Genomes and Genes
Gene Symbol: Il10
Description: interleukin 10
Alias: CSIF, Il-10, cytokine synthesis inhibitory factor, interleukin-10
Publications164 found, 100 shown here
- Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10Tanja Bedke
Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
J Immunol 184:5562-70. 2010..Therefore, one can speculate that T(reg) during transendothelial transmigration become "armed" for their suppressive function(s) to be carried out in peripheral tissues sites...
- Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanismsQian Liu
Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
Infect Immun 77:5347-58. 2009..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
- Pathogen-specific CD8 T cell responses are directly inhibited by IL-10Partha Sarathi Biswas
Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 179:4520-8. 2007..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
- CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in miceChristine M Freeman
Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
J Immunol 174:1962-70. 2005..Thus, IL-10-producing, CCR8+CD4+CD25+CD44+ T cells are generated during SEA challenge, which augment the Th2-mediated eosinophil-rich response to the parasite Ags...
- IL-10 mediates susceptibility to Leishmania donovani infectionM L Murphy
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Eur J Immunol 31:2848-56. 2001..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Interleukin-10-deficient mice develop chronic enterocolitisR Kuhn
Institute for Genetics, University of Cologne, Federal Republic of Germany
Cell 75:263-74. 1993..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
- Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesLaurie E Harrington
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Immunol 6:1123-32. 2005..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
- CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasisCharles F Anderson
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:285-97. 2007....
- A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responsesKoichi Yanaba
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
Immunity 28:639-50. 2008..Thereby, CD1d(hi)CD5(+) B cells represent a unique subset of potent regulatory B cells...
- B cells regulate autoimmunity by provision of IL-10Simon Fillatreau
University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
Nat Immunol 3:944-50. 2002..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
- Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1Olaf Gross
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Immunity 36:388-400. 2012..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
- Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesD F Fiorentino
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
J Exp Med 170:2081-95. 1989A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones...
- The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cureY Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
J Exp Med 194:1497-506. 2001....
- The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27Lionel Apetoh
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Nat Immunol 11:854-61. 2010Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease...
- Type I interferon inhibits interleukin-1 production and inflammasome activationGreta Guarda
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 34:213-23. 2011..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
- Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory functionAsher Maroof
Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, Wentworth Way, York YO10 5YW, UK
Immunity 29:295-305. 2008....
- Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseMargarida Saraiva
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Immunity 31:209-19. 2009..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
- Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virusJie Sun
The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
PLoS Pathog 7:e1002173. 2011..Our findings suggest a potentially critical role of effector T cell-derived IL-10 in controlling disease severity in clinical RSV infection...
- The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signalingOlga Ananieva
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Nat Immunol 9:1028-36. 2008..transcription of the mitogen-activated protein kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10, MSK1 and MSK2 exerted many negative feedback mechanisms...
- Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10Juan M Ilarregui
Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
Nat Immunol 10:981-91. 2009..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
- In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaR T Gazzinelli
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 157:798-805. 1996..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
- Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infectionSeung Hwan Lee
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Exp Med 206:2235-51. 2009..The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses...
- Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cellsDenise C Fitzgerald
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nat Immunol 8:1372-9. 2007..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27...
- A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cellsH Groux
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
J Immunol 162:1723-9. 1999..These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo...
- Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathwaysKatrin Kierdorf
Department of Neuropathology, University of Freiburg, Freiburg, Germany
Nat Neurosci 16:273-80. 2013..Our data provide cellular and molecular insights into the origin and development of microglia...
- A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitisEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
J Neuroimmunol 165:63-74. 2005..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
- TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cellsFrank Kaiser
Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Exp Med 206:1863-71. 2009....
- IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infectionDavid G Brooks
Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:3018-23. 2010..On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination...
- Nonredundant roles for B cell-derived IL-10 in immune counter-regulationRajat Madan
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Immunol 183:2312-20. 2009....
- TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyMandy J McGeachy
Schering Plough Biopharma, Palo Alto, California 94304, USA
Nat Immunol 8:1390-7. 2007..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
- Helminth infection protects mice from anaphylaxis via IL-10-producing B cellsNiamh E Mangan
Department of Biochemistry, Trinity College, Dublin, Ireland
J Immunol 173:6346-56. 2004....
- An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationC Asseman
Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
J Exp Med 190:995-1004. 1999..These findings provide the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens...
- IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infectionMaria A Stacey
Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
J Immunol 187:2944-52. 2011..Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells...
- Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitisKathryn Trandem
Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 186:3642-52. 2011..Furthermore, IL-10 produced by CD8 T cells diminished disease severity in mice with coronavirus-induced acute encephalitis, suggesting a self-regulatory mechanism that minimizes immunopathological changes...
- CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasisAntonella Mencacci
Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
J Immunol 169:3180-90. 2002..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
- Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient miceW Joshua Frazier
Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
J Immunol 183:7411-9. 2009....
- Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitisBrian D Gulbransen
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Nat Med 18:600-4. 2012..Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility...
- Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitisMasako Murai
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Nat Immunol 10:1178-84. 2009..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
- Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subsetYasuhiro Takada
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Immunol 184:2671-6. 2010..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
- Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor siteB K Halak
Kimmel Cancer Center, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Res 59:911-7. 1999..These studies demonstrate that tumor-induced IL-10 can block the generation of a tumor-specific type 1 immune response as well as subvert attempts to elicit a type 1 immune response to a non-tumor antigen at the tumor site...
- Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia modelMarina C Pils
Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Eur J Immunol 40:443-8. 2010..In contrast, in an IL-10-regulated T-cell response to Trichuris muris infection, IL-10 acting on T cells or monocytes/macrophages/neutrophils is not critical for the control of the infection...
- Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouseMasahito Kamanaka
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 25:941-52. 2006..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
- Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cellsGeorgia Perona-Wright
Trudeau Institute, Saranac Lake, NY 12983, USA
Cell Host Microbe 6:503-12. 2009..In contrast to disseminating pathogens, locally restricted infections did not elicit NK cell IL-10. Thus systemic infections uniquely engage NK cells in an IL-10-mediated immunoregulatory circuit that functions to alleviate inflammation...
- Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signalsAndre Boonstra
Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
J Immunol 177:7551-8. 2006....
- IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziC A Hunter
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
J Immunol 158:3311-6. 1997..cruzi there is a critical requirement for IL-10 to prevent the development of a pathologic immune response associated with CD4+ T cells and overproduction of IL-12...
- Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cellsQing Sheng Mi
Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
Diabetes 53:1303-10. 2004..Our data identify an important role for IL-4 in the protection against type 1 diabetes by activated iNKT cells, and these findings have important implications for cytokine-based therapy of type 1 diabetes and islet transplantation...
- Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged miceBo Chin Chiu
Department of Cellular and Molecular Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 181:3156-66. 2008..Our data identify a novel mechanism of age-associated immune deficiency...
- Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10Dorothy K Sojka
The David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 108:18336-41. 2011..Interestingly, Tregs used different regulatory mechanisms to regulate IFN-γ (IL-10-dependent or -independent) subject to the target T-cell stage of activation and its tissue location...
- CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLsJie Sun
The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
Nat Immunol 12:327-34. 2011..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
- Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine productionJose M Gonzalez-Navajas
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 207:2799-807. 2010..Our data identifies a new molecular pathway by which IL-1 signaling attenuates TLR9-mediated proinflammatory responses...
- Interleukin-10 determines viral clearance or persistence in vivoDavid G Brooks
Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Med 12:1301-9. 2006..Genetic removal of Il10 resulted in the maintenance of robust effector T-cell responses, the rapid elimination of virus and the development ..
- An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitisShehzad Z Sheikh
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
J Immunol 186:5506-13. 2011....
- Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J miceGillian L Beamer
Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
J Immunol 181:5545-50. 2008..Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans...
- Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarctionJana S Burchfield
Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Circ Res 103:203-11. 2008..These results suggest that BM-MNCs mediate cardiac protection after myocardial infarction and this is, at least in part, dependent on IL-10...
- Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammationFang Yan
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
J Clin Invest 114:1272-80. 2004..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
- TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cellsAyca Sayi
Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
J Immunol 186:878-90. 2011....
- TLR-activated B cells suppress T cell-mediated autoimmunityVicky Lampropoulou
Deutsches Rheuma ForschungsZentrum, Berlin, Germany
J Immunol 180:4763-73. 2008..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...
- Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10Alma Zernecke
Department of Cardiology, Rheinisch Westfälische Technische Hochschule Aachen University, Germany
Blood 107:4240-3. 2006..Deletion of CCR5 entailed an up-regulation of the anti-inflammatory cytokine interleukin 10 (IL-10) in neointimal smooth muscle cells, and its antibody blockade reversed effects in CCR5(-/-) mice...
- IL-21 mediates suppressive effects via its induction of IL-10Rosanne Spolski
Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 182:2859-67. 2009..Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine...
- NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesTomohiro Watanabe
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
Nat Immunol 5:800-8. 2004..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
- TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activationCheng Qian
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai, 200433, People s Republic of China
Blood 108:2307-15. 2006..Here, we report that unlike immature DCs, diffDCs secrete more interleukin 10 (IL-10) but little IL-12p70 in response to lipopolysaccharide (LPS) or other TLR agonists...
- Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritisT Kasama
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
J Clin Invest 95:2868-76. 1995..macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage inflammatory protein 2 (MIP-2), and interleukin 10 (IL-10) during the evolution of type II collagen-induced arthritis (CIA)...
- 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel diseaseM T Cantorna
Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 130:2648-52. 2000..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
- IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in miceMark S Wilson
Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
J Clin Invest 117:2941-51. 2007..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
- IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathologyPranita P Sarangi
Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
J Immunol 180:6297-306. 2008..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
- MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophagesJoanne Darragh
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 425:595-602. 2010..MSKs therefore act as important negative regulators of inflammation following TLR activation...
- Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-betaAnthony Joetham
Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 178:1433-42. 2007..By analogy, anti-TGF-beta treatment reduced regulatory T cell activity. These data identify naturally occurring lung CD4(+)CD25(+) T cells as capable of regulating lung allergic responses in an IL-10- and TGF-beta-dependent manner...
- Chromatin-level regulation of the IL10 gene in T cellsSin Hyeog Im
Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
J Biol Chem 279:46818-25. 2004The immunoregulatory cytokine interleukin 10 (IL-10) modulates the function of diverse immune and non-immune cells...
- Studies with IL-10-/- mice: an overviewD M Rennick
DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304 1104, USA
J Leukoc Biol 61:389-96. 1997..whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice...
- IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infectionMartin Guilliams
Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
J Immunol 182:1107-18. 2009....
- The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cellsMatthias Hesse
Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:3157-66. 2004..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
- A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigenMarcin P Mycko
Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
Eur J Immunol 38:1999-2013. 2008....
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responsesD J Berg
Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
J Clin Invest 98:1010-20. 1996..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
- A pivotal role for galectin-1 in fetomaternal toleranceSandra M Blois
Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
Nat Med 13:1450-7. 2007..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
- Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulationAtsushi Mizoguchi
Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Immunity 16:219-30. 2002..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
- Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10Gustavo Batista Menezes
Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
J Immunol 183:7557-68. 2009..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
- IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platformPatricia A Darrah
Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 207:1421-33. 2010..Overall, we delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells...
- Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cellsShengli Xu
Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
J Biol Chem 284:7038-46. 2009..Thus, our data indicate that pattern recognition receptors such as Dectin-1 could elicit Ca2+ signaling and that PLCgamma2 is a critical player in the Dectin-1 signal transduction pathway...
- T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient miceN J Davidson
DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
J Exp Med 184:241-51. 1996Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
- Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirusO R Oakley
Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
Clin Exp Immunol 151:155-64. 2008..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...
- IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophagesHirotaka Kuwata
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
Blood 102:4123-9. 2003..These findings suggest that IL-10-induced Bcl-3 is required for suppression of TNF-alpha production in macrophages...
- Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammationD M Rennick
DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
Am J Physiol Gastrointest Liver Physiol 278:G829-33. 2000....
- The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in miceDanielle G Souza
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Immunol 179:8533-43. 2007....
- B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo functionMELANIE A RUFFNER
Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur J Immunol 39:3084-90. 2009..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
- IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic diseaseT A Wynn
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 160:4473-80. 1998..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
- Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1Elaine Y Chung
Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
Immunity 27:952-64. 2007..By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of ..
- Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infectionVishal Sindhava
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
PLoS ONE 5:e11445. 2010..This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity...
- Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent mannerLauren W Collison
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
J Immunol 182:6121-8. 2009..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
- Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1Ryan L Brunsing
Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Immunology 134:93-106. 2011..These results demonstrate that G-1 acts directly on CD4(+) T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL-10 expression in Th17 or hybrid T-cell populations...
- Antifungal type 1 responses are upregulated in IL-10-deficient miceG Del Sero
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Microbes Infect 1:1169-80. 1999..The resulting protective Th1 responses lead to a prompt reduction of fungal growth, thus preventing tissue destruction and lethal levels of proinflammatory cytokines...
- Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1Achara Srisodsai
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:54358-68. 2004..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
- IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoniS C Bosshardt
Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
Parasite Immunol 19:347-53. 1997..This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation that occurs in chronic schistosomiasis...
- Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expressionVirginia S Carl
University of Virginia Health System, Department of Medicine, Digestive Health Center of Excellence and Microbiology, Charlottesville, VA 22908 0708, USA
J Leukoc Biol 76:735-42. 2004..Together, these results demonstrate that endogenously produced IL-10 plays a significant role in LPS-induced sIL-1Ra gene expression via the activation of STAT3...
- Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10Michael Hammer
Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
Eur J Immunol 35:2991-3001. 2005..Thus, these data suggest an operational link between IL-10 and inhibition of p38 MAPK via sustained expression of DUSP1...
- Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shockMichael Hammer
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
J Exp Med 203:15-20. 2006..These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock...
- Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signalingStefan Zimmermann
Institute of Medical Microbiology and Hygiene, Philipps University, Marburg, Germany
J Immunol 176:1840-7. 2006..gondii on IFN-gamma were diminished in macrophages from SOCS-1-/- mice. The results suggest that induction of SOCS proteins within phagocytes due to infection with T. gondii contributes to the parasite's immune evasion strategies...
- Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone miceG J Prud'homme
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
Mol Immunol 32:495-503. 1995..IL-1 beta, IFN gamma and IL-10 are pleiotropic cytokines with pro-inflammatory and B-cell stimulatory effects. These results point to certain cytokines as potential targets for immunotherapy in lupus...
- Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfacesYuri P Rubtsov
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 28:546-58. 2008..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
- IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 miceCharles F Anderson
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
J Immunol 180:4090-7. 2008..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies...
- Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10S Redpath
Department of Immunology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 162:6701-7. 1999..Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-gamma...
- Bromelain Proteinase Activity in IBDLAURA HALE; Fiscal Year: 2006..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Mast Cells and IBD PathogenesisLAURA HALE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Novel Oral Adjuvant for Dental VaccinesLAURA HALE; Fiscal Year: 2005..abstract_text> ..
- Bromelain as a Biologically-Based Therapy for IBDLAURA HALE; Fiscal Year: 2005..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Chemoprevention of IBD-Associated Colon CancerLaura P Hale; Fiscal Year: 2010..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of Immune Modulation by Abscisic AcidJosep Bassaganya Riera; Fiscal Year: 2010..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
- Regulation of Inflammation by Somatostatin via SSTR 2David Elliott; Fiscal Year: 2006..Macrophage SOM production is induced by LPS, IFN-?, IL 10, TNF-?, PgE2 and cAMP. Murine inflammatory T cells express only one type of SOM receptor, SSTR2...
- Novel Molecules that Define Viral PersistenceDavid Brooks; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNILINDA MANSFIELD; Fiscal Year: 2002..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
- Th1-to Th2 shift of HSP65 responses and atherogenesisYoshimi Shibata; Fiscal Year: 2005..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
- Induction of hepatic tolerance to parasitic nematodesSusan Bliss; Fiscal Year: 2007..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
- IMMUNE RESPONSES TO SMALL INTESTINAL SUBMUCOSADENNIS METZGER; Fiscal Year: 2001..The results will provide important insight into the mechanisms responsible for successful xenogeneic transplantation and could lead to targeted cytokine therapies to prevent tissue rejection. ..
- MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATIONLars Eckmann; Fiscal Year: 2008..abstract_text> ..
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- Role of Galectin-4 in ColitisAtsushi Mizoguchi; Fiscal Year: 2008..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
- Immunological Basis for H. Pylori-Related MalignanciesMarygorret Obonyo; Fiscal Year: 2006..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
- Innate Immunity to Salmonella InfectionsJoshua Fierer; Fiscal Year: 2005..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
- HOST IMMUNOMODULATION BY PARASITESRamaswamy Kalyanasundaram; Fiscal Year: 2004..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
- Role of SOCS proteins in host-pathogen responsesPeter Murray; Fiscal Year: 2003..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
- MULTIVALENT VACCINE FOR LYMPHATIC FILARIASISRamaswamy Kalyanasundaram; Fiscal Year: 2010..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..