:1213-21 pubmed
    ..Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity. ..
  57. Price A, Liang H, Sullivan B, Reinhardt R, Eisley C, Erle D, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010;107:11489-94 pubmed publisher
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses. ..
  58. Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy A, et al. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A. 2011;108:2378-83 pubmed publisher
    ..Moreover, maintenance of human stem and progenitor cells was improved, as demonstrated by serial transplantation. Therefore, RAG2(-/-)?(c)(-/-) TPO-humanized mice represent a useful model to study human hematopoiesis in vivo. ..
  59. Quintana E, Shackleton M, Sabel M, Fullen D, Johnson T, Morrison S. Efficient tumour formation by single human melanoma cells. Nature. 2008;456:593-8 pubmed publisher
    ..conditions, including the use of more highly immunocompromised NOD/SCID interleukin-2 receptor gamma chain null (Il2rg(-/-)) mice, can increase the detection of tumorigenic melanoma cells by several orders of magnitude...
  60. Waskow C, Paul S, Haller C, Gassmann M, Rodewald H. Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity. 2002;17:277-88 pubmed
    ..These defects in adult T and B cell development are also evident in a second viable c-Kit(W/W) strain, rescued by overexpression of erythropoietin. ..
  61. Decaluwe H, Taillardet M, Corcuff E, Munitic I, Law H, Rocha B, et al. Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors. Proc Natl Acad Sci U S A. 2010;107:9311-6 pubmed publisher
    Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common gamma chain (gamma(c)) are critical for the generation and peripheral homeostasis of naive and memory T cells...
  62. Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol. 2003;4:680-6 pubmed
    ..Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool. ..