Gene Symbol: Hspa5
Description: heat shock protein 5
Alias: AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP, endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, GRP-78, HSP70 family protein 5, XAP-1 antigen, binding-immunoglobulin protein, glucose regulated protein, 78 kDa, heat shock 70 kDa protein 5, heat shock 70kD protein 5 (glucose-regulated protein, 78kD), heat shock protein 70 family protein 5, heat shock protein family A member 5, immunoglobulin heavy chain-binding protein
Species: mouse
Products:     Hspa5

Top Publications

  1. Nishitani Y, Matsumoto H. Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH. FEBS Lett. 2006;580:9-14 pubmed
    ..Expression of 78 kDa glucose-regulated protein (GRP78) mRNA, a biomarker of ER stress, was detected by quantitative real-time RT-PCR...
  2. Petrova K, Oyadomari S, Hendershot L, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J. 2008;27:2862-72 pubmed publisher
    ..protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly...
  3. Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, et al. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011;71:2848-57 pubmed publisher
    Glucose-regulated protein 78 (GRP78)/BiP is a multifunctional protein which plays a major role in endoplasmic reticulum (ER) protein processing, protein quality control, maintaining ER homeostasis, and controlling cell signaling and ..
  4. Iwawaki T, Akai R, Yamanaka S, Kohno K. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009;106:16657-62 pubmed publisher
    ..These findings reveal that IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals. ..
  5. Kammoun H, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest. 2009;119:1201-15 pubmed publisher
    ..activation and thus contributes to lipogenesis, we overexpressed the chaperone glucose-regulated protein 78 (GRP78) in the livers of ob/ob mice using an adenoviral vector...
  6. Barnes J, Smoak I. Glucose-regulated protein 78 (GRP78) is elevated in embryonic mouse heart and induced following hypoglycemic stress. Anat Embryol (Berl). 2000;202:67-74 pubmed
    ..Results demonstrate that GRP78 is strongly expressed with in the heart, neural tube, gut endoderm, somites, and surface ectoderm of mouse embryos ..
  7. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey J, et al. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008;68:498-505 pubmed publisher
    ..A major UPR protective response is the induction of the ER chaperone GRP78/BiP, which is expressed at high levels in a variety of tumors and confers drug resistance in both proliferating ..
  8. Bhattacharjee G, Ahamed J, Pedersen B, El Sheikh A, Mackman N, Ruf W, et al. Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arterioscler Thromb Vasc Biol. 2005;25:1737-43 pubmed
    To test the hypothesis that Grp78 negatively regulates cell surface tissue factor (TF) procoagulant activity and whether this is mediated by physical interaction...
  9. Shen Y, Hendershot L. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Mol Biol Cell. 2005;16:40-50 pubmed
    We recently identified ERdj3 as a component of unassembled immunoglobulin (Ig) heavy chain:BiP complexes...

More Information


  1. Marcinowski M, Höller M, Feige M, Baerend D, Lamb D, Buchner J. Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. Nat Struct Mol Biol. 2011;18:150-8 pubmed publisher
    ..The ATP-regulated Hsp70 chaperone BiP (heavy chain-binding protein), together with cochaperones, has important roles in all of these processes...
  2. Chevalier M, Rhee H, Elguindi E, Blond S. Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem. 2000;275:19620-7 pubmed
    ..BiP/GRP78 chaperones the translocation and maturation of secreted and membrane proteins in the endoplasmic reticulum...
  3. Shen J, Chen X, Hendershot L, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell. 2002;3:99-111 pubmed
    ..We have found that the ER chaperone BiP/GRP78 binds ATF6 and dissociates in response to ER stress...
  4. Knarr G, Kies U, Bell S, Mayer M, Buchner J. Interaction of the chaperone BiP with an antibody domain: implications for the chaperone cycle. J Mol Biol. 2002;318:611-20 pubmed
    b>BiP is an Hsp70 homologue found in the endoplasmic reticulum of eukaryotic cells. Like other Hsp70 chaperones, BiP interacts with its substrate proteins in an ATP-dependent manner...
  5. Mimura N, Yuasa S, Soma M, Jin H, Kimura K, Goto S, et al. Altered quality control in the endoplasmic reticulum causes cortical dysplasia in knock-in mice expressing a mutant BiP. Mol Cell Biol. 2008;28:293-301 pubmed
    b>Binding immunoglobulin protein (BiP) is an endoplasmic reticulum (ER) molecular chaperone that is central to ER function...
  6. Haas I, Meo T. cDNA cloning of the immunoglobulin heavy chain binding protein. Proc Natl Acad Sci U S A. 1988;85:2250-4 pubmed
    ..poly(A)+ RNA prepared from a murine pre-B-cell hybridoma expressing high levels of immunoglobulin heavy chain binding protein (BiP) and mu heavy chains...
  7. Kim S, Kim Y, Lee A. Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells. Differentiation. 1990;42:153-9 pubmed
    We examined the expression of GRP94 and GRP78 in embryonal carcinoma (EC) cells and during early mouse development...
  8. Wey S, Luo B, Lee A. Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling. PLoS ONE. 2012;7:e39047 pubmed publisher
    b>GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development...
  9. Jiang Y, Lv H, Liao M, Xu X, Huang S, Tan H, et al. GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins. Neurosci Lett. 2012;516:182-7 pubmed publisher
    The ER-localized chaperone glucose-regulated protein (GRP78) protects neurons against excitotoxicity and apoptosis...
  10. Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers J, Tsukamoto K, et al. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med. 2005;11:757-64 pubmed
    ..We propose that translational control couples insulin synthesis with folding capacity to maintain ER integrity and that this signal is essential to prevent diet-induced type 2 diabetes. ..
  11. Mao C, Dong D, Little E, Luo S, Lee A. Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo. Nat Med. 2004;10:1013-4; author reply 1014 pubmed
  12. Hu C, Dougan S, Winter S, Paton A, Paton J, Ploegh H. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med. 2009;206:2429-40 pubmed publisher
    ..SubAB favors cleavage of the newly synthesized immunoglobulin heavy chain-binding protein (BiP) to yield a C-terminal fragment that contains BiP's substrate-binding domain...
  13. Meunier L, Usherwood Y, Chung K, Hendershot L. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell. 2002;13:4456-69 pubmed
    ..of a large endoplasmic reticulum (ER)-localized multiprotein complex that is comprised of the molecular chaperones BiP; GRP94; CaBP1; protein disulfide isomerase (PDI); ERdj3, a recently identified ER Hsp40 cochaperone; cyclophilin B; ..
  14. Mimura N, Hamada H, Kashio M, Jin H, Toyama Y, Kimura K, et al. Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP. Cell Death Differ. 2007;14:1475-85 pubmed
    ..b>Binding immunoglobulin protein (BiP) is an ER chaperone, which is central to ER function...
  15. Anttonen A, Mahjneh I, Hämäläinen R, Lagier Tourenne C, Kopra O, Waris L, et al. The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone. Nat Genet. 2005;37:1309-11 pubmed
    ..mutations in SIL1, which encodes a nucleotide exchange factor for the heat-shock protein 70 (HSP70) chaperone HSPA5. These data, together with the similar spatial and temporal patterns of tissue expression of Sil1 and Hspa5, ..
  16. Misra U, Sharma T, Pizzo S. Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. J Immunol. 2005;175:2525-33 pubmed
    ..Alpha2M* binds to cell surface-associated glucose-regulated protein 78 (GRP78), which activates downstream signaling events...
  17. Mayer M, Reinstein J, Buchner J. Modulation of the ATPase cycle of BiP by peptides and proteins. J Mol Biol. 2003;330:137-44 pubmed
    b>BiP, the Hsp70 homologue of the endoplasmic reticulum, interacts with its non-native substrate proteins in an ATP-dependent manner. This interaction is coupled to the ATPase cycle of the chaperone...
  18. Misra U, Gonzalez Gronow M, Gawdi G, Pizzo S. The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. J Immunol. 2005;174:2092-7 pubmed
    MTJ-1 associates with a glucose-regulated protein of Mr approximately 78,000(GRP78) in the endoplasmic reticulum and modulates GRP78 activity as a chaperone...
  19. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, et al. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010;17:488-98 pubmed publisher
    ..In this study we report the creation of a novel mouse model in which GRP78/BiP, a major ER chaperone and master regulator of UPR, is specifically eliminated in Purkinje cells (PCs)...
  20. Shen Y, Meunier L, Hendershot L. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. J Biol Chem. 2002;277:15947-56 pubmed
    ..ERdj4 co-localized with GRP94 in the ER and associated with BiP in vivo when they were co-expressed in COS-1 cells...
  21. Mao C, Wang M, Luo B, Wey S, Dong D, Wesselschmidt R, et al. Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS ONE. 2010;5:e10852 pubmed publisher
    ..GRP94, a component of the GRP78 chaperone system in protein processing, has pro-survival properties with implicated function in cancer progression ..
  22. Shani G, Fischer W, Justice N, Kelber J, Vale W, Gray P. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77 pubmed
    ..This screen led to our identification of glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) chaperone that is also expressed at the surfaces of tumor cells...
  23. Rutkowski D, Arnold S, Miller C, Wu J, Li J, Gunnison K, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006;4:e374 pubmed
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome. ..
  24. Luo S, Baumeister P, Yang S, Abcouwer S, Lee A. Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem. 2003;278:37375-85 pubmed
    ..of protein translation mediated through the PERK-eIF2alpha pathway and transcriptional activation of genes such as Grp78/BiP encoding ER chaperone proteins...
  25. Misra U, Gonzalez Gronow M, Gawdi G, Wang F, Pizzo S. A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. Cell Signal. 2004;16:929-38 pubmed
    ..We now demonstrate that transfection of macrophages with a double-stranded RNA homologous in sequence to the Grp78 gene markedly decreased induction of inositol 1,4,5-trisphosphate (IP3) and subsequent IP3-dependent elevation of [..
  26. Zhu G, Ye R, Jung D, Barron E, Friedline R, Benoit V, et al. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013;27:955-64 pubmed publisher
    To investigate the role of GRP78 in adipogenesis and metabolic homeostasis, we knocked down GRP78 in mouse embryonic fibroblasts and 3T3-L1 preadipocytes induced to undergo differentiation into adipocytes...
  27. Paton A, Beddoe T, Thorpe C, Whisstock J, Wilce M, Rossjohn J, et al. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature. 2006;443:548-52 pubmed publisher
    ..of this toxin for eukaryotic cells is due to a specific single-site cleavage of the essential endoplasmic reticulum chaperone BiP/GRP78...
  28. Luo S, Mao C, Lee B, Lee A. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006;26:5688-97 pubmed
    b>GRP78, also known as BiP, is a central regulator of endoplasmic reticulum (ER) homeostasis due to its multiple functional roles in protein folding, ER calcium binding, and controlling of the activation of transmembrane ER stress sensors...
  29. Hetz C, Bernasconi P, Fisher J, Lee A, Bassik M, Antonsson B, et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science. 2006;312:572-6 pubmed
    ..Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR. ..
  30. Wey S, Luo B, Tseng C, Ni M, Zhou H, Fu Y, et al. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood. 2012;119:817-25 pubmed publisher
    Traditionally, GRP78 is regarded as protective against hypoxia and nutrient starvation prevalent in the microenvironment of solid tumors; thus, its role in the development of hematologic malignancies remains to be determined...
  31. Fu Y, Wey S, Wang M, Ye R, Liao C, Roy Burman P, et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci U S A. 2008;105:19444-9 pubmed publisher
    b>GRP78/BiP has recently emerged as a novel biomarker for aggressive prostate cancer...
  32. Yamagishi N, Ueda T, Mori A, Saito Y, Hatayama T. Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice. Biochem Biophys Res Commun. 2012;417:364-70 pubmed publisher
    ..two of the decreased proteins are involved in endoplasmic reticulum (ER) stress-related unfolded protein response, GRP78 and protein disulfide isomerase A3, and it was revealed that the decreased GRP78 expression in the liver of ..
  33. Miharada K, Karlsson G, Rehn M, Rörby E, Siva K, Cammenga J, et al. Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78. Cell Stem Cell. 2011;9:330-44 pubmed publisher
    ..Here we demonstrate that Cripto and its receptor GRP78 are important regulators of HSCs in the niche...
  34. Ravindran S, Gao Q, Ramachandran A, Sundivakkam P, Tiruppathi C, George A. Expression and distribution of grp-78/bip in mineralizing tissues and mesenchymal cells. Histochem Cell Biol. 2012;138:113-25 pubmed publisher
    ..Collectively, our observations provide a new perspective on GRP-78 with respect to mineralized matrix formation. ..
  35. Smits P, Bolton A, Funari V, Hong M, Boyden E, Lu L, et al. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010;362:206-16 pubmed publisher
  36. Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, et al. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat Cell Biol. 2009;11:1197-204 pubmed publisher
    ..Our findings provide a new link by which ER stress is converted to signalling for the activation of ER-to-Golgi trafficking. ..
  37. Ye R, Jung D, Jun J, Li J, Luo S, Ko H, et al. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes. 2010;59:6-16 pubmed publisher
    ..Male Grp78(+/-) mice and their wild-type littermates were subjected to a high-fat diet (HFD) regimen...
  38. Kimura K, Jin H, Ogawa M, Aoe T. Dysfunction of the ER chaperone BiP accelerates the renal tubular injury. Biochem Biophys Res Commun. 2008;366:1048-53 pubmed
    ..b>BiP is an essential chaperone molecule that helps with proper protein folding in the ER...
  39. Lee J, Beebe K, Nangle L, Jang J, Longo Guess C, Cook S, et al. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443:50-5 pubmed
    ..These findings demonstrate that disruption of translational fidelity in terminally differentiated neurons leads to the accumulation of misfolded proteins and cell death, and provide a novel mechanism underlying neurodegeneration. ..
  40. Sörgjerd K, Ghafouri B, Jonsson B, Kelly J, Blond S, Hammarstrom P. Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis. J Mol Biol. 2006;356:469-82 pubmed
    ..One essential component of the ER-assisted folding machinery is the molecular chaperone BiP. Co-expression of BiP and D18G TTR, or BiP and wild-type (wt) TTR, or mutants A25T TTR and L55P TTR in Escherichia ..
  41. Zhao T, Huang G, Muna S, Bagalkot T, Jin H, Chae H, et al. Effects of chronic social defeat stress on behavior and choline acetyltransferase, 78-kDa glucose-regulated protein, and CCAAT/enhancer-binding protein (C/EBP) homologous protein in adult mice. Psychopharmacology (Berl). 2013;228:217-30 pubmed publisher
    ..The present study investigated the effects of social defeat stress on the behaviors and expressions of Chat, Grp78, and chop in the brains of adult mice...
  42. Resendez E, Wooden S, Lee A. Identification of highly conserved regulatory domains and protein-binding sites in the promoters of the rat and human genes encoding the stress-inducible 78-kilodalton glucose-regulated protein. Mol Cell Biol. 1988;8:4579-84 pubmed
    The gene encoding GRP78 has been shown to be constitutively expressed in many cell types and is inducible by the calcium ionophore A23187...
  43. Zhang X, Szabo E, Michalak M, Opas M. Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci. 2007;25:455-63 pubmed
    ..Furthermore, our data suggest that ER stress-like mechanism may induce apoptosis via activation of the caspases during embryonic development of the central nervous system. ..
  44. Matsuya S, Sakagami H, Tohgo A, Owada Y, Shin H, Takeshima H, et al. Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. J Neurochem. 2005;93:674-85 pubmed
    ..These findings suggest that EFA6C may be involved in the regulation of the membrane dynamics of the somatodendritic compartments of Purkinje cells through the activation of ARF6. ..
  45. Tamayo A, Slater L, Taylor Parker J, Bharti A, Harrison R, Hung D, et al. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011;81:1390-401 pubmed publisher
    ..We demonstrate by protease protection assays that the molecular chaperone GRP78 mediates the unfolding of LFnDTA and LF at neutral pH and thereby converts these proteins from a trypsin resistant ..
  46. Yan D, Wang H, Bowman R, Joyce J. STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation. Cell Rep. 2016;16:2914-2927 pubmed publisher
    ..Together, these findings demonstrate that cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner. ..
  47. Liang G, Lian C, Huang D, Gao W, Liang A, Peng Y, et al. Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PLoS ONE. 2014;9:e86894 pubmed publisher
    ..The col2a1 p.Gly1170Ser mutated mouse model offered a novel connection between misfolded collagen and skeletal malformation. Further investigation of this mouse mutant model can help us understand mechanisms of type II collagenopathies...
  48. Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, et al. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Peptides. 2012;33:346-50 pubmed publisher
    The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins...
  49. Gunther E, Walter L. Genetic aspects of the hsp70 multigene family in vertebrates. Experientia. 1994;50:987-1001 pubmed
    ..After a detailed description of the various hsp70 genes more general characteristics of the organization and evolution of the multigene family are discussed. ..
  50. Kung L, Rajpar M, Briggs M, Boot Handford R. Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response. J Histochem Cytochem. 2012;60:734-48 pubmed
  51. Kasaikina M, Fomenko D, Labunskyy V, Lachke S, Qiu W, Moncaster J, et al. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011;286:33203-12 pubmed publisher
    ..These cataracts did not appear to be associated with severe oxidative stress or glucose dysregulation. We suggest that the cataracts resulted from an improper folding status of lens proteins caused by Sep15 deficiency. ..
  52. Moyon S, Huynh J, Dutta D, Zhang F, Ma D, Yoo S, et al. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016;15:748-760 pubmed publisher
    ..Therefore, loss of Dnmt1 in OPCs is not sufficient to induce a lineage switch but acts as an important determinant of the coordination between RNA splicing and protein synthesis necessary for myelin formation. ..
  53. Marumoto Y, Terai S, Urata Y, Matsumoto T, Mizunaga Y, Yamamoto N, et al. Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem Biophys Res Commun. 2008;367:546-52 pubmed publisher
    ..XBP1 expression remained high during the late phase, and GRP78 expression increased with XBP1 activation. We also found that GFP-positive BMC expressed XBP1 and GRP78...
  54. Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, et al. MANF is indispensable for the proliferation and survival of pancreatic ? cells. Cell Rep. 2014;7:366-75 pubmed publisher
    ..We demonstrate that MANF specifically promotes ? cell proliferation and survival, thereby constituting a therapeutic candidate for ? cell protection and regeneration. ..
  55. Biswas N, Friese R, Gayen J, Bandyopadhyay G, Mahata S, O Connor D. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS ONE. 2014;9:e84132 pubmed publisher
    ..k.a. "78 kDa Glucose Regulated Protein", HSPA5, BIP) as a major interacting partner of PST...
  56. Panzhinskiy E, Ren J, Nair S. Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis. PLoS ONE. 2013;8:e77228 pubmed publisher
    ..Our data suggest that PTP1B is induced by ER stress via the activation of the ROS-NF?B axis which is causes unfolded protein response and mediates insulin resistance in the skeletal muscle under obese condition. ..
  57. Wang Y, Su K, Sabeva N, Ji A, van der Westhuyzen D, Foufelle F, et al. GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice. Metabolism. 2015;64:1435-43 pubmed publisher
    ..Overexpression of the ER chaperone GRP78 using an adenoviral vector restores ER function and reduces steatosis in ob/ob mice...
  58. Popescu C, Paduraru C, Dwek R, Petrescu S. Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin. J Biol Chem. 2005;280:13833-40 pubmed
    ..Co-immmunoprecipitation experiments showed that soluble tyrosinase interacts with calreticulin and BiP/GRP78 (and not calnexin) during its ER transit...
  59. Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, et al. T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability. Biochem Biophys Res Commun. 2008;371:762-6 pubmed publisher
    The 78-kDa glucose-regulated protein (GRP78) is an important molecular chaperone in the endoplasmic reticulum (ER) induced by various stresses...
  60. Pilz A, Prohaska R, Peters J, Abbott C. Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q. Genomics. 1994;21:104-9 pubmed
    ..The Ak1, Col5a1, Epb7.2, Fpgs, and Pbx3 genes were mapped with respect to the genes for Grp78, Rxra, Notch1 (the mouse homologue of TAN1), Spna2, Abl, and Hc (the mouse homologue of C5), all of which have ..
  61. Chintalapudi S, Wang X, Li H, Lau Y, Williams R, Jablonski M. Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas. Mol Vis. 2016;22:1318-1331 pubmed
    ..previously demonstrated that the photoreceptor membrane-associated protein XAP-1 antigen is a product of the HSPA5 gene...
  62. de Ridder G, Ray R, Pizzo S. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res. 2012;22:225-35 pubmed publisher
    The HSP70 family member GRP78 is a selective tumor marker upregulated on the surface of many tumor cell types, including melanoma, where it acts as a growth factor receptor-like protein...
  63. Zhang B, Zheng C, Zhu M, Tao J, Vasievich M, Baines A, et al. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of ?1-antitrypsin. Blood. 2011;118:3384-91 pubmed publisher
    ..the ER in Lman1(-/-) hepatocytes is slightly distended, with significant accumulation of ?1-antitrypsin and GRP78. An unexpected, partially penetrant, perinatal lethality was observed for Lman1(-/-) mice, dependent on the ..
  64. Manzoni C, Colombo L, Bigini P, Diana V, Cagnotto A, Messa M, et al. The molecular assembly of amyloid a? controls its neurotoxicity and binding to cellular proteins. PLoS ONE. 2011;6:e24909 pubmed publisher
    ..Based on these data we suggest that numerous proteins act as A? receptors in N2a cells, triggering a multi factorial toxicity. ..
  65. Dwyer N, Manning D, Moran J, Mudbhary R, Fleming M, Favero C, et al. A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype. Neural Dev. 2011;6:3 pubmed publisher
    ..The phenotypes highlight vulnerable choice points and latent tendencies of TCAs, and will lead to a refined understanding of the elements and interactions required to form the thalamocortical system. ..
  66. Martindale J, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman M, et al. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ Res. 2006;98:1186-93 pubmed
    ..markers of the UPR, the ER-targeted cytoprotective chaperones glucose-regulated proteins 78 and 94 (GRP78 and GRP94), were increased, consistent with I/R-mediated UPR activation in the heart...
  67. Kaneko Oshikawa C, Nakagawa T, Yamada M, Yoshikawa H, Matsumoto M, Yada M, et al. Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol Cell Biol. 2005;25:10953-64 pubmed
    ..UFD2a thus appears to be essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress. ..
  68. Han X, Zhou J, Zhang P, Song F, Jiang R, Li M, et al. IRE1? dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development. Cell Signal. 2013;25:2136-46 pubmed publisher
    Bone morphogenetic protein 2 is known to activate unfolded protein response signaling molecules, including XBP1S, BiP and IRE1?...