Gene Symbol: Idh1
Description: isocitrate dehydrogenase 1 (NADP+), soluble
Alias: AI314845, AI788952, E030024J03Rik, Id-1, Idh-1, Idpc, isocitrate dehydrogenase [NADP] cytoplasmic, IDH, IDP, NADP(+)-specific ICDH, cytosolic NADP-isocitrate dehydrogenase, oxalosuccinate decarboxylase
Species: mouse
Products:     Idh1

Top Publications

  1. Koh H, Lee S, Son B, Lee S, Ryoo Z, Chang K, et al. Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism. J Biol Chem. 2004;279:39968-74 pubmed
    ..However, the role of cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDPc) is still unclear...
  2. Sasaki M, Knobbe C, MUNGER J, Lind E, Brenner D, Brüstle A, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012;488:656-9 pubmed publisher
    Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML)...
  3. Rohle D, Popovici Muller J, Palaskas N, Turcan S, Grommes C, Campos C, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013;340:626-30 pubmed publisher
    ..One potential drug target is isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers...
  4. Loster J, Pretsch W, Sandulache R, Schmitt John T, Lyon M, Graw J. Close linkage of the dominant cataract mutations (Cat-2) with Idh-1 and cryge on mouse chromosome 1. Genomics. 1994;23:240-2 pubmed
  5. Lee S, Koh H, Park D, Song B, Huh T, Park J. Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic Biol Med. 2002;32:1185-96 pubmed
    ..dehydrogenase (G6PD), malic enzyme, and the cytosolic form of NADP(+)-dependent isocitrate dehydrogenase (IDPc). Little information is available about the role of IDPc in antioxidant defense...
  6. Lemonnier F, Cairns R, Inoue S, Li W, Dupuy A, Broutin S, et al. The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development. Proc Natl Acad Sci U S A. 2016;113:15084-15089 pubmed publisher
    ..In the hematopoietic system, mutations in IDH1 at arginine (R) 132 and in IDH2 at R140 and R172 are commonly observed in acute myeloid leukemia, and elevated 2HG ..
  7. Francke U, Lalley P, Moss W, Ivy J, Minna J. Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19:57-84 pubmed
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome. ..
  8. Chapman V, Ruddle F. Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1. Genetics. 1972;70:299-305 pubmed
    ..Our results demonstrate the utility of sampling Mus from diverse populations to extend the repertoire of polymorphic loci and the genetic linkage map. ..
  9. Chapman V, Ruddle F, Roderick T. Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1). Biochem Genet. 1971;5:101-10 pubmed

More Information


  1. Capeless C, Whitney G, Azen E. Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Behav Genet. 1992;22:655-63 pubmed
    ..The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere. ..
  2. Inoue S, Li W, Tseng A, Beerman I, Elia A, Bendall S, et al. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell. 2016;30:337-348 pubmed publisher
    Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute myeloid leukemia (AML) but their mechanism is not fully understood...
  3. Sweet H. Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983;74:305-6 pubmed
    ..Dilute suppressor is located on chromosome 1 linked to isocitrate dehydrogenase (Idh-I) with 6.25 +/- 3.49 percent recombination, and is not linked to dilute, which is on chromosome 9.
  4. Festenstein H, Berumen L. BALB.D2-Mlsa--a new congenic mouse strain. Transplantation. 1984;37:322-4 pubmed
  5. Lafuse W, Brown D, Zwilling B. Assignment of the microtubule-associated protein 2 gene to mouse chromosome 1. Mamm Genome. 1992;3:48-51 pubmed
  6. Tada N, Kimura S, Liu Lam Y, Hammerling U. Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2:29-38 pubmed
    ..Analysis of BXD and SWXL recombinant inbred strains revealed close linkage between Ly-m22 and Ltw-4 loci on chromosome 1. The estimated recombination frequency is 0.027 +/- 0.081. ..
  7. Skow L, Donner M, Huang S, Gardner J, Taylor B, Beamer W, et al. Mapping of mouse gamma crystallin genes on chromosome 1. Biochem Genet. 1988;26:557-70 pubmed
    ..genes (Cryg) to the proximal region of chromosome 1 closely linked to the loci encoding isocitrate dehydrogenase (Idh-1), a low molecular weight (LM) crystallin protein polymorphism (Len-1), and fibronectin (Fn-1)...
  8. Harada Y, Hayakawa J, Noda E, Tomita T. A gene locus controlling a serum protein migrating electrophoretically in the beta region of mice and detected by using a strain derived from the Japanese wild mouse (Mus musculus molossinus). J Immunogenet. 1987;14:33-41 pubmed
    ..The evidence also suggests that Sas-2 is genetically different from the previously described Sas-1 which controls a serum protein in the mouse. Sas-2 was located by linkage analysis between Idh-1 locus and Akp-1 locus on chromosome 1.
  9. Chu B, Wu T, Miao L, Mei Y, Wu M. MiR-181a regulates lipid metabolism via IDH1. Sci Rep. 2015;5:8801 pubmed publisher
    ..MiR-181a is able to target isocitrate dehydrogenase 1 (IDH1), a metabolic enzyme in TCA cycle...
  10. Hutton J, Roderick T. Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers. Biochem Genet. 1970;4:339-50 pubmed
  11. Danciger M, Kozak C, Tsuda M, Shinohara T, Farber D. The gene for retinal S-antigen (48-kDa protein) maps to the centromeric portion of mouse chromosome 1 near Idh-1. Genomics. 1989;5:378-81 pubmed
    ..We have used a mouse cDNA clone for the S-antigen to map the corresponding gene, Sag, to mouse chromosome 1 near Idh-1...
  12. Kozak C, Rowe W. Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains. J Exp Med. 1980;152:219-28 pubmed
    ..An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction. ..
  13. Bardella C, Al Dalahmah O, Krell D, Brazauskas P, Al Qahtani K, Tomková M, et al. Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis. Cancer Cell. 2016;30:578-594 pubmed publisher
    ..To model this disease, we conditionally expressed Idh1R132H in the subventricular zone (SVZ) of the adult mouse brain...
  14. Epstein C, Tucker G, Travis B, Gropp A. Gene dosage for isocitrate dehydrogenase in mouse embryos trisomic for chromosome 1. Nature. 1977;267:615-6 pubmed
  15. Berk R, Hazlett L, Beisel K. Genetic studies on resistant and susceptibility genes controlling the mouse cornea to infection with Pseudomonas aeruginosa. Antibiot Chemother (1971). 1987;39:83-91 pubmed
  16. Moore K, Swing D, Rinchik E, Mucenski M, Buchberg A, Copeland N, et al. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln. Genetics. 1988;119:933-41 pubmed
    ..These studies provide new insights into the mechanism of action of dsu and into the interrelationships between members of a family of pigment genes. ..
  17. Cobb R, Rinchik E, Barnett L, Burkhart J, Lewis S. A malic enzyme probe detects cross-hybridizing sequences closely linked to loci encoding other metabolic enzymes. Genomics. 1992;12:405-8 pubmed
    ..The other hybridization site, designated D1Rti2, was closely linked to the isocitrate dehydrogenase (Idh-1) locus on Chromosome 1...
  18. Hintz M, Rout U, Holmes R. Genetics and development of ocular oxidases in the mouse: evidence for a new locus (Eox-1) closely linked with the aldehyde oxidase loci on chromosome 1. Anim Genet. 1988;19:227-36 pubmed
    ..These results support the proposal that ocular oxidases are distinct from the major liver AOXs in this organism. ..
  19. Ye J, Gu Y, Zhang F, Zhao Y, Yuan Y, Hao Z, et al. IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization. Proc Natl Acad Sci U S A. 2017;114:292-297 pubmed publisher
    Although the enzymatic activity of isocitrate dehydrogenase 1 (IDH1) was defined decades ago, its functions in vivo are not yet fully understood...
  20. Epstein C, Weston J, Whitten W, Russell E. The expression of the isocitrate dehydrogenase locus (ld-1) during mouse embryogenesis. Dev Biol. 1972;27:430-3 pubmed
  21. Holmes R. Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1. Biochem Genet. 1979;17:517-27 pubmed
    ..Both isozymes were significantly reduced in activity by castration of adult males and increased following testosterone administration to castrated males and normal female mice. ..
  22. Mock B, Krall M, Blackwell J, O BRIEN A, Schurr E, Gros P, et al. A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus. Genomics. 1990;7:57-64 pubmed
    ..Allelic isoforms of Idh-1 and Pep-3 and RFLPs detected by Southern hybridization for Myl-1, Cryg, Vil, Achrg, bcl-2, and Ren-1,2, between ..
  23. Nam W, Park K, Park J. RNA interference targeting cytosolic NADP(+)-dependent isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo. Biochim Biophys Acta. 2012;1822:1181-8 pubmed publisher
    ..Cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDPc) has been proposed as a key enzyme for supplying cytosolic NADPH...
  24. Smith R, Hawes N, Chang B, Roderick T, Akeson E, Heckenlively J, et al. Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract. Genomics. 2000;63:314-20 pubmed
    ..It is predicted that the defective gene product alters protein folding of the gamma-crystallin(s) and results in lens opacity. ..
  25. Yang L, Luo H, Vinay P, Wu J. Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation. J Cell Biochem. 1996;60:400-10 pubmed documents the molecular cloning of the mouse mitochondrial NADP-dependent isocitrate dehydrogenase (mNADP-IDH) cDNA...
  26. Hirata M, Sasaki M, Cairns R, Inoue S, Puviindran V, Li W, et al. Mutant IDH is sufficient to initiate enchondromatosis in mice. Proc Natl Acad Sci U S A. 2015;112:2829-34 pubmed publisher
    ..Somatic mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) are present in the majority of these tumor types. How these mutations cause enchondromas is unclear...
  27. Pirozzi C, Carpenter A, Waitkus M, Wang C, Zhu H, Hansen L, et al. Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. Mol Cancer Res. 2017;15:507-520 pubmed publisher
    i>IDH1 mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG)...
  28. Taylor B, O Brien A. Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium. Infect Immun. 1982;36:1257-60 pubmed
    ..The results of a five-point backcross clearly showed that the correct gene order on chromosome 1 is fz-Idh-1-Ity-ln-Pep-3.
  29. McKenney A, Lau A, Somasundara A, Spitzer B, Intlekofer A, Ahn J, et al. JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. J Clin Invest. 2018;128:789-804 pubmed publisher
    ..leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor outcomes...
  30. Zebedee S, Barritt D, Epstein R, Raschke W. Analysis of Ly5 chromosome 1 position using allelic differences and recombinant inbred mice. Eur J Immunogenet. 1991;18:155-63 pubmed
    ..Placement of the Ly5 gene with respect to other characterized markers of mouse chromosome 1 for these recombinant inbred mouse strains shows a gene order of Idh-1:Ity:Pep3:[Ly5, Cfh].
  31. Watson J, Higgins T, Collins P, Chaykin S. The mouse liver aldehyde oxidase locus (Aox). Biochem Genet. 1972;6:195-204 pubmed
  32. Wilcox F. Genetics of alkaline phosphatase of the small intestine of the house mouser (Mus musculus). Biochem Genet. 1983;21:641-52 pubmed
    ..X PL/J hybrid crossed with the PL/J strain showed linkage with two loci on chromosome 1 as follows: centromere--Idh-1--13.8 cM--Akp-3--8.9 +/- 2.6 cM--Pep-3...
  33. Lush I. Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Anim Blood Groups Biochem Genet. 1978;9:85-96 pubmed
    ..3. The gene determining the electrophoretic variant of aldehyde oxidase is either the same as, or very closely linked to, the Aox gene which determines aldehyde oxidase activity. ..
  34. O Brien S, Nash W. Genetic mapping in mammals: chromosome map of domestic cat. Science. 1982;216:257-65 pubmed
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed. ..
  35. Robert B, Barton P, Minty A, Daubas P, Weydert A, Bonhomme F, et al. Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature. 1985;314:181-3 pubmed
    ..No linkage between these genes was observed. ..
  36. Heidmann O, Buonanno A, Geoffroy B, Robert B, Guenet J, Merlie J, et al. Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse. Science. 1986;234:866-8 pubmed
  37. Su L, Hershberger R, Weissman I. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Genes Dev. 1993;7:735-48 pubmed
    ..The putative gene was mapped on mouse chromosome 1, closely linked to Idh-1, but not linked to the Ly-1 (CD5) gene. The cDNA is therefore named Ly-1 antibody reactive clone (LYAR)...
  38. Caramazza D, Lasho T, Finke C, Gangat N, Dingli D, Knudson R, et al. IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. Leukemia. 2010;24:2120-2 pubmed publisher
  39. Pellegatta S, Valletta L, Corbetta C, Patanè M, Zucca I, Riccardi Sirtori F, et al. Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma. Acta Neuropathol Commun. 2015;3:4 pubmed publisher
    The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas...
  40. Adkison L, Skow L, Thomas T, Petrash M, Womack J. Somatic cell mapping and restriction fragment analysis of bovine genes for fibronectin and gamma crystallin. Cytogenet Cell Genet. 1988;47:155-9 pubmed
    ..FNI) and gamma crystallin (CRYG) fragments were concordant with each other and with isocitrate dehydrogenase 1 (IDH1), representing the bovine syntenic group U17...
  41. Beamer W, Cunliffe Beamer T, Shultz K, Langley S, Roderick T. Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice. Biol Reprod. 1988;38:899-908 pubmed
    ..mapping the jsd gene to the centromeric end of chromosome 1; the gene order is jsd-Isocitrate dehydrogenase-1 (Idh-1)-Peptidase-3 (Pep-3)...
  42. Opalka B, Kölsch E. Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines. Eur J Immunol. 1983;13:24-30 pubmed
    ..BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known. ..
  43. Metellus P, Coulibaly B, Colin C, de Paula A, Vasiljevic A, Taieb D, et al. Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis. Acta Neuropathol. 2010;120:719-29 pubmed publisher
    ..b>IDH1 codon 132 and IDH2 codon 172 sequencing was performed in a series of 47 LGGs and correlated with clinical ..
  44. Kozak C, Filie J, Adamson M, Chen Y, Yu L. Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics. 1994;21:659-61 pubmed
    ..These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene. ..
  45. MacInnes J, Morris V, Flintoff W, Kozak C. Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice. Virology. 1984;132:12-25 pubmed
  46. Kim J, Kim K, Jang H, Yoshida T, Tsuchiya K, Nitta K, et al. Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol. 2009;296:F622-33 pubmed publisher
    Cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) synthesizes reduced NADP (NADPH), which is an essential cofactor for the generation of reduced glutathione (GSH), the most abundant and important antioxidant in mammalian cells...
  47. Amankulor N, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, et al. Mutant IDH1 regulates the tumor-associated immune system in gliomas. Genes Dev. 2017;31:774-786 pubmed publisher
    Gliomas harboring mutations in isocitrate dehydrogenase 1/2 (IDH1/2) have the CpG island methylator phenotype (CIMP) and significantly longer patient survival time than wild-type IDH1/2 (wtIDH1/2) tumors...
  48. Acton R, Blankenhorn E, Douglas T, Owen R, Hilgers J, Hoffman H, et al. Variations among sublines of inbred AKR mice. Nat New Biol. 1973;245:8-10 pubmed
  49. Bradley D, Taylor B, Blackwell J, Evans E, Freeman J. Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp Immunol. 1979;37:7-14 pubmed
    ..The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci. ..
  50. Dowbenko D, Diep A, Taylor B, Lusis A, Lasky L. Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons. Genomics. 1991;9:270-7 pubmed
  51. Bodine D, Birkenmeier C, Barker J. Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes. Cell. 1984;37:721-9 pubmed
    ..Analysis of spectrin synthesis in mice homozygous and heterozygous for several alleles of sph indicates that the sph locus is the structural gene locus for alpha spectrin. We have mapped the sph locus to mouse Chromosome 1. ..
  52. Bogdanovic E, Sadri A, Catapano M, Vance J, Jeschke M. IDH1 regulates phospholipid metabolism in developing astrocytes. Neurosci Lett. 2014;582:87-92 pubmed publisher
    Isocitrate dehydrogenase 1 (IDH1) is an evolutionarily conserved enzyme that catalyzes the interconversion of isocitrate to α-ketoglutarate with the concomitant reduction of NADP(+) to NADPH...
  53. Sato H, Kimura S, Itakura K. Genetic and serologic re-evaluation of LyM-1 antigen specified by a gene closely linked to Mls: establishment of LyM-1 antigen of the mouse. J Immunogenet. 1981;8:27-40 pubmed
    ..2 serum under the condition in which Lyb-2.1 is not involved in analysis. The strain distribution of LyM-1 antigen, its preferential expression on B lymphocytes and close genetic linkage of LyM-1 to Mls have been established. ..
  54. Groen A. Identification and genetic monitoring of mouse inbred strains using biochemical polymorphisms. Lab Anim. 1977;11:209-14 pubmed
    ..These findings emphasize the possibility and the necessity of monitoring the genetic purity of inbred strains of mice. A routine monitoring scheme using body protein-polymorphisms is proposed. ..
  55. Crespo I, Vital A, Gonzalez Tablas M, Patino M, Otero A, Lopes M, et al. Molecular and Genomic Alterations in Glioblastoma Multiforme. Am J Pathol. 2015;185:1820-33 pubmed publisher
    ..alterations and genetic pathways appear to distinguish primary (eg, EGFR amplification) versus secondary (eg, IDH1/2 or TP53 mutation) GBM...
  56. Skow L. Location of a gene controlling electrophoretic variation in mouse gamma-crystallins. Exp Eye Res. 1982;34:509-16 pubmed
  57. Potter M, O Brien A, Skamene E, Gros P, Forget A, Kongshavn P, et al. A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. Infect Immun. 1983;40:1234-5 pubmed
    BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice...
  58. Li W, Zhao Y. Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. Cancer Sci. 2013;104:143-8 pubmed publisher
    ..Interestingly, TPA inactivated isocitrate dehydrogenase 1 (IDH1), which was reversed by WA. Similar results were also observed in mouse skin tissue...
  59. Racine R, Langley C. Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis. Biochem Genet. 1980;18:185-97 pubmed
    ..Out of the 100 loci screened, we have found nine loci showing interstrain differences. We have found also that differences in the protein pattern as seen on two-dimensional gels are small among subspecies of Mus musculus. ..
  60. Lemaire L, Johnson K, Bammer S, Petry P, Ruddle F, Heinlein U. Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994;21:409-14 pubmed
  61. Yamamoto M, Tanaka H, Toki Y, Hatayama M, Ito S, Addo L, et al. Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase. Int J Hematol. 2016;104:491-501 pubmed publisher
    ..we observed that the enzymes, phosphoglucomutase 1, glycogen debranching enzyme, and isocitrate dehydrogenase 1 (Idh1), which are involved in glycogen and glucose metabolism, were increased...
  62. Itsumi M, Inoue S, Elia A, Murakami K, Sasaki M, Lind E, et al. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 2015;22:1837-45 pubmed publisher
    Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to α-ketoglutarate...
  63. Nekrutenko A, Hillis D, Patton J, Bradley R, Baker R. Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. Mol Biol Evol. 1998;15:1674-84 pubmed publisher
    ..A possible scenario of the evolution of NADP-dependent isocitrate dehydrogenases is proposed...
  64. Nichols E, Ruddle F. Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975;13:323-9 pubmed
    ..Using an electrophoretic variant for glutathione reductase, we have been able to map the structural gene for this enzyme to chromosome 8 in Mus musculus. ..
  65. Buchberg A, Taylor B, Jenkins N, Copeland N. Chromosomal localization of Emv-16 and Emv-17, two closely linked ecotropic proviruses of RF/J mice. J Virol. 1986;60:1175-8 pubmed
  66. Koiwai O, Hasada K, Yasui Y, Sakai Y, Sato H, Watanabe T. Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations. Biochem Genet. 1995;33:111-22 pubmed
    ..identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes...
  67. Hinsdale M, Farmer S, Johnson K, Davisson M, Hamm D, Tolwani R, et al. RNA expression and chromosomal location of the mouse long-chain acyl-CoA dehydrogenase gene. Genomics. 1995;28:163-70 pubmed
    ..Quantitative evaluation of a multitissue Northern blot showed a varied ratio of the larger transcript as compared with the smaller transcripts. ..
  68. Wilcox F, Womack J, Roderick T. Linkage of the locus for conversion of albumin (Acf-1) in the house mouse, Mus musculus. Biochem Genet. 1979;17:159-62 pubmed
    ..The linkage of the locus for conversion of albumin (Acf-1) has been established on chromosome 1 with the following gene order and recombination percentages: Id-1 19.3 +/- 5.2% Acf-1 4.2 +/- 1.7% Dip-1 18.4 +/- 4.2% Lp. ..
  69. Bochkis I, Schug J, Ye D, Kurinna S, Stratton S, Barton M, et al. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012;8:e1002770 pubmed publisher
    ..Thus, Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution. ..