Gene Symbol: Hspb2
Description: heat shock protein 2
Alias: 27kDa, 2810021G24Rik, HSP27, MKBP, heat shock protein beta-2, heat shock 27kD protein 2
Species: mouse
Products:     Hspb2

Top Publications

  1. Brady J, Garland D, Green D, Tamm E, Giblin F, Wawrousek E. AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest Ophthalmol Vis Sci. 2001;42:2924-34 pubmed
    ..In targeting the alphaB gene, the adjacent HSPB2 gene, which is not expressed in the lens, was also disrupted...
  2. Benjamin I, Guo Y, Srinivasan S, Boudina S, Taylor R, Rajasekaran N, et al. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol. 2007;293:H3201-9 pubmed
    The abundantly expressed small molecular weight proteins, CRYAB and HSPB2, have been implicated in cardioprotection ex vivo...
  3. Pinz I, Robbins J, Rajasekaran N, Benjamin I, Ingwall J. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008;22:84-92 pubmed
    CryAB and HSPB2 are small heat shock proteins constitutively expressed in the heart. CryAB protects cytoskeletal organization and intermediate filament assembly; the functions of HSPB2 are unknown...
  4. Rayner K, Chen Y, McNulty M, Simard T, Zhao X, Wells D, et al. Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. Circ Res. 2008;103:133-41 pubmed publisher
    We recently identified heat shock protein 27 (HSP27) as an estrogen receptor beta (ERbeta)-associated protein and noted its role as a biomarker for atherosclerosis...
  5. Kumarapeli A, Su H, Huang W, Tang M, Zheng H, Horak K, et al. Alpha B-crystallin suppresses pressure overload cardiac hypertrophy. Circ Res. 2008;103:1473-82 pubmed publisher
    ..and mice with cardiomyocyte-restricted transgenic overexpression of CryAB or with germ-line ablation of the CryAB/HSPB2 genes were subjected to transverse aortic constriction or sham surgery...
  6. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  7. Kadono T, Zhang X, Srinivasan S, Ishida H, Barry W, Benjamin I. CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake. J Mol Cell Cardiol. 2006;40:783-9 pubmed
    Double knockout (DKO) of the small heat shock proteins CRYAB and HSPB2 increases necrosis and apoptosis induced by ischemia/reperfusion (I/R) in vitro, but the mechanisms involved are unknown...
  8. Morozov V, Wawrousek E. Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development. 2006;133:813-21 pubmed
  9. Stetler R, Cao G, Gao Y, Zhang F, Wang S, Weng Z, et al. Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling. J Neurosci. 2008;28:13038-55 pubmed publisher
    Heat shock protein 27 (Hsp27), a recently discovered member of the heat shock protein family, is markedly induced in the brain after cerebral ischemia and other injury states...

More Information


  1. Morrison L, Whittaker R, Klepper R, Wawrousek E, Glembotski C. Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. Am J Physiol Heart Circ Physiol. 2004;286:H847-55 pubmed
    ..The genes for alphaB-crystallin (alphaBC) and HSPB2, two sHSPs that are expressed in high levels in the heart, are in close proximity to one another; as a result, ..
  2. Golenhofen N, Redel A, Wawrousek E, Drenckhahn D. Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium. Pflugers Arch. 2006;451:518-25 pubmed
    The two small heat shock proteins (sHSPs), alphaB-crystallin and HSPB2, have been shown to translocate within a few minutes of cardiac ischemia from the cytosol to myofibrils; and it has been suggested that their chaperone-like ..
  3. Takai S, Tokuda H, Matsushima Nishiwaki R, Hanai Y, Kato K, Kozawa O. Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. J Cell Biochem. 2006;98:1249-56 pubmed
    ..mitogen-activated protein (MAP) kinase plays a part in sphingosine 1-phosphate-stimulated heat shock protein 27 (HSP27) induction in osteoblast-like MC3T3-E1 cells...
  4. Andley U, Song Z, Wawrousek E, Brady J, Bassnett S, Fleming T. Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instability. FASEB J. 2001;15:221-229 pubmed
    ..These observations suggest that the widely distributed molecular chaperone alphaB-crystallin may play an important nuclear role in maintaining genomic integrity. ..
  5. Sharp P, Krishnan M, Pullar O, Navarrete R, Wells D, de Belleroche J. Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function. Exp Neurol. 2006;198:511-8 pubmed
    ..In previous studies, we demonstrated that overexpression of heat shock protein 27 (HSP27) in transgenic mice has significant cytoprotective properties in vivo, reducing caspase-3-mediated cell death in ..
  6. Chen Q, Liu J, Horak K, Zheng H, Kumarapeli A, Li J, et al. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res. 2005;97:1018-26 pubmed
    ..Because of the central role of the UPS in cell regulation and the high intrasarcoplasmic amyloidosis prevalence in failing human hearts, our data suggest a novel pathogenic process in cardiac disorders with abnormal protein aggregation. ..
  7. Lee B, Kim J, Choi J, Lee J, Han S, Kim K, et al. Reconstituted high-density lipoprotein attenuates atherogenesis partly by regulating HSP27 in hyperlipidemic apoE-/- mice. Int J Cardiol. 2013;167:585-7 pubmed publisher
  8. Ishiwata T, Orosz A, Wang X, Mustafi S, Pratt G, Christians E, et al. HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS ONE. 2012;7:e42118 pubmed publisher
    CryAB (HspB5) and HspB2, two small heat shock genes located adjacently in the vertebrate genome, are hypothesized to play distinct roles...
  9. Boyle D, Takemoto L, Brady J, Wawrousek E. Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol. 2003;3:3 pubmed
    ..These results indicated that both alpha A- and alpha B-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation. ..
  10. Andley U, Malone J, Hamilton P, Ravi N, Townsend R. Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins ?A- and ?B-crystallin. Biochemistry. 2013;52:2933-48 pubmed publisher
  11. Meeson A, Radford N, Shelton J, Mammen P, DiMaio J, Hutcheson K, et al. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001;88:713-20 pubmed
  12. Wei L, Liu T, Wang H, Hong H, Yu A, Feng H, et al. Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-?B. Breast Cancer Res. 2011;13:R101 pubmed publisher
    ..The expression of Hsp27, an ATP-independent small HSP, is associated with cell migration and drug resistance of breast cancer cells...
  13. Zheng C, Lin Z, Zhao Z, Yang Y, Niu H, Shen X. MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27. J Biol Chem. 2006;281:37215-26 pubmed
    The p38 MAPK and heat shock protein 27 (hsp27) form a signaling complex with serine/threonine kinase Akt and MAPK-activated protein kinase-2 (MK2), which plays an important role in controlling stress-induced apoptosis and reorganizing ..
  14. Kato K, Tokuda H, Adachi S, Matsushima Nishiwaki R, Yamauchi J, Natsume H, et al. Role of heat shock protein 27 in transforming growth factor-?-stimulated vascular endothelial growth factor release in osteoblasts. Int J Mol Med. 2011;27:423-8 pubmed publisher
    We have previously reported that transforming growth factor-? (TGF-?) stimulates heat shock protein 27 (HSP27) induction via p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP kinase and stress-activated protein kinase/c-Jun N-..
  15. Gao Z, Zhang J, Li L, Shen L, Li Q, Zou Y, et al. Heat shock proteins 27 and 70 contribute to the protection of Schisandrin B against d-galactosamine-induced liver injury in mice. Can J Physiol Pharmacol. 2016;94:373-8 pubmed publisher
    ..Heat shock proteins 27 and 70 were involved in the protective effect of Schisandrin B against d-galactosamine-induced liver injury in mice. ..
  16. Efthymiou C, Mocanu M, de Belleroche J, Wells D, Latchmann D, Yellon D. Heat shock protein 27 protects the heart against myocardial infarction. Basic Res Cardiol. 2004;99:392-4 pubmed
    ..It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ..
  17. Dou G, Sreekumar P, Spee C, He S, Ryan S, Kannan R, et al. Deficiency of ?B crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012;53:1111-22 pubmed publisher
    ..Thus, these data collectively demonstrate that ?B crystallin provides critical protection of mitochondrial function during ER stress-induced RPE apoptosis. ..
  18. Zahari M, Wu X, Pinto S, Nirujogi R, Kim M, Fetics B, et al. Phosphoproteomic profiling of tumor tissues identifies HSP27 Ser82 phosphorylation as a robust marker of early ischemia. Sci Rep. 2015;5:13660 pubmed publisher
    ..The phosphorylation of one of these sites, S82 of the heat shock protein 27 kDa (HSP27), was especially abundant and consistently upregulated in tissues with delays in freezing as short as 2 ..
  19. Bai F, Xi J, Wawrousek E, Fleming T, Andley U. Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice. J Biol Chem. 2003;278:36876-86 pubmed
    ..These results suggest that the stress protein and molecular chaperone alphaB-crystallin protects cells from acquiring impaired p53 protein and genomic instability. ..
  20. Ojha J, Karmegam R, Masilamoni J, Terry A, Cashikar A. Behavioral defects in chaperone-deficient Alzheimer's disease model mice. PLoS ONE. 2011;6:e16550 pubmed publisher
    ..We hypothesized that ?B-crystallin protects cells against A? toxicity. To test this, we crossed ?B-crystallin/HspB2 deficient (CRYAB?/?HSPB2?/?) mice with AD model transgenic mice expressing mutant human amyloid precursor protein...
  21. Swamynathan S, Piatigorsky J. Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genes. J Biol Chem. 2002;277:49700-6 pubmed
    The mouse Shsp/alphaB-crystallin and Mkbp/HspB2 genes are closely linked and divergently transcribed...
  22. Yaung J, Kannan R, Wawrousek E, Spee C, Sreekumar P, Hinton D. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res. 2008;86:355-65 pubmed publisher
    ..We conclude that lack of alpha-crystallins accentuates retinal degeneration in chemically induced hypoxia in vivo. ..
  23. Akbar M, Lundberg A, Liu K, Vidyadaran S, Wells K, Dolatshad H, et al. The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem. 2003;278:19956-65 pubmed
    The 27-kDa heat shock protein (HSP27) has a potent ability to increase cell survival in response to a wide range of cellular challenges...
  24. Bai F, Xi J, Andley U. Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis. 2007;13:1589-600 pubmed
    ..In the present study we examined the expression of the brain microtubule associated protein tau in lenses of alpha-crystallin gene knockout mice...
  25. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, et al. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010;115:3398-406 pubmed publisher
    ..Our studies indicate an important role for alphaB-crystallin as a chaperone for VEGF-A in angiogenesis and its potential as a therapeutic target. ..
  26. Krishnan J, Lemmens R, Robberecht W, van den Bosch L. Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death. Exp Neurol. 2006;200:301-10 pubmed
    ..In order to investigate the role of Hsp27 in mutant SOD1-dependent cell death, we used mutant and wild type SOD1 overexpressing N2a mouse neuroblastoma ..
  27. Ousman S, Tomooka B, van Noort J, Wawrousek E, O Connor K, Hafler D, et al. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 2007;448:474-9 pubmed
    ..Thus, the immune response against a negative regulator of inflammation, CRYAB, in multiple sclerosis, would exacerbate inflammation and demyelination. This can be countered by giving CRYAB itself for therapy of ongoing disease. ..
  28. Leak R, Zhang L, Stetler R, Weng Z, Li P, Atkins G, et al. HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity. CNS Neurol Disord Drug Targets. 2013;12:325-37 pubmed
    ..We previously demonstrated that the phylogenetically conserved small heat shock protein 27 (HSP27) protects against transient middle cerebral artery occlusion (tMCAO)...
  29. Raizman J, Chen Y, Seibert T, Hibbert B, Cuerrier C, Salari S, et al. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-?B signaling. Biochim Biophys Acta. 2013;1831:1721-8 pubmed publisher
    Previously, we showed an inverse correlation between HSP27 serum levels and experimental atherogenesis in ApoE(-/-) mice that over-express HSP27 and speculated that the apparent binding of HSP27 to scavenger receptor-A (SR-A) was of ..
  30. Suzuki A, Yamaguchi Y, Hoshi T, Hayashi A, Baba H. Differential inductions of small heat shock protein 27 and 1-Cys peroxiredoxin in reactive astrocytes in sulfatide-deficient mouse spinal cord. J Neurosci Res. 2007;85:1921-32 pubmed
    ..Interestingly, heat shock protein 27 (Hsp27) and 1-cys peroxiredoxin (1-Cys Prx) were both elevated in CST KO mice...
  31. Toth M, Szegedi V, Varga E, Juhasz G, Horváth J, Borbély E, et al. Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice. Cell Stress Chaperones. 2013;18:759-71 pubmed publisher
    b>Hsp27 belongs to the small heat shock protein family, which are ATP-independent chaperones...
  32. Lin S, Lee Y, Wang J, Miller S, Chiou S, Hung M, et al. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE. 2012;7:e49605 pubmed publisher
    ..Moreover, via screening a panel of tyrosine and serine/threonine kinase pathways, we identified Hsp27 is constitutively activated in CD133+ cells rather than CD133- cell under hypoxia and serum depletion conditions...
  33. Hagemann T, Boelens W, Wawrousek E, Messing A. Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet. 2009;18:1190-9 pubmed publisher
    ..and formation of Rosenthal fibers, complex astrocytic inclusions that contain GFAP, vimentin, plectin, ubiquitin, Hsp27 and alphaB-crystallin...
  34. Minamitani C, Otsuka T, Takai S, Matsushima Nishiwaki R, Adachi S, Hanai Y, et al. Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. Int J Mol Med. 2009;24:77-82 pubmed
    ..present study, we investigated whether Rho-kinase is implicated in sphingosine 1-phosphate-stimulated induction of HSP27 in MC3T3-E1 cells...
  35. Liu S, Yan B, Lai W, Chen L, Xiao D, Xi S, et al. As a novel p53 direct target, bidirectional gene HspB2/?B-crystallin regulates the ROS level and Warburg effect. Biochim Biophys Acta. 2014;1839:592-603 pubmed publisher
    ..Here, we report that bidirectional gene pair HspB2/?B-crystallin, both of which are members of the small heat shock protein gene family, is a novel direct target ..
  36. Dávila D, Jiménez Mateos E, Mooney C, Velasco G, Henshall D, Prehn J. Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism. Mol Biol Cell. 2014;25:3413-23 pubmed publisher
    ..Here we demonstrate that heat shock protein 27 (Hsp27) prevents oxidative stress-induced cell death in cerebellar granule neurons by specific regulation of the mRNA for ..
  37. Li F, Zhang M, Hussain F, Triantaphyllopoulos K, Clark A, Bhavsar P, et al. Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J. 2011;37:933-42 pubmed publisher
    ..p38 MAPK plays a role in maximal ACh-induced isometric contractile responses and increased contractility induced by ozone. Dexamethasone inhibits ACh-induced ASM contraction through phosphorylation of p38 MAPK and HSP27.
  38. Jones T, Adapala R, Geldenhuys W, Bursley C, AbouAlaiwi W, Nauli S, et al. Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization. J Cell Physiol. 2012;227:70-6 pubmed publisher
    ..Finally, we found that the expression of heat shock protein 27 (hsp27) and the phosphorylation of focal adhesion kinase (FAK) are downregulated in the Tg737(orpk/orpk) cells and ..
  39. Cuerrier C, Chen Y, Tremblay D, Rayner K, McNulty M, Zhao X, et al. Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. PLoS ONE. 2013;8:e55867 pubmed publisher
    Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis...
  40. Shao W, Zhang S, Tang M, Zhang X, Zhou Z, Yin Y, et al. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via ?B-crystallin. Nature. 2013;494:90-4 pubmed publisher
  41. Shen L, Qi Z, Zhu Y, Song X, Xuan C, Ben P, et al. Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy. Cell Signal. 2016;28:1086-98 pubmed publisher
    ..Heat shock protein 27 (Hsp27) is involved in autophagy in response to various stimuli...
  42. Xi J, Bai F, McGaha R, Andley U. Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J. 2006;20:846-57 pubmed
    ..SDS-PAGE analysis showed that alpha-crystallin prevented heat-induced aggregation of tubulin, suggesting that alpha-crystallin may affect microtubule assembly by maintaining the pool of unassembled tubulin. ..
  43. Vidyasagar A, Reese S, Hafez O, Huang L, Swain W, Jacobson L, et al. Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy. Kidney Int. 2013;83:84-92 pubmed publisher
    ..Here we tested whether heat-shock protein 27 (HSP27), a small stress response protein involved in cytoskeletal remodeling, protects the kidney from tubulointerstitial ..
  44. Ebert M, Schafer C, Chen J, Hoffmann J, Gu P, Kubisch C, et al. Protective role of heat shock protein 27 in gastric mucosal injury. J Pathol. 2005;207:177-84 pubmed
    Heat shock protein 27 (HSP27) mediates cytoprotective effects through its function as a molecular chaperone and through the phosphorylation-dependent stabilization of actin filaments...
  45. Cheng C, Xia C, Huang Q, Ding L, Horwitz J, Gong X. Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis. J Biol Chem. 2010;285:41187-93 pubmed publisher
    ..Crystallins with different chaperone-like activities are likely required in the lens cortex and nucleus for maintaining transparency. ..
  46. Arac A, Brownell S, Rothbard J, Chen C, Ko R, Pereira M, et al. Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation. Proc Natl Acad Sci U S A. 2011;108:13287-92 pubmed publisher
    ..Cryab is an endogenous anti-inflammatory and neuroprotectant molecule produced after stroke, whose beneficial properties can be augmented when administered therapeutically after stroke. ..
  47. Stetler R, Gao Y, Zhang L, Weng Z, Zhang F, Hu X, et al. Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury. J Neurosci. 2012;32:2667-82 pubmed publisher
    Heat shock protein 27 (HSP27) (or HSPB1) exerts cytoprotection against many cellular insults, including cerebral ischemia...
  48. Choi M, Jung K, Park J, Das N, Chung M, Choi I, et al. Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells. Arch Toxicol. 2011;85:293-304 pubmed publisher
    ..to cell adhesion, including Cadm1, Ncam1, and Ncam2; and genes encoding small heat shock proteins, including HspB2, HspB7, and HspB8...
  49. Ham A, Kim M, Kim J, Brown K, Fruttiger M, D Agati V, et al. Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia-reperfusion injury. Kidney Int. 2014;85:807-23 pubmed publisher
    ..mechanism for exacerbated renal injury, conditional endothelial S1P1R-null mice had markedly reduced endothelial HSP27 expression compared with wild-type mice...
  50. O Shaughnessy R, Welti J, Cooke J, Avilion A, Monks B, Birnbaum M, et al. AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation. J Biol Chem. 2007;282:17297-305 pubmed
    ..This work demonstrates a new role for Akt in epidermis. ..
  51. Saito S, Nakano K, Nabeyama A, Sato M, Okafuji N, Yamamoto A, et al. Immunohistochemical expression of heat shock protein27 in the mouse dental pulp after immediate teeth separation. Eur J Med Res. 2011;16:495-500 pubmed
    After immediate teeth separation, expression of HSP27 in the mouse dental pulp was examined. Immunohistochemistry was performed to examine the incidence of HSP27 expression...
  52. Shao Z, Sharp W, Wojcik K, Li C, Han M, Chang W, et al. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol. 2010;298:H2164-73 pubmed publisher
    ..Phospho (p)-Akt (Thr308), p-Akt (Ser473), and phosphorylated heat shock protein 27 (p-HSP27) (Ser82) were analyzed by Western blot analysis...
  53. Li L, Zhang T, Zhou L, Xing G, Chen Y, Xin Y. Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice. J Gastroenterol Hepatol. 2014;29:640-7 pubmed publisher
    ..blot and real-time quantitative polymerase chain reaction were used to detect the protein and gene expression of HSP27 and HSP70, respectively; the liver tissues were subjected to histological evaluation, and alanine aminotransferase ..
  54. Sharp P, Akbar M, Bouri S, Senda A, Joshi K, Chen H, et al. Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiol Dis. 2008;30:42-55 pubmed publisher
    ..To investigate the therapeutic potential of heat shock protein 27 (HSP27) in a mouse model of ALS, we conducted an extensive characterisation of transgenic mice generated from a cross ..
  55. Swamynathan S, Piatigorsky J. Regulation of the mouse alphaB-crystallin and MKBP/HspB2 promoter activities by shared and gene specific intergenic elements: the importance of context dependency. Int J Dev Biol. 2007;51:689-700 pubmed
    The closely linked (863 bp), divergently arranged mouse myotonic dystrophy kinase binding protein (Mkbp)/HspB2 and small heat shock protein (shsp)/alphaB-crystallin genes have different patterns of tissue-specific expression...
  56. Dimberg A, Rylova S, Dieterich L, Olsson A, Schiller P, Wikner C, et al. alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis. Blood. 2008;111:2015-23 pubmed
    ..Hereby we identify the small heat shock protein family as a novel class of angiogenic modulators. ..
  57. Strey C, Spellman D, Stieber A, Gonatas J, Wang X, Lambris J, et al. Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol. 2004;165:1701-18 pubmed
    ..The up-regulation of peroxiredoxin 6 probably constitutes a defense to oxidative stress induced by SOD1(G93A). Direct effects of SOD1(G93A) or sequential reactions triggered by the mutant may cause the protein changes. ..
  58. Whiston E, Sugi N, Kamradt M, Sack C, Heimer S, Engelbert M, et al. alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis. Infect Immun. 2008;76:1781-90 pubmed publisher
    ..We conclude that alphaB-crystallin is important in protecting sensitive retinal tissue during destructive inflammation that occurs during bacterial endophthalmitis. ..
  59. Kubisch C, DiMagno M, Tietz A, Welsh M, Ernst S, Brandt Nedelev B, et al. Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis. Gastroenterology. 2004;127:275-86 pubmed
    Heat shock protein (Hsp) 27 regulates actin cytoskeletal dynamics, and overexpression of Hsp27 in fibroblasts protects against stress in a phosphorylation-dependent manner...
  60. Yusuf N, Nasti T, Ahmad I, Chowdhury S, Mohiuddin H, Xu H, et al. In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical. J Immunol. 2015;194:4796-803 pubmed publisher
    Heat shock proteins (HSPs) are constitutively expressed in murine skin. HSP27 is present in the epidermis, and HSP70 can be found in both the epidermis and dermis...
  61. Farooqui Kabir S, Diss J, Henderson D, Marber M, Latchman D, Budhram Mahadeo V, et al. Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones. 2008;13:297-312 pubmed publisher
    ..a critical role in regulating expression of genes that control cell fate, including the small heat shock protein Hsp27. The aim of this study was to investigate the relationship between Brn-3a and Brn-3b and Hsp27 expression in the ..
  62. Liu J, Zhang D, Mi X, Xia Q, Yu Y, Zuo Z, et al. p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. J Biol Chem. 2010;285:26058-65 pubmed publisher
    ..depletion of p27 expression by either gene knock-out or knockdown approaches resulted in up-regulation of both Hsp27 and Hsp70 expression at mRNA- and promoter-derived transcription as well as protein levels upon arsenite exposure, ..
  63. Youn B, Lepock J, Borrelli M, Jervis E. In vivo resolution of oligomers with fluorescence photobleaching recovery histograms. Cell Stress Chaperones. 2006;11:170-9 pubmed
    ..Given that oligomerization is often a means of regulation, compartmentalization of different oligomer species could provide a means for efficient regulation and localization of sHsp27 activity. ..
  64. Vleminckx V, Van Damme P, Goffin K, Delye H, Van Den Bosch L, Robberecht W. Upregulation of HSP27 in a transgenic model of ALS. J Neuropathol Exp Neurol. 2002;61:968-74 pubmed
    ..We studied the expression of 3 HSPs (alphaB-crystallin, HSP27, and HSP70) in transgenic mice overexpressing human mutant (G93A and G37R) SOD1, using a combination of ..
  65. Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, et al. Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts. J Cell Biochem. 2002;86:357-64 pubmed
    ..In the present study, we investigated whether glucocorticoid induces HSP27, HSP70, and HSP90 in osteoblast-like MC3T3-E1 cells...
  66. Liu J, Ma X, Cai L, Cui Y, Liu J. Downregulation of both gene expression and activity of Hsp27 improved maturation of mouse oocyte in vitro. Reprod Biol Endocrinol. 2010;8:47 pubmed publisher
    Heat shock protein 27 (Hsp27), a member of the small heat shock protein family, is an apoptosis regulator...
  67. Karch C, Borchelt D. An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis. J Neurochem. 2010;113:1092-100 pubmed publisher
    ..These outcomes have implications regarding the role of chaperones in modulating the tissue specific accumulations of misfolded SOD1. ..
  68. Yusuf N, Nasti T, Huang C, Huber B, Jaleel T, Lin H, et al. Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. J Immunol. 2009;182:675-83 pubmed
    ..Using murine allergic contact hypersensitivity as a model, we investigated the role of two heat shock proteins, HSP27 and HSP70, in the induction of cutaneous cell-mediated immune responses...
  69. Liu L, Zhang X, Qian B, Min X, Gao X, Li C, et al. Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. Eur J Heart Fail. 2007;9:762-9 pubmed
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