Gene Symbol: Htr1f
Description: 5-hydroxytryptamine (serotonin) receptor 1F
Alias: Htr1eb, 5-hydroxytryptamine receptor 1F, 5-HT-1E-beta, 5-HT-1F, 5-HT1F, 5-hydroxytryptamine (serotonin) receptor 1E beta, serotonin receptor 1F
Amlaiky N, Ramboz S, Boschert U, Plassat J, Hen R. Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992;267:19761-4 pubmed
..Our results therefore demonstrate that the 5HT1E receptors constitute a heterogeneous family of receptors. ..
McAllister G, Charlesworth A, Snodin C, Beer M, Noble A, Middlemiss D, et al
. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A. 1992;89:5517-21 pubmed
..The excellent correlation observed between the pharmacology of the expressed receptor encoded by AC1 and the human brain 5HT1E binding site confirms that AC1 encodes a 5HT1E receptor and establishes a fifth 5HT1-like receptor subtype. ..
Adham N, Kao H, Schecter L, Bard J, Olsen M, Urquhart D, et al
. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993;90:408-12 pubmed
..9 nM) in transfected cells. These properties distinguish this receptor from any previously characterized and establish a fifth 5-HT1-like receptor subtype (5-HT1F) coupled to the inhibition of adenylate cyclase. ..
Wen X, Bryce D, Breitman M. Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Hum Mol Genet. 1998;7:743-50 pubmed
..The lpd mutant mice may serve as models for human disorders of fatty livers or hypertriglyceridemia. ..
Mitsikostas D, Sanchez del Rio M, Waeber C. 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002;22:384-94 pubmed
Bonnin A, Peng W, Hewlett W, Levitt P. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience. 2006;141:781-94 pubmed
..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development. ..
Guadiana S, Semple Rowland S, Daroszewski D, Madorsky I, Breunig J, Mykytyn K, et al
. Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. J Neurosci. 2013;33:2626-38 pubmed publisher
..Collectively, our data suggest the formation of neuronal dendrites in developing neocortex requires structurally normal cilia enriched with ACIII. ..
Almaca J, Molina J, Menegaz D, Pronin A, Tamayo A, Slepak V, et al
. Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells. Cell Rep. 2016;17:3281-3291 pubmed publisher
..Thus, modulation of serotonin signaling in the islet represents a drug intervention opportunity. ..