Gene Symbol: Ibsp
Description: integrin binding sialoprotein
Alias: BSP, BSP II, BSPII, Bsp2, bone sialoprotein 2, bone sialoprotein II, cell-binding sialoprotein
Species: mouse
Products:     Ibsp

Top Publications

  1. Oka K, Oka S, Sasaki T, Ito Y, Bringas P, Nonaka K, et al. The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007;303:391-404 pubmed
    ..Collectively, our data suggest that there are differential signal cascades in response to TGF-beta to control chondrogenesis and osteogenesis during mandibular development. ..
  2. Tao J, Chen S, Yang T, Dawson B, Munivez E, Bertin T, et al. Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent. J Bone Miner Res. 2010;25:2175-83 pubmed publisher
    ..As such, it identifies Rbpj as a specific target for manipulating Notch signaling in a cell-autonomous fashion in osteoblasts in bone diseases where Notch may be dysregulated...
  3. Monfoulet L, Malaval L, Aubin J, Rittling S, Gadeau A, Fricain J, et al. Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing. Bone. 2010;46:447-52 pubmed publisher
    ..cortex of mouse femur, a lesion that triggers intramembranous repair, and compared the roles of bone sialoprotein (BSP) and osteopontin (OPN), two proteins of the extracellular matrix, in the repair process...
  4. Tu X, Joeng K, Nakayama K, Nakayama K, Rajagopal J, Carroll T, et al. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007;12:113-27 pubmed
    ..Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation. ..
  5. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn. 1999;214:279-90 pubmed
    ..These findings demonstrate that Cbfa1 is an important factor for chondrocyte differentiation. ..
  6. Rice D, Aberg T, Chan Y, Tang Z, Kettunen P, Pakarinen L, et al. Integration of FGF and TWIST in calvarial bone and suture development. Development. 2000;127:1845-55 pubmed
    ..Beads soaked in FGF2 induced Twist and inhibited Bsp, a marker of functioning osteoblasts. Meanwhile, BMP2 upregulated Id1...
  7. Malaval L, Monfoulet L, Fabre T, Pothuaud L, Bareille R, Miraux S, et al. Absence of bone sialoprotein (BSP) impairs cortical defect repair in mouse long bone. Bone. 2009;45:853-61 pubmed publisher
    ..Within this family, bone sialoprotein (BSP) is highly expressed by osteoblasts, hypertrophic chondrocytes and osteoclasts...
  8. Joeng K, Long F. The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009;136:4177-85 pubmed publisher
    ..These results therefore provide direct genetic evidence that Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development. ..
  9. Hilton M, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008;14:306-14 pubmed publisher
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway. ..

More Information


  1. Akiyama H, Lyons J, Mori Akiyama Y, Yang X, Zhang R, Zhang Z, et al. Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 2004;18:1072-87 pubmed
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway. ..
  2. Malaval L, Wade Gueye N, Boudiffa M, Fei J, Zirngibl R, Chen F, et al. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med. 2008;205:1145-53 pubmed publisher
    Bone sialoprotein (BSP) and osteopontin (OPN) are both highly expressed in bone, but their functional specificities are unknown...
  3. Valverde P, Tu Q, Chen J. BSP and RANKL induce osteoclastogenesis and bone resorption synergistically. J Bone Miner Res. 2005;20:1669-79 pubmed
    ..RANKL and bone sialoprotein II (BSP) have been shown to be upregulated in the serum of individuals with abnormally high osteoclastogenic ..
  4. Bouleftour W, Boudiffa M, Wade Gueye N, Bouet G, Cardelli M, Laroche N, et al. Skeletal development of mice lacking bone sialoprotein (BSP)--impairment of long bone growth and progressive establishment of high trabecular bone mass. PLoS ONE. 2014;9:e95144 pubmed publisher
    Adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption...
  5. Young M, Ibaraki K, Kerr J, Lyu M, Kozak C. Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping. Mamm Genome. 1994;5:108-11 pubmed
  6. Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, et al. EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell. 2005;9:757-67 pubmed
    ..Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts. ..
  7. Shibata S, Fukada K, Suzuki S, Ogawa T, Yamashita Y. In situ hybridization and immunohistochemistry of bone sialoprotein and secreted phosphoprotein 1 (osteopontin) in the developing mouse mandibular condylar cartilage compared with limb bud cartilage. J Anat. 2002;200:309-20 pubmed
    ..with respect to the expression of two major non-collagenous glycoproteins of bone matrix, bone sialoprotein (BSP) and secreted phosphoprotein 1 (Spp1, osteopontin)...
  8. Aqeilan R, Hassan M, de Bruin A, Hagan J, Volinia S, Palumbo T, et al. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008;283:21629-39 pubmed publisher
    ..Our results demonstrate an essential requirement for the WWOX tumor suppressor in postnatal survival, growth, and metabolism and suggest a central role for WWOX in regulation of bone tissue formation. ..
  9. Bègue Kirn C, Smith A, Loriot M, Kupferle C, Ruch J, Lesot H. Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol. 1994;38:405-20 pubmed
  10. Sasaki T, Ito Y, Bringas P, Chou S, Urata M, Slavkin H, et al. TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006;133:371-81 pubmed
  11. Tu Q, Yamauchi M, Pageau S, Chen J. Autoregulation of bone sialoprotein gene in pre-osteoblastic and non-osteoblastic cells. Biochem Biophys Res Commun. 2004;316:461-7 pubmed
    Regulation of the bone sialoprotein (BSP) gene is important in the differentiation of osteoblasts, in bone matrix mineralization, and in tumor metastasis...
  12. Boudiffa M, Wade Gueye N, Guignandon A, Vanden Bossche A, Sabido O, Aubin J, et al. Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro. J Bone Miner Res. 2010;25:2669-79 pubmed publisher
    Bone sialoprotein (BSP) and osteopontin (OPN) belong to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family, whose members interact with bone cells and bone mineral...
  13. Shimazu J, Wei J, Karsenty G. Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148. Cell Rep. 2016;15:27-35 pubmed publisher
    ..These results identify Smurf1 as a determinant of osteoblast differentiation during the development of bone formation and glucose homeostasis post-natally and demonstrate the necessity of S148 for these functions. ..
  14. James M, Järvinen E, Thesleff I. Bono1: a gene associated with regions of deposition of bone and dentine. Gene Expr Patterns. 2004;4:595-9 pubmed
    ..Comparative analysis of the expression of Bono1 in the mandible with Bone sialoprotein (BSP), a marker of advanced osteoblastogenesis, revealed that Bono1 expression starts later in the osteoblast cell ..
  15. Prashar P, Yadav P, Samarjeet F, Bandyopadhyay A. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014;389:192-207 pubmed publisher
  16. Bouleftour W, Bouet G, Granito R, Thomas M, Linossier M, Vanden Bossche A, et al. Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone. J Cell Physiol. 2015;230:568-77 pubmed publisher
    Osteopontin (OPN) and bone sialoprotein (BSP) are coexpressed in osteoblasts and osteoclasts, and display overlapping properties...
  17. Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006;125:971-86 pubmed
    ..Thus, SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation...
  18. Hung I, Schoenwolf G, Lewandoski M, Ornitz D. A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Dev Biol. 2016;411:72-84 pubmed publisher
  19. Wang G, Woods A, Agoston H, Ulici V, Glogauer M, Beier F. Genetic ablation of Rac1 in cartilage results in chondrodysplasia. Dev Biol. 2007;306:612-23 pubmed
    ..In summary, these data identify a novel, essential and tissue-specific role of Rac1 in skeletal development and demonstrate that Rac1 deficiency affects numerous regulatory pathways in cartilage...
  20. Krebsbach P, Lee S, Matsuki Y, Kozak C, Yamada K, Yamada Y. Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. J Biol Chem. 1996;271:4431-5 pubmed
    ..Thus, ameloblastin represents a unique ameloblast-specific gene product that may be important in enamel matrix formation and mineralization. ..
  21. Wang L, Huang J, Moore D, Zuo C, Wu Q, Xie L, et al. SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes. Sci Rep. 2017;7:12699 pubmed publisher
  22. Wei J, Shimazu J, Makinistoglu M, Maurizi A, Kajimura D, Zong H, et al. Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015;161:1576-1591 pubmed publisher
    ..These results reveal an unexpected intricacy between bone and glucose metabolism. ..
  23. Marinovich R, Soenjaya Y, Wallace G, Zuskov A, Dunkman A, Foster B, et al. The role of bone sialoprotein in the tendon-bone insertion. Matrix Biol. 2016;52-54:325-338 pubmed publisher
    ..Here we show that two SIBLING proteins, bone sialoprotein (BSP) and osteopontin (OPN), are present in the mouse enthesis...
  24. Patra D, Xing X, Davies S, Bryan J, Franz C, Hunziker E, et al. Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol. 2007;179:687-700 pubmed
    ..These data suggest that S1P activity is necessary for a specialized ER stress response required by chondrocytes for the genesis of normal cartilage and thus endochondral ossification. ..
  25. Zhang J, Tang J, Wang J, Ma W, Zheng W, Yoneda T, et al. Over-expression of bone sialoprotein enhances bone metastasis of human breast cancer cells in a mouse model. Int J Oncol. 2003;23:1043-8 pubmed
    Bone sialoprotein (BSP) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum...
  26. Ganss B, Kobayashi H. The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation. J Bone Miner Res. 2002;17:2151-60 pubmed
    ..These results suggest a role for Zfp60 as a negative regulator of gene transcription, specifically during the development and/or differentiation of chondrocytes. ..
  27. Lana Elola E, Rice R, Grigoriadis A, Rice D. Cell fate specification during calvarial bone and suture development. Dev Biol. 2007;311:335-46 pubmed
  28. Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, et al. Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012;287:17860-9 pubmed publisher
    ..On the basis of these findings, we propose that upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis. ..
  29. González Martín M, Mallo M, Ros M. Long bone development requires a threshold of Hox function. Dev Biol. 2014;392:454-65 pubmed publisher
    ..Our results support Hox genes being required in a dose-dependent manner for long bone cartilage maturation and suggest that and excess of Gli3R mediates a significant part of the Hoxd(Del(11-13)) chondrogenic phenotype. ..
  30. Chen J, Long F. mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts. PLoS ONE. 2015;10:e0130627 pubmed publisher
    ..that deletion of Raptor reduced the expression of late-stage markers for osteoblast differentiation (Bglap, Ibsp, and Col1a), while slightly increasing early osteoblast markers (Runx2, Sp7, and Alpl)...
  31. Abzhanov A, Rodda S, McMahon A, Tabin C. Regulation of skeletogenic differentiation in cranial dermal bone. Development. 2007;134:3133-44 pubmed
    ..These results provide a framework for understanding dermal bone development with an aim of bringing it closer to the molecular and cellular resolution available for the endochondral bone development. ..
  32. Bouet G, Bouleftour W, Juignet L, Linossier M, Thomas M, Vanden Bossche A, et al. The impairment of osteogenesis in bone sialoprotein (BSP) knockout calvaria cell cultures is cell density dependent. PLoS ONE. 2015;10:e0117402 pubmed publisher
    Bone sialoprotein (BSP) belongs to the "small integrin-binding ligand N-linked glycoprotein" (SIBLING) family, whose members interact with bone cells and bone mineral...
  33. Mukhopadhyay P, Greene R, Zacharias W, Weinrich M, Singh S, Young W, et al. Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004;70:912-26 pubmed
    ..This gene expression profiling study identifies a number of potentially unique developmental participants and serves as a valuable aid in deciphering the complex molecular mechanisms crucial for mammalian orofacial development. ..
  34. Tu X, Joeng K, Long F. Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev Biol. 2012;362:76-82 pubmed publisher
    ..Thus, the mechanism through which Ihh induces osteoblast differentiation requires other effectors in addition to Runx2. ..
  35. Wiszniak S, Harvey N, Schwarz Q. Cell autonomous roles of Nedd4 in craniofacial bone formation. Dev Biol. 2016;410:98-107 pubmed publisher
    ..Nedd4 mutant mice therefore represent a unique mouse model of craniofacial anomalies that provide an ideal resource to explore the cell-intrinsic mechanisms of neural crest cells in craniofacial morphogenesis. ..
  36. Chen J, Jin H, Ranly D, Sodek J, Boyan B. Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice. J Bone Miner Res. 1999;14:221-9 pubmed
    Bone sialoprotein (BSP) and osteopontin (OPN) are two major noncollagenous matrix proteins in mineralized connective tissue that have discrete roles in bone matrix formation, mineralization, and remodeling...
  37. Granito R, Bouleftour W, Sabido O, Lescale C, Thomas M, Aubin J, et al. Absence of bone sialoprotein (BSP) alters profoundly hematopoiesis and upregulates osteopontin. J Cell Physiol. 2015;230:1342-51 pubmed publisher
    ..We investigated the impact on hematopoietic regulation of the absence of the cognate bone sialoprotein (BSP)...
  38. Ehlen H, Chinenkova M, Moser M, Munter H, Krause Y, Gross S, et al. Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013;28:246-59 pubmed publisher
    ..However, mutant mice display increased regions of nonmineralized, Ibsp-expressing osteoblasts in the periosteum during embryonic development and increased areas of uncalcified osteoid ..
  39. Feng J, Luan X, Wallace J, Jing D, Ohshima T, Kulkarni A, et al. Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein. J Biol Chem. 1998;273:9457-64 pubmed
    ..The structural organization of the dentin sialophosphoprotein gene confirms our finding that both dentin sialoprotein and dentin phosphoprotein are encoded by a single gene with a continuous open reading frame. ..
  40. Gorski J, Estrada L, Hu C, Liu Z. Skeletal-specific expression of Fgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome). Dev Dyn. 2000;218:573-86 pubmed
    ..With the observation that FGD1 mutations result in the skeletal dysplasia FGDY, accumulated data indicate that FGD1 signaling plays a critical role in ossification and skeletal development. ..
  41. Wang Y, Sun M, Uhlhorn V, Zhou X, Peter I, Martinez Abadias N, et al. Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol. 2010;10:22 pubmed publisher
    ..We previously reported an inbred transgenic mouse model with the Fgfr2 +/S252W mutation on the C57BL/6J background for Apert syndrome. Here we present a mouse model for the Fgfr2+/P253R mutation...
  42. Rice D, Rice R, Thesleff I. Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis. Eur J Orthod. 2003;25:139-48 pubmed
    ..The microdissection and in vitro culture techniques have begun the task of identifying Fgfrs, Msx2, and Twist interacting in intricate signalling pathways that if disrupted could lead to craniosynostosis. ..
  43. Wilson M, Liaw L, Koopman P. Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005;233:1488-95 pubmed
    ..studied the expression of genes encoding the related SIBLING glycoproteins osteopontin (OPN), bone sialoprotein (BSP), and dentin matrix protein (DMP) during the development of male and female gonads during mouse embryogenesis...
  44. Wu Q, Chen D, Zuscik M, O Keefe R, Rosier R. Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008;23:552-63 pubmed
  45. Elefteriou F, Benson M, Sowa H, Starbuck M, Liu X, Ron D, et al. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab. 2006;4:441-51 pubmed
    ..By showing that ATF4-dependent skeletal dysplasiae are treatable by dietary manipulations, this study reveals a molecular connection between nutrition and skeletal development...
  46. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng J, Behringer R, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108:17-29 pubmed
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells. ..
  47. Gaikwad J, Cavender A, D Souza R. Identification of tooth-specific downstream targets of Runx2. Gene. 2001;279:91-7 pubmed
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development. ..
  48. Sommer B, Bickel M, Hofstetter W, Wetterwald A. Expression of matrix proteins during the development of mineralized tissues. Bone. 1996;19:371-80 pubmed
    ..The expression patterns of the transcripts encoding the bone matrix proteins suggest different biological roles depending on the time and site of expression. ..
  49. Hardouin S, Guo R, Romeo P, Nagy A, Aubin J. Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011;138:203-13 pubmed publisher
  50. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol. 2009;9:47 pubmed publisher
    ..These results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis. ..
  51. Rice R, Rice D, Olsen B, Thesleff I. Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003;262:75-87 pubmed
    ..We therefore suggest that Foxc1 regulates BMP-mediated osteoprogenitor proliferation and that this regulation is required for the progression of osteogenesis beyond the initial condensations in calvarial bone development. ..
  52. Kyrylkova K, Iwaniec U, Philbrick K, Leid M. BCL11B regulates sutural patency in the mouse craniofacial skeleton. Dev Biol. 2016;415:251-260 pubmed publisher
  53. Funato N, Chapman S, McKee M, Funato H, Morris J, Shelton J, et al. Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development. 2009;136:615-25 pubmed publisher
    ..Here, we show that Hand2 acts as a novel inhibitor of the Runx2-DNA interaction and thereby regulates osteoblast differentiation in branchial arch development. ..
  54. Moenning A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H. Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol Cell Biol. 2009;29:881-91 pubmed publisher
    ..Thus, we show for the first time that PDGFRalpha signaling stimulates osteogenesis of NCC-derived osteoblasts by activating the PLC-gamma pathway, suggesting an involvement of this pathway in the etiology of human craniosynostosis. ..
  55. Yamashiro T, Wang X, Li Z, Oya S, Aberg T, Fukunaga T, et al. Possible roles of Runx1 and Sox9 in incipient intramembranous ossification. J Bone Miner Res. 2004;19:1671-7 pubmed
    ..Our results suggest that Runx1 may play a role in incipient intramembranous bone formation. ..
  56. Chen Q, Sinha K, Deng J, Yasuda H, Krahe R, Behringer R, et al. Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res. 2015;30:1608-17 pubmed publisher
    ..an increase in expression of bone formation markers such as osterix (Osx), type I collagen, and bone sialoprotein (Bsp)...
  57. Foster B, Ao M, Willoughby C, Soenjaya Y, Holm E, Lukashova L, et al. Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein. Bone. 2015;78:150-64 pubmed publisher
    Bone sialoprotein (BSP) is a multifunctional extracellular matrix protein found in mineralized tissues, including bone, cartilage, tooth root cementum (both acellular and cellular types), and dentin...
  58. Weishaupt P, Bernimoulin J, Trackman P, Hägewald S. Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:304-8 pubmed publisher
    ..The mRNA expression of bone sialoprotein (BSP), osteopontin (OPN), and runt-related protein 2 (Runx2) was analyzed by real-time polymerase chain reaction...
  59. Kesper D, Didt Koziel L, Vortkamp A. Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification. Dev Dyn. 2010;239:1818-26 pubmed publisher
    ..Furthermore, we show that, in the absence of Gli3, the activator function of Gli2 is sufficient to induce Ihh-dependent osteoblast differentiation. ..
  60. Wang W, Lian N, Ma Y, Li L, Gallant R, Elefteriou F, et al. Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Development. 2012;139:601-11 pubmed publisher
    ..Therefore, the cell-autonomous role of Atf4 in chondrocytes dominates the role of Atf4 in osteoblasts during development for the control of early osteogenesis and skeletal growth. ..
  61. Potter A, Potter S. Molecular Anatomy of Palate Development. PLoS ONE. 2015;10:e0132662 pubmed publisher
    ..This FACEBASE resource is designed to promote discovery by the craniofacial research community. ..
  62. Holm E, Aubin J, Hunter G, Beier F, Goldberg H. Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015;71:145-54 pubmed publisher
    Bone sialoprotein (BSP) is an anionic phosphoprotein in the extracellular matrix of mineralized tissues, and a promoter of biomineralization and osteoblast development...
  63. Bouleftour W, Juignet L, Bouet G, Granito R, Vanden Bossche A, Laroche N, et al. The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics. Matrix Biol. 2016;52-54:60-77 pubmed publisher
    Bone Sialoprotein (BSP) is a member of the "Small Integrin-Binding Ligand N-linked Glycoproteins" (SIBLING) extracellular matrix protein family of mineralized tissues...
  64. Stepp M, Liu Y, Pal Ghosh S, Jurjus R, Tadvalkar G, Sekaran A, et al. Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. J Cell Sci. 2007;120:2851-63 pubmed
    ..Thus, our results identify TGFbeta1 signaling and Sdc1 expression as important factors regulating integrin surface expression, activity and migration in keratinocyte and provide new insight into the functions regulated by Sdc1. ..
  65. Margagliotti S, Clotman F, Pierreux C, Beaudry J, Jacquemin P, Rousseau G, et al. The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol. 2007;311:579-89 pubmed
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis. ..
  66. Curtin P, McHugh K, Zhou H, Fluckiger R, Goldhaber P, Oppenheim F, et al. Modulation of bone resorption by phosphorylation state of bone sialoprotein. Biochemistry. 2009;48:6876-86 pubmed publisher
    ..Overall, these studies provided direct evidence for the involvement of covalently bound phosphates on BSP in receptor mediated "outside-in" signaling via transmembrane tyrosine phosphorylation with concurrent ..
  67. Chen J, Tu X, Esen E, Joeng K, Lin C, Arbeit J, et al. WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014;10:e1004145 pubmed publisher
    ..Genetic disruption of mTORC1 signaling by deleting Raptor in the osteoblast lineage alleviated the WNT7B-induced high-bone-mass phenotype. Thus, WNT7B promotes bone formation in part through mTORC1 activation. ..
  68. Machida A, Okuhara S, Harada K, Iseki S. Difference in apical and basal growth of the frontal bone primordium in Foxc1ch/ch mice. Congenit Anom (Kyoto). 2014;54:172-7 pubmed publisher
    ..in the Foxc1(ch/ch) mouse, the Runx2 expression domain extended only to the basal side and bone sialoprotein (Bsp) and N-cadherin expression domains appeared only in the basal region...
  69. Foster B, Soenjaya Y, Nociti F, Holm E, Zerfas P, Wimer H, et al. Deficiency in acellular cementum and periodontal attachment in bsp null mice. J Dent Res. 2013;92:166-72 pubmed publisher
    Bone sialoprotein (BSP) is an extracellular matrix protein found in mineralized tissues of the skeleton and dentition...
  70. Caparrós Martín J, Valencia M, Reytor E, Pacheco M, Fernandez M, Perez Aytes A, et al. The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. Hum Mol Genet. 2013;22:124-39 pubmed publisher
    ..Together our data reveal that the Hh pathway involves Evc/Evc2-dependent modulations that are necessary for normal endochondral bone formation. ..
  71. García Redondo A, Dols Icardo O, Rojas Garcia R, Esteban Pérez J, Cordero Vázquez P, Munoz Blanco J, et al. Analysis of the C9orf72 gene in patients with amyotrophic lateral sclerosis in Spain and different populations worldwide. Hum Mutat. 2013;34:79-82 pubmed publisher
    ..This haplotype was found in 5.6% Yoruba Africans, 8.9% CEU, 3.9% Japanese, and 1.6% Han Chinese chromosomes. ..
  72. Funato N, Nakamura M, Richardson J, Srivastava D, Yanagisawa H. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet. 2015;24:424-35 pubmed publisher
    ..Taken together, our current studies reveal that Tbx1 is required for mesoderm- and neural crest-derived osteoblast differentiation and normal skeletal development. TBX1 mutation could lead to CCD-like bone phenotypes in human. ..
  73. Lu X, Ding Y, Niu Q, Xuan S, Yang Y, Jin Y, et al. ClC-3 chloride channel mediates the role of parathyroid hormone [1-34] on osteogenic differentiation of osteoblasts. PLoS ONE. 2017;12:e0176196 pubmed publisher
    ..of PTH on the osteogenesis of osteoblasts, and we found an obvious decrease in the expression of bone sialoprotein (Ibsp), osteocalcin (Bglap), osterix (Sp7), Alpl and Runx2, the formation of mineralization nodules as well...
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    ..Bone sialoprotein (BSP) is with osteopontin (OPN) a member of the small integrin binding ligand N-linked glycoprotein (SIBLING) family, ..
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    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses. ..
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    ..Our study identifies requirements for ErbB signaling in the maintenance of chondrocyte and osteoblast proliferation involved in the timely progression of chondrocyte maturation and periosteal osteoblast differentiation. ..
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    ..exhibited increased thickness of predentin, dentin, and enamel over controls and decreased gene expression of Enam, Bsp, Dmp1, Dspp, and Opnby RT-PCR...
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    ..Taken together, we define a novel role for Gli3 in osteoblast development; we describe the first mouse model of lambdoid suture craniosynostosis and show how craniosynostosis can be rescued in this model. ..
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    ..In summary, Nell-1 is required for normal craniofacial membranous and endochondral skeletal development...
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    ..while a subset of these genes were similarly affected in frontal bones and mandibles (Sost, Mepe, Bglap, Alp, Ibsp, Agt), several genes, including Lect1 and Calca, were specifically affected in frontal bones...
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    ..These findings suggest that Dlx5 is a central regulator of bone turnover as it activates bone formation directly and bone resorption indirectly. ..
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    ..These results suggest that tenascin-W is involved in osteoblast maturation (i.e. mineralization). ..