Gene Symbol: Hyal5
Description: hyaluronoglucosaminidase 5
Alias: 4933439A12Rik, hyaluronidase-5, hyaluronidase PH-20, hyal-5, hyaluronidase Hyal-5
Species: mouse
Products:     Hyal5

Top Publications

  1. Zhang H, Shertok S, Miller K, Taylor L, Martin DeLeon P. Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5. Mol Reprod Dev. 2005;72:404-10 pubmed
    ..we show that closely linked family members in the hyaluronidase gene cluster on mouse chromosome 6, Hyalp1 and Hyal5, also harbor point mutations in these Rbs, leading to nonconservative substitutions in both the encoded proteins...
  2. Kim E, Baba D, Kimura M, Yamashita M, Kashiwabara S, Baba T. Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. Proc Natl Acad Sci U S A. 2005;102:18028-33 pubmed
    ..soluble protein extracts released from epididymal sperm by acrosome reaction and identified as a hyaluronidase, Hyal5. Hyal5 was exclusively expressed in the testis and formed a 160-kbp gene cluster together with Hyalp1, Hyal4, and ..
  3. Reitinger S, Laschober G, Fehrer C, Greiderer B, Lepperdinger G. Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan. Biochem J. 2007;401:79-85 pubmed
    Besides SPAM1 (sperm adhesion molecule 1; formerly named PH-20), further hyaluronidase-like proteins, HYAL5 (hyaluronoglucosaminidase 5) and HYALP1 (hyaluronoglucosaminidase pseudogene 1) are also expressed in murine testicular tissue...
  4. Kang W, Zhou C, Koga Y, Baba T. Hyaluronan-degrading activity of mouse sperm hyaluronidase is not required for fertilization?. J Reprod Dev. 2010;56:140-4 pubmed
    ..However, our previous works using male mice lacking either one of two sperm hyaluronidases, SPAM1 and HYAL5, conclusively showed that neither of these hyaluronidases is essential for fertilization...
  5. Kimura M, Kim E, Kang W, Yamashita M, Saigo M, Yamazaki T, et al. Functional roles of mouse sperm hyaluronidases, HYAL5 and SPAM1, in fertilization. Biol Reprod. 2009;81:939-47 pubmed publisher
    ..We also have identified another sperm hyaluronidase, HYAL5, as a candidate enzyme involved in sperm penetration through the cumulus...