Genomes and Genes
Gene Symbol: Il12a
Description: interleukin 12a
Alias: IL-12p35, Il-12a, Ll12a, p35, interleukin-12 subunit alpha, CLMF p35, IL-12 p35 subunit, IL-12 subunit p35, cytotoxic lymphocyte maturation factor 35 kDa subunit, interleukin 12a p35 subunit, interleukin-12 p35 subunit
Publications148 found, 100 shown here
- IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorderK Hong
Protein Design Labs, Inc, Fremont, CA 94555, USA
J Immunol 162:7480-91. 1999..Overall, these results suggest that IL-12, independently of IFN-gamma, is able to induce pathogenic, inflammatory T cells that are able to induce psoriasiform lesions in mice...
- Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12Burkhard Becher
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Clin Invest 110:493-7. 2002..IL-12 is a heterodimer composed of a p35 subunit and a common p40 subunit shared by other cytokines...
- Generation of CD8 T cell memory is regulated by IL-12Erika L Pearce
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 179:2074-81. 2007..These results have implications for understanding memory T cell development and enhancing vaccine efficacy, and offer new insight into the role of IL-12 in coordinating the innate and adaptive immune response...
- IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2M van Den Broek
Institute for Experimental Immunology, Zurich, Switzerland
J Immunol 164:371-8. 2000..Thus, our results identify a new role for IL-12 in defense beyond the induction of IFN-gamma and show that IL-4 and IL-10 modulate host protective responses to VV...
- The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient micePiers Davenport
Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre Level 5 Block E, 246 Clayton Road, Clayton, Victoria, Australia 3168
Am J Pathol 163:1117-25. 2003..05). This suggests that both Th1 and Th2 cytokines play roles throughout the development of atherosclerosis in various vascular sites in apoE(-/-) mice...
- Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cellsMasashi Ohtani
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Blood 112:635-43. 2008..The signaling pathway downstream of PI3K would be a good target to modulate the Th1/Th2 balance in immune responses in vivo...
- Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factorR E Ploemacher
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Leukemia 7:1374-80. 1993..The observed activity of IL-12, however, required the presence of a least two factors, i.e. either IL-3 + IL-11, or IL-3 + SF...
- Signal 3 availability limits the CD8 T cell response to a solid tumorJulie M Curtsinger
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 178:6752-60. 2007....
- Cloning and expression of murine IL-12D S Schoenhaut
Department of Molecular Genetics, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110 1197
J Immunol 148:3433-40. 1992..the murine subunits with their human counterparts revealed that the p40 subunits are more highly conserved than the p35 subunits (70% vs 60% identity, respectively). The sizes of the p35 and p40 subunit mRNA were estimated to be 1...
- IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infectionJ L Flynn
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 155:2515-24. 1995..tuberculosis-infected gko mice, transgenic mice in which the IFN-gamma gene has been disrupted, indicating that IL-12 does not induce protection against tuberculosis in mice in the absence of IFN-gamma...
- Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonistS Gillessen
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110
Eur J Immunol 25:200-6. 1995..has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and p35. It was recently reported that supernatants from cultures of mouse IL-12 (moIL-12) p40-transfected COS cells could ..
- IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responsesJ Magram
Department of Biotechnology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
Immunity 4:471-81. 1996..However, other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL-12...
- Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell responseF Mattner
Department of Infectious Diseases, F Hoffmann La Roche AG, Basel, Switzerland
Eur J Immunol 26:1553-9. 1996Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further ..
- Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient miceK W McIntyre
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110, USA
Eur J Immunol 26:2933-8. 1996..Taken together, these results demonstrate an important role for IL-12 in the pathogenesis of CIA, although it is not absolutely required for disease development...
- Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitisT K Tarrant
Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
J Immunol 161:122-7. 1998..Lastly, the diminished ability of primed wt lymphocytes to induce EAU in 12KO mice indicates a role for endogenous IL-12 in the efferent phase of disease expression that is distinct from its role during Ag priming...
- IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient miceN J Davidson
DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304, USA
J Immunol 161:3143-9. 1998....
- Requirement for type 2 NO synthase for IL-12 signaling in innate immunityA Diefenbach
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
Science 284:951-5. 1999..Activation of Tyk2 in NK cells by IFN-alpha/beta also required NOS2. Thus, NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity...
- IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathologyA R Satoskar
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston 02115, USA
Eur J Immunol 30:834-9. 2000..These findings indicate that although endogenous IL-12 is critical for the development of protective immunity to L. donovani, it is also responsible for inducing the significant immunopathology associated with visceral leishmaniasis...
- Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ Chen
Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
Nature 407:916-20. 2000..Our results demonstrate the existence of a new cytokine receptor involved in regulating the adaptive immune response and critical to the generation of a Th1 response...
- Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is presentAndrea M Cooper
Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 168:1322-7. 2002..of the IL-12p40 subunit is more detrimental to the generation of protective responses than is the absence of the p35 subunit...
- Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 productionCaroline Demangel
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Eur J Immunol 32:994-1002. 2002....
- Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signalingMarina A Freudenberg
Max Planck Institut fur Immunbiologie, Freiburg, Germany
J Immunol 169:1665-8. 2002..This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections...
- A profibrotic function of IL-12p40 in experimental pulmonary fibrosisFrancois Huaux
Units of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Brussels, Belgium
J Immunol 169:2653-61. 2002..Together, our data suggest that IL-12p40 plays an important role in silica-induced pulmonary inflammation and fibrosis, possibly by exacerbating macrophage recruitment...
- Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionKhuong B Nguyen
Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 169:4279-87. 2002....
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainDaniel J Cua
Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
Nature 421:744-8. 2003Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits...
- Intracellular localization of the p35 subunit of murine IL-12Hema Vaidyanathan
Center for Biological Chemistry, University of Nebraska, Lincoln, NE 68588, USA
Cytokine 21:120-8. 2003Production of interleukin-12 (IL-12), a heterodimer of p35 and p40 subunits, is limited by p35 expression. A long and a short murine p35 mRNA potentially encoding proteins differing in pre-sequence size are produced...
- Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activationPing Ying Pan
Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 172:4779-89. 2004....
- IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12Linda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:1887-93. 2004..gondii, mice lacking the p40 subunit (common to IL-12 and IL-23) and mice that lack IL-12 p35 (specific for IL-12) were infected and their responses were compared...
- CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12Anton V Gorbachev
Department of Immunology, Cleveland Clinic Foundation, OH 44195, USA
J Immunol 173:2443-52. 2004..These results indicate that hpLC stimulated by CD40 ligation use a mechanism distinct from increased IL-12 production to promote Ag-specific T cell development to IFN-gamma-producing cells...
- Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cellsJavier O Valenzuela
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 174:600-4. 2005..The time courses of expression suggest that Bcl-2 and Bcl-x(L) promote survival early in the response, whereas Bcl-3 acts later in the response...
- Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper functionRoman Spörri
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
Nat Immunol 6:163-70. 2005....
- Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17Laura I Rutitzky
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 175:3920-6. 2005..Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis...
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6David Yen
Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
J Clin Invest 116:1310-6. 2006..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
- IL-23 promotes tumour incidence and growthJohn L Langowski
Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
Nature 442:461-5. 2006..We show that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours...
- Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivationMichael H Shaw
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA
J Immunol 176:7263-71. 2006..Thus, Tyk2 can be viewed as a dual-function Jak, mediating both pro and anti-inflammatory cytokine responses...
- Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitisChristoph Becker
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 177:2760-4. 2006..Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis...
- Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiationNaofumi Takemoto
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
J Immunol 177:7515-9. 2006....
- CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPSDimitris Skokos
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 204:1525-31. 2007..Thus, activation of the two DC subsets by TLR4 leads to Th1 responses by two distinct MyD88-dependent pathways...
- IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cellsWanda Niedbala
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Eur J Immunol 37:3021-9. 2007Epstein-Barr virus-induced gene 3 (EBI3) and the p35 subunit of IL-12 have been reported to form a heterodimeric hematopoietin in human and mouse...
- IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistanceTeresa Zelante
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Eur J Immunol 37:2695-706. 2007..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
- The inhibitory cytokine IL-35 contributes to regulatory T-cell functionLauren W Collison
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nature 450:566-9. 2007..we demonstrate that Epstein-Barr-virus-induced gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by mouse Foxp3+ (forkhead box P3) T(reg) cells but not by ..
- TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasisJan Liese
Institute of Medical Microbiology and Hygiene, Department of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
Eur J Immunol 37:3424-34. 2007..We conclude that TLR9 signaling is essential for NK cell activation, but dispensable for a protective T cell response to L. major in vivo...
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryDror Luger
Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 205:799-810. 2008..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
- IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii InfectionDouglas C Wilson
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 180:5935-45. 2008..gondii...
- Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17Silke M Schulz
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 181:7891-901. 2008..To analyze the role of IL-23 in the absence of IL-12, low doses of S. Enteritidis were administered to p35(-/-) mice (lacking IL-12), p35/19(-/-) mice (lacking IL-12 and IL-23), p35/40(-/-) mice (lacking IL-12, IL-23, and ..
- Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homingTerrence Town
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 30:242-53. 2009..and mice deficient in IL-12 p40 and IL-23 p40 (Il12b(-/-)) or IL-23 p19 (Il23a(-/-)), but not IL-12 p35 (Il12a(-/-)), responded similarly to Tlr7(-/-) mice, with increased susceptibility to lethal WNV encephalitis...
- Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasisHeather R Conti
Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
J Exp Med 206:299-311. 2009..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
- Programming for CD8 T cell memory development requires IL-12 or type I IFNZhengguo Xiao
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 182:2786-94. 2009..These data demonstrate that IL-12 and type I IFN play an essential early role in determining whether Ag encounter by naive CD8 T cells results in formation of a protective memory population...
- Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memoryPujya Agarwal
Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 183:1695-704. 2009....
- Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensisYinyao Lin
Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
Immunity 31:799-810. 2009..Together, these findings illustrate a biological function for IL-17A in regulating IL-12-Th1 cell immunity and host responses to an intracellular pathogen...
- IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasisMichele W L Teng
Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Proc Natl Acad Sci U S A 107:8328-33. 2010..Overall, these data indicate the general role that IL-23 plays in suppressing natural or cytokine-induced innate immunity, promoting tumor development and metastases independently of IL-17A...
- IL-35-mediated induction of a potent regulatory T cell populationLauren W Collison
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Nat Immunol 11:1093-101. 2010..Thus, iT(R)35 cells constitute a key mediator of infectious tolerance and contribute to T(reg) cell-mediated tumor progression. Furthermore, iT(R)35 cells generated ex vivo might have therapeutic utility...
- H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunitySalvador Iborra
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
Blood 117:5102-11. 2011..Furthermore, we demonstrate for the first time that H-ras and N-ras act as critical controllers of Th1 responses, mostly by transmitting TCR signals for Th1 priming of CD4⁺ T cells...
- IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responsesRita Vasconcellos
Centre for Rheumatology Research, University College London, London WC1E 6JF, United Kingdom
J Immunol 187:3402-12. 2011..The restoration of disease phenotype after anti-IL-27 administration indicates that the IL-12p35 subunit acts as negative regulator of the developing IL-27 response in this model of arthritis...
- CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoitesMona Mashayekhi
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Immunity 35:249-59. 2011..These results reveal that the function of CD8α(+) DCs extends beyond a role in cross-presentation and includes a critical role for activation of innate immunity through IL-12 production during T. gondii infection...
- Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiationJoshua J Obar
Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
J Immunol 187:4967-78. 2011..Thus, our data shed light on how varying the context of T cell priming alters downstream effector and memory CD8(+) T cell differentiation...
- Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responsesSelina Jessica Keppler
Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
PLoS ONE 7:e40865. 2012..Furthermore our results demonstrate that the pathogen-induced overall inflammatory milieu and not the antigen load and/or the quality of antigen presentation critically determine the signal 3 dependence of CD8 T cells...
- Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12Shahin Shafiani
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Immunity 38:1261-70. 2013..These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity...
- Regulation of interleukin 12 p40 expression through an NF-kappa B half-siteT L Murphy
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Cell Biol 15:5258-67. 1995..Finally, we find that IFN-gamma treatment of cells enhances this binding interaction, thus potentially providing a mechanism for IFN-gamma augmentation of IL-12 production by macrophages...
- Expression of murine IL-12 is regulated by translational control of the p35 subunitJ M Babik
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Immunol 162:4069-78. 1999IL-12 is a heterodimer of two subunits, p35 and p40, encoded by separate genes that are regulated independently...
- Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infectionL P Cousens
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Exp Med 189:1315-28. 1999....
- Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infectionG C Pien
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Immunol 165:4787-91. 2000..Taken together, our results delineate contrasting compartmental requirements for IL-18 and suggest that preservation of local, hepatic IFN-gamma production is critical for host defense during murine cytomegalovirus challenge...
- A protective and agonistic function of IL-12p40 in mycobacterial infectionC Holscher
Medical Research Council Unit Immunology in Infectious Diseases, Department of Immunology, University of Cape Town, Cape Town, South Africa
J Immunol 167:6957-66. 2001..Together, these results show evidence for a protective and agonistic role of endogenous and exogenous IL-12p40 in mycobacterial infection, which is independent of IL-12p70...
- IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelinationBruno Gran
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 169:7104-10. 2002..IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, which is thought to play an important role in the development of Th1 cells and can exacerbate EAE...
- IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableShabaana A Khader
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
J Immunol 175:788-95. 2005....
- IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infectionSing Sing Way
Department of Pediatrics, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98195, USA
J Immunol 178:4498-505. 2007..These results demonstrate an important dichotomy between the signals required for priming IFN-gamma production by CD4 and CD8 T cells in response to bacterial infection...
- The central memory CD4+ T cell population generated during Leishmania major infection requires IL-12 to produce IFN-gammaNazzy Pakpour
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 180:8299-305. 2008..Thus, continued IL-12 production may be required to ensure the development of Th1 cells from this central memory T cell pool, a finding that has direct relevance to the design of vaccines dependent upon central memory CD4(+) T cells...
- Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3T J Smith
Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132
Eur J Immunol 24:822-6. 1994..The finding that the MGF-derived connective tissue-like mast cells possess IL-12 transcripts suggests that the development of the TH1 T cell pathway may be positively influenced by this type of mast cell...
- Mice lacking IL-12 develop polarized Th1 cells during viral infectionV E Schijns
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
J Immunol 160:3958-64. 1998..In this study, we demonstrate that mice with a targeted disruption of the IL-12p40 and/or p35 gene effectively control liver damage induced by mouse hepatitis virus (MHV) infection, similar to wild-type ..
- (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repairSyed M Meeran
Department of Dermatology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama 35294, USA
Cancer Res 66:5512-20. 2006..Taken together, these results indicate for the first time that EGCG can prevent photocarcinogenesis through an EGCG-induced IL-12-dependent DNA repair mechanism...
- Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in miceMarcel Wuthrich
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
J Clin Invest 121:554-68. 2011..These data suggest that human vaccines against systemic fungal infections should be designed to induce Th17 cells if they are to be effective...
- The plasticity of regulatory T cell functionMeenu R Pillai
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
J Immunol 187:4987-97. 2011..These data reveal that cross-regulatory pathways exist that control the utilization of suppressive mechanisms, thereby providing T(reg) functional plasticity...
- The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine productionRashmi Jalah
Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702 1201, USA
J Biol Chem 288:6763-76. 2013IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits...
- Structure-function analysis of the p35 subunit of mouse interleukin 12J J Zou
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110 1199
J Biol Chem 270:5864-71. 1995..This species specificity is determined by the p35 subunit of the IL-12 heterodimer...
- Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injuryX Fan
Physiological Institute, University of Zurich Irchel, Switzerland
Kidney Int 51:79-86. 1997..Compared with normal mice RT-PCR products encoding both the p35 and p40 subunits of IL-12 were markedly increased in the kidney of MRL-Fas(lpr)...
- Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12S Lassmann
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 167:5485-93. 2001..These findings indicate that the cytokine milieu of a tissue can dramatically influence the development of intrinsic immune responses and associated pathology...
- Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous systemSusanna Freude
Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
J Virol 76:12223-32. 2002..Our results illustrate that infection of the CNS with a virus that is benign in certain hosts can be harmful in such normally disease-resistant hosts if the tissue is unfavorably preconditioned by proinflammatory cytokines...
- IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12Melanie A Kleinschek
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 176:1098-106. 2006..These results show that IL-23 complements the more dominant role of IL-12 in protection against a chronic fungal infection by an enhanced inflammatory cell response and distinct cytokine regulation...
- Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active ItkJianfang Hu
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Eur J Immunol 37:2892-9. 2007..These results indicate that active signals from Tec kinases regulate the development of memory-like CD8(+) T cells with innate function...
- IL-12 is required for anti-OX40-mediated CD4 T cell survivalCarl E Ruby
Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213, USA
J Immunol 180:2140-8. 2008....
- FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ miceTracy L McGaha
Department of Medicine, Section of Nephrology and Kidney Transplantation, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Immunol 180:5670-9. 2008..Additionally, the data indicates FcgammaRIIB function has a significant impact on APC activity, suggesting a prominent role in dendritic cell activity in response to interaction with particulate autoantigens...
- Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cellsFionnuala B Hickey
Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
J Leukoc Biol 84:234-43. 2008....
- CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 productionKok Loon Wong
Immunology Program and Department of Microbiology, Centre for Life Sciences, National University of Singapore, Singapore
Eur J Immunol 38:2251-62. 2008..Our results suggest that the interaction between CD8alpha(+) DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70...
- Cutting edge: Priming of NK cells by IL-18Julie Chaix
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
J Immunol 181:1627-31. 2008..This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines...
- Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responsesSalome Leibundgut-Landmann
Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
Blood 112:4971-80. 2008..These data highlight the ability of non-TLR receptors to bridge innate and adaptive immunity and suggest that dectin-1 agonists may constitute useful adjuvants for immunotherapy and vaccination...
- A novel role for neutrophils as critical activators of NK cellsRoman Spörri
ETH Zurich, Institute for Microbiology, Zurich, Switzerland
J Immunol 181:7121-30. 2008..We propose a novel central role for neutrophils as essential IL-18 producers and hence NK cell "helpers" in bacterial infection...
- The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanismsKatharina Birkner
Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
Eur J Immunol 38:3395-410. 2008..These findings provide a novel paradigm for the control of an intracellular pathogen, which appears to be strikingly different from the CD4(+) T cell-, IL-12-, and IFN-gamma-dependent immunity to other intracellular bacteria...
- IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivoMasako Yoshimatsu
Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Bone 45:1010-6. 2009..These results suggest that IL-12 inhibits TNF-alpha-mediated osteoclastogenesis and induces apoptotic changes through an interaction between TNF-alpha-induced Fas and IL-12-induced FasL, in vivo, via a T cell-independent mechanism...
- Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine familyWeimin Kong
Department of Microbiology and Immunology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, Pennsylvania 19140, USA
Lipids Health Dis 9:12. 2010....
- IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-betaYuna Park
Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Seoul, South Korea
J Immunol 185:1476-84. 2010....
- Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ TregsKevin R Mott
Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery and Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 52:2321-33. 2011..However, it is unclear whether innate immune cells modulate Treg function. Here the authors examined the role of innate immunity in lymphomyeloid homeostasis...
- Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in miceA G Castro
Center for Experimental Cytology, University of Porto, Portugal
J Immunol 155:2013-9. 1995..Finally, animals whose IL-12 was blocked expressed heightened levels of IL-4 and IL-10 message and reduced expression of IFN-gamma as compared with control mice...
- Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid cultureR E Ploemacher
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Leukemia 7:1381-8. 1993..These data show that IL-12 interacts with IL-3 and SF to regulate survival and growth of myeloid stem cells and progenitor cells...
- Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD miceS Trembleau
Roche Milano Ricerche, Italy
J Exp Med 181:817-21. 1995..These results hold implications for the pathogenesis, and possibly for the therapy of IDDM and of other Th1 cell-mediated autoimmune diseases...
- Interleukin-12 gene expression after viral infection in the mouseJ P Coutelier
Unit of Experimental Medicine, Catholic University of Louvain, Brussels, Belgium
J Virol 69:1955-8. 1995..Interleukin-12 was expressed mainly by macrophages. Therefore, production of interleukin-12 might constitute the initial event that would determine the subsequent characteristics of the immune response elicited by viral infections...
- Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTLE T Bloom
Laboratory of Cellular Immunology, Food and Drug Administration, Bethesda, MD 20892
J Immunol 152:4242-54. 1994..Finally, IL-12 was effective for moderating the age-related decrease in CTL activity, suggesting a potential role for immunomodulation by IL-12...
- Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3P A Schweitzer
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Mamm Genome 7:394-5. 1996
- Induction of IL-12 gene expression in the brain in septic shockJ H Park
Christian Medical Research Center, Presbyterian Medical Center, Chonju, Chonbuk, Korea
Biochem Biophys Res Commun 224:391-6. 1996..Microglia-like cells are the primary producers of the p40 transcripts. In contrast, the IL-12 p35 gene is constitutively expressed in the brain at a very low level.
- IL-12 is a central mediator of acute graft-versus-host disease in miceE Williamson
Department of Immunology, Western Infirmary, University of Glasgow, Scotland
J Immunol 157:689-99. 1996....
- Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesisC M Coughlin
Biomedical Graduate Program, Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 101:1441-52. 1998..This suggests that inhibition of tumor angiogenesis is an important part of the systemic antitumor effect produced by mIL-12 and mIL-18...
- Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivoC S Schmidt
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis 55455, USA
J Immunol 163:2561-7. 1999..Thus, CFA or IL-12 can enhance Ag-specific CD8+ T cell responses to peptide, demonstrating that an inflammatory cytokine(s) can support activation and prevent tolerance induction...
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..
- FLOW CYTOMETRY INSTRUMENTZUHAIR BALLAS; Fiscal Year: 2001..abstract_text> ..
- Role of IL-10 in Periodontal Bone DestructionHajime Sasaki; Fiscal Year: 2005..The long-term goal is to determine the preventive role of lL-10 in periodontitis, and to apply this information to the development of modulators that ameliorate this disease. ..
- Immunogenetics of Leishmania chagasi InfectionMary Wilson; Fiscal Year: 2005..chagasi infection, and to identify specific alleles that influence human immune responses and thereby modify the course of disease. ..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
- KILLER CELLS AND ALCOHOLZUHAIR BALLAS; Fiscal Year: 2008..Preliminary data prompted the hypothesis that ETOH blunts the enhanced NK activity induced by CpG ODN [unreadable] [unreadable]..
- Collaborative Development of a Vaccine against Cutaneous and Visceral LeishmaniasMARY EDYTHE WILSON; Fiscal Year: 2010..Through a coordinated approach in the three laboratories, we will systematically perform pre-clinical testing against several Leishmania species, with the goal of developing a pan-leishmania protective vaccine. ..
- The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosisAndrea M Cooper; Fiscal Year: 2010..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..
- GP63 EXPRESSION IN LEISHMANIA CHAGASIMary Wilson; Fiscal Year: 2001..They will also provide a model for differential expression of tandemly linked genes in this group of protozoa. ..
- IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASEAndrea Cooper; Fiscal Year: 2001..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
- The Major Surface Protease of Trypanosomatid ProtozoaMary Wilson; Fiscal Year: 2003..chagasi whose coding sequences predict they lack the usual GPI anchor, and to contrast the amino acid sequences that regulate the intracellular trafficking of these unusual MSPs with the MSPs that possess a GPI membrane anchor. ..