Il20ra

Summary

Gene Symbol: Il20ra
Description: interleukin 20 receptor, alpha
Alias: E230031K19, interleukin-20 receptor subunit alpha, IL-20 receptor subunit alpha, IL-20R-alpha, IL-20R1, IL-20RA
Species: mouse
Products:     Il20ra

Top Publications

  1. Hsu Y, Chen W, Chan C, Wu C, Sun Z, Chang M. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011;208:1849-61 pubmed publisher
    ..We have identified a pivotal role of IL-20 in osteoclast differentiation, and we conclude that anti-IL-20 monoclonal antibody is a potential therapeutic for protecting against osteoporotic bone loss. ..
  2. Hsu Y, Li H, Sung J, Chen W, Hou Y, Chang M. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS ONE. 2013;8:e56028 pubmed publisher
    ..Therefore, we conclude that IL-19 mediates kidney, liver, and lung tissue damage in murine AKI and that blocking IL-19 signaling may provide a potent therapeutic strategy for treating AKI. ..
  3. Kumari S, Bonnet M, Ulvmar M, Wolk K, Karagianni N, Witte E, et al. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013;39:899-911 pubmed publisher
    ..Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-?B, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation. ..
  4. Wei C, Chang M. Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition. Genes Immun. 2009;10:237-47 pubmed publisher
    ..These effects of mIL-20R1a on CaOx-exposed renal epithelial cells showed that mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice. ..
  5. Abd Nikfarjam B, Ebtekar M, Sabouni F, Pourpak Z, Kheirandish M. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation. Iran J Immunol. 2013;10:62-9 pubmed publisher
    ..IL-20R1 and IL-20R2 are constitutively express in the brain. Since most neuropathological processes involve astrocytes and inflammatory cytokines, these findings have important implications for future therapeutic strategies. ..