Gene Symbol: Il17rb
Description: interleukin 17 receptor B
Alias: Evi27, IL-17ER, IL-17Rh1, IL17RH1, Il17br, interleukin-17 receptor B, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, ecotropic viral integration site 27, interleukin 17B receptor
Species: mouse
Products:     Il17rb

Top Publications

  1. Maezawa Y, Nakajima H, Suzuki K, Tamachi T, Ikeda K, Inoue J, et al. Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. J Immunol. 2006;176:1013-8 pubmed
    ..Taken together, these results indicate that TRAF6 plays a critical role in IL-25R-mediated NF-kappaB activation and gene expression. ..
  2. Rickel E, Siegel L, Yoon B, Rottman J, Kugler D, Swart D, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008;181:4299-310 pubmed
    ..These data demonstrate for the first time that IL-25-mediated activities require both IL-17RB and IL-17RA and provide another example of an IL-17 family ligand that utilizes a heteromeric receptor complex. ..
  3. Pan G, French D, Mao W, Maruoka M, Risser P, Lee J, et al. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J Immunol. 2001;167:6559-67 pubmed
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  4. Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, et al. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J Exp Med. 2008;205:2727-33 pubmed publisher
    ..We identified a novel subset of natural killer T (NKT) cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 (also known as IL-17E) and is essential for the induction of AHR...
  5. Stock P, Lombardi V, Kohlrautz V, Akbari O. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 2009;182:5116-22 pubmed publisher
    ..Overall, our data suggest a critical role for iNKT cells in IL-25-mediated AHR. These results may lead to novel therapeutic approaches to target IL-17RB(+) iNKT cells for the treatment of allergic asthma. ..
  6. Dolgachev V, Petersen B, Budelsky A, Berlin A, Lukacs N. Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. J Immunol. 2009;183:5705-15 pubmed publisher
    ..Overall, these studies suggest a complex relationship between SCF, bone marrow-derived IL-25-responsive myeloid cells, Th2 cytokines, and chronic allergic disease. ..
  7. Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367-70 pubmed publisher
    ..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
  8. Saenz S, Siracusa M, Perrigoue J, Spencer S, Urban J, Tocker J, et al. IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature. 2010;464:1362-6 pubmed publisher
  9. Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, et al. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol. 2014;192:4032-42 pubmed publisher
    ..These findings provide mechanistic insights into the development of type 2 immunity to airborne allergens and recognize airway UA as a key player that regulates the process in respiratory mucosa. ..

More Information


  1. Han H, Thelen T, Comeau M, Ziegler S. Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest. 2014;124:5442-52 pubmed publisher
    ..These results demonstrate a role for TSLP and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions. ..
  2. Tian E, Sawyer J, Largaespada D, Jenkins N, Copeland N, Shaughnessy J. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene. 2000;19:2098-109 pubmed
    b>Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias...
  3. Petersen B, Budelsky A, Baptist A, Schaller M, Lukacs N. Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology. Nat Med. 2012;18:751-8 pubmed publisher
    ..b>Il17rb(-/-) mice showed reduced lung pathology after chronic allergen exposure and decreased type 2 cytokine production ..
  4. Kim B, Siracusa M, Saenz S, Noti M, Monticelli L, Sonnenberg G, et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med. 2013;5:170ra16 pubmed publisher
    ..Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation. ..
  5. Reynolds J, Lee Y, Shi Y, Wang X, Angkasekwinai P, Nallaparaju K, et al. Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation. Immunity. 2015;42:692-703 pubmed publisher
    ..Moreover, IL-25 was found to promote IL-6 production from colon epithelial cells, which was inhibited by IL-17B. Therefore, our data demonstrate that IL-17B is an anti-inflammatory cytokine in the IL-17 family. ..
  6. Watarai H, Sekine Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, et al. Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol. 2012;10:e1001255 pubmed publisher
    ..In this study we demonstrated that the IL-17RB?iNKT cell subsets develop distinct from classical iNKT cell developmental stages in the thymus and play important roles in the pathogenesis of airway diseases...
  7. Iijima K, Kobayashi T, Hara K, Kephart G, Ziegler S, McKenzie A, et al. IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol. 2014;193:1549-59 pubmed publisher
    ..Thus, chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process. ..
  8. Hu Y, Ota N, Peng I, Refino C, Danilenko D, Caplazi P, et al. IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2010;184:4307-16 pubmed publisher
    ..Finally, Il-17rc(-/-) mice develop much milder disease in an experimental autoimmune encephalomyelitis model, supporting an essential role for IL-17RC in mediating immune-mediated CNS inflammation. ..
  9. Hams E, Locksley R, McKenzie A, Fallon P. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191:5349-53 pubmed publisher
    ..Our data identify a mechanism whereby IL-25 eliciting IL-13-producing innate cells regulates inflammation in adipose tissue and prevents diet-induced obesity. ..
  10. Hams E, Armstrong M, Barlow J, Saunders S, Schwartz C, Cooke G, et al. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A. 2014;111:367-72 pubmed publisher
    ..These results suggest the potential of therapeutically targeting IL-25 and ILC2 for the treatment of human fibrotic diseases. ..
  11. Nishihara H, Kobayashi N, Kimura Yoshida C, Yan K, Bormuth O, Ding Q, et al. Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet. 2016;12:e1006380 pubmed publisher
    ..The present study provides a new perspective suggesting that a huge variety of TEs, in combination, could have accelerated the diversity of cis-regulatory elements involved in morphological evolution. ..
  12. Zaiss M, Maslowski K, Mosconi I, Guenat N, Marsland B, Harris N. IL-1? suppresses innate IL-25 and IL-33 production and maintains helminth chronicity. PLoS Pathog. 2013;9:e1003531 pubmed publisher
    ..Taken together, these data indicate that Hp promotes the release of host-derived IL-1? that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity. ..
  13. Horvath D, Radin J, Cho S, Washington M, Algood H. The interleukin-17 receptor B subunit is essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. PLoS ONE. 2013;8:e60363 pubmed publisher
    ..These data indicate that signaling through the IL-17 receptor B subunit is not necessary for control of Helicobacter pylori in our model...
  14. Zhang B, Liu C, Qian W, Han Y, Li X, Deng J. Crystal structure of IL-17 receptor B SEFIR domain. J Immunol. 2013;190:2320-6 pubmed publisher
    ..To our knowledge, this study provides the first structural view of the IL-17R intracellular signaling, unraveling the mechanism for the specificity of SEFIR versus Toll/IL-1R domain in their respective signaling pathways. ..
  15. Siracusa M, Saenz S, Wojno E, Kim B, Osborne L, Ziegler C, et al. Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity. 2013;39:1158-70 pubmed publisher
    ..These data identify that TSLP-induced EMH contributes to the development of allergic inflammation and indicate that EMH is a conserved mechanism of innate immunity. ..
  16. Petersen B, Dolgachev V, Rasky A, Lukacs N. IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease. J Leukoc Biol. 2014;95:809-815 pubmed
  17. Huang C, Yang C, Jeng Y, Chen C, Wu H, Chang Y, et al. Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-?B-mediated antiapoptotic pathway. Oncogene. 2014;33:2968-77 pubmed publisher
    ..These results suggest that the amplified IL-17RB/IL-17B signaling pathways may serve as a therapeutic target for developing treatment to manage IL-17RB-associated breast cancer. ..
  18. Cardoso V, Chesné J, Ribeiro H, García Cassani B, Carvalho T, Bouchery T, et al. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature. 2017;549:277-281 pubmed publisher
    ..Our work reveals that neuron-ILC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses. ..
  19. Byers D, Alexander Brett J, Patel A, Agapov E, Dang Vu G, Jin X, et al. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest. 2013;123:3967-82 pubmed publisher
    ..Together, these findings provide a paradigm for the role of the innate immune system in chronic disease based on the influence of long-term epithelial progenitor cells programmed for excess IL-33 production. ..
  20. Hardman C, Panova V, McKenzie A. IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation. Eur J Immunol. 2013;43:488-98 pubmed publisher
    ..Il33(Cit/+) mice have enabled new insights into the initiation of type-2 responses and will provide an important tool for further dissection of this important inflammatory pathway in vivo. ..
  21. Saenz S, Siracusa M, Monticelli L, Ziegler C, Kim B, Brestoff J, et al. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J Exp Med. 2013;210:1823-37 pubmed publisher