Il2ra

Summary

Gene Symbol: Il2ra
Description: interleukin 2 receptor, alpha chain
Alias: CD25, Il2r, Ly-43, IL-2 receptor subunit alpha, IL-2-RA, IL-2R alpha chain, IL-2R subunit alpha, IL2-RA, interleukin-2 receptor subunit alpha, p55 chain
Species: mouse

Top Publications

  1. ncbi Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    D M Willerford
    Howard Hughes Medical Institute, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:521-30. 1995
  2. pmc Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
    Carsten Krieg
    Division of Immunology and Allergy, University Hospital of Lausanne, CH 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:11906-11. 2010
  3. ncbi Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    Louise M D'Cruz
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 6:1152-9. 2005
  4. ncbi OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet
    Cortny A Williams
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Immunol 178:7694-702. 2007
  5. ncbi Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    M Papiernik
    INSERM U345, Institut Necker, Paris France
    Int Immunol 10:371-8. 1998
  6. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
  7. ncbi Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus
    David B Klug
    Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Smithville, TX 78957, USA
    J Immunol 169:2842-5. 2002
  8. pmc IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25
    Sven Létourneau
    Division of Immunology and Allergy, University Hospital of Lausanne, CH 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:2171-6. 2010
  9. ncbi Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    Afonso R M Almeida
    Lymphocyte Population Biology, Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur, Paris, France
    J Immunol 169:4850-60. 2002
  10. ncbi Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:3738-45. 1997

Scientific Experts

Detail Information

Publications90

  1. ncbi Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    D M Willerford
    Howard Hughes Medical Institute, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:521-30. 1995
    ..Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation...
  2. pmc Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
    Carsten Krieg
    Division of Immunology and Allergy, University Hospital of Lausanne, CH 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:11906-11. 2010
    ..Notably, IL-2-mediated pulmonary edema was abrogated by a blocking antibody to IL-2Ralpha (CD25), genetic disruption of CD25, or the use of IL-2Rbetagamma-directed IL-2/anti-IL-2 antibody complexes, thereby ..
  3. ncbi Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    Louise M D'Cruz
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 6:1152-9. 2005
    Interleukin 2 signaling is believed to be critically involved in several aspects of CD25(+) CD4(+) regulatory T cell biology, such as intrathymic development, peripheral survival and suppressive function...
  4. ncbi OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet
    Cortny A Williams
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Immunol 178:7694-702. 2007
    ..Finally, we show that CD25-deficient CD4 T cells produce little IFN-gamma in the presence of OX40 costimulation compared with wild type, ..
  5. ncbi Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    M Papiernik
    INSERM U345, Institut Necker, Paris France
    Int Immunol 10:371-8. 1998
    We recently characterized a CD4+ T cell population expressing the IL-2R alpha chain (CD25), producing IL-10 and resisting clonal deletion induced by viral superantigen (vSAG) encoded by mouse mammary tumor virus [MMTV(SW)]...
  6. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules...
  7. ncbi Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus
    David B Klug
    Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Smithville, TX 78957, USA
    J Immunol 169:2842-5. 2002
    ..However, thymocyte-derived signals are required during late fetal stages for continued development and maintenance of TEC subsets in the neonate and adult...
  8. pmc IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25
    Sven Létourneau
    Division of Immunology and Allergy, University Hospital of Lausanne, CH 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:2171-6. 2010
    ..We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis...
  9. ncbi Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    Afonso R M Almeida
    Lymphocyte Population Biology, Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur, Paris, France
    J Immunol 169:4850-60. 2002
    ..In chimeras reconstituted with bone marrow cells from IL-2Ralpha-deficient donors, restitution of a population of CD25(+)CD4(+) T cells prevents the chaotic accumulation of lymphoid cells, and rescues the mice from autoimmune disease ..
  10. ncbi Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:3738-45. 1997
    ..processes, we have bred a class II-restricted TCR transgene into mice deficient in the alpha-chain of the IL-2R, CD25. We show that in response to Ag, T cells from these mice are unable to use IL-2 and, as a result, are less ..
  11. pmc Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene
    P Lecine
    INSERM U119, Marseille, France
    Mol Cell Biol 16:6829-40. 1996
    ..Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor...
  12. ncbi CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism
    Takatoku Oida
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:2516-22. 2003
    Murine CD4(+)CD25(+) regulatory cells have been reported to express latency-associated peptide (LAP) and TGF-beta on the surface after activation, and exert regulatory function by the membrane-bound TGF-beta in vitro...
  13. pmc Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
    Olivier Joffre
    Institut National de la Sante et de la Recherche Medicale, U563, Tolerance and Autoimmunity section, Toulouse, F 31300 France
    Nat Med 14:88-92. 2008
    ..Here we show that in mice treated with clinically acceptable levels of irradiation, regulatory CD4+CD25+Foxp3+ T cells stimulated in vitro with alloantigens induced long-term tolerance to bone marrow and subsequent skin ..
  14. ncbi A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    ..mice containing the Foxp3(gfp) knock-in allele that were genetically deficient in either IL-2 (Il2(-/-)) or CD25 (Il2ra(-/-))...
  15. ncbi Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
    Allison L Bayer
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, 1600 Northwest 10th Avenue, Miami, FL 33136, USA
    J Immunol 178:4062-71. 2007
    IL-2 contributes to the production, function, and homeostasis of CD4+CD25+ T(reg) cells...
  16. ncbi Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development
    T Reya
    Department of Microbiology, University of Pennsylvania, Philadelphia 19104 6076, USA
    Blood 87:190-201. 1996
    ..Together, these observations suggest that CD122 plays a role in regulating normal lymphocyte development in vivo...
  17. ncbi Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire
    Sylvain Fisson
    CNRS UMR 7087 and Université Pierre et Marie Curie, CERVI, Hopital de la Pitie Salpetriere, Paris, France
    Eur J Immunol 36:817-27. 2006
    CD4+ CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases...
  18. ncbi IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    Matthew A Burchill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:280-90. 2007
    ..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3...
  19. ncbi Mouse interleukin-2 receptor alpha gene expression. Delimitation of cis-acting regulatory elements in transgenic mice and by mapping of DNase-I hypersensitive sites
    E Soldaini
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
    J Biol Chem 270:10733-42. 1995
    ..Two, at -0.05 and -5.3 kilobase pairs, are present in resting T cells. A third site appears at -1.35 kilobase pairs in activated T cells. It co-localizes with IL-2-responsive elements identified by transient transfection experiments...
  20. ncbi Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements
    P Sperisen
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    J Biol Chem 270:10743-53. 1995
    ..IL-2 responsiveness requires three distinct elements within the enhancer. Two of these are potential binding sites for STAT proteins...
  21. pmc Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    André Ballesteros-Tato
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY 14642, USA
    Immunity 36:847-56. 2012
    ..Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development...
  22. pmc The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets
    Cliff Y Yang
    Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
    Nat Immunol 12:1221-9. 2011
    ..Furthermore, cytokines altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression...
  23. doi The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation
    Di Jin
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Inflamm Res 61:53-60. 2012
    ..The effect of LEF on CD4(+)CD25(+)T regulatory cells (Treg) was determined in a mouse model of allogeneic bone marrow transplantation.
  24. pmc Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    Matthew A Williams
    Howard Hughes Medical Institute and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 441:890-3. 2006
    ..of autoimmunity, attributable to the central role of IL-2 in the generation, maintenance and function of CD4+CD25+ regulatory T cells...
  25. ncbi Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis
    Philip O Scumpia
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Immunol 177:7943-9. 2006
    Regulatory T cells (Tregs), including natural CD4+CD25+ Tregs and inducible IL-10 producing T regulatory type 1 (T(R)1) cells, maintain tolerance and inhibit autoimmunity...
  26. ncbi B-cell CD25 expression in murine primary and secondary lymphoid tissue
    S Amu
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Immunol 64:482-92. 2006
    B cells are in analogy with T cells capable of expressing functional IL-2 receptors. IL-2R alpha-chain (CD25) positive T cells have been studied in detail but not much is known about CD25 positive B cells...
  27. pmc Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs
    Zhaojun Wang
    Joint Immunology Laboratory of Institute of Health Sciences, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Clin Invest 116:2434-41. 2006
    ..provide what we believe is new evidence indicating that IFN-gamma is critically required for the conversion of CD4+ CD25- T cells to CD4+ Tregs during EAE...
  28. ncbi Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum
    Xiao Ping Cai
    Department of Pathogenic Biology, Jiangsu Province Key Laboratory of Modern Pathogenic Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 38:299-304. 2006
    CD4+CD25+ T cells play a major role in modulating immune response, but few reports have been published about schistosomiasis...
  29. ncbi GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  30. ncbi Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    Rafal Pacholczyk
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Immunity 25:249-59. 2006
    Foxp3(+)CD4(+)CD25(+) regulatory T cells can differentiate from Foxp3(-)CD4(+) medullary thymocytes and Foxp3(-)CD4(+) naive T cells...
  31. ncbi Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation
    Catherine Corbel
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Comp Immunol 31:1082-94. 2007
    ..the adult, NP1 is mainly expressed by CD4(-)CD8(-) double negative cells, CD4+CD8+ double positive cells, and CD4+CD25+ regulatory T cells but barely detected in single CD4+ and CD8+ positive thymocytes...
  32. ncbi IL-2Rbeta links IL-2R signaling with Foxp3 expression
    David M Soper
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Eur J Immunol 37:1817-26. 2007
    ..that the forkhead family member Foxp3 is a critical element in the differentiation and function of mouse CD4(+)CD25(+) regulatory T cells (Treg)...
  33. doi Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    J Immunol 185:5188-97. 2010
    ..Second, Th cells provide CD8(+) T cells with IL-2, thereby enhancing their survival. Thus, Th cells are at the center of an important communication loop with a central role for IL-2/IL-2R and bioactive IL-12...
  34. pmc Early signals during CD8 T cell priming regulate the generation of central memory cells
    Joshua J Obar
    Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 185:263-72. 2010
    ..Furthermore, the extent of early Ag availability, which regulated programmed death-1 and CD25 expression levels, controlled the T(CM)/T(EM) cell lineage decision ultimately through IL-2 and IL-15 signaling ..
  35. pmc Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice
    Halvor S McGee
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Respir Cell Mol Biol 42:331-40. 2010
    ..These mice received three intraperitoneal injections of anti-CD25 antibody (PC61; 250 microg) and Flt3-L (3 microg) daily for 10 days...
  36. doi A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice
    Eunkyeong Jang
    Department of Biomedical Sciences and Institute of Biomedical Sciences, College of Medicine, Hanyang University, Seoul, Korea
    J Immunol 182:4649-56. 2009
    ..In this study, we show that the homeostatically proliferating CD4(+)CD25(-) T cells produce IL-21...
  37. doi Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells
    Samuel Huber
    Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Immunol 182:4633-40. 2009
    TGF-beta induces the conversion of CD4(+)CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg). Activin A is a pleiotropic TGF-beta family member and is expressed in response to inflammatory signals...
  38. doi Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells
    C Jackaman
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Eur Respir J 34:162-75. 2009
    ..Finally, removal of CD25(+) Tregs from the tumour site and lymphoid organs did not alter tumour growth with or without interleukin (IL)-2 or ..
  39. doi Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy
    Bole Tian
    Department of Surgery and Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 87:198-206. 2009
    ..We investigated whether CFA treatment up-regulates CD4+CD25+Foxp3+ regulatory T cells and increases transforming growth factor (TGF)-beta1 production in diabetic NOD mice.
  40. pmc Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner
    Guoping Jiang
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 86:1492-502. 2008
    ..We have shown that hepatic stellate cells (HpSC), well known to participate in liver repairing and fibrosis, mediate potent immunomodulatory functions through induction of activated T-cell death...
  41. ncbi SCART scavenger receptors identify a novel subset of adult gammadelta T cells
    Jan Kisielow
    Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology ETH, Zurich Schlieren, Switzerland
    J Immunol 181:1710-6. 2008
    ..Characterization of SCART2 positive immature and peripheral gammadelta T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities...
  42. pmc A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
    Allison L Bayer
    Department of Microbiology and Immunology, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 181:225-34. 2008
    ..IL-2- and IL-2R-deficient mice are not completely devoid of Foxp3+ cells, but rather lack population of mature CD4+CD25+Foxp3high Treg cells and contain few immature CD4+CD25-Foxp3low T cells...
  43. ncbi CD4+CD25+ regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice
    Sang Mee Kang
    Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul 133 791, Korea
    Mol Cells 25:64-9. 2008
    ..B cells specific to the self antigen glucose-6-phosphate isomerase, less is known about the in vivo roles of CD4(+)CD25(+) regulatory T (T(reg)) cells in the pathology of K/BxN mice...
  44. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..normally among the epithelial cells, however, they are severely impaired to proliferate and differentiate to CD25-positive cells...
  45. pmc The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    Yasutaka Motomura
    Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Nat Immunol 12:450-9. 2011
    ..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells...
  46. pmc Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells
    Zhuoxiao Cao
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:24914-24. 2009
    CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely understood...
  47. ncbi Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 81:223-31. 1995
    ..These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation...
  48. pmc Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance
    R S Keller
    Department of Physiology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1751, USA
    Am J Pathol 158:1079-90. 2001
    ..These data support an important role for beta(1) integrin in normal cardiac function...
  49. ncbi Nitrous oxide antinociception in BXD recombinant inbred mouse strains and identification of quantitative trait loci
    R M Quock
    Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford 61107 1897, USA
    Brain Res 725:23-9. 1996
    ..01 level on seven chromosomes with the most promising marker loci being Il2ra, Hbb, Hmg1rs7 and Gsl5 on chromosomes 2, 7, 16 and 19, respectively (P < 0.002).
  50. ncbi IL-2 receptor alpha chain expression during early B lymphocyte differentiation
    J Chen
    Howard Hughes Medical Institute, Boston, MA
    Int Immunol 6:1265-8. 1994
    ..Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation...
  51. ncbi Differential T cell costimulatory requirements in CD28-deficient mice
    A Shahinian
    Department of Medical Biophysics and Immunology, University of Toronto, Canada
    Science 261:609-12. 1993
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
  52. ncbi Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination
    D Watanabe
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Japan
    Cell 95:17-27. 1998
    ..Furthermore, this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors...
  53. ncbi Mapping HSA10 homologous loci in cattle
    D S Threadgill
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Cytogenet Cell Genet 57:123-6. 1991
    ..The genes mapped include: vimentin (VIM) on HSA10 and MMU2; interleukin 2 receptor (IL2R) on HSA10 and MMU?; ornithine aminotransferase (OAT) on HSA10 and MMU7; hexokinase 1 (HK1) on HSA10 and MMU10; ..
  54. pmc Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor
    S M Zurawski
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    EMBO J 12:5113-9. 1993
    ..The relative spatial locations of these three surfaces are different from the two receptor binding sites known for the structurally related human growth hormone and the significance of this observation is discussed...
  55. pmc Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene
    I Serdobova
    Lymphocyte Biology Unit, Swiss Institute for Experimental Cancer Research, Epalinges, France
    J Exp Med 185:1211-21. 1997
    ....
  56. ncbi Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 6:823-4. 1995
  57. ncbi Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice
    W L Hazenbos
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Immunity 5:181-8. 1996
    ..These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy...
  58. ncbi Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites
    Veronique Imbert
    Lymphocyte Biology Unit, ISREC 155 ch des Boveresses, CH 1006 Epalinges Lausanne, Switzerland
    Eur Cytokine Netw 13:331-9. 2002
    ..These data suggest that the segment between the two Stat5 docking sites of the IL-2Rbeta chain mediates signaling events that, together with Stat5 activation, are essential for the stimulation of IL-2Ralpha gene transcription...
  59. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  60. ncbi BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses
    Qunrui Ye
    Department of Pathology and Laboratory Medicine, Joseph Stokes Jr Research Institute and Biesecker Pediatric Liver Center, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Immunol 34:2750-9. 2004
    ..Taken together, these data indicate the BAFF/BAFF-R pathway contributes to both T and B cell responses and may be an attractive target for control of acute and chronic allograft rejection...
  61. ncbi STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus
    Audrey O'Sullivan
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:7339-45. 2004
    ..IL-12 stimulated increases in IL-2 receptor alpha chain gene (CD25) mRNA levels and surface expression require STAT4...
  62. ncbi Peyer's patch dendritic cells capturing oral antigen interact with antigen-specific T cells and induce gut-homing CD4(+)CD25(+) regulatory T cells in Peyer's patches
    Katsuya Nagatani
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Ann N Y Acad Sci 1029:366-70. 2004
    ..DCs that captured oral antigen interacted with these T cells in the IFR of PP. Some of these T cells acquired a similar phenotype to CD4(+) CD25(+) regulatory T cells and CCR9(+) gut-homing T cells.
  63. ncbi The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells
    G Ortega
    J Immunol 133:1970-5. 1984
    ..Collectively, the results support the hypothesis that these antibodies detect two distinct functional regions of the IL 2 receptor...
  64. ncbi IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
    Warren N D'Souza
    Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 171:5727-35. 2003
    ..Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence...
  65. ncbi Fas is not essential for lamina propria T lymphocyte homeostasis
    David L Boone
    Department of Medicine, Inflammatory Bowel Disease Research Center, Committee on Immunology, The University of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 285:G382-8. 2003
    ..Thus our studies reveal that Fas is dispensable for LP T cell homeostasis and suggest that the intestinal inflammation observed in IL2Ralpha-/- mice is independent of defective Fas-induced cell death...
  66. pmc Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells
    Hiroyoshi Nishikawa
    Second Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    J Exp Med 201:681-6. 2005
    The antigenic targets recognized by naturally occurring CD4(+) CD25(+) regulatory T cells (T reg cells) have been elusive...
  67. pmc An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13026-30. 2002
    ..Here, we provide evidence demonstrating that c-maf, independent of IL-4, is essential for normal induction of CD25 in developing Th2 cells...
  68. ncbi Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2
    G C Webb
    Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra
    Cytogenet Cell Genet 54:164-8. 1990
    ..The gene for the alpha chain of the IL2 receptor in the mouse, Il-2ra, localizes to bands 2A2 or 2A3 on Chromosome 2. This is the first assignment of a gene located on chromosome 10 in humans to Chromosome 2 in the mouse...
  69. ncbi Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R
    Reginald M Gorczynski
    The Toronto Hospital, University Health Network, and Department of Surgery, University of Toronto, Canada
    Transplantation 79:1180-3. 2005
    ..of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. The effect of these mAbs on Treg induced in anti-CD3 activated thymocyte cultures is unknown.
  70. ncbi IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development
    A Rolink
    Basel Institute for Immunology, Switzerland
    Int Immunol 6:1257-64. 1994
    The analysis of the expression of the alpha chain of the IL-2 receptor (CD25, TAC) on the surface of B lineage cells in mouse bone marrow reveals that it is a useful marker to distinguish pre-B-I from pre-B-II cells...
  71. doi Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation
    Dong Gyun Lim
    Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea
    Transplantation 89:928-36. 2010
    ..Thus, it is important to know the effect of immunosuppressive agents on Treg cell therapy...
  72. pmc Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally
    M Pekny
    Department of Medical Biochemistry, University of Goteborg, Sweden
    EMBO J 14:1590-8. 1995
    ..The GFAP-negative mice displayed post-traumatic reactive gliosis, which suggests that GFAP up-regulation, a hallmark of reactive gliosis, is not an obligatory requirement for this process...
  73. ncbi Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
    M Turner
    National Institute for Medical Research, Mill Hill, London, UK
    Nature 378:298-302. 1995
    ..Finally, we show that Syk is not required for signalling through the IL-2 and G-CSF receptors...
  74. pmc CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses
    Joshua J Obar
    Department of Immunology, University of Connecticut Health Center, Farmington CT 06030, USA
    Proc Natl Acad Sci U S A 107:193-8. 2010
    ..We found that expression of CD25 on antigen-specific CD8(+) T cells peaked 3-4 days after initial priming and was dependent on CD4(+) T cell help, ..
  75. pmc Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
    G Bouvier
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, France
    Proc Natl Acad Sci U S A 93:7877-81. 1996
    ..These data formally establish the critical role played by Ebeta in cis-activation of the TCR beta locus for V(D)J recombination during alphabeta T-cell development...
  76. ncbi Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice
    Z Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Am J Transplant 6:2841-50. 2006
    ..We herein demonstrated that efficient repopulation of mouse CD4+CD25+Treg cells was achieved in Balb/c nude mice by grafting neonatal porcine thymic tissue (NP THY)...
  77. doi The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 OXY, UK
    J Clin Immunol 28:685-96. 2008
    ..pathway is necessary to discern the functional basis of the genetic association between the IL-2-IL-21 and IL-2RA/CD25 gene regions and T1D in humans...
  78. ncbi Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    R Moriggl
    Howard Hughes Medical Institute, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 10:249-59. 1999
    ..These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells...
  79. ncbi Multiple gamma c-dependent cytokines regulate T-cell development
    T R Malek
    Dept of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA
    Immunol Today 20:71-6. 1999
    ..Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development...
  80. ncbi Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting
    M Matsumoto
    Division of Informative Cytology, University of Tokushima, Japan
    J Med Invest 46:141-50. 1999
    ....
  81. ncbi Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice
    Shelli L Kirstein
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 302:1238-45. 2002
    ..These results suggest that although ethanol sensitivity and cAMP signaling are determined by multiple genes, they may share certain genetic codetermination...
  82. ncbi Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains
    H Benes
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, USA
    J Bone Miner Res 15:626-33. 2000
    ..Such recurrent appearance of QTLs, especially in crosses involving distantly-related strains, implies that polymorphism at these loci may be favored by evolution and might underlie variation in peak bone density among humans...
  83. pmc Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
    Julie Cabarrocas
    Institut National de la Sante et de la Recherche Medicale U563, Purpan Hospital, 31000 Toulouse, France
    Proc Natl Acad Sci U S A 103:8453-8. 2006
    Thymus-derived regulatory T cells (Tregs) expressing CD4, CD25, and the transcription factor Foxp3 play major roles in preventing autoimmunity...
  84. ncbi Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice
    Cedric Hubeau
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 178:1477-87. 2007
    ..Neonatal pretreatment of naive pups with mAb directed against the IL-2Ralpha chain (CD25), the costimulatory molecule glucocorticoid-induced TNFR family related gene, and the inhibitory molecule CTLA-4 ..
  85. ncbi Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells
    Adam P Kohm
    Department of Microbiology Immunology and the Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Immunol 176:3301-5. 2006
    CD4+CD25+ T regulatory (T(R)) cells are an important regulatory component of the adaptive immune system that limit autoreactive T cell responses in various models of autoimmunity...
  86. ncbi Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis
    P Poussier
    Arthritis and Immune Disorder Research Centre, Toronto, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 118:880-91. 2000
    ..This led us to reassess intraintestinal T lymphopoiesis in these 3 mutant strains...
  87. ncbi The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements
    H P Kim
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 15:159-72. 2001
    ..Thus, the IL-2 inducibility of the IL-2Ralpha gene is unexpectedly mediated by two widely separated regulatory Stat5-dependent elements, located both upstream and downstream of the transcription initiation sites...
  88. pmc Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements
    K Maki
    Department of Immunology, Tokyo Metropolitan Organization for Medical Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    J Exp Med 191:1333-40. 2000
    ..Thus, the pre-BCR signaling through Igbeta appears to regulate the ordered Ig gene rearrangement by altering the Ig locus accessibility...
  89. pmc Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice
    Lingjie Zheng
    Department of Microbiology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Int Immunol 20:517-23. 2008
    ..Such changes were not observed with anti-CD3 mAb-treated B6 mice or B6 CD4+CD25- T cells. TCR transgenic (OT-II...

Research Grants19

  1. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  3. Targeting TLR/CLR to enhance immunoregulation and prevent or treat diabetes.
    Pascale Alard; Fiscal Year: 2007
    ..Studies have shown that CD4+CD25+ regulatory T cell function is reduced in NOD mice and diabetic patients...
  4. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  5. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2007
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  6. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  7. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  8. ITK: an emerging target for treatment of T cell-mediated autoimmune disease
    Leslie J Berg; Fiscal Year: 2011
    ..A better understanding of this mechanism may provide opportunities to prevent the onset of autoimmune processes in susceptible individuals and to treat and cure patients with these diseases. ..