Gene Symbol: Ift172
Description: intraflagellar transport 172
Alias: 4930553F24Rik, Slb, avc1, wim, intraflagellar transport protein 172 homolog, intraflagellar transport 172 homolog, intraflagellar transport 172 protein, protein wimple, selective LIM-binding factor Wimple
Species: mouse
Products:     Ift172

Top Publications

  1. Huangfu D, Liu A, Rakeman A, Murcia N, Niswander L, Anderson K. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426:83-7 pubmed
    ..mutations disrupt IFT proteins: the wim mutation is an allele of the previously uncharacterized mouse homologue of IFT172; and fxo is a new hypomorphic allele of polaris, the mouse homologue of IFT88...
  2. Pazour G, Dickert B, Vucica Y, Seeley E, Rosenbaum J, Witman G, et al. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000;151:709-18 pubmed
    ..This indicates that IFT is important for primary cilia assembly in mammals. It is likely that primary cilia have an important function in the kidney and that defects in their assembly can lead to polycystic kidney disease. ..
  3. Hou Y, Qin H, Follit J, Pazour G, Rosenbaum J, Witman G. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J Cell Biol. 2007;176:653-65 pubmed
    ..Axonemal ultrastructure is restored, except that the outer arms are still missing, although outer arm subunits are present in the cytoplasm. Thus, IFT46 is specifically required for transporting outer arms into the flagellum. ..
  4. Gorivodsky M, Mukhopadhyay M, Wilsch Braeuninger M, Phillips M, Teufel A, Kim C, et al. Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol. 2009;325:24-32 pubmed publisher
    b>IFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex...
  5. Liem K, He M, Ocbina P, Anderson K. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2009;106:13377-82 pubmed publisher
    ..We conclude that Kif7 is a core regulator of Shh signaling that may also act as a ciliary motor. ..
  6. Huangfu D, Anderson K. Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005;102:11325-30 pubmed
    The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 and the anterograde IFT motor kinesin-II are required for the production and maintenance of cilia...
  7. Ocbina P, Anderson K. Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev Dyn. 2008;237:2030-8 pubmed publisher
    ..allele of Smo, SmoA1, activates an Hh reporter in wild-type MEFs, but not in MEFs derived from embryos that lack IFT172 or the Dync2h1 subunit of the retrograde IFT motor...
  8. Tuson M, He M, Anderson K. Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development. 2011;138:4921-30 pubmed publisher
  9. Friedland Little J, Hoffmann A, Ocbina P, Peterson M, Bosman J, Chen Y, et al. A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet. 2011;20:3725-37 pubmed publisher
    ..We showed that avc1 is a hypomorphic mutation of intraflagellar transport protein 172 (Ift172), required for ciliogenesis and Hedgehog (Hh) signaling...

More Information


  1. Ocbina P, Tuson M, Anderson K. Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS ONE. 2009;4:e6839 pubmed publisher
    ..that lack primary cilia because of loss of the anterograde IFT kinesin-II motor (Kif3a) or IFT complex B proteins (Ift172 or Ift88). We also analyzed mutant embryos with abnormal primary cilia due to defects in retrograde IFT (Dync2h1)...
  2. Liem K, Ashe A, He M, Satir P, Moran J, Beier D, et al. The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol. 2012;197:789-800 pubmed publisher
  3. Ocbina P, Eggenschwiler J, Moskowitz I, Anderson K. Complex interactions between genes controlling trafficking in primary cilia. Nat Genet. 2011;43:547-53 pubmed publisher
    ..Heterozygosity for Ift172, a gene required for anterograde ciliary trafficking, suppresses cilia phenotypes, Sonic hedgehog signaling ..
  4. Follit J, Xu F, Keady B, Pazour G. Characterization of mouse IFT complex B. Cell Motil Cytoskeleton. 2009;66:457-68 pubmed publisher
    ..We tagged each of these proteins with the FLAG epitope and show that all except IFT172 and IFT20 localize to cilia and the peri-basal body or centrosomal region at the base of cilia...
  5. Howard P, Howard T, Maurer R. Generation of mice with a conditional allele for Ift172. Transgenic Res. 2010;19:121-6 pubmed publisher
    b>Ift172 encodes a gene product that is part of a complex that mediates intraflagellar transport (IFT), a process necessary for the genesis and maintenance of cilia...
  6. Larkins C, Long A, Caspary T. Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev Biol. 2012;367:15-24 pubmed publisher
    ..Symmetric Nodal and Cerl2 in the node could result from defects in either the generation and/ or the detection of Nodal flow, which would account for the subsequent defects in the LPM and organ positioning. ..
  7. Burnett J, LUPU F, Eggenschwiler J. Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017;430:32-40 pubmed publisher
    ..b>Ift172 mutants fail to generate primary cilia and exhibit patterning defects that resemble those of Gli3 mutants, ..
  8. Navarro N, Maga A. Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?. G3 (Bethesda). 2016;6:1153-63 pubmed publisher
    ..Most of the main variation is, nonetheless, preferentially embedded in the natural 2D plane of the hemi-mandible, reinforcing the results of earlier influential investigations. ..
  9. Ishikawa H, Ide T, Yagi T, Jiang X, Hirono M, Sasaki H, et al. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. elife. 2014;3:e01566 pubmed
    ..These results support the concept that different IFT proteins are responsible for different cargo subsets, providing a possible explanation for the complexity of the IFT machinery. DOI: http://dx.doi.org/10.7554/eLife.01566.001...
  10. Sun M, Mondal K, Patel V, Horner V, Long A, Cutler D, et al. Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012;2:143-50 pubmed publisher
  11. Cheng G, Salerno J, Cao Z, Pagano P, Lambeth J. Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med. 2008;45:1682-94 pubmed publisher
    ..5 mM. When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. VPO1 is likely to carry out peroxidative reactions previously attributed exclusively to myeloperoxidase in the vascular system. ..
  12. Ezratty E, Stokes N, Chai S, Shah A, Williams S, Fuchs E. A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell. 2011;145:1129-41 pubmed publisher
    ..These findings unveil temporally and spatially distinct functions for primary cilia at the nexus of signaling, proliferation, and differentiation. ..
  13. Kamp A, Peterson M, Svenson K, Bjork B, Hentges K, Rajapaksha T, et al. Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet. 2010;19:3105-13 pubmed publisher
    ..We mapped the locus responsible for heritable atrioventricular septal defects in six lines (avc1-6)...
  14. Sloboda R, Howard L. Localization of EB1, IFT polypeptides, and kinesin-2 in Chlamydomonas flagellar axonemes via immunogold scanning electron microscopy. Cell Motil Cytoskeleton. 2007;64:446-60 pubmed
    ..polyclonal antibodies to kinesin-2 and monoclonal antibodies to either IFT139 (an IFT complex A polypeptide) or IFT172 (a complex B polypeptide)...
  15. Bay S, Caspary T. What are those cilia doing in the neural tube?. Cilia. 2012;1:19 pubmed publisher
    ..Here, we discuss the links between cilia and Shh signaling, as well as suggesting additional roles for cilia, and mechanisms for their placement, in the neural tube. ..
  16. Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed publisher
    ..This identifies potential novel components of cytoplasmic dynein 2 and furthermore provides fresh insights into the molecular pathogenesis of human skeletal ciliopathies. ..
  17. Liew G, Ye F, Nager A, Murphy J, Lee J, Aguiar M, et al. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev Cell. 2014;31:265-78 pubmed publisher
    ..Thus, we propose that IFT27 separates from IFT-B inside cilia to promote ARL6 activation, BBSome coat assembly, and subsequent ciliary exit, mirroring the process by which BBSome mediates cargo entry into cilia. ..
  18. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..
  19. Ashique A, Choe Y, Karlen M, May S, Phamluong K, Solloway M, et al. The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal. 2009;2:ra70 pubmed publisher
    ..We find that Ift172, which encodes an intraflagellar transport protein necessary for ciliogenesis, is a direct transcriptional target ..
  20. Krähling A, Alvarez L, Debowski K, Van Q, Gunkel M, Irsen S, et al. CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet. 2013;9:e1003960 pubmed publisher
    ..Our results suggest that CRIS interacts during spermiogenesis with Ca(2+)-regulated proteins that--in mature sperm--are involved in flagellar bending. ..