Hvcn1

Summary

Gene Symbol: Hvcn1
Description: hydrogen voltage-gated channel 1
Alias: 0610039P13Rik, AI450555, BTS, HV1, Vsop., mVSOP, voltage-gated hydrogen channel 1, voltage sensor domain-only protein
Species: mouse
Products:     Hvcn1

Top Publications

  1. Koch H, Kurokawa T, Okochi Y, Sasaki M, Okamura Y, Larsson H. Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A. 2008;105:9111-6 pubmed publisher
    ..It has been assumed that VSOP channels are monomeric and contain a single VSD that functions as both the VSD and the pore domain...
  2. Okochi Y, Sasaki M, Iwasaki H, Okamura Y. Voltage-gated proton channel is expressed on phagosomes. Biochem Biophys Res Commun. 2009;382:274-9 pubmed publisher
    ..proton channels was studied by Western blot with the antibody specific to the voltage-sensor domain protein, VSOP/Hv1, that has recently been identified as the molecular correlate for the voltage-gated proton channel...
  3. Ramsey I, Ruchti E, Kaczmarek J, Clapham D. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A. 2009;106:7642-7 pubmed publisher
    ..b>Hv1 mediates a voltage-gated H(+) channel activity that is proposed to serve a charge-balancing role in granulocytic ..
  4. Morgan D, Capasso M, Musset B, Cherny V, Rios E, Dyer M, et al. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009;106:18022-7 pubmed publisher
    ..The pH changes accompanying phagocytosis in bone marrow phagocytes from HVCN1-deficient mice mirrored those in control mouse cells treated with Zn(2+)...
  5. Sasaki M, Takagi M, Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science. 2006;312:589-92 pubmed publisher
    ..Responses of voltage dependence to sequence changes suggest that mouse voltage-sensor domain-only protein is itself a channel, rather than a regulator of another channel protein...
  6. El Chemaly A, Okochi Y, Sasaki M, Arnaudeau S, Okamura Y, Demaurex N. VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med. 2010;207:129-39 pubmed publisher
    ..Voltage-gated proton channels (voltage-sensing domain only protein [VSOP]/Hv1) are required for high-level superoxide production by phagocytes, but the mechanism of this effect is not ..
  7. Capasso M, Bhamrah M, Henley T, Boyd R, Langlais C, Cain K, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol. 2010;11:265-72 pubmed publisher
    ..We report here that the voltage-gated proton channel HVCN1 associated with the BCR complex and was internalized together with the BCR after activation...
  8. El Chemaly A, Nunes P, Jimaja W, Castelbou C, Demaurex N. Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases. J Leukoc Biol. 2014;95:827-839 pubmed
    ..These data indicate that Hvcn1 ablation deregulates neutrophil pHp, leading to alkalinization in phagosomes with residual ROS ..
  9. Zhao Q, Che Y, Li Q, Zhang S, Gao Y, Wang Y, et al. The voltage-gated proton channel Hv1 is expressed in pancreatic islet β-cells and regulates insulin secretion. Biochem Biophys Res Commun. 2015;468:746-51 pubmed publisher
    The voltage-gated proton channel Hv1 is a potent acid extruder that participates in the extrusion of the intracellular acid...

More Information

Publications27

  1. Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson H, Okamura Y. Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol. 2013;591:627-40 pubmed publisher
  2. Rybicka J, Balce D, Chaudhuri S, Allan E, Yates R. Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. EMBO J. 2012;31:932-44 pubmed publisher
    ..The ability of DC phagosomes to reduce disulphides was also compromised by NOX2 activity, implicating this oxidase in the control of an additional antigen processing chemistry of DCs. ..
  3. Szteyn K, Yang W, Schmid E, Lang F, Shumilina E. Lipopolysaccharide-sensitive H+ current in dendritic cells. Am J Physiol Cell Physiol. 2012;303:C204-12 pubmed publisher
    ..The present study demonstrates, for the first time, the functional expression of voltage-gated proton (Hv1) channels in mouse bone marrow-derived DCs...
  4. Suenaga T, Arase H, Yamasaki S, Kohno M, Yokosuka T, Takeuchi A, et al. Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. Eur J Immunol. 2007;37:3197-207 pubmed
    ..We cloned a new B cell-specific tetraspanning (BTS) membrane molecule, which is similar to CD20 in terms of expression, structure and function...
  5. Wang Y, Li S, Wu X, Che Y, Li Q. Clinicopathological and biological significance of human voltage-gated proton channel Hv1 protein overexpression in breast cancer. J Biol Chem. 2012;287:13877-88 pubmed publisher
    In our previous work, we showed for the first time that the voltage-gated proton channel Hv1 is specifically expressed in highly metastatic human breast tumor tissues and cell lines...
  6. Liu J, Tian D, Murugan M, Eyo U, Dreyfus C, Wang W, et al. Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. J Neurochem. 2015;135:347-56 pubmed publisher
    ..The voltage-gated proton channel, Hv1, is selectively expressed in microglia and is required for NOX-dependent ROS generation in the brain...
  7. Levine A, Duchen M, de Villiers S, Rich P, Segal A. Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. PLoS ONE. 2015;10:e0125906 pubmed publisher
    ..In human cells, the vacuolar pH rose to ~9, and the cytosol acidified slightly. By contrast, in Hvcn1 knock out mouse neutrophils, the vacuolar pH rose above 11, vacuoles swelled, and the cytosol acidified ..
  8. El Chemaly A, Demaurex N. Do Hv1 proton channels regulate the ionic and redox homeostasis of phagosomes?. Mol Cell Endocrinol. 2012;353:82-7 pubmed publisher
    Recent work on animal models has revealed the important role played by the voltage-gated proton channel Hv1 during bacterial killing by innate immune cells...
  9. Tombola F, Ulbrich M, Isacoff E. Architecture and gating of Hv1 proton channels. J Physiol. 2009;587:5325-9 pubmed publisher
    ..have been described in different cells and organisms since the early '80s, but the first member of the family, Hv1, was cloned only recently...
  10. Okochi Y, Aratani Y, Adissu H, Miyawaki N, Sasaki M, Suzuki K, et al. The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release. J Leukoc Biol. 2016;99:7-19 pubmed publisher
    ..On activation of NADPH oxidase by PMA and IgG, neutrophils derived from Hvcn1 gene knockout mouse exhibited greater secretion of MPO and elastase than WT cells...
  11. Kurokawa T, Okamura Y. Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection. Biochim Biophys Acta. 2014;1838:382-7 pubmed publisher
    b>Hv1 (also named, voltage-sensor only protein, VSOP) lacks an authentic pore domain, and its voltage sensor domain plays both roles in voltage sensing and proton permeation...
  12. Tian D, Li C, Qin C, Murugan M, Wu L, Liu J. Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke. J Neurochem. 2016;139:96-105 pubmed publisher
    ..The voltage-gated proton channel, Hv1, is selectively expressed in microglia and is required for NOX-dependent ROS generation in the brain...
  13. Wang X, Xi W, Qin J, Lv J, Wang Y, Zhang T, et al. Deficiency of voltage-gated proton channel Hv1 attenuates streptozotocin-induced β-cell damage. Biochem Biophys Res Commun. 2018;498:975-980 pubmed publisher
    ..The voltage-gated proton channel Hv1 contributes a majority of the charge compensation required for ROS production...
  14. Zhu X, Mose E, Zimmermann N. Proton channel HVCN1 is required for effector functions of mouse eosinophils. BMC Immunol. 2013;14:24 pubmed publisher
    Proton currents are required for optimal respiratory burst in phagocytes. Recently, HVCN1 was identified as the molecule required for the voltage-gated proton channel activity associated with the respiratory burst in neutrophils...
  15. Fujiwara Y, Takeshita K, Nakagawa A, Okamura Y. Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel. J Biol Chem. 2013;288:17968-75 pubmed publisher
    ..Thus, the biochemical properties of the cytoplasmic coiled-coil domain in the Hv channel depend on the redox condition, which may play a role in redox sensing in the phagosome. ..
  16. Sasaki M, Tojo A, Okochi Y, Miyawaki N, Kamimura D, Yamaguchi A, et al. Autoimmune disorder phenotypes in Hvcn1-deficient mice. Biochem J. 2013;450:295-301 pubmed publisher
    ..In the present paper we show that Hvcn1 (voltage-gated hydrogen channel 1)-knockout mice show splenomegaly, autoantibodies and nephritis, that are ..
  17. Wu L, Wu G, Akhavan Sharif M, Baker A, Jia Y, Fahey F, et al. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012;15:565-73 pubmed publisher
    ..The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons...
  18. Sakata S, Kurokawa T, Nørholm M, Takagi M, Okochi Y, von Heijne G, et al. Functionality of the voltage-gated proton channel truncated in S4. Proc Natl Acad Sci U S A. 2010;107:2313-8 pubmed publisher
    ..VSD and the recently discovered voltage-gated proton channels (Hv channels) voltage sensor only protein (VSOP) and Hv1 contain four transmembrane segments...