Gene Symbol: Il20ra
Description: interleukin 20 receptor, alpha
Alias: E230031K19, interleukin-20 receptor subunit alpha, IL-20 receptor subunit alpha, IL-20R-alpha, IL-20R1, IL-20RA
Hsu Y, Chen W, Chan C, Wu C, Sun Z, Chang M. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011;208:1849-61 pubmed publisher
..We have identified a pivotal role of IL-20 in osteoclast differentiation, and we conclude that anti-IL-20 monoclonal antibody is a potential therapeutic for protecting against osteoporotic bone loss. ..
Hsu Y, Li H, Sung J, Chen W, Hou Y, Chang M. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS ONE. 2013;8:e56028 pubmed publisher
..Therefore, we conclude that IL-19 mediates kidney, liver, and lung tissue damage in murine AKI and that blocking IL-19 signaling may provide a potent therapeutic strategy for treating AKI. ..
Kumari S, Bonnet M, Ulvmar M, Wolk K, Karagianni N, Witte E, et al
. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013;39:899-911 pubmed publisher
..Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-?B, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation. ..
Wei C, Chang M. Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition. Genes Immun. 2009;10:237-47 pubmed publisher
..These effects of mIL-20R1a on CaOx-exposed renal epithelial cells showed that mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice. ..
Abd Nikfarjam B, Ebtekar M, Sabouni F, Pourpak Z, Kheirandish M. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation. Iran J Immunol. 2013;10:62-9 pubmed publisher
..IL-20R1 and IL-20R2 are constitutively express in the brain. Since most neuropathological processes involve astrocytes and inflammatory cytokines, these findings have important implications for future therapeutic strategies. ..