Hspd1

Summary

Gene Symbol: Hspd1
Description: heat shock protein 1 (chaperonin)
Alias: 60kDa, CPN60, HSP-60, HSP-65, Hsp60, 60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, chaperonin 60, heat shock 60kDa protein 1 (chaperonin), heat shock protein 60, heat shock protein, 60 kDa, mitochondrial matrix protein P1
Species: mouse
Products:     Hspd1

Top Publications

  1. Lu X, Chen D, Endresz V, Xia M, Faludi I, Burian K, et al. Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice. Atherosclerosis. 2010;212:472-80 pubmed publisher
    b>HSP60 is emerging as an immunodominant target of autoantibodies in atherosclerosis and recent studies have revealed oxLDL as a key antigen in the development of atherosclerosis...
  2. Wang G, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003;36:48-61 pubmed
    ..These findings suggest that hsf2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production. ..
  3. Lotscher E, Allison J. Nucleotide and deduced amino acid sequence of a murine cDNA clone encoding one member of the hsp65 multigene family. Nucleic Acids Res. 1990;18:7153 pubmed
  4. Yi Y, Yang X, Brunham R. Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10. Infect Immun. 1997;65:1669-74 pubmed
    ..sequelae of chlamydial infection are correlated with immune responses to the Chlamydia trachomatis heat shock protein 60 (hsp60)...
  5. Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017;31:771-789.e6 pubmed publisher
    ..Thus, Kupffer cell-derived Tnf favors cholangiocellular proliferation/differentiation and carcinogenesis. Targeting the ROS/Tnf/JNK axis may provide opportunities for ICC therapy. ..
  6. Cohen Sfady M, Pevsner Fischer M, Margalit R, Cohen I. Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced. J Immunol. 2009;183:890-6 pubmed publisher
    We recently reported that heat shock protein 60 (HSP60) via TLR4 signaling activates B cells and induces them to proliferate and secrete IL-10...
  7. Habich C, Kempe K, Burkart V, van der Zee R, Lillicrap M, Gaston H, et al. Identification of the heat shock protein 60 epitope involved in receptor binding on macrophages. FEBS Lett. 2004;568:65-9 pubmed
    In the present study, we identified the human heat shock protein 60 (HSP60) epitope responsible for binding to macrophages...
  8. Li Y, Ochs S, Gao Z, Malo A, Chen C, Lv S, et al. Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2009;297:G981-9 pubmed
    The objective of this study was to investigate the role of MAPKAP kinase 2 (MK2) and heat shock protein (HSP) HSP60 in the pathogenesis of a new model of severe acute pancreatitis (AP)...
  9. Osterloh A, Geisinger F, Piedavent M, Fleischer B, Brattig N, Breloer M. Heat shock protein 60 (HSP60) stimulates neutrophil effector functions. J Leukoc Biol. 2009;86:423-34 pubmed publisher
    ..In this study, we show that hHSP60 binds to murine and human PMN strongly and specifically. We demonstrate that HSP60 serves as a chemoattractant and modulates neutrophil functions...

More Information

Publications76

  1. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  2. Chun J, Choi B, Lee K, Lee D, Kang D, Lee J, et al. Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS ONE. 2010;5:e9422 pubmed publisher
    Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown...
  3. Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J. Messenger RNA expression of heat shock proteins (HSPs) during ocular development. Curr Eye Res. 1995;14:1125-33 pubmed
    ..We examined the expression of the major HSP families, HSP60, 70 and 90 families and small HSP32, at the mRNA level in ocular development...
  4. Martin J, Balmer M, Rajendran S, Maurhofer O, Dufour J, St Pierre M. Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am J Physiol Gastrointest Liver Physiol. 2016;310:G497-509 pubmed publisher
    ..The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress. ..
  5. Mortensen M, Ferguson D, Edelmann M, Kessler B, Morten K, Komatsu M, et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A. 2010;107:832-7 pubmed publisher
    ..In summary, we show that the selective removal of mitochondria by autophagy, but not other organelles, during erythropoeisis is essential and that this is a necessary developmental step in erythroid cells...
  6. Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M. Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem. 2007;282:4669-80 pubmed
    ..In this study we show that Hsp60 mediates immune stimulation by different mechanisms, dependent and independent of lipopolysaccharide (LPS)...
  7. Rubel C, Schisler J, Hamlett E, Dekroon R, Gautel M, Alzate O, et al. Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates. Cell Biochem Biophys. 2013;67:127-38 pubmed publisher
  8. Asquith K, Baleato R, McLaughlin E, Nixon B, Aitken R. Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition. J Cell Sci. 2004;117:3645-57 pubmed
    ..Phosphoproteome analysis yielded the first evidence of molecular chaperones, endoplasmin (erp99) and heat shock protein 60 (hsp60), as targets for phosphorylation on the surface of mouse spermatozoa, whereas immunofluorescence ..
  9. Koh J, Lee Y, Kim Y, Park S, Lee S, Kim H, et al. Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency. Bone. 2009;45:650-60 pubmed publisher
    ..Among the nine proteins differentially expressed between OVX and sham-operated rats, heat shock protein 60 (HSP60) was upregulated by 2...
  10. Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M. Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. Int Immunol. 2008;20:433-43 pubmed publisher
    ..We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation...
  11. Ikawa S, Weinberg R. An interaction between p21ras and heat shock protein hsp60, a chaperonin. Proc Natl Acad Sci U S A. 1992;89:2012-6 pubmed
    ..Nucleotide sequence analysis revealed that p60 is the murine heat shock protein hsp60, a chaperonin...
  12. Li H, Ding Y, Yi G, Zeng Q, Yang W. Establishment of nasal tolerance to heat shock protein-60 alleviates atherosclerosis by inducing TGF-?-dependent regulatory T cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:24-30 pubmed publisher
    ..We investigated the effect of nasal administration of heat shock protein-60 (HSP60) on atherogenesis...
  13. Hickey T, Ziltener H, Speert D, Stokes R. Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cell Microbiol. 2010;12:1634-47 pubmed publisher
    ..binding to macrophages is shared by the Escherichia coli homologue, GroEL, but not by the mouse and human Hsp60 homologues...
  14. Magnoni R, Palmfeldt J, Christensen J, Sand M, Maltecca F, Corydon T, et al. Late onset motoneuron disorder caused by mitochondrial Hsp60 chaperone deficiency in mice. Neurobiol Dis. 2013;54:12-23 pubmed publisher
    ..Mutations in Hspd1, the gene encoding Hsp60, are associated with two human inherited diseases of the nervous system, a dominantly ..
  15. Chalmers S, Eidelman A, Ewer J, Ricca J, Serrano A, Tucker K, et al. A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro. Cell Immunol. 2013;282:136-45 pubmed publisher
    ..A screen of mammary carcinoma for DAMP expression showed HMGB1 and HSP60 were significantly elevated relative to normal mammary epithelium, and targeting these DAMPs, or receptors for ..
  16. Yamamoto M, Arimura H, Fukushige T, Minami K, Nishizawa Y, Tanimoto A, et al. Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014;34:1077-84 pubmed publisher
    ..These results suggest a critical role for Abcb10 in heme biosynthesis and provide new insights into the pathogenesis of erythropoietic protoporphyria and sideroblastic anemia. ..
  17. Foteinos G, Afzal A, Mandal K, Jahangiri M, Xu Q. Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage. Circulation. 2005;112:1206-13 pubmed
    Accumulating evidence established a positive association of anti-heat shock protein 60 (HSP60) autoantibodies and the presence of atherosclerosis in humans...
  18. Heiserman J, Chen L, Kim B, Kim S, Tran A, Siebenborn N, et al. TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes. Cell Stress Chaperones. 2015;20:527-35 pubmed publisher
    Extracellular (ex) HSP60 is increasingly recognized as an agent of cell injury. Previously, we reported that low endotoxin exHSP60 causes cardiac myocyte apoptosis...
  19. Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, et al. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol. 2006;36:1598-607 pubmed
    ..We found that HS-Exo, compared with control exosomes derived from the same cells (Exo), contain more HSP60 and HSP90 and increased amounts of molecules involved in immunogenicity including MHC class I, MHC class II, CD40, ..
  20. Haigis M, Mostoslavsky R, Haigis K, Fahie K, Christodoulou D, Murphy A, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006;126:941-54 pubmed
    ..These results indicate that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR. ..
  21. Chen T, Liu S, Chen M, Cho K, Chen T, Chu P, et al. Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression. Biomed Res Int. 2015;2015:539805 pubmed publisher
    Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life...
  22. Dieudé M, Gillis M, Théorêt J, Thorin E, Lajoie G, Levine J, et al. Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis. J Thromb Haemost. 2009;7:710-9 pubmed publisher
    ..However, their role in thrombus formation remains unclear. We hypothesized that anti-HSP60 autoantibodies could potentiate thrombosis, and evaluated the effect of anti-murine HSP60 antibodies in a ferric ..
  23. Guan S, Sheu M, Yang R, Chan D, Wu C, Yang T, et al. The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet ?-cell hypertrophy and dysfunction. Oncotarget. 2016;7:23072-87 pubmed publisher
    b>Heat shock protein 60 (HSP60) is a mitochondrial chaperone. Advanced glycation end products (AGEs) have been shown to interfere with the ?-cell function...
  24. Guimarães A, Frases S, Pontes B, de Cerqueira M, Rodrigues M, Viana N, et al. Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions. Infect Immun. 2011;79:918-27 pubmed publisher
    ..capsulatum surface-expressed heat shock protein of 60 kDa (Hsp60) that modify disease in a murine histoplasmosis model...
  25. Gülden E, Mollérus S, Brüggemann J, Burkart V, Habich C. Heat shock protein 60 induces inflammatory mediators in mouse adipocytes. FEBS Lett. 2008;582:2731-6 pubmed publisher
    ..These results identify Hsp60 as an important regulator of adipocyte functions which contribute to the development of inflammatory processes as ..
  26. Brudzynski K, Martinez V, Gupta R. Immunocytochemical localization of heat-shock protein 60-related protein in beta-cell secretory granules and its altered distribution in non-obese diabetic mice. Diabetologia. 1992;35:316-24 pubmed
    ..microscopy technique was employed to investigate the cellular distribution of 60 kDa heat-shock protein (HSP60) in pancreatic Beta cells of control and non-obese diabetic mice...
  27. Barker R, Wells A, Ghoraishian M, Easterfield A, Hitsumoto Y, Elson C, et al. Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis. Clin Exp Immunol. 1996;103:83-8 pubmed
    Previous work has indicated that autoimmunity to the mammalian 60-kD heat shock protein (hsp60) may be necessary for the development of pristane-induced arthritis (PIA), a murine model of rheumatoid arthritis...
  28. Chen G, Cizeau J, Vande Velde C, Park J, Bozek G, Bolton J, et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999;274:7-10 pubmed
    ..Nix colocalizes with the mitochondrial matrix protein HSP60, and removal of the putative transmembrane domain (TM) results in general cytoplasmic and nuclear expression...
  29. Luth S, Lohse A, Herkel J. Transgenic overproduction of murine 60 kDa heat shock protein in the liver does not prevent type I diabetes in NOD mice. Diabetologia. 2006;49:1123-4 pubmed
  30. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol. 2000;164:558-61 pubmed
    Human heat shock protein 60 (hsp60) elicits a potent proinflammatory response in cells of the innate immune system and therefore has been proposed as a danger signal of stressed or damaged cells...
  31. Breloer M, Dorner B, Moré S, Roderian T, Fleischer B, von Bonin A. Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells. Eur J Immunol. 2001;31:2051-9 pubmed
    The heat shock proteins (HSP) gp96, Hsp70 and Hsp60 activate professional antigen-presenting cells (APC) to secrete proinflammatory cytokines and to express costimulatory molecules...
  32. Danial N, Gramm C, Scorrano L, Zhang C, Krauss S, Ranger A, et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 2003;424:952-6 pubmed
    ..This combination of proteomics, genetics and physiology indicates an unanticipated role for BAD in integrating pathways of glucose metabolism and apoptosis. ..
  33. Magnoni R, Palmfeldt J, Hansen J, Christensen J, Corydon T, Bross P. The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function. Free Radic Res. 2014;48:168-79 pubmed publisher
    ..One of its components is the mitochondrial chaperone Hsp60 assisting the folding of a subset of mitochondrial matrix proteins...
  34. Walls K, Coskun P, Gallegos Perez J, Zadourian N, Freude K, RASOOL S, et al. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012;287:30317-27 pubmed publisher
    ..We used a proteomics approach to identify binding partners and show that heat shock protein 60 (HSP60), a molecular chaperone localized to mitochondria and the plasma membrane, specifically associates ..
  35. Chang M, Jin W, Chang J, Xiao Y, Brittain G, Yu J, et al. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol. 2011;12:1002-9 pubmed publisher
    ..Our results identify Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel regulation. ..
  36. Li Y, Si R, Feng Y, Chen H, Zou L, Wang E, et al. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem. 2011;286:31308-19 pubmed publisher
    ..b>HSP60 protein was markedly increased in serum or in perfusate of isolated heart following ischemia/reperfusion (I/R)...
  37. Oltean M, Dindelegan G, Kurlberg G, Nilsson O, Karlsson Parra A, Olausson M. Intragraft heat shock protein-60 expression after small bowel transplantation in the mouse. Transplant Proc. 2004;36:350-2 pubmed
    The time course of heat shock protein 60 (hsp 60) expression after intestinal transplantation in syngeneic and allogeneic combination was correlated with the degree of rejection...
  38. Zhu Y, Swanson B, Wang M, Hildeman D, Schaefer B, Liu X, et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A. 2004;101:7681-6 pubmed
    ..Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules. ..
  39. Osterloh A, Meier Stiegen F, Veit A, Fleischer B, von Bonin A, Breloer M. Lipopolysaccharide-free heat shock protein 60 activates T cells. J Biol Chem. 2004;279:47906-11 pubmed
    A possible function of eukaryotic heat shock protein 60 (Hsp60) as endogenous danger signal has been controversially discussed in the past...
  40. Gülden E, Märker T, Kriebel J, Kolb Bachofen V, Burkart V, Habich C. Heat shock protein 60: evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation. FEBS Lett. 2009;583:2877-81 pubmed publisher
    ..of heat shock protein (Hsp) 60-induced activation of preadipocytes we investigated whether the capacity of heat shock protein 60 (Hsp60) to interact with adipocytes and to stimulate their proinflammatory activity is determined by the ..
  41. Christensen J, Nielsen M, Hansen J, Füchtbauer A, Füchtbauer E, West M, et al. Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice. Cell Stress Chaperones. 2010;15:851-63 pubmed publisher
    ..the generation and characterization of a mutant mouse line bearing an inactivating gene-trap insertion in the Hspd1 gene encoding Hsp60...
  42. Abdallah M, Pollenz R, Nunamaker R, Murphy K. Identification and characterization of a cDNA clone encoding the heat shock protein (Hsp60) from the biting midge, Culicoides variipennis sonorensis Wirth and Jones. Biochem Genet. 2000;38:157-65 pubmed
    ..expression library constructed from Culicoides variipennis sonorensis was screened using an antibody specific for Hsp60 of Heliothis virescens. A single clone encoding the complete heat shock protein (Hsp60) of C...
  43. Rosenberger K, Dembny P, Derkow K, Engel O, Krüger C, Wolf S, et al. Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway. Mol Neurodegener. 2015;10:5 pubmed publisher
    ..The stress protein heat shock protein 60 (HSP60) released from injured cells is considered an endogenous danger signal of the immune system...
  44. Reverter Branchat G, Cabiscol E, Tamarit J, Ros J. Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction. J Biol Chem. 2004;279:31983-9 pubmed
    ..Common targets include stress resistance proteins (Hsp60 and Hsp70) and enzymes involved in glucose metabolism such as enolase, glyceraldehydes-3-P dehydrogenase, fructose-..
  45. Challen G, Martinez G, Davis M, Taylor D, Crowe M, Teasdale R, et al. Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol. 2004;15:2344-57 pubmed
    ..These findings may assist in the isolation and characterization of potential renal stem cells for use in cellular therapies for kidney disease. ..
  46. Merrick B, Patterson R, Witcher L, He C, Selkirk J. Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. Electrophoresis. 1994;15:735-45 pubmed
    ..Thus, we have found that preparative 2-D PAGE serves as a powerful one-step purification method for protein isolation and characterization from an important in vitro murine model for the study of carcinogenesis. ..
  47. Elias D, Markovits D, Reshef T, van der Zee R, Cohen I. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1990;87:1576-80 pubmed
    ..Other antigens such as the 70-kDa heat shock protein (hsp70) had no effect on the development of diabetes. ..
  48. Venner T, Gupta R. Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA. Biochim Biophys Acta. 1990;1087:336-8 pubmed
    ..The deduced amino acid sequence of mouse hsp60 protein differs from the corresponding proteins from Chinese hamster and human cells in 7 and 13 residues, ..
  49. Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, et al. Mitochondrial function controls intestinal epithelial stemness and proliferation. Nat Commun. 2016;7:13171 pubmed publisher
    ..Using intestinal epithelial cell (IEC)-specific mouse models, we show that loss of HSP60, a mitochondrial chaperone, activates the mitochondrial unfolded protein response (MT-UPR) and results in ..
  50. Kim Y, Koh J, Lee Y, Kim B, Lee S, Lee K, et al. Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors. Bone. 2009;45:68-76 pubmed publisher
    ..Previous studies have reported that the HSP60 stimulates osteoclast formation and bone resorption...
  51. Yang K, Li D, Luo M, Hu Y. Generation of HSP60-specific regulatory T cell and effect on atherosclerosis. Cell Immunol. 2006;243:90-5 pubmed
    ..Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RPM)-treated immature dendritic cells in vitro and explore their ..
  52. Lombard D, Alt F, Cheng H, Bunkenborg J, Streeper R, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27:8807-14 pubmed
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle. ..
  53. Elias D, Reshef T, Birk O, van der Zee R, Walker M, Cohen I. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991;88:3088-91 pubmed
    ..Thus, T-cell vaccination and specific peptide therapy are feasible in spontaneous autoimmune diabetes. ..
  54. Lin D, He H, Ji H, Willis J, Willard L, Jiang Y, et al. Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase ?2 subunit. Mol Nutr Food Res. 2014;58:1005-15 pubmed publisher
    ..lutein and zeaxanthin contents, inhibited protein expression of ?,?-carotene 9',10'-oxygenase 2 (BCO2) and heat shock protein 60 in mitochondria, increased reactive oxygen species level, and suppressed mitophagy and mitochondrial ..
  55. Brudzynski K, Cunningham I, Martinez V. A family of hsp60-related proteins in pancreatic beta cells of non-obese diabetic (NOD) mice. J Autoimmun. 1995;8:859-74 pubmed
    ..whether analogous proteins with related function are expressed in other cellular structures and whether such hsp60-related proteins could serve as antigenic targets in autoimmune diabetes...
  56. Kleinridders A, Lauritzen H, Ussar S, Christensen J, Mori M, Bross P, et al. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest. 2013;123:4667-80 pubmed
    ..hypothalamic insulin resistance and mitochondrial dysfunction due to downregulation of the mitochondrial chaperone HSP60. HSP60 reduction in obese, diabetic mice was due to a lack of proper leptin signaling and was restored by leptin ..
  57. Colley S, Wintle L, Searles R, Russell V, Firman R, Smith S, et al. Loss of the nuclear receptor corepressor SLIRP compromises male fertility. PLoS ONE. 2013;8:e70700 pubmed publisher
    ..In sum, our data implicates SLIRP in regulating male fertility, wherein its loss results in asthenozoospermia associated with compromised sperm structure and mitochondrial morphology. ..
  58. Wilfling F, Weber A, Potthoff S, Vögtle F, Meisinger C, Paschen S, et al. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell Death Differ. 2012;19:1328-36 pubmed publisher
    ..The recognition of C-terminal membrane-insertion of BH3-only proteins will permit the development of a more detailed concept of the initiation of mitochondrial apoptosis. ..
  59. Engl G, Florian S, Tranebjærg L, Rapaport D. Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012;21:287-99 pubmed publisher
    ..Taken together, these results suggest that alterations in the levels of DDP1 can affect the morphology of mitochondria and thus shed new light on the pathogenic mechanisms of DDON. ..
  60. Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed publisher
    ..Thus, the dynamics of mtDNA nucleoids regulated by mitochondrial fission is required for neonatal cardiomyocyte development by promoting homogeneous distribution of active mitochondria throughout the cardiomyocytes. ..
  61. Zhao Y, Zhang C, Wei X, Li P, Cui Y, Qin Y, et al. Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation. Sci Rep. 2015;5:15352 pubmed publisher
    ..However, the precise mechanisms by which HSP60 promotes atherosclerosis remain unclear...
  62. Quintana F, Carmi P, Cohen I. DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J Immunol. 2002;169:6030-5 pubmed
    ..a consequence of an autoimmune process that can be inhibited by immunotherapy with the 60-kDa heat shock protein (hsp60), with its mycobacterial counterpart 65-kDa (hsp65), or with other Ags such as insulin and glutamic acid ..
  63. Barone R, Macaluso F, Sangiorgi C, Campanella C, Marino Gammazza A, Moresi V, et al. Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression. Sci Rep. 2016;6:19781 pubmed publisher
    b>Heat shock protein 60 (Hsp60) is a chaperone localizing in skeletal muscle mitochondria, whose role is poorly understood...
  64. Xie J, Zhu H, Guo L, Ruan Y, Wang L, Sun L, et al. Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway. J Immunol. 2010;185:2306-13 pubmed publisher
    ..Although the receptor for Hsp60 was proposed to be saturable and specific on macrophages, it is not well defined...
  65. Ko J, Sun Y, Li W, Wang F. Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis. J Mol Med (Berl). 2016;94:755-69 pubmed publisher
    ..This study was undertaken to characterize the biological role of HSP60 in the pathogenesis of OA knee...
  66. Johnson B, Le T, Dobbin C, Banovic T, Howard C, Flores F, et al. Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem. 2005;280:4037-47 pubmed
    Heat shock protein 10 (Hsp10) and heat shock protein 60 (Hsp60) were originally described as essential mitochondrial proteins involved in protein folding...
  67. Walsh A, Whelan D, Bielanowicz A, Skinner B, Aitken R, O Bryan M, et al. Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse. Biol Reprod. 2008;78:983-93 pubmed publisher
    ..This chaperone was identified using a coimmunoprecipitation strategy employing HSPD1 as bait...