Il11ra1

Summary

Gene Symbol: Il11ra1
Description: interleukin 11 receptor, alpha chain 1
Alias: AI314697, GP130, Il-11ra, Il11ra, Il11ra2, NR1, interleukin-11 receptor subunit alpha-1, IL-11 receptor subunit alpha-1, IL-11R subunit alpha-1, IL-11R-alpha-1, IL-11RA1, Il-11ra-alpha, NR-1, enhancer trap locus homolog 2, etl-2, interleukin 11 receptor, alpha chain 2, locus 2, novel cytokine receptor 1
Species: mouse
Products:     Il11ra1

Top Publications

  1. Gurfein B, Zhang Y, LOPEZ C, Argaw A, Zameer A, Moran T, et al. IL-11 regulates autoimmune demyelination. J Immunol. 2009;183:4229-40 pubmed publisher
    ..Cytokines of the gp130 family regulate survival and differentiation of both neural and immune cells, and we recently identified ..
  2. Nishina T, Komazawa Sakon S, Yanaka S, Piao X, Zheng D, Piao J, et al. Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal. 2012;5:ra5 pubmed publisher
    ..Conversely, the effects of acetaminophen were exacerbated in mice deficient in the IL-11R ? subunit. Together, these results suggest that IL-11 provides a functional link between oxidative stress and compensatory proliferation. ..
  3. Nandurkar H, Robb L, Tarlinton D, Barnett L, Kontgen F, Begley C. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood. 1997;90:2148-59 pubmed
    ..Two genes potentially encode the IL-11R alpha: the IL11Ra and IL11Ra2 genes...
  4. Robb L, Li R, Hartley L, Nandurkar H, Koentgen F, Begley C. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med. 1998;4:303-8 pubmed
    ..These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction. ..
  5. Bilinski P, Roopenian D, Gossler A. Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998;12:2234-43 pubmed
    ..Therefore, IL-11Ralpha signaling at the implantation site appears to be required for decidua development. ..
  6. Collison L, Delgoffe G, Guy C, Vignali K, Chaturvedi V, Fairweather D, et al. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012;13:290-9 pubmed publisher
    ..Here we found that IL-35 signaled through a unique heterodimer of receptor chains IL-12R?2 and gp130 or homodimers of each chain...
  7. Howlett M, Giraud A, Lescesen H, Jackson C, Kalantzis A, van Driel I, et al. The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology. 2009;136:967-77 pubmed publisher
    ..Gastric cancer is the second most common cause of cancer-related mortality worldwide, mainly as a result of late-stage detection. Interleukin (IL)-11 is a multifunctional cytokine reported to be up-regulated in human gastric cancer...
  8. Ernst M, Najdovska M, Grail D, Lundgren May T, Buchert M, Tye H, et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest. 2008;118:1727-38 pubmed publisher
    ..Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which carries a mutated gp130 cytokine receptor signaling subunit that ..
  9. Van Leuven F, Stas L, Hilliker C, Miyake Y, Bilinski P, Gossler A. Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Genomics. 1996;31:65-70 pubmed
    The human gene coding for the interleukin-11 receptor (IL11RA) was cloned and its structure analyzed. The gene is composed of 13 exons comprising nearly 10 kb of DNA that was completely sequenced...

More Information

Publications48

  1. Zhang J, Zhang Y, Dutta D, Argaw A, Bonnamain V, Seto J, et al. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol. 2011;187:1129-41 pubmed publisher
    ..The gp130 family cytokines ciliary neurotrophic factor, leukemia inhibitory factor, and IL-11 have been identified as ..
  2. Robb L, Hilton D, Brook Carter P, Begley C. Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression. Genomics. 1997;40:387-94 pubmed
    ..In this study we report that the second locus, designated IL11Ra2, encodes an mRNA species...
  3. Srivastava A, Kapur S, Mohan S, Yu H, Kapur S, Wergedal J, et al. Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. J Bone Miner Res. 2005;20:1041-50 pubmed
    ..The 917M locus on chromosome 4 seems to be novel because it does not correspond with those loci previously associated with bone size on chromosome 4 in B6 and C3H/HeJ mice or other crosses. ..
  4. Tamura S, Morikawa Y, Senba E. Localization of oncostatin M receptor beta in adult and developing CNS. Neuroscience. 2003;119:991-7 pubmed
    ..Our results suggest that OSM contributes to the development of specific subpopulations of both neurons and astrocytes in the murine CNS. ..
  5. Neuhaus H, Bettenhausen B, Bilinski P, Simon Chazottes D, Guenet J, Gossler A. Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential. Dev Biol. 1994;166:531-42 pubmed
    ..Here we report on the isolation and embryonic expression of a novel mouse gene, Etl2 (enhancer trap locus 2) which, based on its deduced amino acid sequence, constitutes a new member of the cytokine type-I receptor family...
  6. Nieminen P, Morgan N, Fenwick A, Parmanen S, Veistinen L, Mikkola M, et al. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Am J Hum Genet. 2011;89:67-81 pubmed publisher
    ..662C>G [p.Pro221Arg], c.734C>G [p.Ser245Cys], or c.886C>T [p.Arg296Trp]) in IL11RA (encoding interleukin 11 receptor, alpha) on chromosome 9p13.3. In addition, a homozygous nonsense mutation, c...
  7. Sims N. gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice. Mol Cell Endocrinol. 2009;310:30-9 pubmed publisher
    The receptor subunit gp130 is utilized by a wide range of cytokines, many of which have critical functions in regulating the actions of osteoclasts and osteoblasts...
  8. Robb L, Hilton D, Willson T, Begley C. Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus. J Biol Chem. 1996;271:13754-61 pubmed
    ..Northern analysis showed that IL-11Ralpha is expressed in many adult murine tissues. A second IL-11Ralpha-like locus containing a sequence homologous to exons 2-13 was also identified. ..
  9. Bilinski P, Hall M, Neuhaus H, Gissel C, Heath J, Gossler A. Two differentially expressed interleukin-11 receptor genes in the mouse genome. Biochem J. 1996;320 ( Pt 2):359-63 pubmed
    ..ligand-binding subunit and provides ligand specificity in a functional multimeric signal-transduction complex with gp130. Here we show that the mouse genome contains a second gene encoding an IL-11-binding protein, referred to as IL-..
  10. Yamada A, Miyazaki T, Lu L, Ono M, Ito M, Terada M, et al. Genetic basis of tissue specificity of vasculitis in MRL/lpr mice. Arthritis Rheum. 2003;48:1445-51 pubmed
    ..Systemic vasculitis in MRL/lpr mice is genetically controlled with cumulative effects of multiple gene loci, each of which has tissue specificity. ..
  11. Li R, Hartley L, Robb L. Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Reproduction. 2001;122:593-600 pubmed
    ..5 days after mating. Expression of the genes encoding the two receptor components, IL11Ra and gp130, did not change throughout the peri-implantation period...
  12. Curtis D, Hilton D, Roberts B, Murray L, Nicola N, Begley C. Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist. Blood. 1997;90:4403-12 pubmed
    ..of the murine interleukin-11 (IL-11) receptor alpha-chain (sIL-11R) and examined signaling in cells expressing the gp130 molecule...
  13. Putoczki T, Thiem S, Loving A, Busuttil R, Wilson N, Ziegler P, et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell. 2013;24:257-71 pubmed publisher
    ..cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway...
  14. Davidson A, Freeman S, Crosier K, Wood C, Crosier P. Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues. Stem Cells. 1997;15:119-24 pubmed
    ..In contrast, the IL-11R alpha was found to be expressed in all adult tissues examined, during embryonic development, and in totipotent and differentiating ES cells. ..
  15. Li F, Devi Y, Bao L, Mao J, Gibori G. Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice. Biol Reprod. 2008;78:127-33 pubmed
    Interleukin 11 receptor alpha (Il11ra) null mice are infertile due to defective decidualization and abnormal trophoblast invasion...
  16. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan J, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol. 2004;172:2225-31 pubmed
    ..In this study, we describe that WSX-1 together with gp130 constitutes a functional signal-transducing receptor for IL-27...
  17. Thiem S, Pierce T, Palmieri M, Putoczki T, Buchert M, Preaudet A, et al. mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. J Clin Invest. 2013;123:767-81 pubmed publisher
    ..and excessive secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation of the GP130/JAK/STAT3 pathway...
  18. Figueiredo C, Drohomyrecky P, McCarthy S, Leontyev D, Ma X, Branch D, et al. Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor. PLoS ONE. 2014;9:e101947 pubmed publisher
    ..Finally, IL-11 was shown to directly inhibit IL-17 production of lymph node cells in culture. These results implicate IL-11 as an important immune effector of IVIg in the prevention of Th17-mediated autoimmune inflammation during EAE. ..
  19. Judd L, Ulaganathan M, Howlett M, Giraud A. Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression. J Pathol. 2009;217:552-62 pubmed publisher
    The cytokines IL-6 and IL-11, which signal via the receptor gp130, have been implicated in various gut pathologies, including inflammation and wound healing...
  20. Sims N, Jenkins B, Nakamura A, Quinn J, Li R, Gillespie M, et al. Interleukin-11 receptor signaling is required for normal bone remodeling. J Bone Miner Res. 2005;20:1093-102 pubmed
    ..Because of their common use of the gp130 co-receptor signaling subunit, the roles of these two cytokines are linked, and each may compensate for the ..
  21. Nakano H, Gunn M. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J Immunol. 2001;166:361-9 pubmed
    ..This lack of CCR7 ligands in the secondary lymphoid organs of plt mice provides a basis for their severe abnormalities in leukocyte migration and immune response. ..
  22. Johnson R, McGregor N, Brennan H, Crimeen Irwin B, Poulton I, Martin T, et al. Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone. Bone. 2015;81:343-51 pubmed publisher
    ..IL-6R and IL-11R, respectively) are both expressed in osteoclasts and transduce signal via the glycoprotein130 (gp130) co-receptor, but the physiological role of this pathway is unclear...
  23. Graciarena M, Carbia Nagashima A, Onofri C, Perez Castro C, Giacomini D, Renner U, et al. Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model. Eur J Endocrinol. 2004;151:595-604 pubmed
    b>gp130 cytokines are placed as auto-paracrine regulators of pituitary function, since they, as well as their receptors, have been shown to be expressed in and to act in normal and tumoral anterior pituitary cells...
  24. Ruwanpura S, McLeod L, Miller A, Jones J, Bozinovski S, Vlahos R, et al. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol. 2011;45:720-30 pubmed publisher
    The IL-6 cytokine family, which signals via the shared gp130 coreceptor, is linked with the pathogenesis of emphysema. However, the definitive mechanisms by which these cytokines cause emphysema remain ill-defined...
  25. Ain R, Trinh M, Soares M. Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface. Dev Dyn. 2004;231:700-8 pubmed
    ..Thus, the defect in NK precursor cell maturation was not intrinsic to the NK precursor cells but was dependent upon the tissue environment. In summary, IL-11 signaling is required for decidual-specific maturation of NK cells. ..
  26. Gu D, Fan Q, Zhang X, Xie J. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012;287:38356-66 pubmed publisher
    ..Taken together, our results support an important role of the IL-11R?/STAT3 signaling axis for Hh signaling-mediated signaling and carcinogenesis. ..
  27. Tye H, Kennedy C, Najdovska M, McLeod L, MCCORMACK W, Hughes N, et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell. 2012;22:466-78 pubmed publisher
    ..Collectively, our data reveal an unexpected role for TLR2 in the oncogenic function of STAT3 that may represent a therapeutic target in GC. ..
  28. Howlett M, Judd L, Jenkins B, La Gruta N, Grail D, Ernst M, et al. Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130. Gastroenterology. 2005;129:1005-18 pubmed
    We have shown that mice with a mutation in gp130 (gp130(757F/F)), the signal transducing receptor for interleukin (IL)-6 family cytokines, have chronic gastric inflammation and develop distal stomach tumors associated with deregulated ..
  29. Menkhorst E, Salamonsen L, Robb L, Dimitriadis E. IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice. Biol Reprod. 2009;80:920-7 pubmed publisher
    ..In women, uterine epithelial expression of interleukin 11 (IL11) and its receptor (IL11RA) suggests IL11 is critical for blastocyst attachment during implantation...
  30. Cho N, Nguyen D, Satkunendrarajah K, Branch D, Fehlings M. Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury. J Neuroinflammation. 2012;9:134 pubmed publisher
    ..In this regard, research into cytokine signaling has demonstrated that cytokines of the gp130 family including IL-6 and leukemia inhibitory factor (LIF) play key roles in mediating damage to the spinal cord...
  31. Tebbutt N, Giraud A, Inglese M, Jenkins B, Waring P, Clay F, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002;8:1089-97 pubmed
    ..STAT1/3) and the Src-homology tyrosine phosphatase 2 (SHP2)-Ras-ERK, emanating from the common signal transducer, gp130, in the gastrointestinal tract...
  32. Chen Q, Rabach L, Noble P, Zheng T, Lee C, Homer R, et al. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2005;174:2305-13 pubmed
    ..We hypothesized that IL-11, signaling via the IL-11Ralpha-gp130 receptor complex, plays a key role in IL-13-induced tissue responses...
  33. Nandurkar H, Hilton D, Nathan P, Willson T, Nicola N, Begley C. The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor. Oncogene. 1996;12:585-93 pubmed
    ..chain of the human IL-11 receptor (IL-11R alpha) and demonstrate the requirement of either the human or mouse gp130 molecule for signalling...
  34. Lokau J, Flynn C, Garbers C. Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome. Biochem Biophys Res Commun. 2017;491:296-302 pubmed publisher
  35. Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
    ..expression or Il-11 injection causes heart and kidney fibrosis and organ failure, whereas genetic deletion of Il11ra1 protects against disease...
  36. Lee C, Hartl D, Matsuura H, Dunlop F, Scotney P, Fabri L, et al. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol. 2008;39:739-46 pubmed publisher
    ..They also demonstrate that Th2 and IL-13 responses can be regulated by interventions that manipulate IL-11 signaling in the murine lung. ..
  37. White C, Robb L, Salamonsen L. Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice. Reprod Biol Endocrinol. 2004;2:76 pubmed
    ..Decidualization was artificially induced in pseudopregnant wild type (IL11Ra+/+) and IL-11Ralpha deficient (IL11Ra-/-) littermates by oil injection into the uterine lumen, and gene expression ..
  38. Hilton D, Hilton A, Raicevic A, Rakar S, Harrison Smith M, Gough N, et al. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994;13:4765-75 pubmed
    ..The capacity to bind IL-11 with high affinity (Kd = 300-800 pM) appeared to require coexpression of both NR1 and gp130, the common subunit of the IL-6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic ..
  39. Bollrath J, Phesse T, von Burstin V, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell. 2009;15:91-102 pubmed publisher
    ..loss- and gain-of-function mice in a colitis-associated cancer model, we establish here a link comprising the gp130/Stat3 transcription factor signaling axis...