Hyal 1


Gene Symbol: Hyal 1
Description: hyaluronoglucosaminidase 1
Alias: Hya1, Hyal-1, hyaluronidase-1
Species: mouse
Products:     Hyal 1

Top Publications

  1. Csoka A, Frost G, Heng H, Scherer S, Mohapatra G, Stern R, et al. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics. 1998;48:63-70 pubmed
    ..We also present evidence that human HYAL1 is identical to an uncharacterized gene positionally cloned by others from chromosome 3p21.3 that is homozygously deleted in several small-cell lung carcinoma cell lines. ..
  2. Dogne S, Rath G, Jouret F, Caron N, Dessy C, Flamion B. Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes. Diabetes. 2016;65:2742-53 pubmed publisher
    ..Our findings suggest that HYAL1 contributes to endothelial and glycocalyx dysfunction induced by diabetes. HYAL1 inhibitors could be explored as a new therapeutic approach to prevent vascular complications in diabetes. ..
  3. De Maeyer Guignard J, Lauret E, Eusèbe L, De Maeyer E. Accelerated tumor development in interferon-treated B6.C-Hyal-1 a mice. Proc Natl Acad Sci U S A. 1993;90:5708-12 pubmed
  4. Rai S, Duh F, Vigdorovich V, Danilkovitch Miagkova A, Lerman M, Miller A. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001;98:4443-8 pubmed
    ..The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma. ..
  5. Chang N. Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts. BMC Cell Biol. 2002;3:8 pubmed
    ..Hyal-2-increased TNF cytotoxicity in L929 cells appears to be correlated with upregulation of WOX1, a prolonged NF-kappaB activation, and Hyal-2 translocation to the mitochondria during apoptosis. ..
  6. Orimoto A, Dumaresq Doiron K, Jiang J, Tanphaichitr N, Tsang B, Carmona E. Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia. Endocrinology. 2008;149:5835-47 pubmed publisher
    ..Our present findings provide a better understanding of the role of hyaluronidases in ovarian functions, showing for the first time their involvement in follicular atresia. ..
  7. Dumaresq Doiron K, Edjekouane L, Orimoto A, Yoffou P, Gushulak L, Triggs Raine B, et al. Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process. J Cell Physiol. 2012;227:1911-22 pubmed publisher
    ..Our findings add Hyal-1 as an ovarian regulator factor for follicle development, showing for the first time an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway. ..
  8. De Maeyer E, De Maeyer Guignard J. The growth rate of two transplantable murine tumors, 3LL lung carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus determining hyaluronidase levels and polymorphism. Int J Cancer. 1992;51:657-60 pubmed
    ..These results are in favor of the hypothesis that the Hyal-1a allele, determining higher hyaluronidase levels, enhances resistance to tumor development. ..
  9. Bourguignon V, Flamion B. Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover. FASEB J. 2016;30:2108-14 pubmed publisher
    ..Bourguignon, V., Flamion, B. Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover. ..

More Information


  1. Boonen M, Puissant E, Gilis F, Flamion B, Jadot M. Mouse liver lysosomes contain enzymatically active processed forms of Hyal-1. Biochem Biophys Res Commun. 2014;446:1155-60 pubmed publisher
    ..The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase activity in the mouse liver, confirming that Hyal-1 is a key actor of HA catabolism in this organ. ..
  2. Puissant E, Gilis F, Dogne S, Flamion B, Jadot M, Boonen M. Subcellular trafficking and activity of Hyal-1 and its processed forms in murine macrophages. Traffic. 2014;15:500-15 pubmed publisher
    ..These results suggest that noncovalent associations support the lysosomal activity of Hyal-1. ..
  3. Mikami T, Koyama S, Yabuta Y, Kitagawa H. Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies. J Biol Chem. 2012;287:38531-42 pubmed publisher
    ..Our data suggest that the control of CS abundance is a promising new therapeutic approach for the treatment of skeletal muscle injury and progressive muscular dystrophies...
  4. Gushulak L, Hemming R, Martin D, Seyrantepe V, Pshezhetsky A, Triggs Raine B. Hyaluronidase 1 and ?-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation. J Biol Chem. 2012;287:16689-97 pubmed publisher
    ..These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown. ..
  5. Meuwese M, Broekhuizen L, Kuikhoven M, Heeneman S, Lutgens E, Gijbels M, et al. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice. PLoS ONE. 2010;5:e14262 pubmed publisher
    ..These findings support further efforts to evaluate whether ESL restoration is a valuable target to prevent (micro) vascular disease progression. ..
  6. Shuttleworth T, Wilson M, Wicklow B, Wilkins J, Triggs Raine B. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem. 2002;277:23008-18 pubmed
    ..have been identified, but the only clue to the function of their products has come from the identification of hyaluronidase 1 deficiency in a single patient with a mild clinical phenotype...
  7. De Maeyer Guignard J, Cachard Thomas A, De Maeyer E. Linkage analysis of the murine Hyal-1 locus on chromosome 9. J Exp Zool. 1991;258:246-8 pubmed
    ..The gene order (from centromere) with intervening percentage recombination is d-16.6 (+/- 2.9)-Hyal-1-10.9 (+/- 2.4)-Bgl-s, indicating close linkage to H-7 and Fv-2. ..
  8. Jadin L, Wu X, Ding H, Frost G, Onclinx C, Triggs Raine B, et al. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008;22:4316-26 pubmed publisher
    ..In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans. ..
  9. Martin D, Atmuri V, Hemming R, Farley J, Mort J, Byers S, et al. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum Mol Genet. 2008;17:1904-15 pubmed publisher
    ..Mutations in one of these genes cause a deficiency of hyaluronidase 1 (HYAL1) resulting in a lysosomal storage disorder, mucopolysaccharidosis (MPS) IX...
  10. Fiszer Szafarz B, De Maeyer E. Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet. 1989;15:79-83 pubmed
    ..Hyal-1 is linked to the histocompatibility locus H-7, on chromosome 9. ..
  11. Colombaro V, Jadot I, Declèves A, Voisin V, Giordano L, Habsch I, et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. Acta Histochem. 2015;117:83-91 pubmed publisher
    b>Hyaluronidase 1 (HYAL1) and hyaluronidase 2 (HYAL2) are the major hyaluronidases acting synergistically to degrade hyaluronan (HA). In the kidney, HA is distributed heterogeneously...
  12. Malaisse J, Evrard C, Feret D, Colombaro V, Dogne S, Haftek M, et al. Hyaluronidase-1 Is Mainly Functional in the Upper Granular Layer, Close to the Epidermal Barrier. J Invest Dermatol. 2015;135:3189-3192 pubmed publisher
  13. De Maeyer Guignard J, De Maeyer E. Linkage analysis of the Gi alpha 2 gene on mouse chromosome 9. Mamm Genome. 1992;3:601-3 pubmed