Il10

Summary

Gene Symbol: Il10
Description: interleukin 10
Alias: CSIF, Il-10, cytokine synthesis inhibitory factor, interleukin-10
Species: mouse

Top Publications

  1. ncbi Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:927-38. 1999
  2. ncbi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
  3. ncbi Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
  4. ncbi Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10
    John A Kelly
    Veterans Affairs Medical Center, VT 05009, USA
    Cardiovasc Res 85:224-31. 2010
  5. ncbi IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function
    Ivan Monteleone
    Division of Immunology Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 38:1533-47. 2008
  6. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  7. ncbi Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
  8. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  9. ncbi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
  10. ncbi The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010

Research Grants

  1. Analyzing and modulating immunoregulatory defects in autoimmune disease
    MICHELE KOSIEWICZ; Fiscal Year: 2007
  2. The Role of MerTK in Autoimmune Diabetes
    Roland Tisch; Fiscal Year: 2007
  3. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
  4. Murine models to test parasite products as cures for Inflammatory Bowel Disease
    LINDA MANSFIELD; Fiscal Year: 2007
  5. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
  6. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
  7. Induction of hepatic tolerance to parasitic nematodes
    Susan Bliss; Fiscal Year: 2007
  8. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
  9. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
  10. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2007

Detail Information

Publications122 found, 100 shown here

  1. ncbi Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:927-38. 1999
    ..These results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but, rather, to the induction of both type 1- and type 2-associated immune responses...
  2. ncbi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
    ..Therefore, one can speculate that T(reg) during transendothelial transmigration become "armed" for their suppressive function(s) to be carried out in peripheral tissues sites...
  3. ncbi Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
    ..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
  4. ncbi Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10
    John A Kelly
    Veterans Affairs Medical Center, VT 05009, USA
    Cardiovasc Res 85:224-31. 2010
    ..We therefore analysed the formation of arterial lesions in LDL receptor-deficient (LDLR(-/-)) and FcgRIII(-/-)xLDLR(-/-) double knockout mice at three different points up to 24 weeks of exposure to a high-fat diet...
  5. ncbi IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function
    Ivan Monteleone
    Division of Immunology Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 38:1533-47. 2008
    ..Thus, IL-10 may maintain LP DC in a partially unresponsive state to TLR ligation, allowing them to have a critical role in immune homeostasis in the gut...
  6. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  7. ncbi Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
  8. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  9. ncbi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  10. ncbi The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010
    Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease...
  11. ncbi Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  12. ncbi Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    Masahito Kamanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:941-52. 2006
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
  13. ncbi Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells
    Georgia Perona-Wright
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Host Microbe 6:503-12. 2009
    ..In contrast to disseminating pathogens, locally restricted infections did not elicit NK cell IL-10. Thus systemic infections uniquely engage NK cells in an IL-10-mediated immunoregulatory circuit that functions to alleviate inflammation...
  14. ncbi TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells
    Ayca Sayi
    Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
    J Immunol 186:878-90. 2011
    ....
  15. ncbi Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
    ..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
  16. ncbi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  17. ncbi IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 117:2941-51. 2007
    ..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
  18. ncbi 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease
    M T Cantorna
    Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 130:2648-52. 2000
    ..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
  19. ncbi Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
    Shengli Xu
    Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
    J Biol Chem 284:7038-46. 2009
    ..Thus, our data indicate that pattern recognition receptors such as Dectin-1 could elicit Ca2+ signaling and that PLCgamma2 is a critical player in the Dectin-1 signal transduction pathway...
  20. ncbi Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10
    Gustavo Batista Menezes
    Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    J Immunol 183:7557-68. 2009
    ..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
  21. ncbi Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
    ..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
  22. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  23. ncbi A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen
    Marcin P Mycko
    Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
    Eur J Immunol 38:1999-2013. 2008
    ....
  24. ncbi Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Marina C Pils
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 40:443-8. 2010
    ..In contrast, in an IL-10-regulated T-cell response to Trichuris muris infection, IL-10 acting on T cells or monocytes/macrophages/neutrophils is not critical for the control of the infection...
  25. ncbi A pivotal role for galectin-1 in fetomaternal tolerance
    Sandra M Blois
    Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
    Nat Med 13:1450-7. 2007
    ..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
  26. ncbi T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    N J Davidson
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    J Exp Med 184:241-51. 1996
    Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
  27. ncbi Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  28. ncbi IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:3018-23. 2010
    ..On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination...
  29. ncbi IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:1421-33. 2010
    ..Overall, we delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells...
  30. ncbi TLR-activated B cells suppress T cell-mediated autoimmunity
    Vicky Lampropoulou
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    J Immunol 180:4763-73. 2008
    ..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...
  31. ncbi Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset
    Yasuhiro Takada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 184:2671-6. 2010
    ..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
  32. ncbi Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus
    O R Oakley
    Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
    Clin Exp Immunol 151:155-64. 2008
    ..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...
  33. ncbi Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
    D M Rennick
    DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    Am J Physiol Gastrointest Liver Physiol 278:G829-33. 2000
    ....
  34. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
    ..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27...
  35. ncbi IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages
    Hirotaka Kuwata
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Blood 102:4123-9. 2003
    ..These findings suggest that IL-10-induced Bcl-3 is required for suppression of TNF-alpha production in macrophages...
  36. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  37. ncbi Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    D F Fiorentino
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 170:2081-95. 1989
    A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones...
  38. ncbi Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
    Virginia S Carl
    University of Virginia Health System, Department of Medicine, Digestive Health Center of Excellence and Microbiology, Charlottesville, VA 22908 0708, USA
    J Leukoc Biol 76:735-42. 2004
    ..Together, these results demonstrate that endogenously produced IL-10 plays a significant role in LPS-induced sIL-1Ra gene expression via the activation of STAT3...
  39. ncbi Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling
    Stefan Zimmermann
    Institute of Medical Microbiology and Hygiene, Philipps University, Marburg, Germany
    J Immunol 176:1840-7. 2006
    ..gondii on IFN-gamma were diminished in macrophages from SOCS-1-/- mice. The results suggest that induction of SOCS proteins within phagocytes due to infection with T. gondii contributes to the parasite's immune evasion strategies...
  40. ncbi Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
  41. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  42. ncbi CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Immunol 174:1962-70. 2005
    ..Thus, IL-10-producing, CCR8+CD4+CD25+CD44+ T cells are generated during SEA challenge, which augment the Th2-mediated eosinophil-rich response to the parasite Ags...
  43. ncbi Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of ..
  44. ncbi The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice
    Danielle G Souza
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Immunol 179:8533-43. 2007
    ....
  45. ncbi Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10
    Michael Hammer
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
    Eur J Immunol 35:2991-3001. 2005
    ..Thus, these data suggest an operational link between IL-10 and inhibition of p38 MAPK via sustained expression of DUSP1...
  46. ncbi B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
  47. ncbi IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
    T A Wynn
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:4473-80. 1998
    ..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
  48. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
    ..This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation that occurs in chronic schistosomiasis...
  49. ncbi Antifungal type 1 responses are upregulated in IL-10-deficient mice
    G Del Sero
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 1:1169-80. 1999
    ..The resulting protective Th1 responses lead to a prompt reduction of fungal growth, thus preventing tissue destruction and lethal levels of proinflammatory cytokines...
  50. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  51. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
  52. ncbi Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection
    Vishal Sindhava
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 5:e11445. 2010
    ..This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity...
  53. ncbi Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1
    Ryan L Brunsing
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, USA
    Immunology 134:93-106. 2011
    ..These results demonstrate that G-1 acts directly on CD4(+) T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL-10 expression in Th17 or hybrid T-cell populations...
  54. ncbi Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    Rajat Madan
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Immunol 183:2312-20. 2009
    ....
  55. ncbi Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice
    G J Prud'homme
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Immunol 32:495-503. 1995
    ..IL-1 beta, IFN gamma and IL-10 are pleiotropic cytokines with pro-inflammatory and B-cell stimulatory effects. These results point to certain cytokines as potential targets for immunotherapy in lupus...
  56. ncbi Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 182:6121-8. 2009
    ..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
  57. ncbi Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
    Michael Hammer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    J Exp Med 203:15-20. 2006
    ..These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock...
  58. ncbi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
  59. ncbi Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10
    S Redpath
    Department of Immunology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 162:6701-7. 1999
    ..Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-gamma...
  60. ncbi CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  61. ncbi IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 180:4090-7. 2008
    ..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies...
  62. ncbi Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi
    Latifu A Sanni
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 72:3054-8. 2004
    ..Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice...
  63. ncbi Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    Daniel Rachmilewitz
    Division of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    Gastroenterology 122:1428-41. 2002
    ..We hypothesized that these combined effects of ISS-DNA could inhibit the damage to the colonic mucosa in chemically induced colitis and thereby limit subsequent intestinal inflammation...
  64. ncbi Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production
    Caroline Demangel
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Eur J Immunol 32:994-1002. 2002
    ....
  65. ncbi Interleukin 10 protects mice from lethal endotoxemia
    M Howard
    DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 177:1205-8. 1993
    b>Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha (TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same monokines...
  66. ncbi Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
    Elmer Y Chang
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:6705-9. 2007
    ..Our findings suggest a novel anti-inflammatory role for the type I IFN production and signaling pathway in regulating LPS response in bone marrow-derived macrophages...
  67. ncbi Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages
    Lakshman Chelvarajan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Leukoc Biol 82:403-16. 2007
    ..The anti-inflammatory phenotype of the neonatal Mphi may be unique to the developing organism, although it compromises the neonate's ability to respond to encapsulated bacteria...
  68. ncbi Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
    Benyue Zhang
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Invest 117:3029-41. 2007
    ..These data show that anti-CD137 mAbs can induce T cell activation-induced cell death or enhance antiviral immunity depending on the timing of treatment, which may be important for vaccine development...
  69. ncbi Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille 13288, France
    Cell Host Microbe 6:493-5. 2009
    ..Remarkably, this immunosuppressive activity only occurs during systemic infections...
  70. ncbi Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice
    Z Shen
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 77:2508-16. 2009
    ..These results indicate that WT(Hc) can be used to model inflammatory bowel disease in IL-10(-/-) mice and that CDT contributes to the virulence of H. cinaedi...
  71. ncbi Nramp1-functionality increases iNOS expression via repression of IL-10 formation
    Gernot Fritsche
    Department of Internal Medicine, Innsbruck Medical University, Austria
    Eur J Immunol 38:3060-7. 2008
    ..Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms...
  72. ncbi Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6
    Fabiana S Machado
    Divisions of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Exp Med 205:1077-86. 2008
    ..These findings suggest a new molecular target for drug development for diseases marked by dysregulated inflammatory responses...
  73. ncbi Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process
    Ifeoma Okwor
    Parasite Vaccines Development Laboratory, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada
    Proc Natl Acad Sci U S A 106:13951-6. 2009
    ..This may account for the lack of efficacy of such vaccines in field trials in endemic regions. These findings have important implications for vaccine design and vaccination strategies against human cutaneous leishmaniasis...
  74. ncbi Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection
    A Raisanen-Sokolowski
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 100:2449-56. 1997
    ..Concurrent evaluation of these three isolated cytokine deletions has shown that the recipient environment caused distinct graft modifications...
  75. ncbi Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice
    Young Eun Joo
    Department of Medicine and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e4562. 2009
    ..CONCLUSIONS/ SIGNIFICANCE: These results indicate that TLE prevents LPS-induced proinflammatory gene expression by blocking of NF-kappaB signaling, but aggravates DSS-induced colitis by enhancing epithelial cell apoptosis...
  76. ncbi Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation
    Shien Hu
    The Martin Boyer Laboratories, Department of Medicine, University of Chicago IBD Research Center, Chicago, Illinois, USA
    Gastroenterology 133:1893-904. 2007
    ..We examined the expression and regulation of iHsp in human and experimental inflammatory bowel diseases (IBD) and in vitro...
  77. ncbi Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome
    Giuseppe Malleo
    Department of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Cytokine 41:136-43. 2008
    ..Therefore, this study demonstrates that the absence of endogenous IL-10 enhances the MODS induced by zymosan in mice...
  78. ncbi Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis
    Hiroshi Saito
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Mech Ageing Dev 124:1047-58. 2003
    ..These results clearly demonstrate an age-associated increase in mortality, hypothermia, and induction of IL-6 during endotoxemia and sepsis...
  79. ncbi Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  80. ncbi Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation
    D V Serreze
    The Jackson Laboratory, Bar Harbor, ME 04609 Department of Medicine, University of Alberta, Edmonton, Canada
    J Immunol 166:1352-9. 2001
    ....
  81. ncbi B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance
    P A Gonnella
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:4456-64. 2001
    ..These results demonstrate the importance of the B cell for the induction of cytokine-mediated suppression associated with low doses of Ag...
  82. ncbi Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10
    W Chen
    The Wakefield Gastroenterology Research Laboratory, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 16:377-83. 2001
    ..The objective of this study was to determine the role of endogenous IL-10 in the host defense against gastric colonization by Helicobacter pylori by using IL-10-deficient mice...
  83. ncbi IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies
    - Johansson AC
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    J Immunol 167:3505-12. 2001
    ..These data emphasize the importance of studying IL-10 in a defined genetic context in vivo, to understand its role in a complex disease like arthritis...
  84. ncbi Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans
    D O Beenhouwer
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 69:6445-55. 2001
    ..neoformans requires both Th1- and Th2-associated cytokines and reveal the complexity of the mechanisms through which antibodies modulate infection with this organism...
  85. ncbi IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites
    W L Goff
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 84:237-51. 2002
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  86. ncbi Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages
    Jindrich Soltys
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 168:1903-10. 2002
    ....
  87. ncbi Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity
    Klaus Panthel
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munich, Germany
    Infect Immun 71:794-800. 2003
    ..With exception of the low-level infected C57BL/6J IL-10(-/-) and IL-12(-/-) knockout mice, all knockout mutants were accessible to a prophylactic vaccination and their vaccination behavior was comparable to that of the wt strains...
  88. ncbi IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
    M J Mäkelä
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 97:6007-12. 2000
    ..These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge...
  89. ncbi Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
    K L Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 116:1107-14. 1999
    ..The aim of this study was to determine the role of colonic aerobic luminal bacteria and Lactobacillus species in the development of colitis in interleukin (IL)-10 gene-deficient mice...
  90. ncbi Production of interleukin-10 by mouse glial cells in culture
    T Mizuno
    Department of Neurology, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 205:1907-15. 1994
    ..These results suggest that IL-10 is produced in the CNS and plays a role as an inhibitory regulator in the CNS cytokine network...
  91. ncbi Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
    ..It is possible that this process played a role in enhanced disease observed in infants and children immunized with FI-RSV...
  92. ncbi Differential cytokine expression in maternal blood and placenta during murine gestation
    S Delassus
    Unité de Biologie Moléculaire du Gène, U 277 INSERM, Institut Pasteur, Paris, France
    J Immunol 152:2411-20. 1994
    ..We discuss these results in the context of the placenta as a privileged immune site, where IL-4, being the main cytokine, may play a major regulatory role...
  93. ncbi IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements
    J Lehmann
    Fraunhofer Institute of Toxicology and Molecular Biology, Hannover, Germany
    J Immunol 153:165-72. 1994
    ..These experiments also revealed two distinct RAFTs-IL-10 to be members of the p91 family of proteins. The data suggest GAS-related elements to integrate signals from IFN-gamma-, IL-4- and IL-10-activated signaling paths...
  94. ncbi Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer
    N Kundu
    Department of Pathology and the University of Maryland Cancer Center, Baltimore, 21201, USA
    J Natl Cancer Inst 88:536-41. 1996
    b>Interleukin 10 (IL-10) is a potent immunoregulatory cytokine. It inhibits some cell functions, including T-helper (Th1) cell activity (i.e...
  95. ncbi IL-10 inhibits lipopolysaccharide-induced murine B cell proliferation and cross-linking of surface antigen receptors or ligation of CD40 restores the response
    J F Marcelletti
    LIDAK Pharmaceuticals, La Jolla, CA 92037, USA
    J Immunol 157:3323-33. 1996
    ..These observations suggest that IL-10 has a role in the suppression of inappropriate B cell proliferation, i.e., proliferation by B cells that have not effectively interacted with relevant Ag or CD40 ligand...
  96. ncbi IL-10: a potential therapy for allergic inflammation?
    M Pretolani
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur INSERM U285, Institut Pasteur, Paris, France
    Immunol Today 18:277-80. 1997
  97. ncbi Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site
    B K Halak
    Kimmel Cancer Center, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 59:911-7. 1999
    ..These studies demonstrate that tumor-induced IL-10 can block the generation of a tumor-specific type 1 immune response as well as subvert attempts to elicit a type 1 immune response to a non-tumor antigen at the tumor site...
  98. ncbi Depletion of neutrophils in IL-10(-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter
    Hanan F Ismail
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Immunol 170:3782-9. 2003
    ..These studies identify a role for neutrophils in the local and systemic immune response to gastric Helicobacter in IL-10(-/-) mice...
  99. ncbi The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages
    Shanjin Cao
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 174:3484-92. 2005
    ..Thus, this study uncovers a novel and important function of c-Maf in macrophages and elucidates its transcriptional mechanism in the regulation of IL-10 gene expression...
  100. ncbi Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice
    Aicha Saadane
    Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Allergy Clin Immunol 115:405-11. 2005
    ..Patients with cystic fibrosis (CF) and CF transmembrane conductance regulator knockout (CF-KO) mice are deficient in pulmonary IL-10 and have excessive inflammatory response to Pseudomonas aeruginosa infection...
  101. ncbi TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection
    Judith A Kapp
    Department of Ophthalmology, Spain Wallace Building, 619 South 19th Street, University of Alabama at Birmingham, Birmingham, AL 35233 7331, USA
    Int Immunol 18:1549-62. 2006
    ..These data show that TGFbeta-activated CD8+ T cells mediate antigen-specific, APC-focused patterns of suppression in vitro and in vivo...

Research Grants64

  1. Analyzing and modulating immunoregulatory defects in autoimmune disease
    MICHELE KOSIEWICZ; Fiscal Year: 2007
    ....
  2. The Role of MerTK in Autoimmune Diabetes
    Roland Tisch; Fiscal Year: 2007
    ..In this way, the cellular and molecular contribution of MerTK in regulating APC activation and effector function, and how these events shape ¿ cell-specific T cell reactivity will be ascertained. ..
  3. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    ..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
  4. Murine models to test parasite products as cures for Inflammatory Bowel Disease
    LINDA MANSFIELD; Fiscal Year: 2007
    ..Dr. Mansfield has documented success mentoring graduate students and seeks to expand her mentoring of D.V.M.s in mouse pathobiology. ..
  5. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..Macrophage SOM production is induced by LPS, IFN-?, IL 10, TNF-?, PgE2 and cAMP. Murine inflammatory T cells express only one type of SOM receptor, SSTR2...
  6. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  7. Induction of hepatic tolerance to parasitic nematodes
    Susan Bliss; Fiscal Year: 2007
    ..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
  8. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  9. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  10. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2007
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  11. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  12. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  13. INNATE IMMUNE RECEPTOR ANTAGONISM BY ORTHOPOXVIRUS PROTEINS
    Anthony R French; Fiscal Year: 2010
    ..This work will also provide immunologic insight into the function of these receptors insight that likely is extensible to other infections. ..
  14. B CELL FUNCTION IN AUTOIMMUNE ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ....
  15. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  16. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  17. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  18. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....
  19. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  20. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  21. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006
    ..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
  22. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  23. HOST IMMUNOMODULATION BY PARASITES
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
  24. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ..These studies aim to develop novel insights into the autoimmune disease process that will facilitate the diagnosis and treatment of RA. ..