Genomes and Genes
Gene Symbol: Ifitm5
Description: interferon induced transmembrane protein 5
Alias: 1110003J06Rik, AW213665, Bril, DSPA1, Hrmp1, Hrtm1, interferon-induced transmembrane protein 5, bone-restricted interferon induced transmembrane protein-like protein, dispanin subfamily A member 1, fragilis family member 4, fragilis4, haemopoiesis related membrane protein 1
- Baird J, Ryan K, Hayes I, Hampson L, Heyworth C, Clark A, et al. Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. J Biol Chem. 2001;276:9189-98 pubmed..We have used dot-blot and in situ analysis to indicate that this erythroid preconditioning is probably restricted to primitive but not definitive HSC. ..
- Tsukamoto T, Li X, Morita H, Minowa T, Aizawa T, Hanagata N, et al. Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. PLoS ONE. 2013;8:e75831 pubmed publisher..b>IFITM5 is another IFITM family protein and interacts with the FK506-binding protein 11 (FKBP11) to form a higher-order ..
- Patoine A, Gaumond M, Jaiswal P, Fassier F, Rauch F, Moffatt P. Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination. J Bone Miner Res. 2014;29:2004-16 pubmed publisherBRIL/IFITM5 is a membrane protein present almost exclusively in osteoblasts, which is believed to adopt a type III (N-out/C-out) topology...
- Lange U, Adams D, Lee C, Barton S, Schneider R, Bradley A, et al. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008;28:4688-96 pubmed publisher..Hence, contrary to previous reports, Ifitm genes are not essential for PGC migration. The Ifitm family is a striking example of a conserved gene cluster which appears to be functionally redundant during development. ..