Ifnar1

Summary

Gene Symbol: Ifnar1
Description: interferon (alpha and beta) receptor 1
Alias: Ifar, Ifnar, Ifrc, Infar, interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, IFN-alpha/betaR, INF-a receptor, type I interferon receptor 1
Species: mouse
Products:     Ifnar1

Top Publications

  1. Crotta S, Davidson S, Mahlakõiv T, Desmet C, Buckwalter M, Albert M, et al. Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathog. 2013;9:e1003773 pubmed publisher
    ..on IFNs, as it was reduced to a few upregulated genes in epithelia lacking receptors for both type I and III IFN (IFNAR1(-/-)IL-28R?(-/-))...
  2. Lazear H, Lancaster A, Wilkins C, Suthar M, Huang A, Vick S, et al. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog. 2013;9:e1003118 pubmed publisher
    ..at rates greater than DKO mice and equal to or approaching those of mice lacking the type I IFN receptor (Ifnar(-/-))...
  3. Bourgeois C, Majer O, Frohner I, Lesiak Markowicz I, Hildering K, Glaser W, et al. Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-? signaling. J Immunol. 2011;186:3104-12 pubmed publisher
    ..glabrata in the host. Our data uncover for the first time a pivotal role for endosomal TLR7 signaling in fungal pathogen recognition and highlight the importance of IFNs-I in modulating the host immune response to C. glabrata. ..
  4. Faul E, Wanjalla C, Suthar M, Gale M, Wirblich C, Schnell M. Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLoS Pathog. 2010;6:e1001016 pubmed publisher
    ..Interestingly, we see that the BMDC activation is primarily due to signaling through the IFNAR and only marginally induced by the initial infection...
  5. Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med. 2010;207:2921-30 pubmed publisher
    ..These data uncover a new role of pDCs in sensing tissue damage and promoting wound repair at skin surfaces. ..
  6. Gough D, Messina N, Hii L, Gould J, Sabapathy K, Robertson A, et al. Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol. 2010;8:e1000361 pubmed publisher
    ..This phenomenon was proposed to be because IFNalpha/beta receptor1 (IFNAR1) is a component of the IFNgamma receptor (IFNGR), but our new data are more consistent with a previously proposed ..
  7. Shafiani S, Dinh C, Ertelt J, Moguche A, Siddiqui I, Smigiel K, et al. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity. 2013;38:1261-70 pubmed publisher
    ..These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity...
  8. Fensterl V, Wetzel J, Ramachandran S, Ogino T, Stohlman S, Bergmann C, et al. Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis. PLoS Pathog. 2012;8:e1002712 pubmed publisher
    ..Pathogenesis by another neurotropic RNA virus, encephalomyocarditis virus, was not enhanced in the brains of Ifit2(-/-) mice. Our study provides a clear demonstration of tissue-, virus- and ISG-specific antiviral action of interferon. ..
  9. Gall A, Treuting P, Elkon K, Loo Y, Gale M, Barber G, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012;36:120-31 pubmed publisher
    ..These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders...
  10. Seo S, Kwon H, Ko H, Byun Y, Seong B, Uematsu S, et al. Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog. 2011;7:e1001304 pubmed publisher
    ..IFN-I receptor knockout (Ifnar1?/?) mice develop significant defects in the infiltration of Ly6C(hi) monocytes in the lung after influenza ..

Detail Information

Publications74

  1. Crotta S, Davidson S, Mahlakõiv T, Desmet C, Buckwalter M, Albert M, et al. Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathog. 2013;9:e1003773 pubmed publisher
    ..on IFNs, as it was reduced to a few upregulated genes in epithelia lacking receptors for both type I and III IFN (IFNAR1(-/-)IL-28R?(-/-))...
  2. Lazear H, Lancaster A, Wilkins C, Suthar M, Huang A, Vick S, et al. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog. 2013;9:e1003118 pubmed publisher
    ..at rates greater than DKO mice and equal to or approaching those of mice lacking the type I IFN receptor (Ifnar(-/-))...
  3. Bourgeois C, Majer O, Frohner I, Lesiak Markowicz I, Hildering K, Glaser W, et al. Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-? signaling. J Immunol. 2011;186:3104-12 pubmed publisher
    ..glabrata in the host. Our data uncover for the first time a pivotal role for endosomal TLR7 signaling in fungal pathogen recognition and highlight the importance of IFNs-I in modulating the host immune response to C. glabrata. ..
  4. Faul E, Wanjalla C, Suthar M, Gale M, Wirblich C, Schnell M. Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLoS Pathog. 2010;6:e1001016 pubmed publisher
    ..Interestingly, we see that the BMDC activation is primarily due to signaling through the IFNAR and only marginally induced by the initial infection...
  5. Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med. 2010;207:2921-30 pubmed publisher
    ..These data uncover a new role of pDCs in sensing tissue damage and promoting wound repair at skin surfaces. ..
  6. Gough D, Messina N, Hii L, Gould J, Sabapathy K, Robertson A, et al. Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol. 2010;8:e1000361 pubmed publisher
    ..This phenomenon was proposed to be because IFNalpha/beta receptor1 (IFNAR1) is a component of the IFNgamma receptor (IFNGR), but our new data are more consistent with a previously proposed ..
  7. Shafiani S, Dinh C, Ertelt J, Moguche A, Siddiqui I, Smigiel K, et al. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity. 2013;38:1261-70 pubmed publisher
    ..These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity...
  8. Fensterl V, Wetzel J, Ramachandran S, Ogino T, Stohlman S, Bergmann C, et al. Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis. PLoS Pathog. 2012;8:e1002712 pubmed publisher
    ..Pathogenesis by another neurotropic RNA virus, encephalomyocarditis virus, was not enhanced in the brains of Ifit2(-/-) mice. Our study provides a clear demonstration of tissue-, virus- and ISG-specific antiviral action of interferon. ..
  9. Gall A, Treuting P, Elkon K, Loo Y, Gale M, Barber G, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012;36:120-31 pubmed publisher
    ..These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders...
  10. Seo S, Kwon H, Ko H, Byun Y, Seong B, Uematsu S, et al. Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog. 2011;7:e1001304 pubmed publisher
    ..IFN-I receptor knockout (Ifnar1?/?) mice develop significant defects in the infiltration of Ly6C(hi) monocytes in the lung after influenza ..
  11. Mullally A, Bruedigam C, Poveromo L, Heidel F, Purdon A, Vu T, et al. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-? in a murine model of polycythemia vera. Blood. 2013;121:3692-702 pubmed publisher
  12. Tezuka H, Abe Y, Asano J, Sato T, Liu J, Iwata M, et al. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011;34:247-57 pubmed publisher
    ..Our findings provide insight into the molecular basis of pDC conditioning to induce mucosal TI IgA production, which may lead to improvements in vaccination strategies and treatment for mucosal-related disorders. ..
  13. Wilson E, Yamada D, Elsaesser H, Herskovitz J, DENG J, Cheng G, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013;340:202-7 pubmed publisher
    ..Thus, we demonstrated that interfering with chronic IFN-I signaling during persistent infection redirects the immune environment to enable control of infection...
  14. Green N, Laws A, Kiefer K, Busconi L, Kim Y, Brinkmann M, et al. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009;183:1569-76 pubmed publisher
    ..By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to ..
  15. Daffis S, Szretter K, Schriewer J, Li J, Youn S, Errett J, et al. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature. 2010;468:452-6 pubmed publisher
    ..Differential methylation of cytoplasmic RNA probably serves as an example for pattern recognition and restriction of propagation of foreign viral RNA in host cells. ..
  16. Majer O, Bourgeois C, Zwolanek F, Lassnig C, Kerjaschki D, Mack M, et al. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog. 2012;8:e1002811 pubmed publisher
    ..Using a mouse model lacking a functional IFN-I receptor (Ifnar1?/?), we demonstrate a remarkable protection against invasive Ca infections...
  17. Cervantes Barragan L, Lewis K, Firner S, Thiel V, Hugues S, Reith W, et al. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A. 2012;109:3012-7 pubmed publisher
    ..Thus pDCs provide an essential link between innate and adaptive immunity to chronic viral infection, likely through the secretion of IFN-I and other cytokines. ..
  18. Alazawi W, Heath H, Waters J, Woodfin A, O Brien A, Scarzello A, et al. Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis. Proc Natl Acad Sci U S A. 2013;110:8656-61 pubmed publisher
    ..Thus, our data reveal the existence of a different mechanism of LPS-induced lethality that is independent of NF-?B triggered cytokine storm but dependent on cellular egress. ..
  19. Swanson C, Wilson T, Strauch P, Colonna M, Pelanda R, Torres R. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010;207:1485-500 pubmed publisher
    ..Thus, innate signals have the capacity to enhance TI-2 antibody responses by promoting participation of FO B cells, which then elaborate effective IgG anti-pathogen antibodies. ..
  20. Pinto A, RAMOS H, Wu X, Aggarwal S, Shrestha B, Gorman M, et al. Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. PLoS Pathog. 2014;10:e1004086 pubmed publisher
    ..immunity against West Nile virus (WNV), we infected mice with conditional deletions of the type I IFN receptor (IFNAR) gene...
  21. Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, et al. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol. 2009;183:2286-93 pubmed publisher
  22. Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, et al. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol. 2009;183:6021-9 pubmed publisher
    ..Ab levels are greatly attenuated in New Zealand Mixed (NZM) 2328 mice deficient in type I IFN receptors (IFNAR)...
  23. Wang J, Li J, Wu Q, Yang P, Pawar R, Xie S, et al. Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol. 2010;184:442-51 pubmed publisher
  24. Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz L. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med. 2010;207:327-37 pubmed publisher
    ..Furthermore, the increased resistance of mice lacking the IFN-alphabeta receptor (IFNAR(-/-)) to L...
  25. Taylor J, Minter M, Newman A, Zhang M, Adlard P, Crack P. Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease. Neurobiol Aging. 2014;35:1012-23 pubmed publisher
    ..This study supports a role for type-1 interferons in the pro-inflammatory response and neuronal cell death in AD and suggests that blocking type-1 interferon-? receptor 1 maybe a therapeutic target to limit the disease progression. ..
  26. Qian J, Zheng H, HuangFu W, Liu J, Carbone C, Leu N, et al. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog. 2011;7:e1002065 pubmed publisher
    ..Type I IFNs interact with the Type I IFN receptor, composed of IFNAR1 and IFNAR2 chains, to mount the host defense responses...
  27. Brzoza Lewis K, Hoth J, Hiltbold E. Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes. Cell Immunol. 2012;273:41-51 pubmed publisher
    ..Mice lacking the type I IFN receptor (IFNAR-/-) demonstrate enhanced resistance to infection with Listeriamonocytogenes...
  28. Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Forster I, et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity. 2011;34:213-23 pubmed publisher
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection. ..
  29. Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan G, et al. Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription. Proc Natl Acad Sci U S A. 2011;108:18766-71 pubmed publisher
    ..Further knockout of IFN?/? receptor 1(Ifnar1) abolished poly(I:C)-induced pancreatitis but had no effect on the constitutive up-regulation of trypsinogen5 gene,..
  30. Beuneu H, Deguine J, Bouvier I, Di Santo J, Albert M, Bousso P. Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation. J Immunol. 2011;187:2084-8 pubmed publisher
    ..In the absence of IL-15, the residual NK cell activation was strictly dependent on cell-intrinsic IFNAR signaling in NK cells...
  31. Dann A, Poeck H, Croxford A, Gaupp S, Kierdorf K, Knust M, et al. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci. 2011;15:98-106 pubmed publisher
  32. Chessler A, Caradonna K, Da dara A, Burleigh B. Type I interferons increase host susceptibility to Trypanosoma cruzi infection. Infect Immun. 2011;79:2112-9 pubmed publisher
    ..cruzi infection, groups of wild-type (WT) and type I IFN receptor-deficient (IFNAR(-/-)) 129sv/ev mice were infected with two different T...
  33. Pace L, Vitale S, Dettori B, Palombi C, La Sorsa V, Belardelli F, et al. APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions. J Immunol. 2010;184:5969-79 pubmed publisher
    ..Altogether, these findings indicate that through a direct effect on APC activation and by affecting CD4(+)CD25(+) Treg cell-mediated suppression, IFN-alpha sustains and drives CD4(+)CD25(-) Th cell activation...
  34. Hegazy A, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, et al. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity. 2010;32:116-28 pubmed publisher
    ..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells. ..
  35. Crane M, Hokeness Antonelli K, Salazar Mather T. Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands. J Immunol. 2009;183:2810-7 pubmed publisher
  36. Xin L, Vargas Inchaustegui D, Raimer S, Kelly B, Hu J, Zhu L, et al. Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol. 2010;184:7047-56 pubmed publisher
    ..We found that type I IFNR-deficient (IFNAR-/-) mice developed attenuated lesions and reduced Ag-specific immune responses following infection with Leishmania ..
  37. Hiller B, Achleitner M, Glage S, Naumann R, Behrendt R, Roers A. Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. J Exp Med. 2012;209:1419-26 pubmed publisher
    ..Collectively, we show that RNase H2 is essential to remove ribonucleotides from the mammalian genome to prevent DNA damage. ..
  38. Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, et al. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog. 2012;8:e1002763 pubmed publisher
    ..They further demonstrate a drastic change in the cell type-dependent Stat1 requirement for memory responses to Lm infection. ..
  39. Bhattacharya S, Qian J, Tzimas C, Baker D, Koumenis C, Diehl J, et al. Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. J Biol Chem. 2011;286:22069-76 pubmed publisher
    Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of type I interferon (IFN) receptor is a robust and specific mechanism that limits the magnitude and duration of IFN?/? signaling...
  40. Suthar M, Brassil M, Blahnik G, McMillan A, RAMOS H, Proll S, et al. A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes. PLoS Pathog. 2013;9:e1003168 pubmed publisher
    ..Assessment of infected livers from Mavs(-/-) × Ifnar(-/-) mice revealed the loss of expression of several key components within the natural killer (NK) cell signaling ..
  41. Mizutani T, Neugebauer N, Putz E, Moritz N, Simma O, Zebedin Brandl E, et al. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology. 2012;1:1027-1037 pubmed
    Mice with an impaired Type I interferon (IFN) signaling (IFNAR1- and IFN?-deficient mice) display an increased susceptibility toward v-ABL-induced B-cell leukemia/lymphoma...
  42. Kudva A, Scheller E, Robinson K, Crowe C, Choi S, Slight S, et al. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J Immunol. 2011;186:1666-1674 pubmed publisher
    ..These data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia. ..
  43. Shi C, Jia T, Mendez Ferrer S, Hohl T, Serbina N, Lipuma L, et al. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity. 2011;34:590-601 pubmed publisher
    ..Our findings suggest that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses. ..
  44. Inglis D, Berkes C, Hocking Murray D, Sil A. Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages. Infect Immun. 2010;78:3871-82 pubmed publisher
    ..Interestingly, H. capsulatum growth was restricted in mice lacking the type I IFN receptor, indicating that an intact host type I IFN response is required for full virulence of H. capsulatum in mice. ..
  45. Huys L, Van Hauwermeiren F, Dejager L, Dejonckheere E, Lienenklaus S, Weiss S, et al. Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med. 2009;206:1873-82 pubmed publisher
    ..Mice deficient in the IFN-alpha receptor 1 (IFNAR-1) or in IFN-beta are remarkably resistant to TNF-induced hypothermia and death...
  46. Zheng H, Qian J, Carbone C, Leu N, Baker D, Fuchs S. Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood. 2011;118:4003-6 pubmed publisher
    ..IFNAR), both stimuli activate protein kinase D2 (PKD2) and type 1 IFNs require PKD2 activation and recruitment to IFNAR1 to promote the phosphorylation-dependent ubiquitination, down-regulation, and degradation of the cognate receptor ..
  47. Nakamura S, Davis K, Weiser J. Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice. J Clin Invest. 2011;121:3657-65 pubmed publisher
  48. Baban B, Chandler P, Sharma M, Pihkala J, Koni P, Munn D, et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol. 2009;183:2475-83 pubmed publisher
    ..These findings support the hypothesis that IDO dominantly controls the functional status of Tregs in response to inflammatory stimuli in physiological settings. ..
  49. Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009;15:696-700 pubmed publisher
    ..Our findings provide insight into the molecular basis for the maintenance of HSC quiescence and may lead to improvements in bone marrow transplantation and type I IFN-based therapies for viral infection and cancer. ..
  50. Blanc M, Hsieh W, Robertson K, Watterson S, Shui G, Lacaze P, et al. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol. 2011;9:e1000598 pubmed publisher
    ..of the sterol pathway, while genetic knockout of the receptor for all type I interferon family members, ifnar1, or associated signaling component, tyk2, completely abolishes the reduction of the sterol biosynthetic activity ..
  51. Bereczky S, Lindegren G, Karlberg H, Akerstrom S, Klingstrom J, Mirazimi A. Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice. J Gen Virol. 2010;91:1473-7 pubmed publisher
    ..Using a small-animal model system, this study showed that adult mice missing the type I interferon (IFN) receptor (IFNAR(-/-)) were susceptible to CCHFV and developed an acute disease with fatal outcome...
  52. Geurs T, Zhao Y, Hill E, French A. Ly49H engagement compensates for the absence of type I interferon signaling in stimulating NK cell proliferation during murine cytomegalovirus infection. J Immunol. 2009;183:5830-6 pubmed publisher
    ..These results highlight the contribution of NK cell activation receptors in stimulating proliferation and subsequent expansion of NK cells that are able to recognize virally infected cells. ..
  53. Daffis S, Suthar M, Szretter K, Gale M, Diamond M. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog. 2009;5:e1000607 pubmed publisher
  54. Bhattacharya S, HuangFu W, Liu J, Veeranki S, Baker D, Koumenis C, et al. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. J Biol Chem. 2010;285:2318-25 pubmed publisher
    ..and ensuing down-regulation and lysosomal degradation of the interferon alpha/beta receptor chain 1 (IFNAR1) of the receptor for Type I interferons play important roles in limiting the cellular responses to these cytokines...
  55. Costello D, Lynch M. Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-?. Hippocampus. 2013;23:696-707 pubmed publisher
    ..for the production of IFN? from microglia and astrocytes, and using mice deficient in the type I IFN receptor ? 1 (IFNAR1), demonstrate that its subsequent activation is likely to underlie the TLR3-mediated modulation of hippocampal ..
  56. Baldridge M, King K, Boles N, Weksberg D, Goodell M. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010;465:793-7 pubmed publisher
    ..Our studies contribute to a deeper understanding of haematological responses in patients with chronic infections such as HIV/AIDS or tuberculosis. ..
  57. de Weerd N, Vivian J, Nguyen T, Mangan N, Gould J, Braniff S, et al. Structural basis of a unique interferon-? signaling axis mediated via the receptor IFNAR1. Nat Immunol. 2013;14:901-7 pubmed publisher
    ..All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet some subtypes such as interferon-? (IFN-?) can exhibit distinct functional properties, ..
  58. Yoshimi R, Chang T, Wang H, Atsumi T, Morse H, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol. 2009;182:7527-38 pubmed publisher
  59. Rajagopal D, Paturel C, Morel Y, Uematsu S, Akira S, Diebold S. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood. 2010;115:1949-57 pubmed publisher
    ..This study, therefore, identifies sufficient IFN-alpha production by PDC as an important determinant of vaccine efficacy. ..
  60. Park K, Scott A. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol. 2010;88:1081-7 pubmed publisher
  61. Kelly Scumpia K, Scumpia P, Delano M, Weinstein J, Cuenca A, Wynn J, et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010;207:319-26 pubmed publisher
    ..lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-alpha/beta receptor (IFNAR) display decreased systemic inflammation and improved outcome...
  62. Nakayama Y, Plisch E, Sullivan J, Thomas C, Czuprynski C, Williams B, et al. Role of PKR and Type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 2010;6:e1000966 pubmed publisher
    ..Additionally, the results presented here have furthered our understanding of the immune correlates of anti-viral protective immunity, which have implications in the rational design of vaccines...
  63. Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel Benhassine F, et al. Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med. 2010;207:429-42 pubmed publisher
    ..Moreover, we demonstrate that IFN-alpha/beta receptor (IFNAR) expression is required in the periphery but not on immune cells, as IFNAR(-/-)-->WT bone marrow chimeras are ..
  64. Jia T, Leiner I, Dorothee G, Brandl K, Pamer E. MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection. J Immunol. 2009;183:1271-8 pubmed publisher
    ..phase promotes prolonged, higher level MCP-1 secretion and is dependent on signaling via the type I IFN receptor (IFNAR). Although attenuated L...
  65. Lee P, Li Y, Kumagai Y, Xu Y, Weinstein J, Kellner E, et al. Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. Am J Pathol. 2009;175:2023-33 pubmed publisher
    ..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response. ..
  66. Colpitts S, Stoklasek T, Plumlee C, Obar J, Guo C, Lefrancois L. Cutting edge: the role of IFN-? receptor and MyD88 signaling in induction of IL-15 expression in vivo. J Immunol. 2012;188:2483-7 pubmed publisher
    ..These findings provide evidence of previously unappreciated regulation of IL-15 expression in myeloid lineages during homeostasis and following infection. ..
  67. Prestwood T, Morar M, Zellweger R, Miller R, May M, Yauch L, et al. Gamma interferon (IFN-?) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-?/? receptor-deficient mice. J Virol. 2012;86:12561-70 pubmed publisher
    ..These results demonstrate the roles of IFN-?R signaling in protection from initial systemic and subsequent CNS disease following DENV infection and demonstrate the importance of CD8(+) T cells in preventing DENV-induced CNS disease...
  68. Gill N, Chenoweth M, Verdu E, Ashkar A. NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection. Cell Immunol. 2011;269:29-37 pubmed publisher
    ..Our data clearly suggest that type I IFN receptor signalling is essential for NK cell activation in response to genital HSV-2 infection, and propose that NK cell activation by IL-15 may involve type I IFNs. ..
  69. Mattei F, Bracci L, Tough D, Belardelli F, Schiavoni G. Type I IFN regulate DC turnover in vivo. Eur J Immunol. 2009;39:1807-18 pubmed publisher
    ..We found that DC, especially the CD8alpha(+) subset, from type I IFN receptor knock out (IFNAR KO) mice, display a reduced turnover rate when compared with DC from WT mice, as revealed by BrdU labelling ..
  70. Yun N, Poussard A, Seregin A, Walker A, Smith J, Aronson J, et al. Functional interferon system is required for clearance of lassa virus. J Virol. 2012;86:3389-92 pubmed publisher
    ..Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance. ..
  71. Liu J, Carvalho L, Bhattacharya S, Carbone C, Kumar K, Leu N, et al. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Mol Cell Biol. 2009;29:6401-12 pubmed publisher
    Phosphorylation of the degron of the IFNAR1 chain of the type I interferon (IFN) receptor triggers ubiquitination and degradation of this receptor and, therefore, plays a crucial role in negative regulation of IFN-alpha/beta signaling...