Gene Symbol: Ifi202b
Description: interferon activated gene 202B
Alias: Ifbip-1, Ifi202, Ifi202a, p202, interferon-activable protein 202, Interferon-activatable protein 202a (Ifi-202a) (Interferon-inducible protein p202a), ifi-202, interferon activated gene 202A, interferon-inducible protein p202, lupus susceptibility protein p202
Species: mouse
Products:     Ifi202b

Top Publications

  1. Yamauchi M, Hashimoto M, Ichiyama K, Yoshida R, Hanada T, Muta T, et al. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Int Immunol. 2007;19:935-42 pubmed
    ..The expression of an IFN-inducible gene Ifi202, a candidate gene for lupus, was almost undetectable in NZW BMDCs...
  2. Gubbels Bupp M, Li M, Pashine A, Aud D, Peng S. The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function. Rheumatology (Oxford). 2008;47:103-4 pubmed
  3. Chen J, Panchanathan R, Choubey D. Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway. Immunol Lett. 2008;118:13-20 pubmed publisher
    Studies have revealed that increased expression of interferon (IFN)-inducible Ifi202 gene (encoding p202 protein) in splenic B and T cells from B6...
  4. Vogel H, Scherneck S, Kanzleiter T, Benz V, Kluge R, Stadion M, et al. Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11?-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Hum Mol Genet. 2012;21:3845-57 pubmed publisher
    ..mRNA profiling and western blotting indicated that Ifi202b, a member of the Ifi200 family of interferon inducible transcriptional modulators, was expressed in NZO-allele ..
  5. Xin H, Pramanik R, Choubey D. Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth. Oncogene. 2003;22:4775-85 pubmed
    ..Here, we report that Rb upregulates expression of Ifi202 gene...
  6. Xin H, D Souza S, Jørgensen T, Vaughan A, Lengyel P, Kotzin B, et al. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006;176:5863-70 pubmed
    Increased expression of p202 protein (encoded by the Ifi202 gene) in splenocytes derived from B6...
  7. Roberts T, Idris A, Dunn J, Kelly G, Burnton C, Hodgson S, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009;323:1057-60 pubmed publisher
    ..We identified the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA...
  8. Brunette R, Young J, Whitley D, Brodsky I, Malik H, Stetson D. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J Exp Med. 2012;209:1969-83 pubmed publisher
    ..These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity. ..
  9. Suto J, Satou K. Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss. BMC Genet. 2013;14:35 pubmed publisher
    ..Cg-A(y) females are heavier than DDD females, whereas DDD.Cg-A(y) males are lighter than DDD males. This study aimed to determine the possible cause and identify the genes responsible for the lower body weight of DDD.Cg-A(y) males...

More Information


  1. Panchanathan R, Duan X, Arumugam M, Shen H, Liu H, Choubey D. Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE. Mol Immunol. 2011;49:273-80 pubmed publisher
    ..In contrast, the p202 protein (encoded by the Ifi202 gene) does not form an inflammasome...
  2. Panchanathan R, Choubey D. Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity. Mol Immunol. 2013;53:15-23 pubmed publisher
    ..7 macrophage cells with IFN-?, IFN-?, or E2 induced expression of BAFF. Interestingly, increased expression of p202, an IFN and estrogen-inducible protein, in RAW264...
  3. Ichii O, Kamikawa A, Otsuka S, Hashimoto Y, Sasaki N, Endoh D, et al. Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. Lupus. 2010;19:897-905 pubmed publisher
    ..MRLc1(82-100) contains the interferon activated gene 200 (Ifi200) family, which consists of Ifi202, 203, 204, and 205. Recently, Ifi202 was suggested as a candidate gene for murine lupus...
  4. Choubey D, Snoddy J, Chaturvedi V, Toniato E, Opdenakker G, Thakur A, et al. Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J Biol Chem. 1989;264:17182-9 pubmed
  5. Ma X, Wang H, Ding B, Zhong H, Ghosh S, Lengyel P. The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem. 2003;278:23008-19 pubmed
    ..Transfected ectopic p202a increases the apoptotic effect of tumor necrosis factor (at least in part) by inhibiting NF-kappaB and its antiapoptotic activity. ..
  6. Li H, Liu F, Guo H, Zhu Z, Jiao Y. Role of interferon-inducible protein 202 (p202) in the regulation of adipogenesis in mouse adipose-derived stem cells. Mol Cell Endocrinol. 2014;382:814-24 pubmed publisher
    The interferon-inducible protein 202 (p202) has emerged as a key regulator of cell proliferation and differentiation...
  7. Ludlow L, Purton L, Klarmann K, Gough D, Hii L, Trapani J, et al. The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res. 2008;28:5-11 pubmed publisher
    ..Characterization of the lineage and cell type-dependent expression of Ifi202 revealed little or no expression of Ifi202 in the Lin(-)/c-Kit+ fraction enriched for immature hematopoietic ..
  8. Wang H, Chatterjee G, Meyer J, Liu C, Manjunath N, Bray Ward P, et al. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Genomics. 1999;60:281-94 pubmed
    ..We report here the exon-intron structure of Ifi202 and the discovery of Ifi202b and Ifi202c, close homologs of Ifi202 (whose designation we now change to Ifi202a)...
  9. Li H, Wang J, Wang J, Cao L, Wang Z, Wu J. Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr F Struct Biol Commun. 2014;70:21-9 pubmed publisher
    ..In contrast, p202, a mouse interferon-inducible protein containing two HIN domains (HINa and HINb), has been reported to inhibit Aim2-..
  10. Zimmerman M, Yang D, Hu X, Liu F, Singh N, Browning D, et al. IFN-? upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells. PLoS ONE. 2010;5:e14076 pubmed publisher
    ..Using DNA microarray technology, we identified that survivin and ifi202, two genes with known functions in T cell apoptosis and proliferation, are differentially induced between Ag- and ..
  11. Panchanathan R, Xin H, Choubey D. Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice. J Immunol. 2008;180:5927-34 pubmed
    Studies have identified IFN-inducible Ifi202 gene as a lupus susceptibility gene (encoding p202 protein) in mouse models of lupus disease. However, signaling pathways that regulate the Ifi202 expression in cells remain to be elucidated...
  12. Pramanik R, Jørgensen T, Xin H, Kotzin B, Choubey D. Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. J Biol Chem. 2004;279:16121-7 pubmed
    ..Our previous studies of one mouse model of SLE identified an interferon-inducible gene, Ifi202, as a major contributor to the disease. We now report that IL-6 induces expression of the Ifi202 gene...
  13. Ashley R, Henkes L, Bouma G, Pru J, Hansen T. Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta. Endocrinology. 2010;151:4527-36 pubmed publisher
    ..This fetal death also might relate to impaired IL-1beta signaling, because ISG15 and isgylation are induced by IL-1beta in human and murine endometrial stromal cells. ..
  14. Yin Q, Sester D, Tian Y, Hsiao Y, Lu A, Cridland J, et al. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Rep. 2013;4:327-39 pubmed publisher
    Mouse p202 containing two hemopoietic expression, interferon inducibility, nuclear localization (HIN) domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility...
  15. Manils J, Casas E, Vina Vilaseca A, López Cano M, Díez Villanueva A, Gómez D, et al. The Exonuclease Trex2 Shapes Psoriatic Phenotype. J Invest Dermatol. 2016;136:2345-2355 pubmed publisher
    ..Hence, our data indicate that Trex2 acts as a critical factor in the pathogenesis of psoriasis by promoting keratinocyte apoptosis and enucleation and thereby influencing skin immune responses. ..
  16. Panchanathan R, Shen H, Bupp M, Gould K, Choubey D. Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval. J Immunol. 2009;183:7031-8 pubmed publisher
    Increased expression of IFN-inducible Ifi202 gene in certain strains of female mice is associated with susceptibility to systemic lupus erythematosus (SLE)...
  17. Panchanathan R, Shen H, Duan X, Rathinam V, Erickson L, Fitzgerald K, et al. Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. J Immunol. 2011;186:6762-70 pubmed publisher
    Murine Aim2 and Ifi202 genes (encoding for the Aim2 and p202 proteins) are members of the IFN-inducible Ifi200 gene family...
  18. Dinesh R, Hahn B, La Cava A, Singh R. Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice. Genes Immun. 2011;12:360-9 pubmed publisher
    ..CD8(+) T cells from mice tolerized with pCons showed more than two-fold increase in Ifi202b mRNA, an interferon inducible gene, versus cells from untolerized mice...
  19. Kong L, Liu C. Mediation of chondrogenic and osteogenic differentiation by an interferon-inducible p202 protein. Cell Mol Life Sci. 2008;65:3494-506 pubmed publisher
    b>p202, an interferon-inducible protein that belongs to an interferon-inducible p200 family, was highly induced in the course of osteogenesis of pluripotent C2C12 cells and the chondrogenesis of C3H10T1/2 cells...
  20. Wang H, Ding B, Liu C, Ma X, Deschamps S, Roe B, et al. The increase in levels of interferon-inducible proteins p202a and p202b and RNA-dependent protein kinase (PKR) during myoblast differentiation is due to transactivation by MyoD: their tissue distribution in uninfected mice does not depend on interfer. J Interferon Cytokine Res. 2002;22:729-37 pubmed
    ..This indicates that the synthesis and distribution of these proteins in uninfected adult mice are not affected by endogenous IFNs. ..
  21. Datta B, Li B, Choubey D, Nallur G, Lengyel P. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem. 1996;271:27544-55 pubmed
    b>p202, an interferon-inducible murine protein, is a member of the "200 family" of proteins and is primarily nuclear...
  22. Choubey D, Lengyel P. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J Biol Chem. 1995;270:6134-40 pubmed
    ..Two homologous human genes have also been reported. p202, encoded by the Ifi202 gene in the gene 200 cluster, is a 52-kDa nuclear phosphoprotein...
  23. Panchanathan R, Duan X, Shen H, Rathinam V, Erickson L, Fitzgerald K, et al. Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J Immunol. 2010;185:7385-93 pubmed publisher
    Murine Aim2 and p202 proteins (encoded by the Aim2 and Ifi202 genes) are members of the IFN-inducible p200 protein family. Both proteins can sense dsDNA in the cytoplasm...
  24. Lin M, Chang K, Lin S, Miner J. Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol. 2010;344:707-19 pubmed publisher
    ..These findings have important implications for understanding the pathogenesis of ichthyosis prematurity syndrome, a disease recently shown to be caused by FATP4 mutations. ..
  25. Zhang K, Kagan D, DuBois W, Robinson R, Bliskovsky V, Vass W, et al. Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility. Blood. 2009;114:2952-60 pubmed publisher
    ..Mndal is highly polymorphic among inbred mouse strains, because it is absent in 10 of 24 strains. This polymorphism may have implications for other disease modifiers mapping to the same region...