Il2ra

Summary

Gene Symbol: Il2ra
Description: interleukin 2 receptor, alpha chain
Alias: CD25, Il2r, Ly-43, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R alpha chain, IL-2R subunit alpha, IL2-RA, p55 chain
Species: mouse
Products:     Il2ra

Top Publications

  1. Van Parijs L, Biuckians A, Ibragimov A, Alt F, Willerford D, Abbas A. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol. 1997;158:3738-45 pubmed
    ..processes, we have bred a class II-restricted TCR transgene into mice deficient in the alpha-chain of the IL-2R, CD25. We show that in response to Ag, T cells from these mice are unable to use IL-2 and, as a result, are less ..
  2. Bayer A, Yu A, Malek T. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunol. 2007;178:4062-71 pubmed
    IL-2 contributes to the production, function, and homeostasis of CD4+CD25+ T(reg) cells...
  3. Soldaini E, Pla M, Beermann F, Espel E, Corthesy P, Barangé S, et al. Mouse interleukin-2 receptor alpha gene expression. Delimitation of cis-acting regulatory elements in transgenic mice and by mapping of DNase-I hypersensitive sites. J Biol Chem. 1995;270:10733-42 pubmed
    ..Two, at -0.05 and -5.3 kilobase pairs, are present in resting T cells. A third site appears at -1.35 kilobase pairs in activated T cells. It co-localizes with IL-2-responsive elements identified by transient transfection experiments. ..
  4. Reya T, Yang Snyder J, Rothenberg E, Carding S. Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development. Blood. 1996;87:190-201 pubmed
    ..Together, these observations suggest that CD122 plays a role in regulating normal lymphocyte development in vivo. ..
  5. Amado I, Berges J, Luther R, Mailhé M, Garcia S, Bandeira A, et al. IL-2 coordinates IL-2-producing and regulatory T cell interplay. J Exp Med. 2013;210:2707-20 pubmed publisher
  6. Burchill M, Yang J, Vogtenhuber C, Blazar B, Farrar M. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007;178:280-90 pubmed
    ..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3. ..
  7. Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, et al. CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J Immunol. 2003;170:2516-22 pubmed
    Murine CD4(+)CD25(+) regulatory cells have been reported to express latency-associated peptide (LAP) and TGF-beta on the surface after activation, and exert regulatory function by the membrane-bound TGF-beta in vitro...
  8. Létourneau S, van Leeuwen E, Krieg C, Martin C, Pantaleo G, Sprent J, et al. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A. 2010;107:2171-6 pubmed publisher
    ..We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis...
  9. Soper D, Kasprowicz D, Ziegler S. IL-2Rbeta links IL-2R signaling with Foxp3 expression. Eur J Immunol. 2007;37:1817-26 pubmed
    ..that the forkhead family member Foxp3 is a critical element in the differentiation and function of mouse CD4(+)CD25(+) regulatory T cells (Treg)...

More Information

Publications86

  1. Fisson S, Djelti F, Trenado A, Billiard F, Liblau R, Klatzmann D, et al. Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur J Immunol. 2006;36:817-27 pubmed
    CD4+ CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases...
  2. Lee S, Fragoso M, Biron C. Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells. J Immunol. 2012;189:2712-6 pubmed publisher
    NK cell expression and use of the IL-2R?-chain (CD25), required for the high-affinity IL-2R, remain poorly understood...
  3. Almeida A, Zaragoza B, Freitas A. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells. J Immunol. 2006;177:192-200 pubmed
    ..We have investigated the mechanisms regulating CD4+CD25+ regulatory T (Treg) cell homeostasis...
  4. Fontenot J, Rasmussen J, Gavin M, Rudensky A. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142-51 pubmed
    ..mice containing the Foxp3(gfp) knock-in allele that were genetically deficient in either IL-2 (Il2(-/-)) or CD25 (Il2ra(-/-))...
  5. Johnston R, Choi Y, Diamond J, Yang J, Crotty S. STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med. 2012;209:243-50 pubmed publisher
    ..These results demonstrate that IL-2, STAT5, and Blimp-1 collaborate to negatively regulate T(FH) cell differentiation. ..
  6. Moriggl R, Topham D, Teglund S, Sexl V, McKay C, Wang D, et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 1999;10:249-59 pubmed
    ..These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells. ..
  7. Peffault De Latour R, Dujardin H, Mishellany F, Burlen Defranoux O, Zuber J, Marques R, et al. Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood. 2006;108:2300-6 pubmed
    ..and the premature involution of the thymus in IL-7-/- mice does not change the representation of the CD4+CD25+ T-cell compartment. In addition, CD4+CD25+ T cells expand in the absence of IL-7, without losing Foxp3 expression...
  8. Papiernik M, de Moraes M, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol. 1998;10:371-8 pubmed
    We recently characterized a CD4+ T cell population expressing the IL-2R alpha chain (CD25), producing IL-10 and resisting clonal deletion induced by viral superantigen (vSAG) encoded by mouse mammary tumor virus [MMTV(SW)]...
  9. Hua L, Yao S, Pham D, Jiang L, Wright J, Sawant D, et al. Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. J Virol. 2013;87:11884-93 pubmed publisher
    ..The potential implications for the functions of these cells are discussed. ..
  10. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-64 pubmed
    ..CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules...
  11. Williams C, Murray S, Weinberg A, Parker D. OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet. J Immunol. 2007;178:7694-702 pubmed
    ..Finally, we show that CD25-deficient CD4 T cells produce little IFN-gamma in the presence of OX40 costimulation compared with wild type, ..
  12. Dooms H, Wolslegel K, Lin P, Abbas A. Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med. 2007;204:547-57 pubmed
    ..Primed IL-2(-/-) or CD25(-/-) (IL-2Ralpha(-/-)) CD4(+) T cells, despite showing normal induction of activation markers and cell division, ..
  13. Pipkin M, Sacks J, Cruz Guilloty F, Lichtenheld M, Bevan M, Rao A. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity. 2010;32:79-90 pubmed publisher
    ..Thus, inflammation influences both effector and memory CTL differentiation, whereas persistent IL-2 stimulation promotes effector at the expense of memory CTL development. ..
  14. Sperisen P, Wang S, Soldaini E, Pla M, Rusterholz C, Bucher P, et al. Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements. J Biol Chem. 1995;270:10743-53 pubmed
    ..IL-2 responsiveness requires three distinct elements within the enhancer. Two of these are potential binding sites for STAT proteins. ..
  15. Williams M, Tyznik A, Bevan M. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature. 2006;441:890-3 pubmed
    ..of autoimmunity, attributable to the central role of IL-2 in the generation, maintenance and function of CD4+CD25+ regulatory T cells...
  16. Bayer A, Yu A, Adeegbe D, Malek T. Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med. 2005;201:769-77 pubmed
    Although many aspects of CD4(+)CD25(+) T regulatory (T(reg)) cell development remain largely unknown, signaling through the IL-2R represents one feature for the production of T(reg) cells...
  17. Krieg C, Létourneau S, Pantaleo G, Boyman O. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci U S A. 2010;107:11906-11 pubmed publisher
    ..Notably, IL-2-mediated pulmonary edema was abrogated by a blocking antibody to IL-2Ralpha (CD25), genetic disruption of CD25, or the use of IL-2Rbetagamma-directed IL-2/anti-IL-2 antibody complexes, thereby ..
  18. Kalia V, Sarkar S, Subramaniam S, Haining W, Smith K, Ahmed R. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity. 2010;32:91-103 pubmed publisher
    b>CD25, the high-affinity interleukin-2 (IL-2) receptor alpha chain, is rapidly upregulated by antigen-specific CD8(+) T cells after T cell receptor stimulation...
  19. Rahimy E, Pitcher J, Pangelinan S, Chen W, Farley W, Niederkorn J, et al. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010;177:744-53 pubmed publisher
    ..Taken together, autoimmune LG infiltration with loss of LG function was observed in CD25KO mice as early as 8 weeks of age. Time-related switch from Th-17 to Th-1 inflammation was noted in CD25KO mice...
  20. Klug D, Carter C, Gimenez Conti I, Richie E. Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol. 2002;169:2842-5 pubmed
    ..However, thymocyte-derived signals are required during late fetal stages for continued development and maintenance of TEC subsets in the neonate and adult. ..
  21. Joffre O, Santolaria T, Calise D, Al Saati T, Hudrisier D, Romagnoli P, et al. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med. 2008;14:88-92 pubmed
    ..Here we show that in mice treated with clinically acceptable levels of irradiation, regulatory CD4+CD25+Foxp3+ T cells stimulated in vitro with alloantigens induced long-term tolerance to bone marrow and subsequent skin ..
  22. Almeida A, Legrand N, Papiernik M, Freitas A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol. 2002;169:4850-60 pubmed
    ..In chimeras reconstituted with bone marrow cells from IL-2Ralpha-deficient donors, restitution of a population of CD25(+)CD4(+) T cells prevents the chaotic accumulation of lymphoid cells, and rescues the mice from autoimmune disease ..
  23. Ballesteros Tato A, León B, Graf B, Moquin A, Adams P, Lund F, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity. 2012;36:847-56 pubmed publisher
    ..Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development...
  24. Kim H, Kelly J, Leonard W. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001;15:159-72 pubmed
    ..Thus, the IL-2 inducibility of the IL-2Ralpha gene is unexpectedly mediated by two widely separated regulatory Stat5-dependent elements, located both upstream and downstream of the transcription initiation sites. ..
  25. D Cruz L, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol. 2005;6:1152-9 pubmed
    Interleukin 2 signaling is believed to be critically involved in several aspects of CD25(+) CD4(+) regulatory T cell biology, such as intrathymic development, peripheral survival and suppressive function...
  26. Willerford D, Chen J, Ferry J, Davidson L, Ma A, Alt F. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3:521-30 pubmed
    ..Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation. ..
  27. Lecine P, Algarte M, Rameil P, Beadling C, Bucher P, Nabholz M, et al. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene. Mol Cell Biol. 1996;16:6829-40 pubmed
    ..Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor. ..
  28. Ortega G, Robb R, Shevach E, Malek T. The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984;133:1970-5 pubmed
    ..Collectively, the results support the hypothesis that these antibodies detect two distinct functional regions of the IL 2 receptor. ..
  29. Levin A, Bates D, Ring A, Krieg C, Lin J, Su L, et al. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 2012;484:529-33 pubmed publisher
    ..T cells, IL-2 signals through a quaternary 'high affinity' receptor complex consisting of IL-2, IL-2R? (termed CD25), IL-2R? and IL-2R?...
  30. Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, et al. Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy. PLoS ONE. 2017;12:e0179431 pubmed publisher
    ..are located at the region of IL2 that contacts the alpha (?) subunit of the heterotrimeric IL2 receptor complex, IL2R???, reducing its ability to bind and activate the heterotrimer...
  31. Sharma R, Bagavant H, Jarjour W, Sung S, Ju S. The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis. J Immunol. 2005;175:1965-73 pubmed
    ..Consistent with a defect in CD4+CD25+ regulatory T (Treg) cell expression, spontaneous lymphocyte activation in lymphoid organs was observed in 6-wk-old ..
  32. Dumoutier L, de Heusch M, Orabona C, Satoh Takayama N, Eberl G, Sirard J, et al. IL-22 is produced by ?C-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Eur J Immunol. 2011;41:1075-85 pubmed publisher
    ..activating gene (Rag2)-deficient mice, and correspond to a discrete innate lymphoid cell population expressing CD25, CCR6 and IL-7R...
  33. Kozak C, Leonard W. Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse. Mamm Genome. 1995;6:823-4 pubmed
  34. Shahinian A, Pfeffer K, Lee K, Kundig T, Kishihara K, Wakeham A, et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 1993;261:609-12 pubmed
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist. ..
  35. Terauchi M, Li J, Bedi B, Baek K, Tawfeek H, Galley S, et al. T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab. 2009;10:229-40 pubmed publisher
  36. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor ?-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. J Immunol. 2011;186:3808-21 pubmed
  37. Engelbertsen D, Foks A, Alberts Grill N, Kuperwaser F, Chen T, Lederer J, et al. Expansion of CD25+ Innate Lymphoid Cells Reduces Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:2526-35 pubmed publisher
    ..We demonstrate that CD25(+) ILCs that produce type 2 cytokines (ILC2s) are present in the aorta of atherosclerotic immunodeficient ldlr(-/-)..
  38. Egawa T, Albrecht B, Favier B, Sunshine M, Mirchandani K, O BRIEN W, et al. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003;13:1252-8 pubmed
    ..Together, these results show that CARMA1 has a central role in antigen receptor signaling that results in activation and proliferation of both B and T lymphocytes. ..
  39. Betts R, Ho A, Kemeny D. Partial depletion of natural CD4?CD25? regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. PLoS ONE. 2011;6:e27849 pubmed publisher
    ..Recent studies have demonstrated treatment with PC61 CD25-depleting antibody potentiates inflammation in a murine model of RSV infection, while paradoxically delaying ..
  40. Stuller K, Ding H, Redline R, Czinn S, Blanchard T. CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness. Eur J Immunol. 2008;38:3426-35 pubmed publisher
    ..To study the lack of protective H. pylori immunity, CD4(+)CD25(+) T(reg) cells were investigated for their ability to down-regulate H...
  41. Nowell C, Bredenkamp N, Tételin S, Jin X, Tischner C, Vaidya H, et al. Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011;7:e1002348 pubmed publisher
    ..Our novel revertible hypomorph system may be similarly applied to analyzing other regulators of development. ..
  42. Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, et al. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. 1998;95:17-27 pubmed
    ..Furthermore, this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors. ..
  43. Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009;114:1355-65 pubmed publisher
    ..We think that our data provide insight into expression regulation of Fas in T cells. ..
  44. Vomhof DeKrey E, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, et al. Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells. Proc Natl Acad Sci U S A. 2015;112:12474-9 pubmed publisher
  45. Zurawski S, Vega F, Doyle E, Huyghe B, Flaherty K, McKay D, et al. Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J. 1993;12:5113-9 pubmed
    ..The relative spatial locations of these three surfaces are different from the two receptor binding sites known for the structurally related human growth hormone and the significance of this observation is discussed. ..
  46. Xie Y, Zhang X, Zhao T, Li W, Xiang J. Natural CD8?25? regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma. Biochem Biophys Res Commun. 2013;438:152-5 pubmed publisher
    ..with 50-100 nm in diameter, contained EXO-associated markers LAMP-1 and CD9, and expressed natural Tr cell markers CD25 and GITR. To assess immunomodulatory effect, we i.v...
  47. Ye Q, Wang L, Wells A, Tao R, Han R, Davidson A, et al. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol. 2004;34:2750-9 pubmed
    ..Taken together, these data indicate the BAFF/BAFF-R pathway contributes to both T and B cell responses and may be an attractive target for control of acute and chronic allograft rejection. ..
  48. Yeh J, Spicuglia S, Kumar S, Sanchez Sevilla A, Ferrier P, Imbert J. Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development. Nucleic Acids Res. 2002;30:1944-51 pubmed
    During T-cell development in thymus, CD25, the IL-2 receptor alpha chain (IL-2Ralpha) is already expressed in early double-negative (DN) thymocytes where commitment to T-cell lineage has been established, but subsequently IL-2Ralpha is ..
  49. Arce Vargas F, Furness A, Solomon I, Joshi K, Mekkaoui L, Lesko M, et al. Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Immunity. 2017;46:577-586 pubmed publisher
    b>CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors...
  50. Nelson B. IL-2, regulatory T cells, and tolerance. J Immunol. 2004;172:3983-8 pubmed
    ..been resolved with the discovery that IL-2 is critical for the development and peripheral expansion of CD4(+)CD25(+) regulatory T cells, which promote self-tolerance by suppressing T cell responses in vivo...
  51. Melum E, Franke A, Schramm C, Weismüller T, Gotthardt D, Offner F, et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 2011;43:17-9 pubmed publisher
    ..We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10?¹? and P = 4.1 × 10??, respectively). ..
  52. Nishibori T, Tanabe Y, Su L, David M. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004;199:25-34 pubmed
    ..this autoimmune disease appears to be triggered by a reduced number as well as a functional impairment of the CD4+ CD25+ regulatory T cells in STAT1-deficient animals...
  53. Shin H, Kapoor V, Guan T, Kaech S, Welsh R, Berg L. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013;39:661-75 pubmed publisher
    ..Silencing of Il2ra and Cd27 reduced the Blimp-1-deficient CD8? T cell response...
  54. Chen Z, Herman A, Matos M, Mathis D, Benoist C. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med. 2005;202:1387-97 pubmed
    Foxp3 is required for the generation and activity of CD4(+)CD25(+) regulatory T (T reg) cells, which are important controllers of autoimmunity, including type-1 diabetes...
  55. Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS ONE. 2008;3:e2705 pubmed publisher
    ..These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses. ..
  56. Gorczynski R, Lee L, Boudakov I. Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R. Transplantation. 2005;79:1180-3 pubmed
    ..IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. The effect of these mAbs on Treg induced in anti-CD3 activated thymocyte cultures is unknown...
  57. Jackaman C, Cornwall S, Lew A, Zhan Y, Robinson B, Nelson D. Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells. Eur Respir J. 2009;34:162-75 pubmed publisher
    ..Finally, removal of CD25(+) Tregs from the tumour site and lymphoid organs did not alter tumour growth with or without interleukin (IL)-2 or ..
  58. Walsh P, Buckler J, Zhang J, Gelman A, Dalton N, Taylor D, et al. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest. 2006;116:2521-31 pubmed
    One of the greatest barriers against harnessing the potential of CD4+ CD25+ Tregs as a cellular immunotherapy is their hypoproliferative phenotype...
  59. Nishikawa H, Kato T, Tawara I, Saito K, Ikeda H, Kuribayashi K, et al. Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells. J Exp Med. 2005;201:681-6 pubmed
    The antigenic targets recognized by naturally occurring CD4(+) CD25(+) regulatory T cells (T reg cells) have been elusive...
  60. Serdobova I, Pla M, Reichenbach P, Sperisen P, Ghysdael J, Wilson A, et al. Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene. J Exp Med. 1997;185:1211-21 pubmed
  61. Marchingo J, Kan A, Sutherland R, Duffy K, Wellard C, Belz G, et al. T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion. Science. 2014;346:1123-7 pubmed publisher
    ..These data resolve a long-standing costimulation paradox and provide a quantitative paradigm for therapeutically manipulating immune response strength. ..
  62. Petitto J, Huang Z. Molecular cloning of the coding sequence of an interleukin-2 receptor alpha subunit cDNA in murine brain. J Neuroimmunol. 1995;59:135-41 pubmed
  63. Nishikawa H, Kato T, Tawara I, Takemitsu T, Saito K, Wang L, et al. Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts. Proc Natl Acad Sci U S A. 2005;102:9253-7 pubmed
    We examined the role of CD4+CD25+ regulatory T cells in the development of 3-methylcholanthrene (MCA)-induced tumors...
  64. Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A. 2009;106:13974-9 pubmed publisher
    ..Here, we show that IL-10-secreting Tregs can be delineated in normal mice as CD4(+)CD25(-)Foxp3(-) T cells that express lymphocyte activation gene 3 (LAG-3), an MHC-class-II-binding CD4 homolog...
  65. Pontoux C, Banz A, Papiernik M. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int Immunol. 2002;14:233-9 pubmed
    In normal mice a subpopulation of CD4 T cells constitutively expresses the IL-2 receptor alpha chain (CD25)...
  66. Felices M, Lenvik T, Ankarlo D, Foley B, Curtsinger J, Luo X, et al. Functional NK cell repertoires are maintained through IL-2R? and Fas ligand. J Immunol. 2014;192:3889-97 pubmed publisher
    ..These findings show that education-dependent NK cell survival advantages and killing of uneducated NK cells result in the maintenance of a functional repertoire, which may be manipulated to exploit NK cells for cancer immunotherapy. ..
  67. van Hamburg J, de Bruijn M, Ribeiro de Almeida C, Van Zwam M, van Meurs M, de Haas E, et al. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol. 2008;38:2573-86 pubmed publisher
    ..We therefore conclude that although GATA3 allows Th17 differentiation, it acts as an inhibitor of Th17-mediated pathology, through IL-4-dependent and IL-4-independent pathways. ..
  68. Hetzer Egger C, Schorpp M, Haas Assenbaum A, Balling R, Peters H, Boehm T. Thymopoiesis requires Pax9 function in thymic epithelial cells. Eur J Immunol. 2002;32:1175-81 pubmed
    ..Whereas expression of TCRbeta chain genes is readily detectable in the mutant thymus, no expression of the TCRgamma chain was detectable. Our results identify a new genetically defined control point of thymopoiesis. ..
  69. Bachmann M, Wolint P, Walton S, Schwarz K, Oxenius A. Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Eur J Immunol. 2007;37:1502-12 pubmed
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