Il27

Summary

Gene Symbol: Il27
Description: interleukin 27
Alias: IL-27, IL-27p28, Il30, p28, IL-27 p28 subunit, IL-27 subunit alpha, IL-27-A, IL27-A, interleukin 30, interleukin-27 subunit alpha
Species: mouse

Top Publications

  1. ncbi Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:7684-91. 2005
  2. ncbi Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes
    Manuel Koch
    Biochemisches Institut, Christian Albrechts Universitat, Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    Biochem Biophys Res Commun 364:483-7. 2007
  3. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
  4. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
  5. ncbi IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 37:1809-16. 2007
  6. pmc IL-27 promotes T cell-dependent colitis through multiple mechanisms
    Jennifer H Cox
    Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 208:115-23. 2011
  7. ncbi Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 180:2752-6. 2008
  8. ncbi IL-27 inhibits the development of regulatory T cells via STAT3
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
    Int Immunol 20:223-34. 2008
  9. ncbi A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    Amit Awasthi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 8:1380-9. 2007
  10. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002

Scientific Experts

  • T Yoshimoto
  • Tetsuaki Hirase
  • Georgia Perona-Wright
  • Marcel Batten
  • Urvashi Bhan
  • Magdalena Huber
  • Jurgen Siebler
  • Anne Elisabeth Mas
  • Toshiyuki Owaki
  • Christiaan J M Saris
  • Junichiro Mizuguchi
  • Jason S Stumhofer
  • Christopher A Hunter
  • Masayuki Asakawa
  • Jidong Zhang
  • Fumio Fukai
  • Cristina M Tato
  • Noriko Morishima
  • Jianguo Liu
  • Stefan Rose-John
  • Sadahiro Kamiya
  • Jürgen Scheller
  • Denise C Fitzgerald
  • Stefan Wirtz
  • Cheng Rong Yu
  • Ahjoku Amadi-Obi
  • Charles E Egwuagu
  • Shulin Li
  • Masanori Matsui
  • Daniel J Cua
  • Yi Chen
  • Yijun Carrier
  • Terrill K McClanahan
  • Amit Awasthi
  • Abdolmohamad Rostami
  • Bruno Gran
  • Guang Xian Zhang
  • Nico Ghilardi
  • Zhenzhen Liu
  • Junfeng Zhang
  • Yuquan Wei
  • Karlo D T Natividad
  • Alejandro V Villarino
  • Xiao Liu
  • Christoph Garbers
  • Sayaka Shibata
  • Akihiko Yoshimura
  • Seung Hoon Baek
  • Ren Xi Wang
  • Julia Diegelmann
  • Jeong su Do
  • Ekaterina K Koltsova
  • Benjamin M Matta
  • Ana Paula Freitas do Rosario
  • Joachim Grötzinger
  • Björn Spudy
  • Jennifer H Cox
  • Yun Sang Lee
  • Hye Sung Kim
  • Atsunobu Takeda
  • Manjiri Sathe
  • Barbara Joyce-Shaikh
  • Huan Ning
  • Xuesong Qian
  • Sophie Lucas
  • Shankar Subramanian Iyer
  • Brandi J Baker
  • Gopal Murugaiyan
  • Céline Molle
  • Shiguo Zhu
  • Christian M Hedrich
  • Jing Jing Li
  • Francois Rousseau
  • Yun Chen
  • Osamu Shimozato
  • Caroline Pot
  • Christoph Holscher
  • Amy E Troy
  • Caroline Diveu
  • Peng Hu
  • Richard S Blumberg
  • Charles F Anderson
  • Aya Shiokawa
  • Juan M Ilarregui
  • Denada Dibra
  • Sandrine Crabé
  • Howard L Weiner
  • Yanxia Cao
  • Vijay K Kuchroo
  • R Wang

Detail Information

Publications89

  1. ncbi Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:7684-91. 2005
    ....
  2. ncbi Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes
    Manuel Koch
    Biochemisches Institut, Christian Albrechts Universitat, Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    Biochem Biophys Res Commun 364:483-7. 2007
    ..Interleukin 27 (IL27) is a recently identified member of this family and has been implicated in the inhibition of TH17 T-cell-responses...
  3. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
    ..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27...
  4. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells...
  5. ncbi IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 37:1809-16. 2007
    ..Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1...
  6. pmc IL-27 promotes T cell-dependent colitis through multiple mechanisms
    Jennifer H Cox
    Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 208:115-23. 2011
    ....
  7. ncbi Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 180:2752-6. 2008
    ..The data presented here indicate a novel mechanism for the induction of IL-10 expression by T cells and provide a mechanistic basis for the suppressive effects of IL-27...
  8. ncbi IL-27 inhibits the development of regulatory T cells via STAT3
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
    Int Immunol 20:223-34. 2008
    ..Thus, IL-27 and TGFbeta mutually control their effects on CD4+ T-cell differentiation, whereby IL-27 favours inflammatory conditions through a STAT3-dependent inhibition of Treg generation...
  9. ncbi A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    Amit Awasthi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 8:1380-9. 2007
    ..Thus, IL-27 and transforming growth factor-beta promote the generation of IL-10-producing Tr1 cells...
  10. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide...
  11. doi IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    Caroline Diveu
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 182:5748-56. 2009
    ..By generating mice deficient for the p28 subunit of IL-27, we showed that IL-27 regulated the severity of delayed-type hypersensitivity response and EAE ..
  12. ncbi Antiproliferative activity of IL-27 on melanoma
    Takayuki Yoshimoto
    Intractable Immune System Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Immunol 180:6527-35. 2008
    ..These results suggest that IL-27 has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy...
  13. pmc IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis
    Amy E Troy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 183:2037-44. 2009
    ..Collectively, these data identify a role for IL-27-IL-27R interaction in controlling the homeostasis of the intestinal T cell pool and in limiting intestinal inflammation through regulation of innate and adaptive immune cell function...
  14. ncbi IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3
    Toshiyuki Owaki
    Intractable Immune System Disease Research Center, Tokyo Medical University, Shinjuku, Tokyo, Japan
    J Immunol 176:2773-80. 2006
    ..These results suggest that IL-27 inhibits CD28-mediated IL-2 production and also IL-2 responses, and that SOCS3, whose expression is induced by IL-27, plays a critical role in the inhibitory effect in a negative feedback mechanism...
  15. ncbi Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism
    Takeru Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
    J Immunol 177:5377-85. 2006
    ..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1...
  16. pmc Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Exp Med 204:141-52. 2007
    ..newest member of the IL-12 family of heterodimeric cytokines composed of the Epstein-Barr virus-induced gene 3 and p28 chains...
  17. doi The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    Sandrine Crabé
    Departement de Pharmacologie, Universite de Montreal, Montreal, Canada
    J Immunol 183:7692-702. 2009
    IL-27 is formed by the association of a cytokine subunit, p28, with the soluble cytokine receptor EBV-induced gene 3 (EBI3). The IL-27R comprises gp130 and WSX-1...
  18. pmc The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Centre Research Institute, Nitona, Chiba, Japan
    Immunology 128:e816-25. 2009
    Interleukin-27 (IL-27) is a new IL-12-related heterodimeric cytokine comprising a novel p28 molecule and the Epstein-Barr-virus-induced gene 3 (EBI3) molecules...
  19. ncbi IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells
    Rosalba Salcedo
    Pediatric Oncology Branch, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
    J Immunol 173:7170-82. 2004
    ..Collectively, these studies suggest that IL-27 could be used therapeutically to potentiate the host antitumor immune response in patients with malignancy...
  20. ncbi Induction of IgG2a class switching in B cells by IL-27
    Takayuki Yoshimoto
    Intractable Immune System Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Immunol 173:2479-85. 2004
    ..Thus, IL-27 may be a novel attractive candidate as a therapeutic agent against diseases such as allergic disorders by not only regulating Th1 differentiation but also directly acting on B cells and inducing IgG2a class switching...
  21. ncbi Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
    Nat Immunol 7:929-36. 2006
    ..Finally, IL-27 suppressed IL-6-mediated T cell proliferation. These data provide a mechanistic explanation for the IL-27-mediated immune suppression noted in several in vivo models of inflammation...
  22. ncbi An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells
    Sadahiro Kamiya
    Intractable Immune System Disease Research Center, Tokyo Medical University, Japan
    J Immunol 173:3871-7. 2004
    ....
  23. ncbi IL-27 induces a Th1 immune response and susceptibility to experimental arthritis
    Yanxia Cao
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 180:922-30. 2008
    ..Our results indicate that IL-27 is critically involved in the induction of inflammation in PGIA. IL-27 functions by inducing the differentiation of IFN-gamma-producing T cells in vivo that are essential for the development of arthritis...
  24. ncbi Antiangiogenic and antitumor activities of IL-27
    Motomu Shimizu
    Medical R and D Center, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Bunkyo ku, Japan
    J Immunol 176:7317-24. 2006
    ..These results suggest that IL-27 possesses potent antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities...
  25. ncbi IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis
    Jifen Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neurol Sci 232:3-9. 2005
    ..Our findings show that IL-27 EBI3 and p28 mRNA were up-regulated to a maximum level at the peak of disease in APC from the CNS and lymph nodes, but not in ..
  26. ncbi No inhibition of IL-27 signaling by soluble gp130
    Jürgen Scheller
    Institut fur Biochemie, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Biochem Biophys Res Commun 326:724-8. 2005
    ..The novel heterodimeric cytokine IL-27 (p28/EBV-induced gene 3) has been shown to act via a heterodimeric receptor complex of gp130 and the WSX-1 receptor, and ..
  27. pmc Interleukin-27 signaling promotes immunity against endogenously arising murine tumors
    Karlo D T Natividad
    Immunological Diseases Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 8:e57469. 2013
    ..This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent...
  28. doi Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice
    Tetsuaki Hirase
    Department of Cardiovascular Medicine, Saga University, Saga, Japan
    Am J Physiol Heart Circ Physiol 305:H420-9. 2013
    ..These findings define a novel inhibitory role for IL-27 in atherosclerosis that regulates macrophage activation in mice. ..
  29. pmc IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    Ana Paula Freitas do Rosario
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Immunol 188:1178-90. 2012
    ..Finally, in this model of malaria, we demonstrate that the generation of protective IL10(+)IFN-γ(+) Th1 cells is dependent on IL-27 signaling and independent of IL-21...
  30. doi Increased synovial expression of IL-27 by IL-17 in rheumatoid arthritis
    Seung Hoon Baek
    Department of Internal Medicine, School of Medicine, Pusan National University, Yangsan si, Gyeongsangnam do, Korea
    Inflamm Res 61:1339-45. 2012
    ..Our aim was to study the influence of IL-17 on IL-27 production in RA...
  31. doi A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation
    Xiao Liu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, PR China
    Biochem Biophys Res Commun 435:306-12. 2013
    IL-30, the p28 subunit of IL-27, interacts with the Epstein-Barr virus-induced gene 3 (EBI3) to form IL-27, which modulates the inflammatory responses in autoimmune and infectious diseases...
  32. pmc Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice
    Ekaterina K Koltsova
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Circ Res 111:1274-85. 2012
    ..The expression of the IL-27 subunit Ebi3 is elevated in human atheromas, yet its function in atherosclerosis remains unknown...
  33. doi Antitumor effects obtained by autologous Lewis lung cancer cell vaccine engineered to secrete mouse interleukin 27 by means of cationic liposome
    Junfeng Zhang
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    Mol Immunol 55:264-74. 2013
    ..Our data suggested that DOTAP:cholesterol cationic liposome was quite useful in generating an autologous tumor cell vaccine and mIL-27 could be therapeutically used to potentiate the host antitumor immunity...
  34. pmc IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
    Benjamin M Matta
    Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 188:5227-37. 2012
    ..These data suggest that IL-27 signaling in pDCs promotes their immunoregulatory function and that IL-27 produced by pDCs contributes to their capacity to regulate immune responses in vitro and in vivo...
  35. pmc IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells
    Zhenzhen Liu
    Department of Pathology and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Eur J Immunol 43:468-79. 2013
    ..cytokines that is comprised of an IL-12 p40-related protein subunit, EBV-induced gene 3, and a p35-related subunit, p28. IL-27 functions through IL-27R and has been shown to have potent antitumor activity via activation of a variety of ..
  36. pmc An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
    Christoph Garbers
    Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany
    J Biol Chem 288:4346-54. 2013
    IL-27 consists of the cytokine subunit p28 and the non-signaling α-receptor EBI3...
  37. pmc The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production
    Cristina M Tato
    Merck Research Laboratories, Palo Alto, California, United States of America
    PLoS ONE 7:e31680. 2012
    ..the absence of activating signals from PILRβ, antigen-presenting cells (APCs) produced increased amounts of IL-27, p28 and promoted IL-10 production in effector T cells...
  38. pmc Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response
    Georgia Perona-Wright
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 109:18535-40. 2012
    ..Our data suggest that CD8+ T-cell activation involves a persistent loss of specific cytokine receptors that determines the functional potential of these cells during rechallenge infection...
  39. pmc Interleukin 27 induces the expression of complement factor H (CFH) in the retina
    Ahjoku Amadi-Obi
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 7:e45801. 2012
    ....
  40. pmc Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells
    Ren Xi Wang
    Molecular Immunology Section, Laboratory of Immunology, NEI, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    J Biol Chem 287:36012-21. 2012
    ..In this study, we have genetically engineered a novel IL27p28/IL12p40 heterodimeric cytokine (p28/p40) that antagonizes signaling downstream of the gp130 receptor...
  41. doi IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions
    Sayaka Shibata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 133:479-88. 2013
    ..These results indicate that IL-27 would act in a proinflammatory manner, and thereby exacerbate the psoriasis-like skin inflammation induced by IMQ...
  42. pmc A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory protei
    Julia Diegelmann
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 287:286-98. 2012
    ..For the first time, we characterize IL-27 as a mediator of intestinal epithelial barrier protection mediated via transcriptional activation of anti-inflammatory and antibacterial target genes...
  43. pmc Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation
    Jeong su Do
    Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 188:230-7. 2012
    ..We propose a new model for maintaining peripheral T cell homeostasis via memory CD4 T cells and CD8(+) DC-derived IL-27 in vivo...
  44. doi Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells
    Yijun Carrier
    Inflammation and Immunology, Pfizer, Cambridge, MA 02118, USA
    Eur J Immunol 42:1393-404. 2012
    ....
  45. ncbi Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells
    J H Zhang
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biol Reprod 69:404-11. 2003
    ..The four genes were induced by gd6, and uNK cells isolated from midgestation transcribed IL-23alpha and IL-27R. This study advances the understanding of uNK cell activation during normal pregnancy...
  46. ncbi Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
    Christine Brender
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    Blood 110:2528-36. 2007
    ..We conclude that enhanced responses to TCR ligation by SOCS3-deficient CD8 T cells are not caused by aberrant TCR-signaling pathways but, rather, that increased IL-27 signaling drives unregulated proliferation in the absence of SOCS3...
  47. ncbi Expression of IL-27 p28 by Theiler's virus-infected macrophages depends on TLR3 and TLR7 activation of JNK-MAP-kinases
    Lara Hause
    Department of Oral Biology and the Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Antiviral Res 76:159-67. 2007
    ..Because expression of IL-27, a macrophage cytokine composed of p28 and EBI3 subunits, has been implicated in DD, we examined IL-27 subunit mRNA expression during TMEV infection of ..
  48. ncbi Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA
    J Immunol 179:3268-75. 2007
    ..IL-27 can potently suppress the effector phase of EAE in vivo and, thus, may have therapeutic potential in autoimmune diseases such as multiple sclerosis...
  49. doi TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice
    Hye Sung Kim
    Department of Pathology, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Immunol 187:4007-17. 2011
    ..TLR2 signaling promotes BIPF by inducing IL-27 and chemokine production by respiratory epithelial cells, thereby inhibiting IL-17 production and recruiting inflammatory cells into the lungs...
  50. pmc Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding
    Jidong Zhang
    Division of Infectious Diseases, Allergy, and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Immunol 186:5885-95. 2011
    ..tuberculosis lysates could activate IL-27 expression in human and mouse macrophages by induction of p28 subunit transcription. However, in parallel with these effects, BCG and M...
  51. pmc Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10
    Yun Sang Lee
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Immunology 132:492-502. 2011
    ..Targeted delivery of IL-27 into immune privileged tissues of the CNS may therefore be beneficial in the treatment of CNS inflammatory diseases, such as uveitis and multiple sclerosis...
  52. ncbi IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan
    J Immunol 179:4415-23. 2007
    ..Thus, IL-27 could provide us with a novel therapeutic way for treating Th2-associated diseases such as bronchial asthma...
  53. pmc A role for IL-27p28 as an antagonist of gp130-mediated signaling
    Jason S Stumhofer
    University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Nat Immunol 11:1119-26. 2010
    ..Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique functions...
  54. ncbi IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways
    Toshiyuki Owaki
    Intractable Immune System Disease Research Center, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    J Immunol 177:7579-87. 2006
    ..This is in contrast to IL-12, which induces it via only p38 MAPK/T-bet-dependent pathway...
  55. ncbi Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells
    Maki Kamakura
    Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Kochi, Japan
    Biochem Biophys Res Commun 349:1372-7. 2006
    ..4 cells with or without lipopolysaccharide (LPS)-treatment. The results indicate that a region (-648 to -364) of p28 promoter was responsible for LPS-induction...
  56. ncbi Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:4886-90. 2003
    ..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
  57. pmc IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    Sophie Lucas
    Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:15047-52. 2003
    ..Therefore, although IL-27 is unable to drive IFN gamma production on its own, it plays an important role in the early steps of TH1 commitment by contributing in a paracrine manner to the control of IL-12 responsiveness...
  58. ncbi New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27
    Masaaki Murakami
    Department of Molecular Oncology, Graduate School of Medicine, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Growth Factors 22:75-7. 2004
  59. ncbi Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27
    Ruth Goldberg
    Department of Immunology, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    J Immunol 173:6465-71. 2004
    ..member of the long-chain, four-helix bundle cytokines, which consist of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related polypeptide...
  60. ncbi IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice
    John E Pearl
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Immunol 173:7490-6. 2004
    ..Because IFN-gamma is detrimental to the survival of effector T cells, we hypothesize that the reduced IFN-gamma within the IL-27R(-/-) lung is responsible for the increased accumulation of lymphocytes within the mycobacterial granuloma...
  61. ncbi Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27
    Noriko Morishima
    Intractable Immune System Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Immunol 175:1686-93. 2005
    ..These results suggest that IL-27 directly acts on naive CD8+ T cells in T-bet-dependent and -independent manners and augments generation of CTL with enhanced granzyme B expression...
  62. ncbi A role for IL-27 in early regulation of Th1 differentiation
    Toshiyuki Owaki
    Intractable Immune System Disease Research Center, Tokyo Medical University, Japan
    J Immunol 175:2191-200. 2005
    ..Considering that IL-27 is produced from macrophages and DCs earlier than IL-12, the present results suggest that IL-27 may play a pivotal role in early efficient induction of Th1 differentiation until sufficient IL-12 is produced...
  63. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
    ..Collectively, these data identify IL-27 as a key negative regulator of innate immune cell function in septic peritonitis. Furthermore, in vivo blockade of IL-27 is a novel potential therapeutic target for treatment of sepsis...
  64. doi Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages
    Shankar Subramanian Iyer
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 185:6599-607. 2010
    ..Finally, through systematic functional promoter-reporter analysis, we identify three cis elements within the proximal IL-10 promoter that play an important role in regulating transcription of IL-10 in response to IL-27...
  65. pmc IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants
    Francois Rousseau
    Unité Mixte Institut National de la Santé et de la Recherche Médicale 564, Centre Hospitalier Universitaire d Angers, 49033 Angers, France
    Proc Natl Acad Sci U S A 107:19420-5. 2010
    ..structural proximities with the ciliary neurotrophic factor group of cytokines and highlighted the contribution of p28 Trp(97), as well as of EBI3 Phe(97), Asp(210), and Glu(159), as key residues in the interactions between both ..
  66. pmc Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27
    Yun Chen
    Department of Immunology, Learner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Hepatol 51:510-9. 2009
    ..The aim of this study was to evaluate liver DC response to LPS stimulation...
  67. pmc Notch regulates IL-10 production by T helper 1 cells
    Sascha Rutz
    Deutsches Rheuma ForschungsZentrum Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 105:3497-502. 2008
    ..This pathway may provide unique opportunities for therapeutic intervention in Th1-driven immune diseases and for Th1-associated vaccination strategies...
  68. pmc Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    Caroline Pot
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 183:797-801. 2009
    ..ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells...
  69. pmc IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    Marcel Batten
    Garvan Institute of Medical Research, Darlinghurst, Sydney NSW 2010, Australia
    J Exp Med 207:2895-906. 2010
    ..Together, our data show a nonredundant role for IL-27 in the development of T cell-dependent antibody responses...
  70. ncbi STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production
    Toshiyuki Owaki
    Intractable Immune System Disease Research Center, Department of Immunology, Tokyo Medical University, Tokyo, Japan
    J Immunol 180:2903-11. 2008
    ..Thus, IL-27 may be a cytokine, which activates both STAT1 and STAT3 through distinct receptor subunits, WSX-1 and gp130, respectively, to mediate its individual immune functions...
  71. doi Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK
    Anne Elisabeth Mas
    Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
    Am J Reprod Immunol 59:323-38. 2008
    ..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation...
  72. ncbi [Expression of EBI3 and p28 mRNA in the brain and spinal cord of chronic model of experimental autoimmune encephalomyelitis in C57BL/6J mice]
    Jin jin Yan
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:1028-36. 2008
    To investigate the expression of EBI3 and p28 mRNA (the 2 subunits of IL-27) in the brain and spinal cord of the model of experimental autoimmune encephalomyelitis (EAE), and to explore their effect on EAE.
  73. ncbi Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis
    Juergen Siebler
    First Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 180:30-3. 2008
    ..We found an up-regulation of hepatic EBI3 and p28 expression and augmented levels of IL-27 in wild-type mice after ConA administration, suggesting a potential ..
  74. doi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  75. pmc IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:4619-27. 2009
    ..The results demonstrate the pleiotropic effects that IL-27 has on L. major-driven Th1, Th2, and Th17 development, and reinforce its function as a key regulatory cytokine that controls the balance between immunity and pathology...
  76. doi Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process
    Céline Molle
    Institute for Medical Immunology, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 184:1784-92. 2010
    ..These results highlight the complex molecular interplay between TLRs and type I IFNs for the control of IL-27 synthesis...
  77. pmc Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4+ T cell activation; influence of IL-27
    Christian M Hedrich
    Johns Hopkins Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, N Wolfe Street, E5410, Baltimore, MD 21205, USA
    Mol Immunol 48:73-81. 2010
    ....
  78. doi IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  79. pmc IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors
    Shiguo Zhu
    School of Medicine, Institute of Medical Science, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Immunol 184:2348-54. 2010
    ..m. electroporation, provides a simple but effective approach for eliminating inaccessible residual tumors...
  80. pmc Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia
    Urvashi Bhan
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e9896. 2010
    ..In conclusion, our studies indicate that TLR4 and TLR9 have both non-redundant and cooperative roles in lung innate responses during Gram-negative bacterial pneumonia and are both critical for IL-17 driven antibacterial host response...
  81. pmc Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    Jidong Zhang
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 285:21269-81. 2010
    ..IL-27 consists of EBI3 (Epstein-Barr virus-induced gene 3) and p28 subunits...
  82. pmc Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:11495-500. 2010
    ..Thus, our results identify a previously unknown pathway by which IFN-gamma limits IL-17-mediated autoimmune inflammation through differential regulation of OPN and IL-27 expression in DCs...
  83. pmc IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia
    Brandi J Baker
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Glia 58:1082-93. 2010
    ..These studies are the first to demonstrate the proinflammatory effects of OSM in microglia, and also identify IL-27 as a novel inhibitor of inflammatory processes in these cells...
  84. doi The pathogenic role of interleukin-27 in autoimmune diabetes
    R Wang
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road, No 27, Beijing 100850, China
    Cell Mol Life Sci 65:3851-60. 2008
    ..These results demonstrate a pathogenic role of IL-27 in T cell-mediated autoimmune diabetes...
  85. pmc Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance
    Denada Dibra
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Cancer Res 69:5505-13. 2009
    ..Our results reveal an IL-27-independent function of WSX1: sensitizing NK cell-mediated antitumor surveillance via a NKG2D-dependent mechanism...
  86. doi IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance
    Aya Shiokawa
    Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Immunol Lett 125:7-14. 2009
    ..These results suggest that IL-10 and IL-27 producing DC are increased by interaction with antigen specific T cells in PP, and these DC act as an inducer of IL-10 producing T cells in oral tolerance...
  87. ncbi Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis
    Sabine Siegemund
    Institute of Immunology, College of Veterinary Medicine, An den Tierkliniken 11, 04103, Leipzig, Germany
    Immunobiology 212:739-50. 2007
    ..Taken together, our results point to cDC rather than MPhi as the major producers of the IL-12 family members during in vitro infection with SE. The mechanisms of recognition of SE, however, appear to be the same for cDC and MPhi...
  88. doi Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma
    Peng Hu
    Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Mol Immunol 46:1654-62. 2009
    ..Together our data suggest that IL-27 and IL-23 may be two novel and attractive candidate agents to apply to cancer immunotherapy...
  89. pmc Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice
    Masanori Matsui
    Department of Microbiology, Saitama Medical School, Saitama, Japan
    J Virol 78:9093-104. 2004
    ..The two novel cytokines might offer new prophylactic and therapeutic strategies against infectious pathogens such as HCV...