Gene Symbol: Ifitm5
Description: interferon induced transmembrane protein 5
Alias: 1110003J06Rik, AW213665, Bril, DSPA1, Hrmp1, Hrtm1, interferon-induced transmembrane protein 5, bone-restricted interferon induced transmembrane protein-like protein, dispanin subfamily A member 1, fragilis family member 4, fragilis4, haemopoiesis related membrane protein 1
Species: mouse
Products:     Ifitm5

Top Publications

  1. Lange U, Saitou M, Western P, Barton S, Surani M. The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev Biol. 2003;3:1 pubmed
    ..Furthermore, its evolutionary conservation suggests that it probably plays a critical role in all mammals. Detailed analysis of these genes may also elucidate the role of interferons as signalling molecules during development. ..
  2. Moffatt P, Gaumond M, Salois P, Sellin K, Bessette M, Godin E, et al. Bril: a novel bone-specific modulator of mineralization. J Bone Miner Res. 2008;23:1497-508 pubmed publisher
    ..Although previously identified in silico as ifitm5, no localization or functional studies had been undertaken on this gene...
  3. Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
    ..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
  4. Hanagata N, Li X, Morita H, Takemura T, Li J, Minowa T. Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice. J Bone Miner Metab. 2011;29:279-90 pubmed publisher
    Interferon-inducible transmembrane protein 5 (IFITM5) is an osteoblast-specific membrane protein whose expression peaks around the early mineralization stage during the osteoblast maturation process...
  5. Hanagata N, Li X. Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes. Biochem Biophys Res Commun. 2011;409:378-84 pubmed publisher
    Osteoblasts are rich in interferon-inducible transmembrane protein 5 (IFITM5), the expression of which peaks around the early mineralization stage. This membrane protein directly associates with FK506 binding protein 11 (FKBP11)...
  6. Liu Y, Liu H, Titus L, Boden S. Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription. Bone. 2012;51:933-8 pubmed publisher
    b>Interferon induced transmembrane protein 5 (IFITM5) has been recognized as an osteoblast differentiation factor. Its regulation, however, is still unclear...
  7. Kasaai B, Gaumond M, Moffatt P. Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. J Biol Chem. 2013;288:13278-94 pubmed publisher
    b>BRIL is a bone-specific membrane protein that is involved in osteogenesis imperfecta type V. Bril transcription is activated by Sp1, Sp3, OSX, and GLI2 and by CpG demethylation...
  8. Moffatt P, Lee E, St Jacques B, Matsumoto K, Yamaguchi Y, Roughley P. Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Dev Dyn. 2011;240:404-12 pubmed publisher
    ..Thus, hyaluronan production by chondrocytes is not only essential for formation of an organized growth plate and subsequent long bone growth but also for normal modeling of the diaphyseal bone. ..
  9. Lietman C, Marom R, Munivez E, Bertin T, Jiang M, Chen Y, et al. A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation. J Bone Miner Res. 2015;30:489-98 pubmed publisher
    ..It is caused by a recurrent mutation in the 5' UTR of the IFITM5 gene (c.-14C > T)...

More Information


  1. Baird J, Ryan K, Hayes I, Hampson L, Heyworth C, Clark A, et al. Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. J Biol Chem. 2001;276:9189-98 pubmed
    ..We have used dot-blot and in situ analysis to indicate that this erythroid preconditioning is probably restricted to primitive but not definitive HSC. ..
  2. Tsukamoto T, Li X, Morita H, Minowa T, Aizawa T, Hanagata N, et al. Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. PLoS ONE. 2013;8:e75831 pubmed publisher
    ..b>IFITM5 is another IFITM family protein and interacts with the FK506-binding protein 11 (FKBP11) to form a higher-order ..
  3. Patoine A, Gaumond M, Jaiswal P, Fassier F, Rauch F, Moffatt P. Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination. J Bone Miner Res. 2014;29:2004-16 pubmed publisher
    BRIL/IFITM5 is a membrane protein present almost exclusively in osteoblasts, which is believed to adopt a type III (N-out/C-out) topology...
  4. Lange U, Adams D, Lee C, Barton S, Schneider R, Bradley A, et al. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008;28:4688-96 pubmed publisher
    ..Hence, contrary to previous reports, Ifitm genes are not essential for PGC migration. The Ifitm family is a striking example of a conserved gene cluster which appears to be functionally redundant during development. ..