Il2rg

Summary

Gene Symbol: Il2rg
Description: interleukin 2 receptor, gamma chain
Alias: CD132, gamma(c), p64, cytokine receptor common subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, common gamma chain, gamma C receptor, interleukin-2 receptor subunit gamma
Species: mouse

Top Publications

  1. ncbi Humanized mice in translational biomedical research
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:118-30. 2007
  2. ncbi NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells
    Mamoru Ito
    Central Institute for Experimental Animals, Department of Pediatrics, Graduate School of Medicine, Kyoto University, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216 0001, Japan
    Blood 100:3175-82. 2002
  3. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
  4. pmc T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    Priti Kumar
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:577-86. 2008
  5. ncbi Quantitative assessment of human T lymphocytes in RAG2(-/-)gammac(-/-) mice: the impact of ex vivo manipulation on in vivo functionality
    Rozemarijn S van Rijn
    Jordan Laboratory for Hemato Oncology, Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Hematol 35:117-27. 2007
  6. ncbi Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chain
    L I Sharara
    INSERM U429, Hopital Necker, Paris, France
    Eur J Immunol 27:990-8. 1997
  7. pmc PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1059-68. 1999
  8. ncbi Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis
    Claudia Waskow
    Department for Immunology, University of Ulm, Ulm, Germany
    Immunity 17:277-88. 2002
  9. ncbi A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
  10. pmc Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
    Joseph C Sun
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 183:2911-4. 2009

Research Grants

  1. FLOW CYTOMETRY INSTRUMENT
    ZUHAIR BALLAS; Fiscal Year: 2001
  2. KILLER CELLS AND ALCOHOL
    ZUHAIR BALLAS; Fiscal Year: 2008
  3. Modeling RNA-based HIV gene therapeutics in SCID-hu mice
    Ramesh Akkina; Fiscal Year: 2006
  4. SiRNA Gene Therapy for HIV/AIDS
    Ramesh Akkina; Fiscal Year: 2008
  5. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. ncbi Humanized mice in translational biomedical research
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:118-30. 2007
    ....
  2. ncbi NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells
    Mamoru Ito
    Central Institute for Experimental Animals, Department of Pediatrics, Graduate School of Medicine, Kyoto University, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216 0001, Japan
    Blood 100:3175-82. 2002
    ....
  3. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  4. pmc T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    Priti Kumar
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:577-86. 2008
    ..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model...
  5. ncbi Quantitative assessment of human T lymphocytes in RAG2(-/-)gammac(-/-) mice: the impact of ex vivo manipulation on in vivo functionality
    Rozemarijn S van Rijn
    Jordan Laboratory for Hemato Oncology, Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Hematol 35:117-27. 2007
    ..In this study, we investigated the feasibility of using the huPBMC- RAG2(-/-)gammac(-/-) xenogeneic mouse model. As a first example, we compared 3 different ex vivo culture conditions for human T cells...
  6. ncbi Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chain
    L I Sharara
    INSERM U429, Hopital Necker, Paris, France
    Eur J Immunol 27:990-8. 1997
    Deficiency of the cytokine receptor common gamma chain (gamma c) results in abnormal lymphoid development and a severe immunodeficiency disease due to the combined loss of the receptors for interleukins (IL)-2, -4, -7, -9, and -15...
  7. pmc PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1059-68. 1999
    ..Pim1 reconstitutes thymic cellularity in interleukin (IL)-7- and common gamma chain-deficient mice...
  8. ncbi Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis
    Claudia Waskow
    Department for Immunology, University of Ulm, Ulm, Germany
    Immunity 17:277-88. 2002
    ..These defects in adult T and B cell development are also evident in a second viable c-Kit(W/W) strain, rescued by overexpression of erythropoietin...
  9. ncbi A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
    ..Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not...
  10. pmc Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
    Joseph C Sun
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 183:2911-4. 2009
    ..Remarkably, even in Rag2(-/-) x Il2rg(-/-) mice, a widely used model of NK cell deficiency, we detected a significant number of NK cells 1 wk after ..
  11. ncbi Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain
    J P Goldman
    Molecular Immunology Unit, Institute of Child Health, London, UK
    Br J Haematol 103:335-42. 1998
    ..cross with a recombinase activating gene 2 (RAG2)-deficient strain produced mice doubly homozygous for the gamma c and RAG2 null alleles (gamma c-/RAG2-)...
  12. pmc Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
    George Kassiotis
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 197:1007-16. 2003
    ..In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals...
  13. ncbi Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France
    Nat Immunol 4:773-9. 2003
    ..receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability ..
  14. ncbi A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    ..In contrast, Foxp3 was not expressed in thymocytes or peripheral T cells from Il2rg(-/-) mice...
  15. ncbi Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    X Cao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Immunity 2:223-38. 1995
    The common gamma chain (gamma c) of the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors is defective in humans with XSCID...
  16. pmc Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
    J P DiSanto
    Institut National de la Sante et de la Recherche Medicale, Unité 132, Hopital Necker Enfants Malades, Paris, France
    Proc Natl Acad Sci U S A 92:377-81. 1995
    ..Thus, IL-2R gamma facilitates mainstream B- and T-cell generation and function and also appears to be essential for NK-cell development...
  17. ncbi Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain
    K Ohbo
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Blood 87:956-67. 1996
    ..These results indicate that functional loss of the gamma chain causes significant effects on the immunological system in mice...
  18. ncbi Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation
    H R Rodewald
    Basel Institute for Immunology, Switzerland
    Immunity 6:265-72. 1997
    ..essential, overlapping, and synergistic functions for two distinct signaling pathways, one utilizing c-kit and the other cytokine receptor gamma c complexes coupling to Janus kinases and signal transducers and activators of transcription.
  19. ncbi Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
    ..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
  20. pmc Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility
    S K Durum
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21702, USA
    J Exp Med 188:2233-41. 1998
    ..This data supports the model that IL-7R promotes TCR-gamma gene rearrangement by regulating accessibility of the locus via demethylation and histone acetylation of the locus...
  21. pmc The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development
    J P Di Santo
    Institut National de la Santé et de la Recherche Médicale INSERM U429, Hopital Necker Enfants Malades, F 75743 Paris, France
    J Exp Med 189:563-74. 1999
    ..Thus, a series of overlapping signals derived from cytokine and T cell receptors guide the process of alpha/beta thymocyte development...
  22. ncbi Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation
    F Colucci
    Institut National de la Sante et de la Recherche Medicale, Unite 429, Hopital Necker Enfants Malades, Paris, France
    J Immunol 162:2761-5. 1999
    ..Taken together, these results exclude any essential role for c-abl in murine NK cell differentiation in vivo. The RAG2/gammac model thereby provides a novel approach to establish a genetic map of NK cell development...
  23. ncbi A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment
    F Mazurier
    Laboratoire de Pathologie Moléculaire et Thérapie Génique, UMR CNRS 5540, Fédération de Recherche 60 Biologie des Greffes, Universite Victor Segalen, Bordeaux, France
    J Interferon Cytokine Res 19:533-41. 1999
    ..This unique feature of the RAG2-/-/gamma c- mouse model should be particularly well suited for assessing the role of different cytokines in human lymphopoiesis and stem/progenitor cell function in vivo...
  24. ncbi Following the development of a CD4 T cell response in vivo: from activation to memory formation
    S Garcia
    Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, United Kingdom
    Immunity 11:163-71. 1999
    ..They differ qualitatively from naive T cells, suggesting that accelerated CD4 memory responses can occur without the need for increased frequencies of specific T cells...
  25. ncbi Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response
    T Ohteki
    Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Immunol 2:1138-43. 2001
    ..This shows that the IL-15-IL-15R interaction is critical in early activation of antigen-presenting cells and plays an important role in the innate immune system...
  26. pmc The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 196:705-11. 2002
    ..of CLPs and downstream pre-pro- and pro-B cells in adult mice lacking either the alpha chain or the common gamma chain (gamma(c)) of the IL-7R...
  27. ncbi A role for Stat5 in CD8+ T cell homeostasis
    John Kelly
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:210-7. 2003
    ..Moreover, CD8+ memory T cells are substantially affected by Stat5 levels. These findings identify Stat5 proteins as critical signaling mediators used by cytokines to regulate CD8+ T cell homeostasis...
  28. ncbi IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells...
  29. ncbi Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model
    Hidefumi Hiramatsu
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Blood 102:873-80. 2003
    ..NOD/SCID/ gammacnull mice provide a unique model to investigate human lymphopoiesis without the cotransplantation of human tissues...
  30. ncbi Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
    Benedict Seddon
    Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Immunol 4:680-6. 2003
    ..Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool...
  31. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  32. pmc A role for thymic stromal lymphopoietin in CD4(+) T cell development
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:159-68. 2004
    ..Thus, as compared with other known cytokines, TSLP is distinctive in exhibiting a lineage preference for the expansion and survival of CD4(+) T cells...
  33. ncbi Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Nationale de la Santé et Recherche Médicale Equipe 101, Institut Pasteur, Paris, France
    J Immunol 174:1213-21. 2005
    ..Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity...
  34. ncbi Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
    ..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment...
  35. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  36. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
    ..These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells...
  37. ncbi IL-4 induces in vivo production of IFN-gamma by NK and NKT cells
    Suzanne C Morris
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 176:5299-305. 2006
    ..This explains how IL-4 can contribute to Th1 cytokine-associated immune effector functions and suggests how IL-13 can have stronger proallergic effects than IL-4...
  38. ncbi STAT1 acts as a tumor promoter for leukemia development
    Boris Kovacic
    Department of Pharmacology, Medical University of Vienna MUW, Vienna A 1090, Austria
    Cancer Cell 10:77-87. 2006
    ..Furthermore, we describe the upregulation of MHC class I expression as a general mechanism that allows for the escape of hematopoietic malignancies from immune surveillance...
  39. pmc Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway
    Linrong Lu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Immunity 26:593-604. 2007
    ....
  40. pmc Gamma c cytokines condition the progressive differentiation of CD4+ T cells
    Guillemette X Masse
    Cytokines and Lymphoid Development Unit, Immunology Department, Institut Pasteur, F 75724 Paris, France
    Proc Natl Acad Sci U S A 104:15442-7. 2007
    ..These results define a late checkpoint in T cell differentiation in the tissues where gamma(c) cytokines, including IL-15, authenticate CD4(+) T cell effector functions...
  41. pmc Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
    Ravindra Majeti
    Department of Internal Medicine, Division of Hematology, Stanford University, Palo Alto, CA 94304, USA
    Cell Stem Cell 1:635-45. 2007
    ..Furthermore, we report the first prospective isolation of a population of candidate human multipotent progenitors, Lin-CD34+CD38-CD90-CD45RA- cord blood...
  42. ncbi Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice
    Michelle R Simpson-Abelson
    State University of New York, Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    J Immunol 180:7009-18. 2008
    ..We conclude that the NOD-scid IL2Rgamma(null) tumor xenograft model provides an opportunity to study tumor and tumor-stromal cell interactions in situ for prolonged periods...
  43. doi Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains
    Alice Agliano
    Division of Hematology Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy
    Int J Cancer 123:2222-7. 2008
    ..Cg-Prkdc(scid)B2m(tm1Unc)/J, abbreviated NOD/scid/beta2 null, NSB; and NOD.Cg-Prkdc(scid)Il2rg(tm1Wjll)/SzJ, abbreviated NOD/scid/IL-2Rgamma null, NSG)...
  44. pmc Efficient tumour formation by single human melanoma cells
    Elsa Quintana
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 456:593-8. 2008
    ..conditions, including the use of more highly immunocompromised NOD/SCID interleukin-2 receptor gamma chain null (Il2rg(-/-)) mice, can increase the detection of tumorigenic melanoma cells by several orders of magnitude...
  45. doi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  46. pmc Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
    Martin Guimond
    Pediatric Oncology Branch, National Cancer Institute, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 10:149-57. 2009
    ..Our results indicate that IL-7Ralpha(+) DCs are regulators of the peripheral CD4(+) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4(+) T cell population expansion in vivo...
  47. pmc Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
    Till Strowig
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1423-34. 2009
    ..Both loss of CD4(+) and CD8(+) T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation...
  48. pmc Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model
    Amanda Kwant-Mitchell
    Michael G DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Virol 83:10664-76. 2009
    ..This approach provides a means for studying human immune responses in vivo using a small-animal model and may become an important preclinical tool...
  49. pmc Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex
    M A King
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 157:104-18. 2009
    ..This model now provides the opportunity to investigate in vivo mechanisms of xenogeneic GVHD as well as to assess the efficacy of therapeutic agents rapidly...
  50. pmc Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice
    Smita Jaiswal
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e7251. 2009
    ..The lack of a suitable animal model to study viral and immunological mechanisms of human dengue disease has been a deterrent to dengue research...
  51. doi The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 183:6579-87. 2009
    ..Our results provide further evidence for functional heterogeneity in intestinal NKp46(+) cells that contrast with splenic NK cells...
  52. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'...
  53. doi Comparison of human cord blood engraftment between immunocompromised mouse strains
    Sean P McDermott
    Department of Molecular Genetics, University of Toronto, University Health Network, 101 College St, Toronto, ON, Canada
    Blood 116:193-200. 2010
    ....
  54. pmc Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors
    Hélène Decaluwe
    Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F 75015, France
    Proc Natl Acad Sci U S A 107:9311-6. 2010
    Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common gamma chain (gamma(c)) are critical for the generation and peripheral homeostasis of naive and memory T cells...
  55. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  56. pmc Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 107:13022-7. 2010
    ..To achieve HLA-restricted human immune response, we created an immune-compromised non-obese diabetic/SCID/IL2rg(null) strain (NSG) with homozygous expression of HLA class I heavy chain and light chain (NSG-HLA-A2/HHD)...
  57. pmc Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
    Till Strowig
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Blood 116:4158-67. 2010
    ..These data suggest that a functional, but resting, NK-cell compartment can be established in immune-compromised mice after human hematopoietic progenitor cell transfer...
  58. pmc Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    Anthony E Boitano
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1345-8. 2010
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy...
  59. pmc Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses
    Silke Paust
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1127-35. 2010
    ..Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6...
  60. pmc Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice
    Eva Billerbeck
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Blood 117:3076-86. 2011
    ....
  61. pmc Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
    Tim Willinger
    Department of Immunobiology, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:2390-5. 2011
    ..The hIL-3/GM-CSF KI mice represent a unique mouse model that permits the study of human mucosal immune responses to lung pathogens...
  62. pmc Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice
    Till Strowig
    Department of Immunobiology, Bill and Melinda Gates Foundation Grand Challenges in Global Health GC 4 Consortia, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:13218-23. 2011
    ..In summary, hSIRPa-transgenic Rag2(-/-)γ(c)(-/-) mice represent a unique mouse strain supporting high levels of human cell engraftment, which can easily be genetically manipulated...
  63. doi The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas
    Christian Schuster
    Center for Pharmacology and Physiology, Medical University of Vienna, Vienna, Austria
    Blood 118:4635-45. 2011
    ..Our findings provide first evidence that the nature of the second hit affects tumor immunosurveillance in c-MYC-driven lymphomas and define a potential shortcoming of antitumor therapies targeting BCL-2...
  64. pmc Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF
    Michael A Brehm
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 119:2778-88. 2012
    ..HSC engraftment are observed in immunodeficient mice expressing mutations in the IL2-receptor common γ chain (IL2rg) gene, including NOD-scid IL2rγ(null) (NSG) mice...
  65. doi GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice
    Marcos E Garcia-Ojeda
    Innate Immunity Unit, Institut Pasteur, Paris, France
    Blood 121:1749-59. 2013
    ..As such, GATA-3 is essential to sealing in Notch-induced T-cell fate in early thymocyte precursors by promoting T-cell identity through the repression of alternative developmental options...
  66. doi A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells
    Christoph S N Klose
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Nature 494:261-5. 2013
    ....
  67. pmc The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Nat Immunol 14:389-95. 2013
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  68. pmc CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance
    Eva Maria Putz
    Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
    Cell Rep 4:437-44. 2013
    ..Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8). Inhibition of CDK8-mediated STAT1-S727 phosphorylation may thus represent a therapeutic strategy for stimulating NK cell-mediated tumor surveillance...
  69. pmc Development and function of human innate immune cells in a humanized mouse model
    Anthony Rongvaux
    1 Department of Immunobiology, Yale University, New Haven, Connecticut, USA 2
    Nat Biotechnol 32:364-72. 2014
    ..This humanized mouse model may be used to model the human immune system in scenarios of health and pathology, and may enable evaluation of therapeutic candidates in an in vivo setting relevant to human physiology. ..
  70. doi Kit regulates HSC engraftment across the human-mouse species barrier
    Kadriye Nehir Cosgun
    Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Stem Cell 15:227-38. 2014
    ..Thus, we have found that the capacity of this Kit mutation to open up stem cell niches across species barriers has significant potential and broad applicability in human HSC research...
  71. pmc The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    J Exp Med 185:189-95. 1997
    ....
  72. pmc The common cytokine receptor gamma chain controls survival of gamma/delta T cells
    M Malissen
    Centre d Immunologie Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique de Marseille Luminy, France
    J Exp Med 186:1277-85. 1997
    We have investigated the role of common gamma chain (gamma c)-signaling pathways for the development of T cell receptor for antigen (TCR)-gamma/delta T cells...
  73. ncbi IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    Matthew A Burchill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:280-90. 2007
    ..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3...
  74. ncbi Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal
    D Guy-Grand
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 28:730-44. 1998
    ..This insures the rapid epithelial renewal of the villi, which in turn helps maintain the functional integrity of the barrier...
  75. ncbi Antigen-receptor junctional diversity in growth-factor-receptor mutant mice
    H R Rodewald
    Basel Institute for Immunology, Basel, Switzerland
    Dev Comp Immunol 22:351-65. 1998
    ..Thus, the two analyzed growth factor receptors mediate signaling pathways required for progenitor expansion and generation of junctional diversity at TCR loci, but have less influence on the diversity of IgH junctions...
  76. ncbi Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    J Immunol 162:782-90. 1999
    ..In contrast, KJ1-26+ T cells exist in the periphery in both the H-2d/d and H-2d/b backgrounds in DO10 transgenic gamma c wild-type mice...
  77. pmc Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice
    H R Rodewald
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Proc Natl Acad Sci U S A 96:15068-73. 1999
    ....
  78. pmc Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2
    H R Rodewald
    Department for Immunology, University of Ulm, D 89081 Ulm, Germany
    J Exp Med 193:1431-7. 2001
    ..These data argue strongly against a role for Bcl-2 as a key mediator in signaling pathways linked to cytokine and growth factor receptors driving early thymocyte development...
  79. ncbi Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice
    Takashi Yahata
    Research Center for Cell Transplantation, Kanagawa, Japan
    J Immunol 169:204-9. 2002
    ..This newly developed mouse model is expected to become a useful tool for the analysis of human T lymphopoiesis and immune response, and an animal model for studying T lymphotropic viral infections, such as HIV...
  80. pmc Macrophages prevent human red blood cell reconstitution in immunodeficient mice
    Zheng Hu
    Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China
    Blood 118:5938-46. 2011
    ..Thus, strategies for preventing human RBC rejection by macrophages are required for using immunodeficient mice as an in vivo model to study human erythropoiesis and RBC function...
  81. pmc Densely granulated murine NK cells eradicate large solid tumors
    Rebecca B Liu
    Committee on Immunology, Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 72:1964-74. 2012
    ..These results indicate that IL-15 released at the cancer site induces highly activated NK cells that lead to eradication of large solid tumors...
  82. pmc JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate
    Anette Hübner
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12046-51. 2012
    ..These data demonstrate that the JNK and PTEN signaling pathways can cooperate to regulate the progression of prostate neoplasia to invasive adenocarcinoma...
  83. ncbi Differential control of connexin-32 and connexin-43 expression in thyroid epithelial cells: evidence for a direct relationship between connexin-32 expression and histiotypic morphogenesis
    Y Munari-Silem
    Institut National de la Santé et de la Recherche Médicale U 369, Faculte de Medecine A Carrel, Lyon, France
    Endocrinology 135:724-34. 1994
    ..2 x 10(6) cells/cm2) to prevent follicle formation, a TSH-dependent increase in Cx43 was observed in monolayer cells. However, TSH did not cause any reexpression of Cx32.(ABSTRACT TRUNCATED AT 400 WORDS)..
  84. pmc Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor
    S M Zurawski
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    EMBO J 12:5113-9. 1993
    ..The relative spatial locations of these three surfaces are different from the two receptor binding sites known for the structurally related human growth hormone and the significance of this observation is discussed...
  85. ncbi Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination
    U A Betz
    Institute for Genetics, University of Cologne, Germany
    Curr Biol 6:1307-16. 1996
    ..To generate mosaic animals, we used the bacteriophage P1-derived Cre-loxP recombination system, which allows gene alteration by Cre-mediated deletion of loxP-flanked gene segments...
  86. ncbi Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy
    Ali A Ashkar
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 171:2937-44. 2003
    ..These studies indicate that uNK cell development and maturation share some aspects with NK cell development in other tissues, but also display distinctive tissue-specific regulation...
  87. ncbi Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 171:3878-85. 2003
    ..We concluded that the effector mechanisms in diabetic NOD hosts are inherently complex, and rejection in this model involves CD28/CD154/gammac-dependent and -independent mechanisms...
  88. pmc NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection
    Navkiran Gill
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    J Virol 79:4470-8. 2005
    ..The results of these studies indicate that IL-15 can act independently of NK/NKT cells in mediating the innate defense against viral infection...
  89. ncbi IL-13 regulates the immune response to inhaled antigens
    Jocelyn Padilla
    James P Mara Center for Lung Diseases, St Luke s Roosevelt Hospital and Department of Pathology, Columbia University, New York, NY 10019, USA
    J Immunol 174:8097-105. 2005
    ..These data indicate that blockade of IL-13 may have therapeutic potential for controlling the immune response to inhaled Ags...
  90. pmc Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells
    Jakub Tolar
    Pediatric Hematology Oncology Blood and Marrow Transplantation Program, MMC 366, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 107:4182-8. 2006
    ..Our data indicate that the biodistribution and persistence of reporter gene-labeled MAPCs are maximized after intra-arterial delivery or host irradiation and that T cells, B cells, and NK cells contribute to in vivo MAPC rejection...
  91. pmc Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
    Mark C Coles
    Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Proc Natl Acad Sci U S A 103:13457-62. 2006
    ..Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role...
  92. ncbi Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly
    Maki Touma
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 178:3668-79. 2007
    ..The implications of these results for CD3epsilongamma and TCR structure and signaling function are discussed...
  93. pmc Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor
    Martin Guimond
    Blood 111:969-70. 2008
  94. doi IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis
    R H Fontaine
    INSERM, U676, Paris, France
    Cell Death Differ 15:1542-52. 2008
    ..Together, these data suggest that IL-9/IL-9 receptor signaling pathway represents a novel endogenous antiapoptotic mechanism for cortical neurons by controlling JAK/STAT and Bax levels...
  95. doi Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells
    Min Lu
    Terry Fox Laboratory, British Columbia Cancer Agency, BC, Canada
    Exp Hematol 37:924-36. 2009
    ..Here we evaluated the ability of MEDII (medium conditioned by HepG2 cells, a human hepatocarcinoma cell line) to selectively enhance generation of mesodermal derivatives, including hematopoietic cells, from hESCs and hiPSCs...
  96. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
    ..The demonstration that a minority of CCR5(-/-) HSPCs can populate an infected animal with HIV-1-resistant, CCR5(-/-) progeny supports the use of ZFN-modified autologous hematopoietic stem cells as a clinical approach to treating HIV-1...
  97. pmc A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma
    Elena Beltran
    Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Proc Natl Acad Sci U S A 108:12461-6. 2011
    ..This effective combination therapy also might be exploited in other cyclin-D1-expressing tumors...
  98. ncbi Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding
    J P DiSanto
    INSERM U132, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 24:475-9. 1994
    ..In addition, these data provide insight into the structure/function relationship of the IL-2R gamma chain by identifying residues required for the formation of a high-affinity IL-2R complex...
  99. ncbi Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma
    N Kobayashi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Gene 130:303-4. 1993
    ..The primary amino acid sequence deduced from the nucleotide sequence exhibits 70% overall similarity with human IL-2R gamma and, in particular, the predicted cytoplasmic region shows a higher degree of similarity (about 84.7%)...
  100. pmc Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression
    X Cao
    Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:8464-8. 1993
    ..Finally, we have localized the murine IL-2R gamma gene, Il2rg, to the X chromosome between Rsvp and Plp and demonstrated that a defect in IL-2R gamma is not responsible for the ..
  101. ncbi Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors
    S Kumaki
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 193:356-63. 1993
    ..These results indicate that the mouse functional IL-2 receptor is a complex comprising three distinct subunits, alpha, beta and gamma chains, but the beta gamma heterodimer is not functional and different from the human heterodimer...

Research Grants5

  1. FLOW CYTOMETRY INSTRUMENT
    ZUHAIR BALLAS; Fiscal Year: 2001
    ..abstract_text> ..
  2. KILLER CELLS AND ALCOHOL
    ZUHAIR BALLAS; Fiscal Year: 2008
    ..Preliminary data prompted the hypothesis that ETOH blunts the enhanced NK activity induced by CpG ODN [unreadable] [unreadable]..
  3. Modeling RNA-based HIV gene therapeutics in SCID-hu mice
    Ramesh Akkina; Fiscal Year: 2006
    ..4) Determine the engraftment and thymopoietic potential of lentivirally transduced primitive hematopoietic precursor cells i.e., a) CD34+ and KDR+ cells, b) SP cells in the SCID-hu mouse thymic microenvironment. ..
  4. SiRNA Gene Therapy for HIV/AIDS
    Ramesh Akkina; Fiscal Year: 2008
    ..4. Transduce siRNA constructs into the newly described CD34+/KDR+ primitive hematopoietic progenitor cells and derive macrophages in vitro and thymocytes in vivo, and evaluate their HIV-1 resistance. [unreadable] [unreadable]..
  5. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009
    ..abstract_text> ..