Igbp1

Summary

Gene Symbol: Igbp1
Description: immunoglobulin (CD79A) binding protein 1
Alias: AI115586, AI662457, AW208785, C81413, Pc52, Tap42, p52, CD79a-binding protein 1, alpha 4, alpha4 phosphoprotein, immunoglobulin-binding protein 1, lymphocyte signal transduction molecule alpha 4, phosphoprotein, component, 52 kDa, protein phosphatase 2/4/6 regulatory subunit
Species: mouse

Top Publications

  1. ncbi Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway
    M Onda
    Department of Immunology, Kumamoto University School of Medicine, Japan
    Genomics 46:373-8. 1997
  2. ncbi Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4
    J Liu
    Center for Cell Signaling, University of Virginia School of Medicine, P O Box 800577, Charlottesville, VA 22908 0577, USA
    Proc Natl Acad Sci U S A 98:6650-5. 2001
  3. ncbi Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
    S Inui
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    J Immunol 154:2714-23. 1995
  4. ncbi The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis
    Mei Kong
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 306:695-8. 2004
  5. ncbi Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory
    Takeshi Yamashita
    Department of Immunology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1, Honjo, Kumamoto 860 8556, Japan
    Brain Res 1082:1-10. 2006
  6. ncbi The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A
    Todd D Prickett
    Center for Cell Signaling and Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:30503-11. 2006
  7. ncbi Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3
    Todd D Prickett
    Center for Cell Signaling and Department of Microbiology, University of Virginia School of Medicine, Jefferson Park Avenue, Hospital West Complex, Room 7225, Charlottesville, VA 22908 1400, USA
    Mol Cell Biol 27:4217-27. 2007
  8. ncbi Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation
    Godfrey Grech
    Department of Hematology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Blood 112:2750-60. 2008
  9. ncbi Alpha4 is an essential regulator of PP2A phosphatase activity
    Mei Kong
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 36:51-60. 2009
  10. ncbi Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits
    Todd D Prickett
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:38912-20. 2004

Scientific Experts

  • A D Everett
  • Kieran M Short
  • Todd D Prickett
  • Mei Kong
  • Takeshi Yamashita
  • Ding Rong Hua
  • Seiji Inui
  • David L Brautigan
  • K Maeda
  • S Inui
  • Michele Lenoue-Newton
  • Kazuhiko Maeda
  • Nobuo Sakaguchi
  • N Sakaguchi
  • Godfrey Grech
  • Tullia Lindsten
  • Craig B Thompson
  • Katsumasa Takagi
  • J Liu
  • Katherine L Germane
  • Brian E Wadzinski
  • Lisa R McCorvey
  • Benjamin W Spiller
  • Guy R Watkins
  • Ping Zou
  • Dara Ditsworth
  • Montserrat Blázquez-Domingo
  • Ernst W Mullner
  • Andrea Kolbus
  • Walbert J Bakker
  • Marieke von Lindern
  • Hartmut Beug
  • M Nanahoshi
  • Kohji Fukunaga
  • Casey J Fox
  • Anne Xu
  • M Onda
  • Laura Solt
  • James Mu
  • Morris J Birnbaum
  • Ryan M Cinalli
  • K Kuwahara
  • Junji Takeda
  • Eishichi Miyamoto
  • Shinichi Aizawa
  • Hideyuki Yamamoto
  • E Elliott
  • T D Prickett
  • G Meroni
  • D L Brautigan
  • H Tanaka
  • H Sanjo
  • K Hara
  • K Yonezawa
  • Y Tsujishita
  • T Nishiuma
  • M Suzuki
  • E Takahashi
  • J Mizutani
  • H Nakayasu
  • T Kawai
  • M Kimoto
  • H Igarashi
  • T Matsuo
  • J Nomura

Detail Information

Publications19

  1. ncbi Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway
    M Onda
    Department of Immunology, Kumamoto University School of Medicine, Japan
    Genomics 46:373-8. 1997
    To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction ..
  2. ncbi Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4
    J Liu
    Center for Cell Signaling, University of Virginia School of Medicine, P O Box 800577, Charlottesville, VA 22908 0577, USA
    Proc Natl Acad Sci U S A 98:6650-5. 2001
    ..Human birth defects may result from environmental or genetic disruption of this regulatory cycle...
  3. ncbi Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
    S Inui
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    J Immunol 154:2714-23. 1995
    ..Here we isolated a cDNA clone (alpha 4) from a murine bone marrow cDNA library in lambda gt-11 vector by the 19-14 mAb...
  4. ncbi The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis
    Mei Kong
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 306:695-8. 2004
    ..Thus, mammalian cell viability depends on repression of transcription-initiated apoptosis mediated by a component of PP2A...
  5. ncbi Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory
    Takeshi Yamashita
    Department of Immunology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1, Honjo, Kumamoto 860 8556, Japan
    Brain Res 1082:1-10. 2006
    ..These results suggest that alpha4 and PP2A may thus play an important role in CaMKIIalpha regulation and thereby also influence learning...
  6. ncbi The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A
    Todd D Prickett
    Center for Cell Signaling and Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:30503-11. 2006
    ..These catalytic subunits associate with a common subunit called alpha4 (related to yeast Tap42). Here, we characterized recombinant PP6 and PP2A catalytic monomers and alpha4.phosphatase heterodimers...
  7. ncbi Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3
    Todd D Prickett
    Center for Cell Signaling and Department of Microbiology, University of Virginia School of Medicine, Jefferson Park Avenue, Hospital West Complex, Room 7225, Charlottesville, VA 22908 1400, USA
    Mol Cell Biol 27:4217-27. 2007
    ..The results show that alpha-4 targets PP2A activity to MEK3 to suppress p38 MAPK activation by cytokines, thereby inhibiting apoptosis and anoikis...
  8. ncbi Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation
    Godfrey Grech
    Department of Hematology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Blood 112:2750-60. 2008
    ..One of the targets, Immunoglobulin binding protein 1 (Igbp1), is a regulatory subunit of protein phosphatase 2A (Pp2a) sustaining mTOR signaling...
  9. ncbi Alpha4 is an essential regulator of PP2A phosphatase activity
    Mei Kong
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 36:51-60. 2009
    ..These findings demonstrate that alpha4 plays a required role in regulating the assembly and maintenance of adaptive PP2A phosphatase complexes...
  10. ncbi Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits
    Todd D Prickett
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:38912-20. 2004
    ..a scaffold subunit (A subunit or PR65); however, PP2Ac alternatively binds to alpha-4, a subunit related to yeast Tap42 protein, which also associates with phosphatases PP4 or PP6...
  11. ncbi T cell-specific gene targeting reveals that alpha4 is required for early T cell development
    Ding Rong Hua
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Eur J Immunol 33:1899-906. 2003
    ..A severe impairment of CD3-induced expression of CD25 was also observed. These data suggest that alpha4 plays a critical role in the proliferation of thymocytes, which is necessary for early T cell development...
  12. ncbi Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome
    Allen D Everett
    Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Dev Dyn 224:461-4. 2002
    ..The alpha4 gene lies in the linkage interval for FG syndrome, characterized by skeletal muscle and brain defects that coincide closely to the expression pattern of alpha4...
  13. ncbi BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation
    Seiji Inui
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Int Immunol 14:177-87. 2002
    b>alpha 4 potentially mediates BCR signals through a rapamycin-sensitive TOR pathway...
  14. ncbi MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
    Kieran M Short
    Department of Molecular Biosciences and ARC Special Research Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, Australia 5005
    BMC Cell Biol 3:1. 2002
    ..A protein highly related to MID1, called MID2, has also been described that similarly associates with microtubules...
  15. ncbi A new member of the alpha4-related molecule (alpha4-b) that binds to the protein phosphatase 2A is expressed selectively in the brain and testis
    K Maeda
    Department of Immunology, Kumamoto University School of Medicine, Kumamoto, Japan
    Eur J Biochem 264:702-6. 1999
    ..The alpha4-b protein associates with the catalytic subunit of PP2A (PP2Ac), suggesting that the alpha4-b protein is involved in the regulation of phosphatase activity in neuronal cells...
  16. ncbi Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42
    M Nanahoshi
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe, 657 8501, Japan
    Biochem Biophys Res Commun 251:520-6. 1998
    Recent studies have revealed that the alpha4 protein, a mammalian homolog of yeast Tap42, is associated with the protein phosphatase 2A catalytic subunit (PP2A-C), however, effects of the association of alpha4 with PP2A-C on its ..
  17. ncbi The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule alpha 4 that is related to the yeast TAP42 involved in a rapamycin-sensitive pathway
    K Maeda
    Department of Immunology, Kumamoto University School of Medicine, Japan
    Gene 210:287-95. 1998
    The mouse alpha 4 phosphoprotein encoding a component associated with the B cell antigen receptor (BCR)-mediated signal transduction is suggested to be involved in a unique rapamycin-sensitive pathway...
  18. ncbi Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate
    K Kuwahara
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    J Immunol 152:2742-52. 1994
    ..prepared by immunizing the 52-kDa protein purified from SDS-PAGE, could detect the similar 52-kDa phosphoprotein (p52) expressed on the cell surface...
  19. ncbi The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation
    Michele Lenoue-Newton
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 286:17665-71. 2011
    ..Structurally, Alpha4 differs from its yeast homolog, Tap42, in two important ways: 1) the position of the helix containing the PP2Ac-binding residues is in a more open ..