Igf1r

Summary

Gene Symbol: Igf1r
Description: insulin-like growth factor I receptor
Alias: A330103N21Rik, CD221, D930020L01, IGF-1R, hyft, insulin-like growth factor 1 receptor, IGF-I receptor, line 186
Species: mouse
Products:     Igf1r

Top Publications

  1. DeAngelis T, Chen J, Wu A, Prisco M, Baserga R. Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling. Oncogene. 2006;25:32-42 pubmed
    ..We propose that the requirement for a tyrosyl-phosphorylated IRS-1 provides a mechanism to explain the failure of T antigen to transform MEFs with deleted IGF-IR genes. ..
  2. Yang S, Chen C, Chang G, Wen H, Chen C, Chang S, et al. Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. PLoS ONE. 2013;8:e58100 pubmed publisher
  3. Kloting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, et al. Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes. 2008;57:2074-82 pubmed publisher
  4. Xiong L, Kou F, Yang Y, Wu J. A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop. J Cell Biol. 2007;178:995-1007 pubmed
    ..The eukaryotic translation initiation factor 4F complex is also involved in this translational inhibition. These results demonstrate an unexpected role for translational control by IGF-1R in p53-mediated apoptosis. ..
  5. Zeger M, Popken G, Zhang J, Xuan S, Lu Q, Schwab M, et al. Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination. Glia. 2007;55:400-11 pubmed
    ..on the cells of oligodendrocyte lineage, we generated lines of mice in which the type 1 IGF receptor gene (igf1r) was conditionally ablated either in Olig1 or proteolipid protein expressing cells (termed IGF1R(pre-oligo-ko) and ..
  6. Ahamed K, Epaud R, Holzenberger M, Bonora M, Flejou J, Puard J, et al. Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury. Respir Res. 2005;6:31 pubmed
    ..Together, these data demonstrate that a decrease in IGF-1R signaling in mice protects against oxidant-induced lung injury. ..
  7. Liang H, Masoro E, Nelson J, Strong R, McMahan C, Richardson A. Genetic mouse models of extended lifespan. Exp Gerontol. 2003;38:1353-64 pubmed
    ..receptor/binding protein (GHR/BP(-/-)) or p66(shc) (p66(shc-/-)), mice heterozygous for the IGF-I receptor (Igf1r(+/-)), and fat-specific insulin receptor knockout mice...
  8. Kondo T, Vicent D, Suzuma K, Yanagisawa M, King G, Holzenberger M, et al. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003;111:1835-42 pubmed
    ..These data indicate that both insulin and IGF-1 signaling in endothelium play a role in retinal neovascularization through the expression of vascular mediators, with the effect of insulin being most important in this process. ..
  9. Pitetti J, Torre D, Conne B, Papaioannou M, Cederroth C, Xuan S, et al. Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice. Sex Dev. 2009;3:264-72 pubmed publisher
    ..and IGF2) act through 2 structurally related receptors, the insulin receptor (INSR) and the type 1 IGF receptor (IGF1R), both of which are expressed in developing oocytes...

More Information

Publications63

  1. Boucher J, Mori M, Lee K, Smyth G, Liew C, Macotela Y, et al. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun. 2012;3:902 pubmed publisher
    ..Thus, insulin/IGF-1 signalling has a crucial role in the control of brown and white fat development, and, when disrupted, leads to defective thermogenesis and a paradoxical increase in basal metabolic rate. ..
  2. Dietrich P, Dragatsis I, Xuan S, Zeitlin S, Efstratiadis A. Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mamm Genome. 2000;11:196-205 pubmed
    ..homolog (Hdh), the epidermal growth factor receptor (Egfr), and the type 1 insulin-like growth factor receptor (Igf1r)...
  3. Jones R, Campbell C, Gunther E, Chodosh L, Petrik J, Khokha R, et al. Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007;26:1636-44 pubmed
  4. Hermanto U, Zong C, Li W, Wang L. RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002;22:2345-65 pubmed
  5. Kappeler L, De Magalhaes Filho C, Dupont J, Leneuve P, Cervera P, Perin L, et al. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 2008;6:e254 pubmed publisher
    ..Our results also suggest that tonic somatotropic signaling entails the risk of shortened lifespan. ..
  6. Mavalli M, DiGirolamo D, Fan Y, Riddle R, Campbell K, van Groen T, et al. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. J Clin Invest. 2010;120:4007-20 pubmed publisher
    ..These results identify distinct signaling pathways through which GHR regulates skeletal muscle development and modulates nutrient metabolism...
  7. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland K, Smith R. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564-73 pubmed
    ..Grb10 and GIGYFs may act cooperatively to regulate receptor signaling. ..
  8. Esquiliano D, Guo W, Liang L, Dikkes P, Lopez M. Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations. Placenta. 2009;30:693-9 pubmed publisher
    ..Taken together, these results support a role for Igf2 and Akt1, but not the insulin nor the IGF Type 1 receptors, in the regulation of placental growth and glycogen metabolism. ..
  9. Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher P, et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest. 2002;110:1011-9 pubmed
    ..antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling...
  10. Kulkarni R, Holzenberger M, Shih D, Ozcan U, Stoffel M, Magnuson M, et al. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002;31:111-5 pubmed
    ..10). When mice deficient for the Igf1 receptor (Igf1r(+/-)) are bred with mice lacking insulin receptor substrate 2 (Irs2(-/-)), the resulting compound knockout mice ..
  11. Boucher J, Tseng Y, Kahn C. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010;285:17235-45 pubmed publisher
    ..differentiation into adipocytes that express both receptors, but at different ratios; 2) insulin receptor (IR) or IGF1R knock-out preadipocytes that only express the complimentary receptor; and 3) IR/IGF1R double knock-out (DKO) cells ..
  12. Zhang M, Xuan S, Bouxsein M, Von Stechow D, Akeno N, Faugere M, et al. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002;277:44005-12 pubmed
    ..Cre-mediated recombination to disrupt selectively in mouse osteoblasts the gene encoding the type 1 IGF receptor (Igf1r)...
  13. Wang Y, Nishida S, Sakata T, Elalieh H, Chang W, Halloran B, et al. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006;147:4753-61 pubmed
    ..Our results indicate that IGF-I plays an important role in skeletal development by promoting chondrocyte proliferation and maturation while inhibiting apoptosis to form bones of appropriate size and strength. ..
  14. Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. 2002;1:339-53 pubmed
    ..Notably, encapsulated tumors were absent; instead, invasive carcinomas with downregulated E-cadherin were prevalent, and the majority of mice had local lymph node metastasis. ..
  15. Gatchel J, Watase K, Thaller C, Carson J, Jafar Nejad P, Shaw C, et al. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A. 2008;105:1291-6 pubmed publisher
    ..These data define one common pathogenic response in SCA1 and SCA7 and reveal the importance of intercellular mechanisms in their pathogenesis. ..
  16. Rajwani A, Ezzat V, Smith J, Yuldasheva N, Duncan E, Gage M, et al. Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes. 2012;61:915-24 pubmed publisher
  17. Baserga R. The IGF-I receptor in cancer research. Exp Cell Res. 1999;253:1-6 pubmed
    ..However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation. ..
  18. Nadjar A, Berton O, Guo S, Leneuve P, Dovero S, Diguet E, et al. IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP. Neurobiol Aging. 2009;30:2021-30 pubmed publisher
    ..Collectively, these data indicate that IGF signaling can reduce neuro-inflammation dependent sensitivity of neurons to MPTP. ..
  19. Nef S, Verma Kurvari S, Merenmies J, Vassalli J, Efstratiadis A, Accili D, et al. Testis determination requires insulin receptor family function in mice. Nature. 2003;426:291-5 pubmed
    ..Here we show that the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation...
  20. Liu J, Baker J, Perkins A, Robertson E, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993;75:59-72 pubmed
    ..In contrast, null mutants for the Igf1r gene die invariably at birth of respiratory failure and exhibit a more severe growth deficiency (45% normal size)...
  21. McElroy B, Powell J, McCarthy J. The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis. Biochem Biophys Res Commun. 2007;358:1136-41 pubmed
    ..This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase. ..
  22. Cohen E, Paulsson J, Blinder P, Burstyn Cohen T, Du D, Estepa G, et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 2009;139:1157-69 pubmed publisher
  23. Wang E, Wang J, Chin E, Zhou J, Bondy C. Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. Endocrinology. 1995;136:2741-51 pubmed
  24. Pehar M, O Riordan K, Burns Cusato M, Andrzejewski M, del Alcazar C, Burger C, et al. Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death. Aging Cell. 2010;9:174-90 pubmed publisher
    ..In fact, they were rescued by either Igf1r or Mapt haploinsufficiency...
  25. Moreno Barriuso N, López Malpartida A, de Pablo F, Pichel J. Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006;235:2040-50 pubmed
    ..The differentiation of type I cells barely occurred and capillaries remained in the abundant mesenchyme. These results indicate that LIF collaborates with IGF-I in lung alveolar epithelium and vascular maturation. ..
  26. Entingh Pearsall A, Kahn C. Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. J Biol Chem. 2004;279:38016-24 pubmed
    ..Taken together, these results indicate that the insulin and IGF-I receptors contribute distinct signals to common downstream components in response to both insulin and IGF-I. ..
  27. Freude S, Hettich M, Schumann C, Stöhr O, Koch L, Kohler C, et al. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J. 2009;23:3315-24 pubmed publisher
    ..However, neuronal IR deletion had no influence on lethality of Tg2576 mice. Thus, impaired IGF-1/IRS-2 signaling prevents premature death and delays amyloid accumulation in a model of AD. ..
  28. Liu W, Ye P, O Kusky J, D Ercole A. Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus. J Neurosci Res. 2009;87:2821-32 pubmed publisher
    Type 1 insulin-like growth factor receptor (IGF1R) signaling in neuronal development was studied in mutant mice with blunted igf1r gene expression in nestin-expressing neuronal precursors...
  29. Rubini M, Hongo A, D Ambrosio C, Baserga R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res. 1997;230:284-92 pubmed
    ..These experiments indicate that a small increment in the number of receptors per cell, well within the physiological range, can modulate the mitogenic and transforming activities of the IGF-IR in 3T3-like cells. ..
  30. Garg N, Thakur S, McMahan C, Adamo M. High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice. Biochem Biophys Res Commun. 2011;413:476-80 pubmed publisher
    ..Mice lacking one of the IGF-1R alleles (Igf1r(+/-)) exhibit a 10% reduction in post-natal growth, and develop glucose intolerance (males) and insulin resistance ..
  31. Sutherland B, Knoblaugh S, Kaplan Lefko P, Wang F, Holzenberger M, Greenberg N. Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res. 2008;68:3495-504 pubmed publisher
    ..Collectively, these data support a critical role for IGF-IR signaling in prostate tumorigenesis and identify an important IGF-IR-dependent growth control mechanism. ..
  32. Manna P, Chandrala S, King S, Jo Y, Counis R, Huhtaniemi I, et al. Molecular mechanisms of insulin-like growth factor-I mediated regulation of the steroidogenic acute regulatory protein in mouse leydig cells. Mol Endocrinol. 2006;20:362-78 pubmed
    ..Collectively, the present studies identify molecular events in IGF-I signaling that may influence testicular growth, development, and the Leydig cell steroidogenic machinery through autocrine/paracrine regulation. ..
  33. Engberding N, San Martin A, Martin Garrido A, Koga M, Pounkova L, Lyons E, et al. Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2009;29:408-15 pubmed publisher
    ..Thus we hypothesized that regulation of IGF1R expression may impact cellular insulin sensitivity. IGF1R expression was increased in aortas from diabetic mice...
  34. Girnita L, Shenoy S, Sehat B, Vasilcanu R, Girnita A, Lefkowitz R, et al. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem. 2005;280:24412-9 pubmed
    ..To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer. ..
  35. Ueki K, Okada T, Hu J, Liew C, Assmann A, Dahlgren G, et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet. 2006;38:583-8 pubmed
    ..We propose that therapeutic improvement of insulin and IGF-I signaling in beta cells might protect against type 2 diabetes. ..
  36. Withers D, Burks D, Towery H, Altamuro S, Flint C, White M. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet. 1999;23:32-40 pubmed
    ..To establish a role for the Igf-1 receptor in beta-cells, we intercrossed mice heterozygous for null alleles of Igf1r and Irs2...
  37. Liu X, Turbyville T, Fritz A, Whitesell L. Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Res. 1998;58:5432-8 pubmed
    Several lines of evidence now indicate that type 1 insulin-like growth factor receptor (IGF1R) function may be particularly important in the pathogenesis of the pediatric cancer neuroblastoma...
  38. Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon R, et al. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes. 2011;60:2169-78 pubmed publisher
    ..These data demonstrate that IGF-1R is a critical negative regulator of insulin sensitivity and NO bioavailability in the endothelium. ..
  39. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even P, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182-7 pubmed
    ..To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r)...
  40. Holzenberger M, Lenzner C, Leneuve P, Zaoui R, Hamard G, Vaulont S, et al. Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res. 2000;28:E92 pubmed
  41. Holzenberger M, Hamard G, Zaoui R, Leneuve P, Ducos B, Beccavin C, et al. Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular. Endocrinology. 2001;142:4469-78 pubmed
    ..Thus, IGF type I receptor deficiency produced mice with disproportionate postnatal organ growth, and these effects depended strongly on sex. A marked reduction in IGF-IR levels resulted in a major defect in adipose tissue. ..
  42. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol. 1994;14:3604-12 pubmed
    ..R- and W cells, were generated, respectively, from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 insulin-like growth factor receptor, and from their wild-type littermates...
  43. Baserga R, Sell C, Porcu P, Rubini M. The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell Prolif. 1994;27:63-71 pubmed
    ..The picture emerging from these studies is that several transforming agents may exert their growth promoting effects through the direct or indirect activation of the IGF autocrine loop. ..
  44. Holzenberger M, Leneuve P, Hamard G, Ducos B, Perin L, Binoux M, et al. A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000;141:2557-66 pubmed
    ..The phenotype of these mice developed exclusively postnatally, and body proportions were maintained. IGF-IRneo mice constitute a new model for human postnatal growth deficiency. ..
  45. Desbois Mouthon C, Wendum D, Cadoret A, Rey C, Leneuve P, Blaise A, et al. Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout. FASEB J. 2006;20:773-5 pubmed
    ..Using the LIGFREKO model, we provide new evidence that IGF-1R/IRS-1/ERK signaling may be the intracellular pathway controlling the cell cycle via cyclin D1 and cyclin A in the regenerating liver. ..
  46. Fulzele K, DiGirolamo D, Liu Z, Xu J, Messina J, Clemens T. Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J Biol Chem. 2007;282:25649-58 pubmed
    ..We conclude that insulin exerts direct anabolic actions in osteoblasts by activation of its cognate receptor and that the strength of insulin-generated signals is tempered through interactions with the IGF-1R. ..
  47. Nagata K, Masumoto K, Uesugi T, Yamamoto S, Yoshizaki K, Fukumoto S, et al. Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. Pediatr Surg Int. 2007;23:953-9 pubmed
    ..Therefore, the administration of IGFs to the fetal CDH lung may thus be able to effectively improve the symptoms of hypoplastic lung. ..
  48. Huo H, Guo X, Hong S, Jiang M, Liu X, Liao K. Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction. J Biol Chem. 2003;278:11561-9 pubmed
  49. Boucher J, Macotela Y, Bezy O, Mori M, Kriauciunas K, Kahn C. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Sci Signal. 2010;3:ra87 pubmed publisher
    ..We found that, unexpectedly, double-knockout (DKO) cells that lacked both insulin and IGF-1 receptors (IR and IGF1R, respectively) were resistant to apoptosis induced through either the intrinsic or the extrinsic pathway...
  50. Landau D, Eshet R, Troib A, Gurman Y, Chen Y, Rabkin R, et al. Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation. Endocrine. 2009;36:126-34 pubmed publisher
    ..We investigated renal GH receptor (GHR) and IGF-type 1 receptor (IGF1R) signaling in an animal model of type I DM. Kidney tissue was examined for GHR and IGF1R key signaling molecules...
  51. Baker J, Liu J, Robertson E, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 1993;75:73-82 pubmed
    ..null mutations of the genes encoding insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor (IGF1R), alone or in combination, defined the onset of mutational effects leading to growth deficiency and indicated that ..
  52. Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich F, et al. Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation. EMBO J. 2008;27:2091-101 pubmed publisher
    ..Our results identify the small GTPase Rac as a key target of epidermal IR/IGF-1R signalling crucial for proliferative potential and interfollicular morphogenesis. ..
  53. Kido Y, Nakae J, Hribal M, Xuan S, Efstratiadis A, Accili D. Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem. 2002;277:36740-7 pubmed
    ..Combined inactivation of insulin receptor (Insr) and Igf1 receptor (Igf1r), but not of either receptor alone, resulted in a 90% decrease in the size of the exocrine pancreas, because of ..
  54. Bokov A, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo R, et al. Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?. PLoS ONE. 2011;6:e26891 pubmed publisher
    ..Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/6 mice using rigorous criteria where lifespan and end-of-life ..