Gene Symbol: Hspb7
Description: heat shock protein family, member 7 (cardiovascular)
Alias: 27kDa, Hsp25-2, cvHsp, heat shock protein beta-7, cardiovascular heat shock protein, heat shock 27kDa protein family, member 7 (cardiovascular), heat shock protein 25 kDa 2 (cardiovascular), protein p19/6.8
Species: mouse
Products:     Hspb7

Top Publications

  1. Lowell B. PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell. 1999;99:239-42 pubmed
  2. Krief S, Faivre J, Robert P, Le Douarin B, Brument Larignon N, Lefrere I, et al. Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues. J Biol Chem. 1999;274:36592-600 pubmed
    ..we have identified by focusing on heart libraries a novel small stress protein of 170 amino acids that we named cvHsp. cvHsp was found as being computationally selectively and highly (0.3% of the total RNA) expressed in human heart...
  3. Chiu T, Li C, Chen C, Chen C, Cheng C, Yan Y, et al. Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome. Circ J. 2012;76:2226-33 pubmed
    ..The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported...
  4. Juo L, Liao W, Shih Y, Yang B, Liu A, Yan Y. HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. J Cell Sci. 2016;129:1661-70 pubmed publisher
    b>HSPB7 belongs to the small heat-shock protein (sHSP) family, and its expression is restricted to cardiac and skeletal muscles from embryonic stages to adulthood...
  5. Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak R, et al. HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017;114:11956-11961 pubmed publisher
    Small heat shock protein HSPB7 is highly expressed in the heart. Several mutations within HSPB7 are associated with dilated cardiomyopathy and heart failure in human patients...
  6. Kappé G, Franck E, Verschuure P, Boelens W, Leunissen J, de Jong W. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. Cell Stress Chaperones. 2003;8:53-61 pubmed
    ..recognized human sHsps (Hsp27/HspB1, HspB2, HspB3, alphaA-crystallin/HspB4, alphaB-crystallin/HspB5, Hsp20/HspB6, cvHsp/HspB7, H11/HspB8, and HspB9) and a sperm tail protein known since 1993 as outer dense fiber protein 1 (ODF1)...
  7. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  8. Vos M, Kanon B, Kampinga H. HSPB7 is a SC35 speckle resident small heat shock protein. Biochim Biophys Acta. 2009;1793:1343-53 pubmed publisher
    ..A novel and non-predicted finding was that HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus...
  9. Tobin S, Yang D, Girgis J, Farahzad A, Blais A, McDermott J. Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy. J Cell Sci. 2016;129:4076-4090 pubmed
    ..of the actin cytoskeleton, we characterized the expression of putative MEF2 and AP-1 target genes (Dstn, Flnc, Hspb7, Lmod3 and Plekhh2) under atrophic conditions using dexamethasone (Dex) treatment in skeletal myoblasts...

More Information


  1. Choi M, Jung K, Park J, Das N, Chung M, Choi I, et al. Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells. Arch Toxicol. 2011;85:293-304 pubmed publisher
    ..cell adhesion, including Cadm1, Ncam1, and Ncam2; and genes encoding small heat shock proteins, including HspB2, HspB7, and HspB8...
  2. Liao W, Juo L, Shih Y, Chen Y, Yan Y. HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity. PLoS Genet. 2017;13:e1006984 pubmed publisher
    b>HSPB7 is a member of the small heat-shock protein (HSPB) family and is expressed in the cardiomyocytes from cardiogenesis onwards...