Gene Symbol: Htr1d
Description: 5-hydroxytryptamine (serotonin) receptor 1D
Alias: 5-HT-1D, 5-HT1D, AI853647, Gpcr14, Htr1db, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine (serotonin) receptor 1D beta, G-protein coupled receptor 14, serotonin receptor 1D
Species: mouse
Products:     Htr1d

Top Publications

  1. Maroteaux L, Saudou F, Amlaiky N, Boschert U, Plassat J, Hen R. Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992;89:3020-4 pubmed
    ..The predominant expression of the 5HT1B receptor in the striatum and cerebellum points to an involvement of this receptor in motor control. ..
  2. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci. 2007;10:588-97 pubmed
    ..These data demonstrate that serotonergic signaling has a previously unrecognized role in the modulation of axonal responsiveness to a classic guidance cue. ..
  3. Zhao X, Zhang Y, Qin W, Cao J, Zhang Y, Ni J, et al. Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons. Cell Signal. 2016;28:979-88 pubmed publisher
    ..This 5-HT1D receptor effect may contribute to neuronal hypoexcitability in small TG neurons. ..
  4. Enjin A, Leao K, Mikulovic S, Le Merre P, Tourtellotte W, Kullander K. Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Mol Cell Neurosci. 2012;49:322-32 pubmed publisher
    ..Here we show that the serotonin receptor 1d (5-ht1d) is specifically expressed by gamma MNs and proprioceptive sensory neurons...
  5. Bonnin A, Peng W, Hewlett W, Levitt P. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience. 2006;141:781-94 pubmed
    ..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development. ..
  6. Teuscher C, Doerge R, Fillmore P, Blankenhorn E. eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter. Genetics. 2006;172:1147-53 pubmed
  7. Pietri M, Schneider B, Mouillet Richard S, Ermonval M, Mutel V, Launay J, et al. Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J. 2005;19:1078-87 pubmed
  8. Mouillet Richard S, Pietri M, Schneider B, Vidal C, Mutel V, Launay J, et al. Modulation of serotonergic receptor signaling and cross-talk by prion protein. J Biol Chem. 2005;280:4592-601 pubmed
    ..They provide a foundation for uncovering the impact of prion infection on serotonergic functions. ..
  9. Il kova G, Rehák P, Veselá J, Cikos S, Fabian D, Czikková S, et al. Serotonin localization and its functional significance during mouse preimplantation embryo development. Zygote. 2004;12:205-13 pubmed
    ..It appears that endogenous and/or exogenous serotonin in preimplantation embryos could be involved in complex autocrine/paracrine regulations of embryo development and embryo-maternal interactions. ..

More Information


  1. Zhang S, Gershenfeld H. Genetic contributions to body weight in mice: relationship of exploratory behavior to weight. Obes Res. 2003;11:828-38 pubmed
    ..In mice, loci influencing exploratory activity play a modest role in body-weight regulation. Some forms of obesity may emerge from loci regulating normal body weight. ..
  2. Vesela J, Rehak P, Mihalik J, Czikková S, Pokorny J, Koppel J. Expression of serotonin receptors in mouse oocytes and preimplantation embryos. Physiol Res. 2003;52:223-8 pubmed
    ..Demonstration of the expression of 5-HT1D serotonin receptor in mouse oocytes and preimplantation embryos supports the idea of a functional serotonin (5-HT1D) receptor in early mammalian development. ..
  3. Mitsikostas D, Sanchez del Rio M, Waeber C. 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 2002;22:384-94 pubmed
  4. Wurch T, Palmier C, Colpaert F, Pauwels P. Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily. J Neurochem. 1997;68:410-8 pubmed
    ..In conclusion, the pharmacology of the cloned 5-HT1D receptor subtype seems, unlike the 5-HT1B receptor subtype, conserved among various mammal species such as the human, guinea pig, and rat. ..
  5. Birkeland M, Copeland N, Gilbert D, Jenkins N, Barclay A. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. Eur J Immunol. 1995;25:926-30 pubmed
  6. Langlois X, Gerard C, Darmon M, Chauveau J, Hamon M, El Mestikawy S. Immunolabeling of central serotonin 5-HT1D beta receptors in the rat, mouse, and guinea pig with a specific anti-peptide antiserum. J Neurochem. 1995;65:2671-81 pubmed
  7. Mundo E, Richter M, Zai G, Sam F, McBride J, Macciardi F, et al. 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study. Mol Psychiatry. 2002;7:805-9 pubmed
    ..Further genetic investigations on this marker considering additional polymorphisms and other quantitative phenotypes related to OCD are warranted. ..
  8. Cox G, Lutz C, Yang C, Biemesderfer D, Bronson R, Fu A, et al. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997;91:139-48 pubmed
    ..This first example of a disease-causing mutation in an Nhe gene provides a new tool for studying the delicate balance of neuroexcitability and cell survival within the CNS. ..
  9. Pathak B, Shull G, Jenkins N, Copeland N. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996;31:261-3 pubmed
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping. ..
  10. Sun D, Chang A, Jenkins N, Gilbert D, Copeland N, Chang N. Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics. 1996;36:54-62 pubmed
    ..Interspecific backcross analyses have mapped Luzp to mouse chromosome 4 in proximity to Gpcr14. Comparative mapping data suggest that the human homolog of Luzp will map to human chromosome 1p36.
  11. Weydert A, Cloez Tayarani I, Fillion M, Simon Chazottes D, Guenet J, Fillion G. Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig. C R Acad Sci III. 1992;314:429-35 pubmed
    ..A homologous sequence to one of them was cloned in guinea pig. ..