Gene Symbol: Ifitm6
Description: interferon induced transmembrane protein 6
Alias: A330075D07, Dspa2f, Fgls5, fragilis5, interferon induced transmembrane protein 6, fragilis 5
Lange U, Saitou M, Western P, Barton S, Surani M. The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev Biol. 2003;3:1 pubmed
..Furthermore, its evolutionary conservation suggests that it probably plays a critical role in all mammals. Detailed analysis of these genes may also elucidate the role of interferons as signalling molecules during development. ..
Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al
. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
Lange U, Adams D, Lee C, Barton S, Schneider R, Bradley A, et al
. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008;28:4688-96 pubmed publisher
..Hence, contrary to previous reports, Ifitm genes are not essential for PGC migration. The Ifitm family is a striking example of a conserved gene cluster which appears to be functionally redundant during development. ..
Han J, Lee S, Park Y, Park J, Kim K, Lim J, et al
. IFITM6 expression is increased in macrophages of tumor-bearing mice. Oncol Rep. 2011;25:531-6 pubmed publisher
..IFITM1 and 6 were found to be significantly increased. IFITM6 gene expression was increased only in the spleen of tumor-bearing mice but not in the bone marrow, lymph node, or ..
Hickford D, Frankenberg S, Shaw G, Renfree M. Evolution of vertebrate interferon inducible transmembrane proteins. BMC Genomics. 2012;13:155 pubmed publisher
..The differing expression patterns for many of the paralogues, together with poor sequence conservation between species, suggests that IFITM genes have acquired many different roles during vertebrate evolution...