Gene Symbol: Ifitm2
Description: interferon induced transmembrane protein 2
Alias: DSPA2c, Ifitm3l, fragilis3, mil-3, interferon-induced transmembrane protein 2, dispanin subfamily A member 2c, fragilis R, fragilis protein 3, interferon induced transmembrane protein, like
Species: mouse
Products:     Ifitm2

Top Publications

  1. Lange U, Saitou M, Western P, Barton S, Surani M. The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev Biol. 2003;3:1 pubmed
    ..In the mouse, fragilis2 and fragilis3, which are proximate to fragilis, exhibit expression that overlaps with the latter in the region of ..
  2. Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
    ..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. ..
  3. Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
    ..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
  4. Tanaka S, Matsui Y. Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells. Mech Dev. 2002;119 Suppl 1:S261-7 pubmed
    ..5-7.5 days post coitum. In migrating PGCs, mil-1 expression was continuously observed and mil-2 expression was first detected during germ cell differentiation. ..
  5. Smith R, Young J, Weis J, Weis J. Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Genes Immun. 2006;7:113-21 pubmed
    ..Expression of some of these genes (fragilis and fragilis3) is wide spread in a variety of mouse immune (and nonimmune) tissues while others (fragilis5) appear to be much ..
  6. Lange U, Adams D, Lee C, Barton S, Schneider R, Bradley A, et al. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008;28:4688-96 pubmed publisher
    ..Hence, contrary to previous reports, Ifitm genes are not essential for PGC migration. The Ifitm family is a striking example of a conserved gene cluster which appears to be functionally redundant during development. ..
  7. Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, et al. APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans. Stem Cell Rev. 2011;7:43-52 pubmed publisher
    ..Moreover, APOA-1 gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans. ..
  8. Jia R, Ding S, Pan Q, Liu S, Qiao W, Liang C. The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity. PLoS ONE. 2015;10:e0118794 pubmed publisher
    ..The results also demonstrate the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization. ..