If1

Summary

Gene Symbol: If1
Description: NDV-induced circulating interferon
Alias: If-1, NDV-induced circulating interferon
Species: mouse

Top Publications

  1. Slate D, Ruddle F. Genetics of the interferon system. Pharmacol Ther. 1979;4:221-30 pubmed
  2. Raj N, Cheung S, Rosztoczy I, Pitha P. Mouse genotype affects inducible expression of cytokine genes. J Immunol. 1992;148:1934-40 pubmed
    ..We propose that the If-1 locus affects the early stages of a signal transduction pathway which are common to the virus-mediated induction of IFN, TNF-alpha, and IL-6 genes. ..
  3. De Maeyer E, De Maeyer Guignard J. Gene with quantitative effect on circulating interferon induced by Newcastle disease virus. J Virol. 1969;3:506-12 pubmed
    ..The results indicate that a single, partly dominant, autosomal factor is responsible for the difference in circulating interferon production between both parent strains. ..
  4. Zawatzky R, Gresser I, Demaeyer E, Kirchner H. The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1. J Infect Dis. 1982;146:405-10 pubmed
    ..Thus, endogenous IFN induced after injection with 250 LD50 of HSV-1 protects B6 mice, whereas low doses of virus kill the animals because they do not generate a detectable IFN response at the infection site. ..
  5. Mobraaten L, Bunker H, DeMaeyer Guignard J, Demaeyer E, Bailey D. Location of histocompatibility and interferon loci on chromosome 3 of the mouse. J Hered. 1984;75:233-4 pubmed
    ..The gene order (from centromere) with intervening percent recombination is: ma-19.1(+/- 4.9)-H-23-12.0(+/- 4.0)-VaJ-7.7(+/- 2.2)-H-28-5.9(+/- 2.2)-If-1. ..
  6. Zawatzky R, Wurmbaeck H, Falk W, Homfeld A. Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages. J Virol. 1991;65:4839-46 pubmed
    ..These data suggest that the If-1h and If-1l alleles harbor IFN-inducible genes that, following activation, specifically suppress subsequent cytokine gene expression in response to NDV. ..
  7. Paul P, Elliott R. Analysis of the mouse Amy locus in recombinant inbred mouse strains. Biochem Genet. 1987;25:569-79 pubmed
    ..Previously reported differences for strains YBR and CE have been confirmed. New segregation data for carbonic anhydrase, a locus near the proximal end of mouse chromosome 3, are presented. ..
  8. Zawatzky R, Wurmbaeck H. Downregulation of Newcastle disease virus (NDV)-dependent IFN-alpha/beta production in macrophages by IFN-induced gene products of the locus If-1. Res Immunol. 1992;143:57-63 pubmed
    ..abstract truncated at 250 words) ..
  9. Lai M, Yeow W, Boyer S, Beilharz M. Differential expression patterns of type I interferon subtypes in mouse embryo fibroblasts: influence of genotype and viral inducer. Antiviral Res. 1994;24:327-40 pubmed
    ..The latter observation fits the proposition that "cross-talk" or feedback between the type I interferon genes and their products is is occurring and that the inducer determines the level of response. ..
  10. Elliott R. Use of two-dimensional electrophoresis to identify and map new mouse genes. Genetics. 1979;91:295-308 pubmed
    ..These eight genes will be useful reference markers in future crosses designed to map new genes. ..

Detail Information

Publications12

  1. Slate D, Ruddle F. Genetics of the interferon system. Pharmacol Ther. 1979;4:221-30 pubmed
  2. Raj N, Cheung S, Rosztoczy I, Pitha P. Mouse genotype affects inducible expression of cytokine genes. J Immunol. 1992;148:1934-40 pubmed
    ..We propose that the If-1 locus affects the early stages of a signal transduction pathway which are common to the virus-mediated induction of IFN, TNF-alpha, and IL-6 genes. ..
  3. De Maeyer E, De Maeyer Guignard J. Gene with quantitative effect on circulating interferon induced by Newcastle disease virus. J Virol. 1969;3:506-12 pubmed
    ..The results indicate that a single, partly dominant, autosomal factor is responsible for the difference in circulating interferon production between both parent strains. ..
  4. Zawatzky R, Gresser I, Demaeyer E, Kirchner H. The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1. J Infect Dis. 1982;146:405-10 pubmed
    ..Thus, endogenous IFN induced after injection with 250 LD50 of HSV-1 protects B6 mice, whereas low doses of virus kill the animals because they do not generate a detectable IFN response at the infection site. ..
  5. Mobraaten L, Bunker H, DeMaeyer Guignard J, Demaeyer E, Bailey D. Location of histocompatibility and interferon loci on chromosome 3 of the mouse. J Hered. 1984;75:233-4 pubmed
    ..The gene order (from centromere) with intervening percent recombination is: ma-19.1(+/- 4.9)-H-23-12.0(+/- 4.0)-VaJ-7.7(+/- 2.2)-H-28-5.9(+/- 2.2)-If-1. ..
  6. Zawatzky R, Wurmbaeck H, Falk W, Homfeld A. Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages. J Virol. 1991;65:4839-46 pubmed
    ..These data suggest that the If-1h and If-1l alleles harbor IFN-inducible genes that, following activation, specifically suppress subsequent cytokine gene expression in response to NDV. ..
  7. Paul P, Elliott R. Analysis of the mouse Amy locus in recombinant inbred mouse strains. Biochem Genet. 1987;25:569-79 pubmed
    ..Previously reported differences for strains YBR and CE have been confirmed. New segregation data for carbonic anhydrase, a locus near the proximal end of mouse chromosome 3, are presented. ..
  8. Zawatzky R, Wurmbaeck H. Downregulation of Newcastle disease virus (NDV)-dependent IFN-alpha/beta production in macrophages by IFN-induced gene products of the locus If-1. Res Immunol. 1992;143:57-63 pubmed
    ..abstract truncated at 250 words) ..
  9. Lai M, Yeow W, Boyer S, Beilharz M. Differential expression patterns of type I interferon subtypes in mouse embryo fibroblasts: influence of genotype and viral inducer. Antiviral Res. 1994;24:327-40 pubmed
    ..The latter observation fits the proposition that "cross-talk" or feedback between the type I interferon genes and their products is is occurring and that the inducer determines the level of response. ..
  10. Elliott R. Use of two-dimensional electrophoresis to identify and map new mouse genes. Genetics. 1979;91:295-308 pubmed
    ..These eight genes will be useful reference markers in future crosses designed to map new genes. ..
  11. Zawatzky R, Kirchner H, DeMaeyer Guignard J, Demaeyer E. An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1. J Gen Virol. 1982;63:325-32 pubmed
    ..It is concluded that the levels of HSV-induced early IFN production are influenced by several autosomal loci and one X-linked locus. ..
  12. Aly M, Wiltshire S, Chahrour G, Osti J, Vidal S. Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. Genes Immun. 2007;8:193-204 pubmed
    ..7 (P=0.0045), as well as sarcolemmal disruption in females (P=0.0015). These results provide strong evidence for the presence of loci contributing to the susceptibility of mice to viral myocarditis. ..