Gene Symbol: Hyal3
Description: hyaluronoglucosaminidase 3
Alias: Hyl3, hyaluronidase-3, hyal-3
Strobl B, Wechselberger C, Beier D, Lepperdinger G. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998;53:214-9 pubmed
..The gene is expressed ubiquitously, the sole exception being adult brain. ..
Atmuri V, Martin D, Hemming R, Gutsol A, Byers S, Sahebjam S, et al
. Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation. Matrix Biol. 2008;27:653-60 pubmed publisher
..3 (HYAL2-HYAL1-HYAL3) and 7q31.3 (SPAM1-HYAL4-HYALP1)...
Reese K, Aravindan R, Griffiths G, Shao M, Wang Y, Galileo D, et al
. Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm. Mol Reprod Dev. 2010;77:759-72 pubmed publisher
..Here we report that acidic "somatic" Hyaluronidase 3 (HYAL3), a homolog of SPAM1 with 74...
Rai S, Duh F, Vigdorovich V, Danilkovitch Miagkova A, Lerman M, Miller A. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001;98:4443-8 pubmed
..The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma. ..
Shuttleworth T, Wilson M, Wicklow B, Wilkins J, Triggs Raine B. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem. 2002;277:23008-18 pubmed
..approaches to examine the organization of the mouse chromosome 9 region containing, in order, Hyal2, Hyal1, and Hyal3. This region was found to be complex, with Fus2 partially embedded in Hyal3, and Ifrd2 immediately downstream from ..
Dumaresq Doiron K, Edjekouane L, Orimoto A, Yoffou P, Gushulak L, Triggs Raine B, et al
. Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process. J Cell Physiol. 2012;227:1911-22 pubmed publisher
..Our findings add Hyal-1 as an ovarian regulator factor for follicle development, showing for the first time an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway. ..
Hemming R, Martin D, Slominski E, Nagy J, Halayko A, Pind S, et al
. Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells. Glycobiology. 2008;18:280-9 pubmed publisher
..We have now expressed the mouse Hyal3 gene product, hyaluronidase 3 (Hyal3), in Baby Hamster Kidney (BHK) cells and demonstrated the presence of multiple forms of Hyal3 ranging ..
Orimoto A, Dumaresq Doiron K, Jiang J, Tanphaichitr N, Tsang B, Carmona E. Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia. Endocrinology. 2008;149:5835-47 pubmed publisher
..Our present findings provide a better understanding of the role of hyaluronidases in ovarian functions, showing for the first time their involvement in follicular atresia. ..
Jadin L, Wu X, Ding H, Frost G, Onclinx C, Triggs Raine B, et al
. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008;22:4316-26 pubmed publisher
..In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans. ..