Gene Symbol: Iigp1
Description: interferon inducible GTPase 1
Alias: 2900074L10Rik, AI046432, AW111922, Ifgga1, Iigp, Irga6, interferon-inducible GTPase 1, interferon-gamma-inducible GTPase Ifgga1 protein
Species: mouse
Products:     Iigp1

Top Publications

  1. Uthaiah R, Praefcke G, Howard J, Herrmann C. IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization. J Biol Chem. 2003;278:29336-43 pubmed
    b>IIGP1 belongs to a well defined family of 47-kDa GTPases whose members are present at low resting levels in mouse cells but are strongly induced transcriptionally by interferons and are implicated in cell-autonomous resistance to ..
  2. Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E. Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases. Mol Cell. 2004;15:727-39 pubmed
    ..Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form...
  3. Martens S, Sabel K, Lange R, Uthaiah R, Wolf E, Howard J. Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis. J Immunol. 2004;173:2594-606 pubmed
    ..Unlike LRG-47, but like the published p47 resistance GTPase, IGTP, a further p47 GTPase, IIGP1, is associated with the endoplasmic reticulum...
  4. Martens S, Parvanova I, Zerrahn J, Griffiths G, Schell G, Reichmann G, et al. Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS Pathog. 2005;1:e24 pubmed
    ..We show that the p47 GTPases, including IIGP1, accumulate at vacuoles containing T. gondii. The accumulation is GTP-dependent and requires live parasites...
  5. Pawlowski N, Khaminets A, Hunn J, Papic N, Schmidt A, Uthaiah R, et al. The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii. BMC Biol. 2011;9:7 pubmed publisher
    ..The IRG protein, Irga6 (IIGP1), participates in the disruption of the vacuolar membrane surrounding the intracellular parasite, Toxoplasma ..
  6. Zeng J, Parvanova I, Howard J. A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver. PLoS ONE. 2009;4:e6787 pubmed publisher
    ..However, strong constitutive expression of the cell-autonomous resistance GTPase, Irga6 (IIGP1), was found in mouse liver, contrasting with previous evidence that expression of this protein is exclusively ..
  7. Boehm U, Guethlein L, Klamp T, Ozbek K, Schaub A, Fütterer A, et al. Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol. 1998;161:6715-23 pubmed
    ..Understanding the role of these GTPases in IFN-gamma-mediated resistance against pathogens is the task for the future. ..
  8. Kaiser F, Kaufmann S, Zerrahn J. IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. J Cell Sci. 2004;117:1747-56 pubmed
    ..The association of IGTP and IIGP with membranous compartments, the endoplasmic reticulum and, in addition in case of IIGP, the Golgi, implicate ..
  9. Al Zeer M, Al Younes H, Braun P, Zerrahn J, Meyer T. IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy. PLoS ONE. 2009;4:e4588 pubmed publisher
    ..In this study, we identify Irga6 as an important resistance factor against C. trachomatis, but not C...

More Information


  1. Liesenfeld O, Parvanova I, Zerrahn J, Han S, Heinrich F, Munoz M, et al. The IFN-?-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS ONE. 2011;6:e20568 pubmed publisher
    ..The in vivo role of another member of this family, Irga6 (IIGP, IIGP1) has been studied in less detail...
  2. Coers J, Bernstein Hanley I, Grotsky D, Parvanova I, Howard J, Taylor G, et al. Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol. 2008;180:6237-45 pubmed
    ..It has previously been suggested that C. muridarum inactivates the IRG protein Irga6 (Iigp1) to dampen the murine immune response. However, we show that Irga6 is dispensable for the control of C...
  3. Hunn J, Koenen Waisman S, Papic N, Schroeder N, Pawlowski N, Lange R, et al. Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. EMBO J. 2008;27:2495-509 pubmed publisher
    ..nucleotide-binding site, regulate the intracellular positioning of the conventional GKS subfamily members, Irga6 and Irgb6...
  4. Papic N, Hunn J, Pawlowski N, Zerrahn J, Howard J. Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo. J Biol Chem. 2008;283:32143-51 pubmed publisher
    b>Irga6, a myristoylated, interferon-inducible member of the immunity-related GTPase family, contributes to disease resistance against Toxoplasma gondii in mice. Accumulation of Irga6 on the T...
  5. Steinfeldt T, Könen Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley L, et al. Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol. 2010;8:e1000576 pubmed publisher
    ..We show that the parasite kinase phosphorylates host Irga6 at two threonines in the nucleotide-binding domain, biochemically inactivating the GTPase and inhibiting its ..
  6. Zerrahn J, Schaible U, Brinkmann V, Guhlich U, Kaufmann S. The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis. J Immunol. 2002;168:3428-36 pubmed
    ..We analyzed the expression of the 47-kDa GTPase cognate, IIGP, in splenic sections from mice infected with the intracellular pathogen Listeria monocytogenes by ..
  7. Traver M, Henry S, Cantillana V, Oliver T, Hunn J, Howard J, et al. Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem. 2011;286:30471-80 pubmed publisher
    ..Both in Atg5- and IRGM-deficient cells, the IRG protein Irga6 relocalized to the same compartments as Gbp2, raising the possibility of a common regulatory mechanism...
  8. Fleckenstein M, Reese M, Könen Waisman S, Boothroyd J, Howard J, Steinfeldt T. A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins. PLoS Biol. 2012;10:e1001358 pubmed publisher
    ..This represents a novel mechanism in which a pseudokinase facilitates the phosphorylation of a target by a partner kinase by preparing the substrate for phosphorylation, rather than by upregulation of the activity of the kinase itself. ..
  9. Reese M, Shah N, Boothroyd J. The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases. J Biol Chem. 2014;289:27849-58 pubmed publisher
  10. Ferreira da Silva M, da Fonseca Ferreira da Silva M, Springer Frauenhoff H, Bohne W, Howard J. Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance system. PLoS Pathog. 2014;10:e1004449 pubmed publisher
  11. Lapaque N, Takeuchi O, Corrales F, Akira S, Moriyon I, Howard J, et al. Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell Microbiol. 2006;8:401-13 pubmed
    ..Classical but not non-classical LPSs efficiently induced TNF-alpha, IIGP and IGTP p47-GTPase expression...
  12. Lemay A, Haston C. Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice. Physiol Genomics. 2005;23:54-61 pubmed
    ..4%) of which were also differentially expressed. Genomic approaches were combined to produce a set of candidate genes that may influence susceptibility to bleomycin-induced pulmonary fibrosis in the A/J:B6 mouse model...
  13. Schulte K, Pawlowski N, Faelber K, Fröhlich C, Howard J, Daumke O. The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion. BMC Biol. 2016;14:14 pubmed publisher
    ..b>Irga6 is a dynamin-like protein that oligomerizes at the parasitophorous vacuolar membrane (PVM) of Toxoplasma gondii ..
  14. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011;359:163-75 pubmed publisher
    ..As an initial step in this direction we describe a regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development. ..
  15. Hermanns T, Müller U, Könen Waisman S, Howard J, Steinfeldt T. The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7. Cell Microbiol. 2016;18:244-59 pubmed publisher
    ..The absence of GRA7 results in reduced phosphorylation of Irga6 correlated with increased vacuolar IRG protein amounts and attenuated virulence...