Ifna11

Summary

Gene Symbol: Ifna11
Description: interferon alpha 11
Alias: IFN-[a]11, interferon alpha-11, IFN-alpha-11, interferon alpha family, gene 11, limitin
Species: mouse
Products:     Ifna11

Top Publications

  1. van Pesch V, Lanaya H, Renauld J, Michiels T. Characterization of the murine alpha interferon gene family. J Virol. 2004;78:8219-28 pubmed
    ..IFN-alpha, as well as IFN-beta, IFN-kappa, IFN-epsilon, and limitin, are thought to bind the same receptor, raising the question of whether different IFN subtypes possess specific ..
  2. Coulombel C, Vodjdani G, Doly J. Isolation and characterization of a novel interferon-alpha-encoding gene, IFN-alpha 11, within a murine IFN cluster. Gene. 1991;104:187-95 pubmed
    ..Mu IFN-alpha 11, as well as alpha 7 and alpha 8, are not expressed in L929 nor in C243 cells upon viral induction and therefore constitute an interesting model to study Mu IFN-alpha gene repression. ..
  3. Civas A, Dion M, Vodjdani G, Doly J. Repression of the murine interferon alpha 11 gene: identification of negatively acting sequences. Nucleic Acids Res. 1991;19:4497-502 pubmed
    The uninducible murine interferon alpha 11 gene (Mu IFN-alpha 11) shows strong homology with the highly inducible Mu IFN-alpha 4 gene in the promoter region...
  4. Navarro S, Dion M, Vodjdani G, Berlot Picard F, Doly J. Isolation and characterization of a functional murine interferon alpha gene which is not expressed in fibroblasts upon virus induction. J Gen Virol. 1989;70 ( Pt 6):1381-9 pubmed
    ..Although the 5' flanking sequence shows features characteristic of an IFN regulatory region, the MuIFN-alpha 8 gene is not expressed in murine fibroblasts treated with Newcastle disease virus or poly(I).poly(C). ..
  5. Roffet P, Lopez S, Navarro S, Bandu M, Coulombel C, Vignal M, et al. Identification of distal silencing elements in the murine interferon-A11 gene promoter. Biochem J. 1996;317 ( Pt 3):697-706 pubmed
    ..The Mu IFN-A11 gene is the first example within the murine IFN-A family, in which a distal promoter element has been identified that can negatively modulate the transcriptional response to viral induction. ..
  6. Morin P, Braganca J, Bandu M, Lin R, Hiscott J, Doly J, et al. Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. J Mol Biol. 2002;316:1009-22 pubmed
  7. Chen J, Baig E, Fish E. Diversity and relatedness among the type I interferons. J Interferon Cytokine Res. 2004;24:687-98 pubmed
  8. Nacionales D, Kelly K, Lee P, Zhuang H, Li Y, Weinstein J, et al. Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). Am J Pathol. 2006;168:1227-40 pubmed
    ..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice. ..
  9. Gibbert K, Joedicke J, Meryk A, Trilling M, Francois S, Duppach J, et al. Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection. PLoS Pathog. 2012;8:e1002868 pubmed publisher
    ..The type I IFN subtypes 2 and 5, which bind the same receptor as IFN-?11, did not elicit similar antiviral effects. These results demonstrate a unique and subtype-specific activation of NK cells by IFN-?11...

Detail Information

Publications9

  1. van Pesch V, Lanaya H, Renauld J, Michiels T. Characterization of the murine alpha interferon gene family. J Virol. 2004;78:8219-28 pubmed
    ..IFN-alpha, as well as IFN-beta, IFN-kappa, IFN-epsilon, and limitin, are thought to bind the same receptor, raising the question of whether different IFN subtypes possess specific ..
  2. Coulombel C, Vodjdani G, Doly J. Isolation and characterization of a novel interferon-alpha-encoding gene, IFN-alpha 11, within a murine IFN cluster. Gene. 1991;104:187-95 pubmed
    ..Mu IFN-alpha 11, as well as alpha 7 and alpha 8, are not expressed in L929 nor in C243 cells upon viral induction and therefore constitute an interesting model to study Mu IFN-alpha gene repression. ..
  3. Civas A, Dion M, Vodjdani G, Doly J. Repression of the murine interferon alpha 11 gene: identification of negatively acting sequences. Nucleic Acids Res. 1991;19:4497-502 pubmed
    The uninducible murine interferon alpha 11 gene (Mu IFN-alpha 11) shows strong homology with the highly inducible Mu IFN-alpha 4 gene in the promoter region...
  4. Navarro S, Dion M, Vodjdani G, Berlot Picard F, Doly J. Isolation and characterization of a functional murine interferon alpha gene which is not expressed in fibroblasts upon virus induction. J Gen Virol. 1989;70 ( Pt 6):1381-9 pubmed
    ..Although the 5' flanking sequence shows features characteristic of an IFN regulatory region, the MuIFN-alpha 8 gene is not expressed in murine fibroblasts treated with Newcastle disease virus or poly(I).poly(C). ..
  5. Roffet P, Lopez S, Navarro S, Bandu M, Coulombel C, Vignal M, et al. Identification of distal silencing elements in the murine interferon-A11 gene promoter. Biochem J. 1996;317 ( Pt 3):697-706 pubmed
    ..The Mu IFN-A11 gene is the first example within the murine IFN-A family, in which a distal promoter element has been identified that can negatively modulate the transcriptional response to viral induction. ..
  6. Morin P, Braganca J, Bandu M, Lin R, Hiscott J, Doly J, et al. Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. J Mol Biol. 2002;316:1009-22 pubmed
  7. Chen J, Baig E, Fish E. Diversity and relatedness among the type I interferons. J Interferon Cytokine Res. 2004;24:687-98 pubmed
  8. Nacionales D, Kelly K, Lee P, Zhuang H, Li Y, Weinstein J, et al. Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). Am J Pathol. 2006;168:1227-40 pubmed
    ..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice. ..
  9. Gibbert K, Joedicke J, Meryk A, Trilling M, Francois S, Duppach J, et al. Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection. PLoS Pathog. 2012;8:e1002868 pubmed publisher
    ..The type I IFN subtypes 2 and 5, which bind the same receptor as IFN-?11, did not elicit similar antiviral effects. These results demonstrate a unique and subtype-specific activation of NK cells by IFN-?11...