Gene Symbol: Hspa8
Description: heat shock protein 8
Alias: 2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10, heat shock cognate 71 kDa protein, heat shock 70 kDa protein 8, heat shock 70kD protein 8, heat shock cognate hsc73, heat shock protein cognate 70
Species: mouse
Products:     Hspa8

Top Publications

  1. Yamagishi N, Ishihara K, Saito Y, Hatayama T. Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP. FEBS Lett. 2003;555:390-6 pubmed
    ..In contrast, Hsc70/Hsp40 suppressed the aggregation of heat-denatured protein in the presence of ATP rather than ADP...
  2. Watanabe K, Tachibana M, Kim S, Watarai M. Participation of ezrin in bacterial uptake by trophoblast giant cells. Reprod Biol Endocrinol. 2009;7:95 pubmed publisher
    ..We previously reported that heat shock cognate protein 70 (Hsc70) present on the surface of TG cells mediated the uptake of Brucella abortus...
  3. Watanabe K, Tachibana M, Tanaka S, Furuoka H, Horiuchi M, Suzuki H, et al. Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion. BMC Microbiol. 2008;8:212 pubmed publisher
    ..In the present study, we investigated mechanism of B. abortus invasion into TG cells...
  4. Dokladny K, Lobb R, Wharton W, Ma T, Moseley P. LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB. Cell Stress Chaperones. 2010;15:153-63 pubmed publisher
    ..We conclude that the effects of heat stress-induced increase in HSP70 protein expression on LPS-induced cytokine elaboration in whole animals can be reproduced by the actions of a single gene product. ..
  5. Radovanac K, Morgner J, Schulz J, Blumbach K, Patterson C, Geiger T, et al. Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBO J. 2013;32:1409-24 pubmed publisher
    ..Together, our results uncover how Hsp90 regulates ILK stability and identify a potential therapeutic strategy to alleviate fibrotic diseases. ..
  6. Vijayaraj P, Kröger C, Reuter U, Windoffer R, Leube R, Magin T. Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol. 2009;187:175-84 pubmed publisher
    ..Our findings demonstrate a novel keratin function upstream of mTOR signaling via GLUT localization and have implications for pathomechanisms and therapy approaches for keratin disorders and the analysis of other gene families. ..
  7. Ryu J, Kim H, Lee S, Chang E, Kim H, Kim H. Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function. Proteomics. 2005;5:4152-60 pubmed
    ..Our study identified V-ATPase as a TRAF6-binding protein using a proteomics strategy and proved a direct link between these two important molecules for osteoclast function. ..
  8. Kaur G, Lieu K, Jans D. 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY. J Biol Chem. 2013;288:4148-57 pubmed publisher
    ..Here, we show, for the first time, that the 70-kDa heat shock cognate protein hsc70 plays a key role in CaM-dependent nuclear import of SRY...
  9. Notsu K, Nakagawa M, Nakamura M. Ubiquitin-like protein MNSF? noncovalently binds to molecular chaperone HSPA8 and regulates osteoclastogenesis. Mol Cell Biochem. 2016;421:149-56 pubmed publisher
    ..MALDI-TOF MS fingerprinting revealed that the MNSF?-interacting protein is HSPA8 (heat shock 70-kDa protein 8). We observed that MNSF? noncovalently binds to HSPA8 in the presence of ATP in vitro...

More Information


  1. Morozova K, Clement C, Kaushik S, Stiller B, Arias E, Ahmad A, et al. Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. J Biol Chem. 2016;291:18096-106 pubmed publisher
    hsc-70 (HSPA8) is a cytosolic molecular chaperone, which plays a central role in cellular proteostasis, including quality control during protein refolding and regulation of protein degradation...
  2. Alejandre Alcazar M, Michiels Corsten M, Vicencio A, Reiss I, Ryu J, de Krijger R, et al. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn. 2008;237:259-69 pubmed
    ..These data suggest that active TGF-beta signaling is required for normal late lung development. ..
  3. Fontaine S, Zheng D, Sabbagh J, Martin M, Chaput D, Darling A, et al. DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins. EMBO J. 2016;35:1537-49 pubmed publisher
    ..The interaction of neurodegenerative disease-associated proteins with the molecular chaperone Hsc70 is well known, and we hypothesized that much like disaggregation, refolding, degradation, and even normal function,..
  4. Vega I, Traverso E, Ferrer Acosta Y, Matos E, Colon M, Gonzalez J, et al. A novel calcium-binding protein is associated with tau proteins in tauopathy. J Neurochem. 2008;106:96-106 pubmed publisher
  5. Posokhova E, Uversky V, Martemyanov K. Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis. J Proteome Res. 2010;9:1510-21 pubmed publisher
    ..In this study, we report an identification of molecular chaperone Hsc70 (Heat shock cognate protein 70) as a critical mediator of RGS9-2 expression that is specifically recruited to the ..
  6. Ryu J, Vicencio A, Yeager M, Kashgarian M, Haddad G, Eickelberg O. Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost. 2005;94:175-83 pubmed
    ..MMP-2, TIMP-2, and TIMP-3 may be key regulatory enzymes during lung development, possibly through their complex action on ECM components, membrane receptor ectodomain shedding, and growth factor bioactivity. ..
  7. Loones M, Morange M. Hsp and chaperone distribution during endochondral bone development in mouse embryo. Cell Stress Chaperones. 1998;3:237-44 pubmed
    ..The involvement of chaperones during these important differentiation steps will be discussed. ..
  8. Liu J, Maxwell E. Mouse U14 snRNA is encoded in an intron of the mouse cognate hsc70 heat shock gene. Nucleic Acids Res. 1990;18:6565-71 pubmed
    ..the presence of three U14 snRNA-homologous regions positioned within introns 5, 6, and 8 of the mouse cognate hsc70 heat shock gene...
  9. Yu A, Shibata Y, Shah B, Calamini B, Lo D, Morimoto R. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A. 2014;111:E1481-90 pubmed publisher
    ..mammalian cells by aggregate-driven sequestration of the major molecular chaperone heat shock cognate protein 70 (HSC70), which is required to drive multiple steps of CME...
  10. Adhikari A, Sridhar Rao K, Rangaraj N, Parnaik V, Mohan Rao C. Heat stress-induced localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for alphaB-crystallin and Hsp25. Exp Cell Res. 2004;299:393-403 pubmed
    We examined the effect of heat stress on localization of two sHsps, alphaB-crystallin and Hsp25, and of Hsc70, a member of a different class of heat shock proteins (Hsps), in both undifferentiated and differentiated mouse C2C12 cells...
  11. Singh V, Finke Isami J, Hopper Chidlaw A, Schwerk P, Thompson A, Tedin K. Salmonella Co-opts Host Cell Chaperone-mediated Autophagy for Intracellular Growth. J Biol Chem. 2017;292:1847-1864 pubmed publisher
    ..Here, we show that intracellular Salmonella recruit the host proteins LAMP-2A and Hsc73, key components of the host protein turnover pathway known as chaperone-mediated autophagy involved in transport ..
  12. Liu Y, Hogan B. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002;2:229-33 pubmed
    ..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization. ..
  13. Wang J, Farr G, Zeiss C, Rodriguez Gil D, Wilson J, Furtak K, et al. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009;106:1392-7 pubmed publisher
    ..and mass spectrometry revealed association of G85R SOD-YFP, but not WT SOD-YFP, with the cytosolic chaperone Hsc70 at all ages. In addition, 3 Hsp110's, nucleotide exchange factors for Hsp70s, were captured at 6 and 9 months...
  14. Elliott E, Tsvetkov P, Ginzburg I. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem. 2007;282:37276-84 pubmed
    ..Hsp70/Hsc70, a member of the chaperone protein family, interacts with Tau protein and mediates proper folding of Tau and can ..
  15. Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 2011;108:458-68 pubmed publisher
    ..Heat shock protein (Hsp)70 is known to promote maturation of hERG. Hsp70 and heat shock cognate (Hsc70) 70 has been suggested to play a similar function. However, Hsc70 has recently been reported to counteract Hsp70...
  16. Geng J, Li H, Huang C, Chai J, Zheng R, Li F, et al. Functional analysis of HSPA1A and HSPA8 in parturition. Biochem Biophys Res Commun. 2017;483:371-379 pubmed publisher
    ..for regulating parturition, we overexpressed and knocked down two representative members of HSP70 (HSPA1A and HSPA8) through transfection of their recombinant plasmid and si-RNA separately in WISH (human amniotic epithelial) cells...
  17. Maxwell E, Martin T. A low-molecular-weight RNA from mouse ascites cells that hybridizes to both 18S rRNA and mRNA sequences. Proc Natl Acad Sci U S A. 1986;83:7261-5 pubmed
    ..The complementary and homologous character of hybridizing RNA with respect to rRNA and mRNA sequences suggests a potential regulatory role for this RNA in the coupling of ribosome and mRNA functions. ..
  18. Wilhelmsen K, Copp J, Glenn G, Hoffman R, Tucker P, van der Geer P. Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents. Mol Cell Proteomics. 2004;3:887-95 pubmed
    ..Novel protein-protein interactions may provide useful targets for the development of drugs that interfere with the activation of signaling cascades used by protein-tyrosine kinases to turn on cell division. ..
  19. Yildirim A, Bulau P, Zakrzewicz D, Kitowska K, Weissmann N, Grimminger F, et al. Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol. 2006;35:436-43 pubmed
    ..These data suggest that structural and functional changes caused by hypoxia may be linked to ADMA metabolism. ..
  20. Li P, Kurata Y, Maharani N, Mahati E, Higaki K, Hasegawa A, et al. E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in mammalian cells. J Mol Cell Cardiol. 2015;86:138-46 pubmed publisher
    ..Immunoprecipitation showed that CHIP formed complexes with Kv1.5 proteins and heat shock cognate protein 70 (Hsc70). Effects of Hsc70 on Kv1.5 were similar to CHIP by altering interaction of CHIP with Kv1.5 protein...
  21. Yamagishi N, Ishihara K, Hatayama T. Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity. J Biol Chem. 2004;279:41727-33 pubmed
    ..Hsp105alpha associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo...
  22. Leverette R, Andrews M, Maxwell E. Mouse U14 snRNA is a processed intron of the cognate hsc70 heat shock pre-messenger RNA. Cell. 1992;71:1215-21 pubmed
    ..snRNA genes are positioned within introns 5, 6, and 8 on the coding strand of the constitutively expressed cognate hsc70 heat shock gene...
  23. Shiota M, Kusakabe H, Izumi Y, Hikita Y, Nakao T, Funae Y, et al. Heat shock cognate protein 70 is essential for Akt signaling in endothelial function. Arterioscler Thromb Vasc Biol. 2010;30:491-7 pubmed publisher
    ..Herein, we investigate the role of Hsp70s, including heat shock cognate protein 70 (Hsc70), which is constitutively expressed in nonstressed cells (ie, ECs)...
  24. Wang G, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003;36:48-61 pubmed
    ..These findings suggest that hsf2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production. ..
  25. Terada S, Kinjo M, Aihara M, Takei Y, Hirokawa N. Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport. EMBO J. 2010;29:843-54 pubmed publisher
    ..on the interaction between the DnaJ-like domain of the kinesin light chain in the Kinesin-1 motor complex and Hsc70, scaffolding between cytoplasmic proteins and Kinesin-1...
  26. Yim Y, Sun T, Wu L, Raimondi A, De Camilli P, Eisenberg E, et al. Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci U S A. 2010;107:4412-7 pubmed publisher
    ..expressed cyclin-G-dependent kinase (GAK) are homologous proteins that act as cochaperones to support the Hsc70-dependent clathrin uncoating of clathrin-coated vesicles...
  27. Hatayama T, Yasuda K. Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. Biochem Biophys Res Commun. 1998;248:395-401 pubmed
    ..The association of HSP105 with HSC70 was shown by immunoprecipitation using anti-HSP105 antibody...
  28. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches. ..
  29. Gunther E, Walter L. Genetic aspects of the hsp70 multigene family in vertebrates. Experientia. 1994;50:987-1001 pubmed
    ..After a detailed description of the various hsp70 genes more general characteristics of the organization and evolution of the multigene family are discussed. ..
  30. Sharma M, Burr J, S dhof T. CSP? promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol. 2011;13:30-9 pubmed publisher
    ..The protein CSP? resides in presynaptic terminals, where it forms a chaperone complex with Hsc70 and SGT. Deletion of CSP? results in massive neurodegeneration that impairs survival in mice and flies...
  31. Alpi E, Landi E, Barilari M, Serresi M, Salvadori P, Bachi A, et al. Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics. Biochem J. 2009;419:289-300 pubmed publisher
    ..Analysis of the puncta nature, using various endocytic markers, revealed that they are not related to cytoplasmic vesicles, but rather represent multi-protein assemblies, where CIPP can tether other potential interactors. ..
  32. Machado P, Rostaing P, Guigonis J, Renner M, Dumoulin A, Samson M, et al. Heat shock cognate protein 70 regulates gephyrin clustering. J Neurosci. 2011;31:3-14 pubmed publisher
    ..We found that heat shock cognate protein 70 (Hsc70), a constitutive member of the heat shock protein 70 (Hsp70) family, selectively binds to the gephyrin G-domain...
  33. Ngalame N, Micciche A, Feil M, States J. Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure. Toxicol Sci. 2013;131:225-33 pubmed publisher
    ..Earlier microarray analyses showed prenatal arsenic exposure increased Hsc70 (HspA8) and Hsp70 (HspA1a) mRNAs in livers of 10-week-old mice...
  34. Park B, Yim Y, Zhao X, Olszewski M, Eisenberg E, Greene L. The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain. J Cell Sci. 2015;128:3811-21 pubmed publisher
    ..protein, is essential for the chaperoning and uncoating of clathrin that is mediated by Hsc70 (also known as HSPA8)...
  35. Shanab G, Maxwell E. Determination of the nucleotide sequences in mouse U14 small nuclear RNA and 18S ribosomal RNA responsible for in vitro intermolecular base-pairing. Eur J Biochem. 1992;206:391-400 pubmed
    ..However, the strong evolutionary conservation of both U14-snRNA.18S-rRNA hybrid structures and their juxtapositioning within the folded secondary structure of 18S rRNAs argues for a biological role for each in U14 snRNA function. ..
  36. Lee J, Beebe K, Nangle L, Jang J, Longo Guess C, Cook S, et al. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443:50-5 pubmed
    ..These findings demonstrate that disruption of translational fidelity in terminally differentiated neurons leads to the accumulation of misfolded proteins and cell death, and provide a novel mechanism underlying neurodegeneration. ..
  37. Frydman J, Hohfeld J. Chaperones get in touch: the Hip-Hop connection. Trends Biochem Sci. 1997;22:87-92 pubmed
    ..cooperation are now emerging from studies on the regulation of certain signal transduction pathways mediated by Hsc70 and Hsp90 in the eukaryotic cytosol...
  38. Ishiguro T, Nakajima M, Naito M, Muto T, Tsuruo T. Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials. Cancer Res. 1996;56:875-9 pubmed
    ..TI-241 may regulate the expression of various genes as a transcription factor in the complex process of metastasis. ..
  39. Yamaza H, Matsuo K, Kiyoshima T, Shigemura N, Kobayashi I, Wada H, et al. Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Int J Dev Biol. 2001;45:675-80 pubmed
    ..reverse transcription-polymerase chain reaction (RT-PCR), we thus found Pgk-1, Ccte, Hsp86, Nucleolin, Hsc73, Frg1, N-ras, Set alpha and Hsj2 from the E10...
  40. Diehl J, Yang W, Rimerman R, Xiao H, Emili A. Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol. 2003;23:1764-74 pubmed
    ..In this report, we describe the identification of Hsc70 and its functional importance for cyclin D1 and cyclin D1-dependent kinase maturation...
  41. Kaushik S, Cuervo A. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17:759-70 pubmed publisher
    ..We propose a role for CMA in LD biology and in the maintenance of lipid homeostasis. ..
  42. Takayama S, Bimston D, Matsuzawa S, Freeman B, Aime Sempe C, Xie Z, et al. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 1997;16:4887-96 pubmed
    ..We present evidence that the protein BAG-1 is a potential modulator of the molecular chaperones, Hsp70 and Hsc70. BAG-1 binds to the ATPase domain of Hsp70 and Hsc70, without requirement for their carboxy-terminal peptide-..
  43. Soulier S, Vilotte J, L Huillier P, Mercier J. Developmental regulation of murine integrin beta 1 subunit- and Hsc73-encoding genes in mammary gland: sequence of a new mouse Hsc73 cDNA. Gene. 1996;172:285-9 pubmed
    A partial integrin beta 1 subunit-encoding cDNA (Itg beta 1) and a new heat-shock protein 70-like-encoding cDNA (Hsc73) homologous to rat Hsc73 were cloned by differential display and RT-PCR from mouse mammary gland...
  44. Urquhart K, Zhao Y, Baker J, Lu Y, Yan L, Cook M, et al. A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors. Neurogenetics. 2016;17:91-105 pubmed publisher
    ..Heat shock protein alpha 8 (Hspa8) is a molecular chaperone and member of the heat shock protein family that plays an integral role in the stress ..
  45. Stanhill A, Haynes C, Zhang Y, Min G, Steele M, Kalinina J, et al. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol Cell. 2006;23:875-85 pubmed
    ..These features include enhanced cleavage of peptide substrates and suggest that AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin. ..
  46. Jana N, Tanaka M, Wang G, Nukina N. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet. 2000;9:2009-18 pubmed
    ..Of these interacting chaperones, only Hdj-2 and Hsc70 frequently (Hdj-2 > Hsc70) co-localize with both the aggregates in the cellular model and with the NIs in the ..
  47. Callahan M, Chaillot D, Jacquin C, Clark P, Menoret A. Differential acquisition of antigenic peptides by Hsp70 and Hsc70 under oxidative conditions. J Biol Chem. 2002;277:33604-9 pubmed
    Hsp70 and Hsc70 are two chaperones of high homology expressed under contrasting situations...
  48. Eriksson M, Jokinen E, Sistonen L, Leppa S. Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000;44:471-7 pubmed
    ..Taken together, our results indicate that HSF2 activation is associated with specific stages of heart formation but is not involved in the regulation of inducible heat shock gene expression. ..
  49. Giebel L, Dworniczak B, Bautz E. Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988;125:200-7 pubmed
    Multiple heat shock cognate (hsc70) cDNA clones were isolated from the mouse embryonal carcinoma cell line F9...
  50. Zhang X, Heckmann B, Xie X, Saarinen A, Liu J. Regulation of FSP27 protein stability by AMPK and HSC70. Am J Physiol Endocrinol Metab. 2014;307:E1047-56 pubmed publisher
    ..Furthermore, mass spectrometry-based proteomic analysis identified heat shock cognate 70 (HSC70) as a novel binding protein of FSP27...
  51. Sahu R, Kaushik S, Clement C, Cannizzo E, Scharf B, Follenzi A, et al. Microautophagy of cytosolic proteins by late endosomes. Dev Cell. 2011;20:131-9 pubmed publisher
    ..Protein cargo selection is mediated by the chaperone hsc70 and requires the cationic domain of hsc70 for electrostatic interactions with the endosomal membrane...
  52. Barbhaiya H, Leverette R, Liu J, Maxwell E. Processing of U14 small nucleolar RNA from three different introns of the mouse 70-kDa-cognate-heat-shock-protein pre-messenger RNA. Eur J Biochem. 1994;226:765-71 pubmed
    ..and trout are encoded within introns of the constitutively expressed 70-kDa-cognate-heat-shock protein gene (hsc70). We demonstrate here that U14.6 and U14.8 snRNAs, in addition to the previously characterized U14...
  53. Finlay C, Hinds P, Tan T, Eliyahu D, Oren M, Levine A. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 1988;8:531-9 pubmed
    ..PAb246 (localized at amino acids 88 to 110 in the protein) and preferentially bound to a heat shock protein, hsc70. In rat cells transformed by a genomic p53 clone plus ras, two populations of p53 proteins were detected, PAb246+ ..
  54. Hjerpe R, Bett J, Keuss M, Solovyova A, McWilliams T, Johnson C, et al. UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell. 2016;166:935-949 pubmed publisher
    ..Finally, we found that mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice. ..
  55. Huang Z, Nie L, Xu M, Sun X. Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. Mol Cell Biol. 2004;24:8951-62 pubmed
    ..E2A ubiquitination and degradation, we conducted a yeast two-hybrid screen and identified the carboxyl terminus of Hsc70-interacting protein (CHIP) as an E47 binding protein...
  56. Jana N, Nukina N. Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD. Neurotox Res. 2004;6:523-33 pubmed
  57. Parra L, Baust T, Smith A, Jaumotte J, Zigmond M, Torres S, et al. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. J Biol Chem. 2016;291:17510-22 pubmed publisher
    ..previously reported that the vesicular monoamine transporter 2 (VMAT2) is physically and functionally coupled with Hsc70 as well as with the dopamine synthesis enzymes tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase, ..
  58. Kauppinen K, Duan F, Wels J, Manor D. Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70). J Biol Chem. 2005;280:21638-44 pubmed
    ..We identified the molecular chaperone heat shock cognate protein (Hsc70) as a binding partner that preferentially interacts with the proto-oncogenic form of Dbl...
  59. Wilhelm D, Huang E, Svingen T, Stanfield S, Dinnis D, Koopman P. Comparative proteomic analysis to study molecular events during gonad development in mice. Genesis. 2006;44:168-76 pubmed
    ..Three proteins, hnRPA1, TRA1, and HSC71, were found to be expressed in a male-specific manner and this expression was confirmed by real-time reverse ..
  60. Zaprjanova S, Rashev P, Zasheva D, Martinova Y, Mollova M. Electrophoretic and immunocytochemical analysis of Hsp72 and Hsp73 expression in heat-stressed mouse testis and epididymis. Eur J Obstet Gynecol Reprod Biol. 2013;168:54-9 pubmed publisher
    ..Expression of the main isoforms of the Hsp70 family (constitutive Hsp73 and stress-inducible Hsp72) was determined in normal and heat-stressed mouse testes and epididymis from sexually ..
  61. Doucet Beaupré H, Gilbert C, Profes M, Chabrat A, Pacelli C, Giguère N, et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016;113:E4387-96 pubmed publisher
    ..These results reveal the key role of these transcription factors beyond the early developmental stages and provide mechanistic links between mitochondrial dysfunctions, ?-synuclein aggregation, and the survival of dopaminergic neurons. ..
  62. Kohl A, Alonso A, Hovemann B. Hsp90, hsc73 and EF-1 alpha gene expression in nonheatshocked and heatshocked LMTK- cells. Nucleic Acids Res. 1987;15:6756 pubmed
  63. Yagi H, Takabayashi T, Xie M, Kuroda K, Sato M. Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. PLoS ONE. 2017;12:e0172257 pubmed publisher
    ..Pull-down assays detected a 70-kDa protein that was identified by mass spectrometry to be the chaperone protein Hsc70. The binding of Hsc70 to FILIP was controlled by the adenosine triphosphatase (ATPase) activity of Hsc70...
  64. Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, et al. Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 2013;8:e65280 pubmed publisher
    ..In this study we used mass spectrometry to identify novel interactors of NF-?B p65 within the brain. Hsc70 was identified as a novel neuronal interactor of NF-?B p65...
  65. Zheng S, Damoiseaux R, Chen L, Black D. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013;23:998-1007 pubmed publisher
    ..These results identify multiple new regulators of Dlg4 splicing, and validate an approach to isolating splicing regulators for almost any cassette exon from libraries of cDNAs, shRNAs, or small molecules. ..
  66. Hunt C, Parsian A, Goswami P, Kozak C. Characterization and expression of the mouse Hsc70 gene. Biochim Biophys Acta. 1999;1444:315-25 pubmed
    A genomic clone encoding the mouse Hsc70 gene has been isolated and characterized by DNA sequence analysis. The gene is approximately 3...
  67. Wada H, Kobayashi I, Yamaza H, Matsuo K, Kiyoshima T, Akhtar M, et al. In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar. Histochem J. 2002;34:105-9 pubmed
    This study examined the detailed gene expression pattern of three different heat shock proteins (HSPs), Hsc73, Hsj2, and Hsp86, by means of an in situ hybridization method...
  68. Liu C, Yang C, Lin D, Wu M, Tsai K. Stored of Hsp72/Hsp73 in germinal vesicle-stage mouse oocytes. Reprod Domest Anim. 2004;39:19-24 pubmed
    Heat-shock proteins (hsps) Hsp72 and Hsp73 are the stored maternal proteins found in mouse oocytes...
  69. Ao L, Zou N, Cleveland J, Fullerton D, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol. 2009;297:H21-8 pubmed publisher
    ..recent study, in an isolated mouse heart model of global I/R, found that the 70-kDa heat shock cognate protein (HSC70) is released from cardiac cells and mediates the expression of cardiodepressant cytokines via a TLR4-dependent ..
  70. Wang T, Gu S, Ronni T, Du Y, Chen X. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res. 2005;4:941-9 pubmed
    ..This integrated approach provides global information on the functional link between MyD88 and other proteins in transducing the TLR-mediated signal and is generally applicable to in vivo analyses of other signaling pathways. ..
  71. Salinas E, Byrum S, Moreland L, Mackintosh S, Tackett A, Forrest J. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016;90:1397-413 pubmed publisher
    ..Among the top prioritized mLANA-binding proteins was a cellular chaperone, heat shock cognate protein 70 (Hsc70)...
  72. Wang X, Chen X, Oh H, Repasky E, Kazim L, Subjeck J. Characterization of native interaction of hsp110 with hsp25 and hsc70. FEBS Lett. 2000;465:98-102 pubmed
    ..Immunoblot analysis and co-immunoprecipitation studies identified two other HSPs as components of this complex, hsc70 and hsp25...
  73. Odunuga O, Hornby J, Bies C, Zimmermann R, Pugh D, Blatch G. Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction. Molecular characterization of the critical contacts for successful binding and specificity. J Biol Chem. 2003;278:6896-904 pubmed
    ..for the N-terminal tetratricopeptide repeat domain (TPR1) of mSTI1 to bind to heat shock cognate protein 70 (Hsc70) and to discriminate between Hsc70 and Hsp90...
  74. Blanc L, Liu J, Vidal M, Chasis J, An X, Mohandas N. The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood. 2009;114:3928-34 pubmed publisher
    ..These results lead us to suggest that AQP-1 sorting into exosomes may be the mechanism by which the reticulocyte adapts to environmental changes during its maturation...
  75. Liu Y, Zhao J, Liu J, Zhang H, Liu M, Xiao X. Upregulation of the constitutively expressed HSC70 by KLF4. Cell Stress Chaperones. 2008;13:337-45 pubmed publisher
    ..However, the regulation of the expression of inducible heat shock protein 70 (HSP72) and heat shock cognate 70 (HSP73) by KLF4 is not defined...