Gene Symbol: Icam5
Description: intercellular adhesion molecule 5, telencephalin
Alias: CD50, ICAM-3, Icam3, TLN, Tlcn, intercellular adhesion molecule 5, ICAM-5, intercellular adhesion molecule 3, telencephalin
Species: mouse
Products:     Icam5

Top Publications

  1. Ning L, Tian L, Smirnov S, Vihinen H, Llano O, Vick K, et al. Interactions between ICAM-5 and ?1 integrins regulate neuronal synapse formation. J Cell Sci. 2013;126:77-89 pubmed publisher
    ..In this study, we found that ablation of ICAM5 expression resulted in a significant increase in the formation of synaptic contacts and the frequency of miniature ..
  2. Tian L, Stefanidakis M, Ning L, Van Lint P, Nyman Huttunen H, Libert C, et al. Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol. 2007;178:687-700 pubmed
    ..Intercellular adhesion molecule-5 (ICAM-5; Telencephalin) is a neuronal adhesion molecule that regulates dendritic elongation and spine maturation...
  3. Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004;166:1041-54 pubmed
    Presenilin 1 (PS1) interacts with telencephalin (TLN) and the amyloid precursor protein via their transmembrane domain (Annaert, W.G., C. Esselens, V. Baert, C. Boeve, G. Snellings, P. Cupers, K. Craessaerts, and B. De Strooper. 2001...
  4. Yoshihara Y, Oka S, Nemoto Y, Watanabe Y, Nagata S, Kagamiyama H, et al. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron. 1994;12:541-53 pubmed
    b>Telencephalin (TLN) is a 130 kd glycoprotein expressed exclusively in neurons of the telencephalon, the most rostral brain segment. In the neurons, TLN is localized to soma-dendritic membrane but not to axonal membrane...
  5. Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, et al. Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci. 2001;13:179-89 pubmed
    b>Telencephalin (TLCN) is a cell adhesion molecule selectively expressed in the telencephalon of the mammalian brain. The mutant mice lacking TLCN had no detectable abnormalities in their neural development and synaptic structures...
  6. Annaert W, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron. 2001;32:579-89 pubmed
    The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain...
  7. Fuse T, Kanai Y, Kanai Azuma M, Suzuki M, Nakamura K, Mori H, et al. Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation. Biochem Biophys Res Commun. 2004;318:665-72 pubmed
    Gastrulation is a pivotal event of mouse early embryogenesis. In telencephalin (TLCN)-Cre mice carrying the Cre recombinase gene inserted into the translational initiation site of the TLCN gene, Cre-mediated recombination took place at ..
  8. Mitsui S, Saito M, Hayashi K, Mori K, Yoshihara Y. A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites. J Neurosci. 2005;25:1122-31 pubmed
    Neurons sort out a variety of functional molecules to appropriate subcellular destinations. Telencephalin (TLCN; intercellular adhesion molecule-5) is a cell adhesion molecule specifically localized to somatodendritic membranes in the ..
  9. Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, et al. ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J. 2012;31:3252-69 pubmed publisher
    ..b>Telencephalin (TLN/intercellular adhesion molecule-5 (ICAM5)) localizes to dendritic filopodia, where it facilitates their ..

More Information


  1. Matsuno H, Okabe S, Mishina M, Yanagida T, Mori K, Yoshihara Y. Telencephalin slows spine maturation. J Neurosci. 2006;26:1776-86 pubmed
    ..Here, we report that telencephalin (TLCN), a cell adhesion molecule belonging to the Ig superfamily, is a negative regulator of spine maturation...
  2. Barkat T, Polley D, Hensch T. A critical period for auditory thalamocortical connectivity. Nat Neurosci. 2011;14:1189-94 pubmed publisher
    ..Gene-targeted deletion of a forebrain-specific cell-adhesion molecule (Icam5) accelerated plasticity in this critical period...
  3. Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010;432:47-55 pubmed publisher
    ..Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage. ..
  4. Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, et al. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010;65:320-7 pubmed publisher
    ..We conclude that 2-AG produced by DGLalpha, but not by DGLbeta, mediates retrograde suppression at central synapses. ..
  5. Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, et al. Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab. 2014;20:295-305 pubmed publisher
    ..We propose a model of harmonized processes for phospholipid diversification to satisfy in vivo requirements, with an example of its biological relevance. ..
  6. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, et al. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. Eneuro. 2016;3: pubmed
    ..These results suggest that BEGAIN was involved in pathological pain transmission through NMDA receptor activation by the phosphorylation of GluN2B at Y1472 in spinal inner lamina II. ..
  7. Sugino H, Yoshihara Y, Copeland N, Gilbert D, Jenkins N, Mori K. Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family. Genomics. 1997;43:209-15 pubmed
    b>Telencephalin is a cell adhesion molecule belonging to the immunoglobulin (Ig) superfamily, whose expression is restricted to subsets of neurons in the telencephalon, the most rostral segment of brain...
  8. Kitaura H, Tsujita M, Huber V, Kakita A, Shibuki K, Sakimura K, et al. Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res. 2009;64:208-12 pubmed publisher
    ..We conclude that AQP4 likely plays a significant role in neural activity-dependent glial swelling. ..
  9. Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, et al. Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PLoS ONE. 2008;3:e2297 pubmed publisher
  10. Desai S, Libutti S. Tumor angiogenesis and endothelial cell modulatory factors. J Immunother. 1999;22:186-211 pubmed
    ..Additionally, we discuss select proteases and their importance in the development of neovasculature. A better understanding of these components will help in the development of novel therapeutic strategies. ..
  11. Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, et al. Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur J Neurosci. 2006;24:2177-90 pubmed
    ..Variable degrees of reduction further suggest that other TARPs may also mediate this function at different potencies depending on hippocampal subregions, input sources and neuronal compartments. ..
  12. Miyazaki T, Yamasaki M, Hashimoto K, Yamazaki M, Abe M, Usui H, et al. Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. J Neurosci. 2012;32:1311-28 pubmed publisher
    ..1 KO mice. Therefore, Cav2.1 in PCs is essential for competitive synaptic wiring, cell survival, and the establishment of precise boundaries and reciprocity of biochemical compartments in PCs. ..
  13. Ning L, Paetau S, Nyman Huttunen H, Tian L, Gahmberg C. ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin. Biol Open. 2015;4:125-36 pubmed publisher
    ..The results indicate that ICAM-5 retards spine maturation by preventing reorganization of the actin cytoskeleton, but NMDA receptor activation is sufficient to relieve the brake and promote the maturation of spines. ..
  14. Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y. Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. J Biol Chem. 2012;287:39041-9 pubmed publisher
    ..However, its definite function in the brain remains largely unknown. Here we report the identification of telencephalin (TLCN/ICAM-5) as a novel VN receptor on neuronal dendrites...
  15. Mitsui S, Saito M, Mori K, Yoshihara Y. A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain. Cereb Cortex. 2007;17:522-30 pubmed
    b>Telencephalin (TLCN, intercellular adhesion molecule-5 [ICAM-5]) is a cell adhesion molecule belonging to the immunoglobulin superfamily, which plays important roles in dendritic morphogenesis and synaptic plasticity...
  16. Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M, et al. Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci. 2011;31:7700-14 pubmed publisher
    ..This molecular-anatomical configuration will contribute to adjust network activity in the dentate gyrus after enhanced excitation. ..
  17. Hasegawa S, Yamaguchi M, Nagao H, Mishina M, Mori K. Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. J Neuroimmunol. 2007;186:75-85 pubmed
    ..A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family...
  18. Torr E, Gardner D, Thomas L, Goodall D, Bielemeier A, Willetts R, et al. Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells. Cell Death Differ. 2012;19:671-9 pubmed publisher
    ..b>Intercellular adhesion molecule 3 (ICAM-3, also known as CD50), a human leukocyte-restricted immunoglobulin super-family (IgSF) member,..
  19. Pathak S, Sköld A, Mohanram V, Persson C, Johansson U, Spetz A. Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and ?2 integrins. J Biol Chem. 2012;287:13731-42 pubmed publisher
    ..These studies provide important mechanistic insight into the responses of DCs during encounter with cells undergoing immunogenic cell death. ..
  20. Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, et al. TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum. Eur J Neurosci. 2010;31:2204-20 pubmed publisher
    ..Therefore, gamma-2 and gamma-7 cooperatively promote synaptic expression of cerebellar AMPA receptors, and the latter also promotes glial expression. ..
  21. Tse M, Lane C, Mott K, Onlamoon N, Hsiao H, Perng G. ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection. J Neuroimmunol. 2009;213:12-9 pubmed publisher
    ..Two-hybrid binding assays identified that intercellular adhesion molecule 5 (ICAM-5), an immune modulator in the CNS, interacted with neurovirulence factor, UOL, of HSV-1...
  22. Eckstrum K, Weis K, Baur N, Yoshihara Y, Raetzman L. Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A. Endocrinology. 2016;157:1408-20 pubmed publisher
    ..3 genes were differentially expressed between males and females: Lhb, Fshb, and intracellular adhesion molecule-5 (Icam5)...
  23. Serrador J, Vicente Manzanares M, Calvo J, Barreiro O, Montoya M, Schwartz Albiez R, et al. A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem. 2002;277:10400-9 pubmed
    b>Intercellular adhesion molecule 3 (ICAM-3) is a leukocyte-specific receptor involved in primary immune responses...
  24. Niedringhaus M, Chen X, Dzakpasu R, Conant K. MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons. PLoS ONE. 2012;7:e42631 pubmed publisher
    ..They also support the possibility that MMP dependent shedding of specific synaptic CAMs can contribute to these effects. ..
  25. Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. FASEB J. 2016;30:2027-39 pubmed publisher
    ..Akagi, S., Kono, N., Ariyama, H., Shindou, H., Shimizu, T., Arai, H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. ..
  26. Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita Takahashi M, Yamazaki M, et al. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Eur J Immunol. 2015;45:1512-23 pubmed publisher
  27. Honda A, Usui H, Sakimura K, Igarashi M. Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity. J Biol Chem. 2017;292:20936-20946 pubmed publisher
    ..Taken together, we conclude that Rufy3 is a physiological adapter for Rap2 and activates Tiam2/STEF in glycoprotein M6A-regulated neuronal polarity and axon growth. ..
  28. Kelly E, Tremblay M, Gahmberg C, Tian L, Majewska A. Subcellular localization of intercellular adhesion molecule-5 (telencephalin) in the visual cortex is not developmentally regulated in the absence of matrix metalloproteinase-9. J Comp Neurol. 2014;522:676-88 pubmed publisher
    The telencephalon-associated intercellular adhesion molecule-5 (telencephalin; ICAM-5) regulates dendritic morphology in the developing brain...
  29. Leeb T, Muller M. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. Gene. 2004;343:239-44 pubmed
    ..During evolution, the ICAM3 gene was inactivated by mutation in the mouse and rat genome, whereas it is still present in the human and pig ..
  30. Sugino H. ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome. FEBS Lett. 2005;579:2901-6 pubmed
    ..Thus, ICAM-3 arose from ICAM-1 in the mammalian evolution, but was lost in the rodent's genome. Our study suggests the different immune response in the rodents in comparison with other mammals. ..
  31. Petrenko A, Tsujita M, Kohno T, Sakimura K, Baba H. Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology. 2007;106:1177-85 pubmed
    ..However, the timely induction of anesthesia/hypnosis by volatile anesthetic agents and some intravenous anesthetic agents may require the normal functioning of these channel subunits. ..
  32. Kumar A, Thakur M. Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014;38:138-46 pubmed publisher