Il10

Summary

Gene Symbol: Il10
Description: interleukin 10
Alias: CSIF, Il-10, cytokine synthesis inhibitory factor, interleukin-10
Species: mouse

Top Publications

  1. doi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
  2. pmc Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
  3. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
  4. pmc CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Immunol 174:1962-70. 2005
  5. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
  6. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
  7. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  8. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  9. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
  10. doi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008

Research Grants

  1. Analyzing and modulating immunoregulatory defects in autoimmune disease
    MICHELE KOSIEWICZ; Fiscal Year: 2007
  2. The Role of MerTK in Autoimmune Diabetes
    Roland Tisch; Fiscal Year: 2007
  3. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
  4. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
  5. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2007
  6. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
  7. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
  8. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
  9. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
  10. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005

Detail Information

Publications164 found, 100 shown here

  1. doi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
    ..Therefore, one can speculate that T(reg) during transendothelial transmigration become "armed" for their suppressive function(s) to be carried out in peripheral tissues sites...
  2. pmc Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
    ..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
  3. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  4. pmc CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Immunol 174:1962-70. 2005
    ..Thus, IL-10-producing, CCR8+CD4+CD25+CD44+ T cells are generated during SEA challenge, which augment the Th2-mediated eosinophil-rich response to the parasite Ags...
  5. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  6. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  7. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  8. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  9. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  10. doi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008
    ..Thereby, CD1d(hi)CD5(+) B cells represent a unique subset of potent regulatory B cells...
  11. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
  12. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  13. pmc Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    D F Fiorentino
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 170:2081-95. 1989
    A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones...
  14. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  15. pmc The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010
    Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease...
  16. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  17. pmc Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function
    Asher Maroof
    Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, Wentworth Way, York YO10 5YW, UK
    Immunity 29:295-305. 2008
    ....
  18. pmc Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
    ..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
  19. pmc Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 7:e1002173. 2011
    ..Our findings suggest a potentially critical role of effector T cell-derived IL-10 in controlling disease severity in clinical RSV infection...
  20. doi The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
    Olga Ananieva
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:1028-36. 2008
    ..transcription of the mitogen-activated protein kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10, MSK1 and MSK2 exerted many negative feedback mechanisms...
  21. doi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  22. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  23. pmc Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
    Seung Hwan Lee
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Exp Med 206:2235-51. 2009
    ..The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses...
  24. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
    ..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27...
  25. ncbi A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
    H Groux
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:1723-9. 1999
    ..These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo...
  26. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  27. ncbi A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Neuroimmunol 165:63-74. 2005
    ..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
  28. pmc TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
    Frank Kaiser
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 206:1863-71. 2009
    ....
  29. pmc IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:3018-23. 2010
    ..On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination...
  30. pmc Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    Rajat Madan
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Immunol 183:2312-20. 2009
    ....
  31. ncbi TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    ..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
  32. ncbi Helminth infection protects mice from anaphylaxis via IL-10-producing B cells
    Niamh E Mangan
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 173:6346-56. 2004
    ....
  33. pmc An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    C Asseman
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Exp Med 190:995-1004. 1999
    ..These findings provide the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens...
  34. pmc IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
    Maria A Stacey
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    J Immunol 187:2944-52. 2011
    ..Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells...
  35. pmc Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis
    Kathryn Trandem
    Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:3642-52. 2011
    ..Furthermore, IL-10 produced by CD8 T cells diminished disease severity in mice with coronavirus-induced acute encephalitis, suggesting a self-regulatory mechanism that minimizes immunopathological changes...
  36. ncbi CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
    ..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
  37. pmc Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice
    W Joshua Frazier
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Immunol 183:7411-9. 2009
    ....
  38. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
    ..Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility...
  39. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
  40. doi Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset
    Yasuhiro Takada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 184:2671-6. 2010
    ..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
  41. ncbi Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site
    B K Halak
    Kimmel Cancer Center, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 59:911-7. 1999
    ..These studies demonstrate that tumor-induced IL-10 can block the generation of a tumor-specific type 1 immune response as well as subvert attempts to elicit a type 1 immune response to a non-tumor antigen at the tumor site...
  42. doi Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Marina C Pils
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 40:443-8. 2010
    ..In contrast, in an IL-10-regulated T-cell response to Trichuris muris infection, IL-10 acting on T cells or monocytes/macrophages/neutrophils is not critical for the control of the infection...
  43. ncbi Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    Masahito Kamanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:941-52. 2006
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
  44. pmc Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells
    Georgia Perona-Wright
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Host Microbe 6:503-12. 2009
    ..In contrast to disseminating pathogens, locally restricted infections did not elicit NK cell IL-10. Thus systemic infections uniquely engage NK cells in an IL-10-mediated immunoregulatory circuit that functions to alleviate inflammation...
  45. ncbi Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  46. ncbi IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 158:3311-6. 1997
    ..cruzi there is a critical requirement for IL-10 to prevent the development of a pathologic immune response associated with CD4+ T cells and overproduction of IL-12...
  47. ncbi Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells
    Qing Sheng Mi
    Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Diabetes 53:1303-10. 2004
    ..Our data identify an important role for IL-4 in the protection against type 1 diabetes by activated iNKT cells, and these findings have important implications for cytokine-based therapy of type 1 diabetes and islet transplantation...
  48. ncbi Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged mice
    Bo Chin Chiu
    Department of Cellular and Molecular Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 181:3156-66. 2008
    ..Our data identify a novel mechanism of age-associated immune deficiency...
  49. pmc Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10
    Dorothy K Sojka
    The David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:18336-41. 2011
    ..Interestingly, Tregs used different regulatory mechanisms to regulate IFN-γ (IL-10-dependent or -independent) subject to the target T-cell stage of activation and its tissue location...
  50. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
    ..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
  51. pmc Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
    Jose M Gonzalez-Navajas
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 207:2799-807. 2010
    ..Our data identifies a new molecular pathway by which IL-1 signaling attenuates TLR9-mediated proinflammatory responses...
  52. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Genetic removal of Il10 resulted in the maintenance of robust effector T-cell responses, the rapid elimination of virus and the development ..
  53. pmc An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis
    Shehzad Z Sheikh
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Immunol 186:5506-13. 2011
    ....
  54. pmc Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice
    Gillian L Beamer
    Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:5545-50. 2008
    ..Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans...
  55. doi Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction
    Jana S Burchfield
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 103:203-11. 2008
    ..These results suggest that BM-MNCs mediate cardiac protection after myocardial infarction and this is, at least in part, dependent on IL-10...
  56. pmc Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
    ..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
  57. doi TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells
    Ayca Sayi
    Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
    J Immunol 186:878-90. 2011
    ....
  58. ncbi TLR-activated B cells suppress T cell-mediated autoimmunity
    Vicky Lampropoulou
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    J Immunol 180:4763-73. 2008
    ..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...
  59. ncbi Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10
    Alma Zernecke
    Department of Cardiology, Rheinisch Westfälische Technische Hochschule Aachen University, Germany
    Blood 107:4240-3. 2006
    ..Deletion of CCR5 entailed an up-regulation of the anti-inflammatory cytokine interleukin 10 (IL-10) in neointimal smooth muscle cells, and its antibody blockade reversed effects in CCR5(-/-) mice...
  60. pmc IL-21 mediates suppressive effects via its induction of IL-10
    Rosanne Spolski
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2859-67. 2009
    ..Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine...
  61. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    ..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
  62. ncbi TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation
    Cheng Qian
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai, 200433, People s Republic of China
    Blood 108:2307-15. 2006
    ..Here, we report that unlike immature DCs, diffDCs secrete more interleukin 10 (IL-10) but little IL-12p70 in response to lipopolysaccharide (LPS) or other TLR agonists...
  63. pmc Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
    T Kasama
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Clin Invest 95:2868-76. 1995
    ..macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage inflammatory protein 2 (MIP-2), and interleukin 10 (IL-10) during the evolution of type II collagen-induced arthritis (CIA)...
  64. ncbi 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease
    M T Cantorna
    Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 130:2648-52. 2000
    ..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
  65. pmc IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 117:2941-51. 2007
    ..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
  66. ncbi IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology
    Pranita P Sarangi
    Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Immunol 180:6297-306. 2008
    ..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
  67. doi MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages
    Joanne Darragh
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 425:595-602. 2010
    ..MSKs therefore act as important negative regulators of inflammation following TLR activation...
  68. ncbi Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta
    Anthony Joetham
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:1433-42. 2007
    ..By analogy, anti-TGF-beta treatment reduced regulatory T cell activity. These data identify naturally occurring lung CD4(+)CD25(+) T cells as capable of regulating lung allergic responses in an IL-10- and TGF-beta-dependent manner...
  69. ncbi Chromatin-level regulation of the IL10 gene in T cells
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
    J Biol Chem 279:46818-25. 2004
    The immunoregulatory cytokine interleukin 10 (IL-10) modulates the function of diverse immune and non-immune cells...
  70. ncbi Studies with IL-10-/- mice: an overview
    D M Rennick
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304 1104, USA
    J Leukoc Biol 61:389-96. 1997
    ..whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice...
  71. ncbi IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection
    Martin Guilliams
    Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
    J Immunol 182:1107-18. 2009
    ....
  72. ncbi The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Matthias Hesse
    Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3157-66. 2004
    ..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
  73. doi A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen
    Marcin P Mycko
    Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
    Eur J Immunol 38:1999-2013. 2008
    ....
  74. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  75. ncbi A pivotal role for galectin-1 in fetomaternal tolerance
    Sandra M Blois
    Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
    Nat Med 13:1450-7. 2007
    ..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
  76. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  77. doi Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10
    Gustavo Batista Menezes
    Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    J Immunol 183:7557-68. 2009
    ..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
  78. pmc IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:1421-33. 2010
    ..Overall, we delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells...
  79. pmc Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
    Shengli Xu
    Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
    J Biol Chem 284:7038-46. 2009
    ..Thus, our data indicate that pattern recognition receptors such as Dectin-1 could elicit Ca2+ signaling and that PLCgamma2 is a critical player in the Dectin-1 signal transduction pathway...
  80. pmc T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    N J Davidson
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    J Exp Med 184:241-51. 1996
    Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
  81. pmc Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus
    O R Oakley
    Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
    Clin Exp Immunol 151:155-64. 2008
    ..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...
  82. ncbi IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages
    Hirotaka Kuwata
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Blood 102:4123-9. 2003
    ..These findings suggest that IL-10-induced Bcl-3 is required for suppression of TNF-alpha production in macrophages...
  83. ncbi Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
    D M Rennick
    DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    Am J Physiol Gastrointest Liver Physiol 278:G829-33. 2000
    ....
  84. ncbi The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice
    Danielle G Souza
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Immunol 179:8533-43. 2007
    ....
  85. pmc B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
  86. ncbi IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
    T A Wynn
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:4473-80. 1998
    ..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
  87. pmc Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of ..
  88. pmc Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection
    Vishal Sindhava
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 5:e11445. 2010
    ..This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity...
  89. pmc Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 182:6121-8. 2009
    ..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
  90. pmc Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1
    Ryan L Brunsing
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, USA
    Immunology 134:93-106. 2011
    ..These results demonstrate that G-1 acts directly on CD4(+) T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL-10 expression in Th17 or hybrid T-cell populations...
  91. ncbi Antifungal type 1 responses are upregulated in IL-10-deficient mice
    G Del Sero
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 1:1169-80. 1999
    ..The resulting protective Th1 responses lead to a prompt reduction of fungal growth, thus preventing tissue destruction and lethal levels of proinflammatory cytokines...
  92. ncbi Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
  93. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
    ..This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation that occurs in chronic schistosomiasis...
  94. ncbi Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
    Virginia S Carl
    University of Virginia Health System, Department of Medicine, Digestive Health Center of Excellence and Microbiology, Charlottesville, VA 22908 0708, USA
    J Leukoc Biol 76:735-42. 2004
    ..Together, these results demonstrate that endogenously produced IL-10 plays a significant role in LPS-induced sIL-1Ra gene expression via the activation of STAT3...
  95. ncbi Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10
    Michael Hammer
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
    Eur J Immunol 35:2991-3001. 2005
    ..Thus, these data suggest an operational link between IL-10 and inhibition of p38 MAPK via sustained expression of DUSP1...
  96. pmc Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
    Michael Hammer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    J Exp Med 203:15-20. 2006
    ..These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock...
  97. ncbi Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling
    Stefan Zimmermann
    Institute of Medical Microbiology and Hygiene, Philipps University, Marburg, Germany
    J Immunol 176:1840-7. 2006
    ..gondii on IFN-gamma were diminished in macrophages from SOCS-1-/- mice. The results suggest that induction of SOCS proteins within phagocytes due to infection with T. gondii contributes to the parasite's immune evasion strategies...
  98. ncbi Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice
    G J Prud'homme
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Immunol 32:495-503. 1995
    ..IL-1 beta, IFN gamma and IL-10 are pleiotropic cytokines with pro-inflammatory and B-cell stimulatory effects. These results point to certain cytokines as potential targets for immunotherapy in lupus...
  99. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
  100. ncbi IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 180:4090-7. 2008
    ..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies...
  101. ncbi Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10
    S Redpath
    Department of Immunology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 162:6701-7. 1999
    ..Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-gamma...

Research Grants90

  1. Analyzing and modulating immunoregulatory defects in autoimmune disease
    MICHELE KOSIEWICZ; Fiscal Year: 2007
    ....
  2. The Role of MerTK in Autoimmune Diabetes
    Roland Tisch; Fiscal Year: 2007
    ..In this way, the cellular and molecular contribution of MerTK in regulating APC activation and effector function, and how these events shape ¿ cell-specific T cell reactivity will be ascertained. ..
  3. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive. ..
  4. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  5. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2007
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  6. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  7. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..If indicated, follow-up studies will be aimed at determining the mechanisms underlying mast cell activity in IBD as well as more rigorous studies of the efficacy of mast cell inhibitors for therapy of established IBD. ..
  8. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..rhsp 60 serves as a paradigm, and the data emerging from this proposal may be broadly applicable to other antigens against intracellular pathogens. ..
  9. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  10. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  11. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  12. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....
  13. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  14. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  15. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  16. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  17. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  18. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  19. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  20. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  21. Murine models to test parasite products as cures for Inflammatory Bowel Disease
    LINDA MANSFIELD; Fiscal Year: 2007
    ..Dr. Mansfield has documented success mentoring graduate students and seeks to expand her mentoring of D.V.M.s in mouse pathobiology. ..
  22. Induction of hepatic tolerance to parasitic nematodes
    Susan Bliss; Fiscal Year: 2007
    ..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
  23. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    ..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
  24. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..Macrophage SOM production is induced by LPS, IFN-?, IL 10, TNF-?, PgE2 and cAMP. Murine inflammatory T cells express only one type of SOM receptor, SSTR2...
  25. Mechanisms of Immune Modulation and Periodontal Disease
    Jannet Katz; Fiscal Year: 2005
    ....
  26. IMMUNE RESPONSES TO SMALL INTESTINAL SUBMUCOSA
    DENNIS METZGER; Fiscal Year: 2001
    ..The results will provide important insight into the mechanisms responsible for successful xenogeneic transplantation and could lead to targeted cytokine therapies to prevent tissue rejection. ..
  27. B CELL FUNCTION IN AUTOIMMUNE ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ....
  28. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  29. INNATE IMMUNE RECEPTOR ANTAGONISM BY ORTHOPOXVIRUS PROTEINS
    Anthony R French; Fiscal Year: 2010
    ..This work will also provide immunologic insight into the function of these receptors insight that likely is extensible to other infections. ..
  30. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006
    ..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
  31. HOST IMMUNOMODULATION BY PARASITES
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
  32. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2007
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  33. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  34. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  35. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  36. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ..These studies aim to develop novel insights into the autoimmune disease process that will facilitate the diagnosis and treatment of RA. ..