Gene Symbol: Idd4
Description: insulin dependent diabetes susceptibility 4
Alias: Idd-4, insulin dependent diabetes susceptibility 4
Species: mouse

Top Publications

  1. Todd J, Aitman T, Cornall R, Ghosh S, Hall J, Hearne C, et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 1991;351:542-7 pubmed
    ..On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17. ..
  2. Gill B, Jaramillo A, Ma L, Laupland K, Delovitch T. Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes. Diabetes. 1995;44:614-9 pubmed
    ..This finding raises the possibility that a beta-chemokine(s) may regulate T-cell unresponsiveness as well as diabetes susceptibility in NOD mice. ..
  3. Cornall R. Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus. Clin Sci (Lond). 1993;84:257-62 pubmed
    ..3. The homologues of these genes may reside on human chromosomes 1 or 4 (Idd-3), 17 (Idd-4) and 2q (Idd-5). ..
  4. Grattan M, Mi Q, Meagher C, Delovitch T. Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes. 2002;51:215-23 pubmed
    ..that the genetic control of T-cell proliferative unresponsiveness in nonobese diabetic (NOD) mice is linked to Idd4 on mouse chromosome 11. Here, we show by congenic mapping of three newly generated NOD...
  5. Yui M, Muralidharan K, Moreno Altamirano B, Perrin G, Chestnut K, Wakeland E. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome. 1996;7:331-4 pubmed
    ..These results demonstrate the utility of this congenic approach for the study of complex genetic traits. ..
  6. Babaya N, Ikegami H, Fujisawa T, Nojima K, Itoi Babaya M, Inoue K, et al. Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11. Biochem Biophys Res Commun. 2005;328:158-64 pubmed
    ..These data, together with the co-localization of type 1 (Idd4) and type 2 (Nidd1n) susceptibility genes on Chr 11, suggest that the intrinsic vulnerability of pancreatic beta ..
  7. Ivakine E, Fox C, Paterson A, Mortin Toth S, Canty A, Walton D, et al. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. J Immunol. 2005;174:7129-40 pubmed
    ..x NOR) x NOD backcross mice that progression to severe islet inflammation after CY treatment was controlled by the Idd4 and Idd9 loci...
  8. Ivakine E, Gulban O, Mortin Toth S, Wankiewicz E, Scott C, Spurrell D, et al. Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. J Immunol. 2006;176:2976-90 pubmed
    ..Previously, we used NOD and a nonobese diabetes-resistant strain to map the susceptibility to T1D to the Idd4 locus on chromosome 11. Here, we report high-resolution mapping of this locus to 1.4 megabases...
  9. Laloraya M, Davoodi Semiromi A, Kumar G, McDuffie M, She J. Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice. Diabetes. 2006;55:734-41 pubmed
    ..Therefore, the defective Crkl expression may contribute to the development of diabetes in the NOD mice by exacerbating the defective Stat5b binding ability. ..

More Information


  1. Davoodi Semiromi A, McDuffie M, Litherland S, Clare Salzler M. Truncated pStat5B is associated with the Idd4 locus in NOD mice. Biochem Biophys Res Commun. 2007;356:655-61 pubmed
    ..0001) when compared with normal B6 mice. Additionally, EMSAs data from B6.NOD/c11 suggest contribution of Idd4 susceptibility locus on chromosome 11 in constitutive phosphorylation of Stat5 in NOD mice...
  2. Simpson P, Mistry M, Maki R, Yang W, Schwarz D, Johnson E, et al. Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice. J Immunol. 2003;171:3333-7 pubmed
    ..Only macrophages from the congenic strains containing the Idd4 locus showed IL-12p40 overproduction/expression...
  3. Takenaka K, Prasolava T, Wang J, Mortin Toth S, Khalouei S, Gan O, et al. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol. 2007;8:1313-23 pubmed
    ..Thus, we have identified Sirpa polymorphism as a potent genetic determinant of the engraftment of human hematopoietic stem cells. ..
  4. Ghosh S, Palmer S, Rodrigues N, Cordell H, Hearne C, Cornall R, et al. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat Genet. 1993;4:404-9 pubmed
  5. Matsuki N, Stanic A, Embers M, Van Kaer L, Morel L, Joyce S. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol. 2003;170:5429-37 pubmed
    ..The most notable of these map to the Idd4, Idd5, Idd9.1, and Idd13 regions of the mouse genome...
  6. Gonzalez C, Cuvellier S, Hue Beauvais C, Levi Strauss M. Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia. 2003;46:1291-5 pubmed
    ..high dose streptozotocin-induced diabetes, the latter being co-localized with the autoimmune diabetes-predisposing idd4 locus...