Gene Symbol: HTm4
Description: membrane-spanning 4-domains, subfamily A, member 3
Alias: HTm4, membrane-spanning 4-domains subfamily A member 3, haematopoietic cell-specific transmembrane-4, hematopoietic-specific transmembrane protein 4
Hulett M, Pagler E, Hornby J. Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4. Immunol Cell Biol. 2001;79:345-9 pubmed
Haematopoietic cell-specific transmembrane-4 (HTm4) is a four-transmembrane protein most closely related to CD20 and the beta subunit of the high affinity receptor for IgE (Fc(epsilon)RIbeta)...
Kutok J, Yang X, Folkerth R, Imitola J, Raddassi K, Yano Y, et al
. The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. J Mol Histol. 2005;36:77-87 pubmed
b>HTm4 is a member of a newly defined family of human and murine proteins, the MS4 (membrane-spanning four) protein group, which has a distinctive four-transmembrane structure...
Ishibashi T, Yokota T, Satoh Y, Ichii M, Sudo T, Doi Y, et al
. Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis. Biochem Biophys Res Commun. 2018;495:2338-2343 pubmed publisher
..In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis. ..
Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
CD20, high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are structurally related cell-surface proteins expressed by hematopoietic cells...
Kutok J, Yang X, Folkerth R, Adra C. Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. J Cell Mol Med. 2011;15:86-93 pubmed publisher
b>HTm4 (MS4A3) is a member of a family of four-transmembrane proteins designated MS4A. MS4A proteins fulfil diverse functions, acting as cell surface signalling molecules and intracellular adapter proteins...