Gene Symbol: Ift52
Description: intraflagellar transport 52
Alias: BC037708, NGD5, intraflagellar transport protein 52 homolog, intraflagellar transport 52 homolog
Species: mouse
Products:     Ift52

Top Publications

  1. Baker S, Freeman K, Luby Phelps K, Pazour G, Besharse J. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003;278:34211-8 pubmed
    ..we investigated protein interactions among four mammalian IFT proteins: IFT88/Polaris, IFT57/Hippi, IFT52/NGD5, and IFT20...
  2. Follit J, Xu F, Keady B, Pazour G. Characterization of mouse IFT complex B. Cell Motil Cytoskeleton. 2009;66:457-68 pubmed publisher
    ..This suggests that IFT54s effect on IFT20 is a dominant negative phenotype caused by its overexpression. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc. ..
  3. Brazelton W, Amundsen C, Silflow C, Lefebvre P. The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly. Curr Biol. 2001;11:1591-4 pubmed
    ..The protein product of the BLD1 gene corresponds to IFT52, a protein component of "raft" particles shown to undergo rapid transport up and down Chlamydomonas ..
  4. Follit J, Tuft R, Fogarty K, Pazour G. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell. 2006;17:3781-92 pubmed
    ..This work suggests that IFT20 functions in the delivery of ciliary membrane proteins from the Golgi complex to the cilium. ..
  5. Sedmak T, Wolfrum U. Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J Cell Biol. 2010;189:171-86 pubmed publisher
    ..Collectively, we provide evidence to implicate the differential composition of IFT systems in cells with and without primary cilia, thereby supporting new functions for IFT beyond its well-established role in cilia. ..
  6. Howard P, Jue S, Maurer R. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp Cell Res. 2013;319:2275-81 pubmed publisher
    ..provide evidence that, TTC30A1, TTC30A2 or TTC30B can be incorporated into a complex with a known IFT B protein, IFT52. We also found that TTC30B can interact with mouse KIF17, a kinesin which participates in IFT...
  7. Zhao C, Malicki J. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 2011;30:2532-44 pubmed publisher
    ..These studies reveal a molecular mechanism that mediates the transport of selected ciliary cargos and is of fundamental importance for the differentiation and survival of sensory cells. ..
  8. Ezratty E, Stokes N, Chai S, Shah A, Williams S, Fuchs E. A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell. 2011;145:1129-41 pubmed publisher
    ..These findings unveil temporally and spatially distinct functions for primary cilia at the nexus of signaling, proliferation, and differentiation. ..
  9. Ishikawa H, Ide T, Yagi T, Jiang X, Hirono M, Sasaki H, et al. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. elife. 2014;3:e01566 pubmed
    ..These results support the concept that different IFT proteins are responsible for different cargo subsets, providing a possible explanation for the complexity of the IFT machinery. DOI: http://dx.doi.org/10.7554/eLife.01566.001...

More Information


  1. Wick M, Ann D, Loh H. Molecular cloning of a novel protein regulated by opioid treatment of NG108-15 cells. Brain Res Mol Brain Res. 1995;32:171-5 pubmed
    A new cDNA clone, NGD5, has been identified from a subtraction cDNA library constructed with mRNA isolated from control neuroblastoma x glioma NG108-15 cells and cells treated for 48 h with the delta-opioid agonist, D-Ala2, D-Leu5 ..
  2. Liu A, Wang B, Niswander L. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005;132:3103-11 pubmed
    ..In addition, we show that partial loss-of-function mutations in another mouse IFT gene, Ift52 (Ngd5), result in similar phenotypes and abnormal Hh signaling as Fxo, indicating a general requirement for IFT ..
  3. Ye X, Zeng H, Ning G, Reiter J, Liu A. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014;111:2164-9 pubmed publisher
    ..C2cd3 is also required for recruiting the intraflagellar transport proteins Ift88 and Ift52 to the mother centriole...
  4. Liew G, Ye F, Nager A, Murphy J, Lee J, Aguiar M, et al. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev Cell. 2014;31:265-78 pubmed publisher
    ..Thus, we propose that IFT27 separates from IFT-B inside cilia to promote ARL6 activation, BBSome coat assembly, and subsequent ciliary exit, mirroring the process by which BBSome mediates cargo entry into cilia. ..
  5. Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J. The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol. 2012;14:950-7 pubmed publisher
    ..Our results identify the BBSome as the key player regulating IFT assembly and turnaround in cilia...