Hspa1b

Summary

Gene Symbol: Hspa1b
Description: heat shock protein 1B
Alias: Hsp70, Hsp70-1, Hsp70.1, hsp68, heat shock 70 kDa protein 1B, 68 kDa heat shock protein, heat shock 70 kDa protein 1, heat shock 70kDa protein 1B, heat shock protein 70.1, heat shock protein, 70 kDa 1
Species: mouse
Products:     Hspa1b

Top Publications

  1. Dix D, Garges J, Hong R. Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol Reprod Dev. 1998;51:373-80 pubmed
    Mouse 70-kDa heat shock proteins Hsp70-1 and Hsp70-3 (Hsp70-1/3) are stress-inducible protein chaperones thought to protect embryonic cells and tissues from the effects of a wide range of environmental exposures...
  2. Qian S, McDonough H, Boellmann F, Cyr D, Patterson C. CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature. 2006;440:551-5 pubmed
    ..b>Hsp70 is one of the most highly inducible molecular chaperones, but its expression must be maintained at low levels ..
  3. Stangl S, Gehrmann M, Riegger J, Kuhs K, Riederer I, Sievert W, et al. Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A. 2011;108:733-8 pubmed publisher
    ..termed "TKD," comprising amino acids 450-461 (aa(450-461)) in the C terminus of inducible Hsp70, resulted in the generation of an IgG1 mouse mAb cmHsp70.1. The epitope recognized by cmHsp70...
  4. Hunt C, Gasser D, Chaplin D, Pierce J, Kozak C. Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78. Genomics. 1993;16:193-8 pubmed
    The 70,000-D heat shock protein (HSP70) gene family includes both heat-inducible and constitutively expressed genes. We have mapped five murine HSP70 genes to specific sites on three separate chromosomes...
  5. Chen S, Smith D. Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. J Biol Chem. 1998;273:35194-200 pubmed
    Hop, an abundant and conserved protein of unresolved function, binds concomitantly with heat shock protein 70 (Hsp70) and Hsp90, participates with heat shock proteins at an intermediate stage of progesterone receptor assembly, and is ..
  6. Jana N, Tanaka M, Wang G, Nukina N. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet. 2000;9:2009-18 pubmed
    ..demonstrate that newly synthesized polyglutamine-expanded truncated huntingtin interacts with members of Hsp40 and Hsp70 families of chaperones in a polyglutamine length-dependent manner...
  7. Dai Q, Zhang C, Wu Y, McDonough H, Whaley R, Godfrey V, et al. CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 2003;22:5446-58 pubmed
    ..depends on heat shock factor 1 (HSF1), which is normally under negative regulatory control by molecular chaperones Hsp70 and Hsp90. In metazoan species, the chaperone system also provides protection against apoptosis...
  8. Lancaster G, Febbraio M. Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem. 2005;280:23349-55 pubmed
    ..show that exosomes, small membrane vesicles that are secreted by numerous cell types, contribute to the release of HSP70 from human peripheral blood mononuclear cells (PBMCs) in both basal and stress-induced (heat shock at 40 or 43 ..
  9. Koyama S, Arawaka S, Chang Hong R, Wada M, Kawanami T, Kurita K, et al. Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70. Biochem Biophys Res Commun. 2006;343:719-30 pubmed
    ..In contrast, overexpression of Hsp70 reduced accumulation of mutant-specific insoluble SOD1...

More Information

Publications104 found, 100 shown here

  1. Cummings C, Sun Y, Opal P, Antalffy B, Mestril R, Orr H, et al. Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet. 2001;10:1511-8 pubmed
    ..mitigate the phenotype in a mammalian model, we crossbred SCA1 mice with mice over-expressing a molecular chaperone (inducible HSP70 or iHSP70). We found that high levels of HSP70 did indeed afford protection against neurodegeneration.
  2. Van Molle W, Wielockx B, Mahieu T, Takada M, Taniguchi T, Sekikawa K, et al. HSP70 protects against TNF-induced lethal inflammatory shock. Immunity. 2002;16:685-95 pubmed
    ..The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species...
  3. Hunt C, Dix D, Sharma G, Pandita R, Gupta A, Funk M, et al. Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol. 2004;24:899-911 pubmed
    ..In mice, the HSP genes Hsp70.1 and Hsp70.3 are induced by both endogenous and exogenous stressors, such as heat and toxicants...
  4. Mycko M, Cwiklinska H, Walczak A, Libert C, Raine C, Selmaj K. A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen. Eur J Immunol. 2008;38:1999-2013 pubmed publisher
    ..In this respect, increase in the chaperonin, heat shock protein 70 (hsp70) is an outcome of prolonged inflammatory stress...
  5. Zhang X, Qian S. Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes. Mol Biol Cell. 2011;22:3277-88 pubmed publisher
    ..the chaperone requirements for the fate of misfolded proteins reveals an unexpected role of heat shock protein 70 (Hsp70) in promoting aggresome formation...
  6. Seo H, Chung D, Lee Y, Lee D, Kim J, Bae S, et al. Heat shock protein 25 or inducible heat shock protein 70 activates heat shock factor 1: dephosphorylation on serine 307 through inhibition of ERK1/2 phosphorylation. J Biol Chem. 2006;281:17220-7 pubmed
    ..In the present study, we show that stable transfection of either Hsp25 or inducible Hsp70 (Hsp70i) increased expression of endogenous HSPs such as HSP25 and HSP70i through HSF1 activation...
  7. Shi Y, Tu Z, Tang D, Zhang H, Liu M, Wang K, et al. The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways. Shock. 2006;26:277-84 pubmed
    The objective of this study was to evaluate the negative regulatory role of heat shock protein 70 (HSP70) on endotoxin-induced activation of inflammatory cytokine signaling pathways in a macrophage cell line...
  8. Seo H, Chung H, Lee Y, Bae S, Lee S, Lee Y. p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive response by low dose radiation. J Radiat Res. 2006;47:83-90 pubmed
    ..RIF) cells have been reported to show adaptive response to 1 cGy of low dose radiation, and hsp25 and inducible hsp70 are involved in this process...
  9. Swayne L, Braun J. Aggregate-centered redistribution of proteins by mutant huntingtin. Biochem Biophys Res Commun. 2007;354:39-44 pubmed
    ..Here, we report that upon the formation of huntingtin aggregates; endogenous cytosolic huntingtin, Hsc70/Hsp70 (heat shock protein and cognate protein of 70kDa) and syntaxin 1A become aggregate-centered...
  10. Lim Y, Lee J, Huang T, Seo J. Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Exp Mol Med. 2008;40:596-606 pubmed
    Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress, heavy metals, heat ..
  11. Sramek C, Mackanos M, Spitler R, Leung L, Nomoto H, Contag C, et al. Non-damaging retinal phototherapy: dynamic range of heat shock protein expression. Invest Ophthalmol Vis Sci. 2011;52:1780-7 pubmed publisher
    ..of cellular responses to sublethal hyperthermia, expression of the gene encoding a 70 kDa heat shock protein (HSP70) was evaluated after laser irradiation using a transgenic reporter mouse...
  12. Mendes F, Farinha C, Felício V, Alves P, Vieira I, Amaral M. BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner. Cell Physiol Biochem. 2012;30:1120-33 pubmed publisher
    ..undergoes complex biosynthesis at the endoplasmic reticulum involving several molecular chaperones including Hsp70 and many co-chaperones...
  13. Lee J, Park S, Kim W. Exercise preconditioning reduces acute ischemic renal injury in Hsp70.1 knockout mouse. Histol Histopathol. 2013;28:1223-33 pubmed publisher
    Heat shock protein 70 (Hsp70) is an anti-apoptotic protein that has a protective effect in renal ischemic injury. Exercise up-regulates Hsp family proteins (Hsps), antioxidants and anti-apoptotic proteins...
  14. Okamoto Y, Pehlivan D, Wiszniewski W, Beck C, Snipes G, Lupski J, et al. Curcumin facilitates a transitory cellular stress response in Trembler-J mice. Hum Mol Genet. 2013;22:4698-705 pubmed publisher
    ..in gene expression for hypoxia, inflammatory response and heat-shock proteins, the latter specifically the Hsp70 family, in Tr-J mice...
  15. Wolf J, Bhatti T, Fouraschen S, Chakravorty S, Wang L, Kurian S, et al. Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice. Liver Transpl. 2014;20:376-85 pubmed publisher
    ..Heat shock protein 70 (Hsp70) functions as a chaperone during periods of cellular stress and induces the expression of several inflammatory ..
  16. Wadhwa R, Kaul S, Ikawa Y, Sugimoto Y. Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. J Biol Chem. 1993;268:6615-21 pubmed
    ..cDNA cloning and homology search placed it in the heat shock protein 70 (hsp70) family...
  17. McMurtry A, Cho K, Young L, Nelson C, Greenhalgh D. Expression of HSP70 in healing wounds of diabetic and nondiabetic mice. J Surg Res. 1999;86:36-41 pubmed
    ..Tissues underwent immunohistochemical (IHC) and RT-PCR analyses for inducible HSP70. HSP70 protein expression in the wound bed by IHC peaked at 24 h in the nondiabetic mice...
  18. Lau P, Villanueva H, Kobayashi K, Nakamuta M, Chang B, Chan L. A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing. J Biol Chem. 2001;276:46445-52 pubmed
    Mammalian homologues of DnaJ proteins, also known as Hsp40 proteins, are co-chaperonins that complement Hsp70 chaperone function...
  19. Lee J, Kim Y, Kim T, Koh J, Kim Y. Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection. J Neurosci. 2008;28:10919-27 pubmed publisher
    ..Zn PC exhibited the characteristic features of ischemic PC, including caspase-3 activation, PARP-1 cleavage, and HSP70 induction, all of which are crucial for subsequent neuroprotection against NMDA or zinc toxicity...
  20. Dun M, Smith N, Baker M, Lin M, Aitken R, Nixon B. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. J Biol Chem. 2011;286:36875-87 pubmed publisher
    ..Collectively, these data provide an important biochemical insight into the molecular basis of sperm-zona pellucida interaction and a plausible explanation for how spermatozoa gain their ability to fertilize. ..
  21. Johnston R, Kucey B. Competitive inhibition of hsp70 gene expression causes thermosensitivity. Science. 1988;242:1551-4 pubmed
    ..The gene studied was the hsp70 gene, which encodes a 72-kilodalton (kD) heat shock protein that is synthesized after thermal stress...
  22. Thompson E, Christians E, Stinnakre M, Renard J. Scaffold attachment regions stimulate HSP70.1 expression in mouse preimplantation embryos but not in differentiated tissues. Mol Cell Biol. 1994;14:4694-703 pubmed
    ..These results suggest a limited capacity of SARs to act as insulating elements but are consistent with a proposed model of SAR-mediated chromatin opening and closing. ..
  23. Ohtsuka Y, Brunson K, Jedlicka A, Mitzner W, Clarke R, Zhang L, et al. Genetic linkage analysis of susceptibility to particle exposure in mice. Am J Respir Cell Mol Biol. 2000;22:574-81 pubmed
  24. Binder R, Srivastava P. Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nat Immunol. 2005;6:593-9 pubmed
  25. Yusuf N, Nasti T, Ahmad I, Chowdhury S, Mohiuddin H, Xu H, et al. In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical. J Immunol. 2015;194:4796-803 pubmed publisher
    Heat shock proteins (HSPs) are constitutively expressed in murine skin. HSP27 is present in the epidermis, and HSP70 can be found in both the epidermis and dermis...
  26. Palis J, Kingsley P. Differential gene expression during early murine yolk sac development. Mol Reprod Dev. 1995;42:19-27 pubmed
    ..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue. ..
  27. Singleton K, Wischmeyer P. Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. Am J Physiol Lung Cell Mol Physiol. 2006;290:L956-61 pubmed
    ..Studies utilizing sublethal heat stress or chemical enhancers to induce in vivo HSP70 expression have demonstrated survival benefit after experimental sepsis...
  28. Taleb M, Brandon C, Lee F, Lomax M, Dillmann W, Cunningham L. Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol. 2008;9:277-89 pubmed publisher
    ..In our system, Hsp70 is the most strongly induced Hsp, which is upregulated over 250-fold at the level of mRNA 2 h after heat shock...
  29. Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita T, et al. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A. 2013;110:6841-6 pubmed publisher
    ..Acetylated hsp70 also recruits E3 ligase for SUMOylation, KRAB-ZFP-associated protein 1 (KAP1), inducing Lys840 SUMOylation and ..
  30. Zakeri Z, Wolgemuth D, Hunt C. Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol. 1988;8:2925-32 pubmed
    A unique member of the mouse HSP70 gene family has been isolated and characterized with respect to its DNA sequence organization and expression...
  31. Ohashi M, Oyanagi M, Hatakeyama K, Inoue M, Kominami R. The gene encoding PBP74/CSA/motalin-1, a novel mouse hsp70, maps to mouse chromosome 18. Genomics. 1995;30:406-7 pubmed
  32. Loeb C, Harris J, Craik C. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. J Biol Chem. 2006;281:28326-35 pubmed
    ..Thirteen prospective granzyme B substrates were identified from a cDNA expression-cleavage screen, including Hsp70, Notch1, fibroblast growth factor receptor-1 (FGFR1), poly-A-binding protein, cAbl, heterogeneous nuclear ..
  33. Hamiel C, Pinto S, Hau A, Wischmeyer P. Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. Am J Physiol Cell Physiol. 2009;297:C1509-19 pubmed publisher
    Glutamine (GLN) plays a key role in cellular protection following injury via enhancement of heat shock protein 70 (HSP70). The pathway by which GLN enhances HSP70 is unknown...
  34. Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula S, et al. Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Am J Respir Crit Care Med. 2014;189:16-29 pubmed publisher
    ..Our study identified a previously uncharacterized role for STUB1 in regulating IL-4R signaling, which might provide a new strategy for attenuating airway inflammation. ..
  35. Fijneman R, Oomen L, Snoek M, Demant P. A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex. Immunogenetics. 1995;41:106-9 pubmed
    ..genetic difference has been reduced to a region of approximately 50 kilobases within the C4-H2D interval, between Hsp70.3 and G7. After transplacental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10...
  36. Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J. Messenger RNA expression of heat shock proteins (HSPs) during ocular development. Curr Eye Res. 1995;14:1125-33 pubmed
    ..Expression of HSP32, HSP60, HSP70, HSP84, HSP86 and heat shock cognate protein (HSC)70 mRNAs was examined by in situ hybridization...
  37. Bagchi M, Besser D, Reddy T, Skoff R, Maisel H. Effect of thermal stress on early and late passaged mouse lens epithelial cells. J Cell Biochem. 2007;102:1036-42 pubmed
    ..The data presented here suggests a relationship between the presence of functional HSF-1 and sustained proliferative activities of the late passaged alphaTN-4 cell. ..
  38. Wilhide M, Tranter M, Ren X, Chen J, Sartor M, Medvedovic M, et al. Identification of a NF-?B cardioprotective gene program: NF-?B regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion. J Mol Cell Cardiol. 2011;51:82-9 pubmed publisher
    ..The genes encoding heat shock protein 70.3 (hspa1a) and heat shock protein 70.1 (hspa1b) were the most significantly regulated genes after PO and were up-regulated by NF-?B...
  39. Wang R, Kovalchin J, Muhlenkamp P, Chandawarkar R. Exogenous heat shock protein 70 binds macrophage lipid raft microdomain and stimulates phagocytosis, processing, and MHC-II presentation of antigens. Blood. 2006;107:1636-42 pubmed
    The extracellular presence of endotoxin-free heat shock protein 70 (HSP70) enhances the rate and capacity of macrophage-mediated phagocytosis at 6 times the basal rate...
  40. McConnell K, Fox A, Clark A, Chang N, Dominguez J, Farris A, et al. The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol. 2011;186:3718-25 pubmed publisher
    ..The purpose of this study was to determine the role of HSP70 in mediating mortality and the host inflammatory response in aged septic hosts...
  41. Mathur S, Walley K, Wang Y, Indrambarya T, Boyd J. Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2. Circ J. 2011;75:2445-52 pubmed
    ..DAMPs, HSP60, HSP70 and HMGB1, increased NF?B transcriptional activity compared to controls...
  42. Bevilacqua A, Fiorenza M, Mangia F. Developmental activation of an episomic hsp70 gene promoter in two-cell mouse embryos by transcription factor Sp1. Nucleic Acids Res. 1997;25:1333-8 pubmed
    ..by the promoter of one of the earliest genes activated after fertilization in this system, the heat shock gene hsp70. Cis-acting elements required for hsp70 activation were first investigated by mutational analysis...
  43. Loones M, Rallu M, Mezger V, Morange M. HSP gene expression and HSF2 in mouse development. Cell Mol Life Sci. 1997;53:179-90 pubmed
    ..HSF2 might be involved in the onset of expression of HSPs, regulate (inhibit) their expression, or control the expression of other developmental genes yet to be discovered. ..
  44. Lin J, Hemenway C. Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. J Biol Chem. 2010;285:11966-73 pubmed publisher
    ..report indicate that the heat shock protein Hsp90 directly and specifically interacts with AF9 as part of an Hsp90-Hsp70-p60/Hop chaperone complex...
  45. Makowski A, Davidson J, Mahadevan Jansen A, Jansen E. In vivo analysis of laser preconditioning in incisional wound healing of wild-type and HSP70 knockout mice with Raman spectroscopy. Lasers Surg Med. 2012;44:233-44 pubmed publisher
    ..2009) J Invest Dermatol 129(1): 205-216]. Recent studies have optimized treatments or confirmed results using HSP70 as a biomarker...
  46. Dong F, Shinohara K, Botilde Y, Nabeshima R, Asai Y, Fukumoto A, et al. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. J Cell Biol. 2014;204:203-13 pubmed publisher
    ..in the mutant testis and sperm, and Pih1d3 was found to interact with an intermediate chain of ODA as well as with Hsp70 and Hsp90...
  47. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, et al. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017;127:3189-3200 pubmed publisher
    ..Further experiments revealed that the E455K mutation disrupted the interaction between BAG3 and HSP70. In both mutants, decreased levels of small heat shock proteins (sHSPs) were observed, and a subset of proteins ..
  48. Stoka V, Turk V, Bredesen D. Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med. 2007;9:255-63 pubmed
    ..These results indicate that the activation pattern of the intrinsic pathway of apoptosis undergoes a marked shift during postnatal maturation. ..
  49. Sonehara H, Nagata M, Aoki F. Roles of the first and second round of DNA replication in the regulation of zygotic gene activation in mice. J Reprod Dev. 2008;54:381-4 pubmed
    ..the respective roles of the two rounds of DNA replication in ZGA, we analyzed the expression of four ZGA genes (hsp70.1, eif-1a, muerv and zscan4d) in embryos whose DNA replication was inhibited by treatment with aphidicolin, an ..
  50. Echeverria P, Mazaira G, Erlejman A, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009;29:4788-97 pubmed publisher
    ..We found that importin beta and the integral nuclear pore glycoprotein Nup62 interact with hsp90, hsp70, p23, and the TPR domain proteins FKBP52 and PP5...
  51. Hatayama T, Tsujioka K, Wakatsuki T, Kitamura T, Imahara H. Effects of low culture temperature on the induction of hsp70 mRNA and the accumulation of hsp70 and hsp105 in mouse FM3A cells. J Biochem. 1992;111:484-90 pubmed
    We have shown that heat shock does not induce the synthesis of hsp70 in FM3A cells maintained at a low culture temperature of 33 degrees C although it does so in cells maintained at 37 degrees C [T. Hatayama et al. (1991) Biochem. Int...
  52. Manejwala F, Logan C, Schultz R. Regulation of hsp70 mRNA levels during oocyte maturation and zygotic gene activation in the mouse. Dev Biol. 1991;144:301-8 pubmed
    ..in transcriptional activation of the embryonic genome in the two-cell mouse embryo, while heat shock protein (hsp70) has been identified as one of the first products of zygotic gene activation...
  53. Feige U, Polla B. Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applications. Experientia. 1994;50:979-86 pubmed
  54. Czar M, Owens Grillo J, Dittmar K, Hutchison K, Zacharek A, Leach K, et al. Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. J Biol Chem. 1994;269:11155-61 pubmed
    We have reported previously that the three heat shock proteins hsp56, hsp70, and hsp90 exist together in a heterocomplex in human lymphocyte cytosol (Sanchez, E. R., Faber, L. E., Henzel, W. J., and Pratt, W. B...
  55. Stuart J, Myszka D, Joss L, Mitchell R, McDonald S, Xie Z, et al. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J Biol Chem. 1998;273:22506-14 pubmed
    The anti-cell death protein BAG-1 binds to 70-kDa heat shock proteins (Hsp70/Hsc70) and modulates their chaperone activity...
  56. Bardag Gorce F, van Leeuwen F, Nguyen V, French B, Li J, Riley N, et al. The role of the ubiquitin-proteasome pathway in the formation of mallory bodies. Exp Mol Pathol. 2002;73:75-83 pubmed
    ..In conclusion, the results support the concept that Mallory bodies are aggresomes which form as the result of the failure of the ubiquitin-proteasome complex to adequately eliminate cytokeratins destined for proteolysis. ..
  57. Hampton C, Shimamoto A, Rothnie C, Griscavage Ennis J, Chong A, Dix D, et al. HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts. Am J Physiol Heart Circ Physiol. 2003;285:H866-74 pubmed
    We investigated the role of inducible heat shock proteins 70.1 and 70.3 (HSP70.1 and HSP70.3, respectively) in myocardial ischemic preconditioning (IP) in mice. Wild-type (WT) mice and HSP70.1- and HSP70.3-null [HSP70...
  58. Hu S, Claud E, Musch M, Chang E. Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010;298:G481-92 pubmed publisher
    ..epithelium, including selective translational inhibition of the cytoprotective protein heat shock protein 70 (Hsp70)...
  59. Choi K, Ni L, Jonakait G. Fas ligation and tumor necrosis factor ? activation of murine astrocytes promote heat shock factor-1 activation and heat shock protein expression leading to chemokine induction and cell survival. J Neurochem. 2011;116:438-48 pubmed publisher
    ..These data suggest that the induction of heat shock proteins via HSF-1 contribute to the TNF?- and FasL-induced expression of chemokines in astrocytes. ..
  60. Zhang L, Liu Q, Yuan X, Wang T, Luo S, Lei H, et al. Requirement of heat shock protein 70 for inducible nitric oxide synthase induction. Cell Signal. 2013;25:1310-7 pubmed publisher
    ..But the role of the closely related heat shock protein 70 (Hsp70) in iNOS induction remains unknown. We address this issue in cultured cells and endotoxemic mice...
  61. Huang L, Mivechi N, Moskophidis D. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Mol Cell Biol. 2001;21:8575-91 pubmed
    The murine hsp70 gene family includes the evolutionarily conserved hsp70.1 and hsp70.3 genes, which are the major proteins induced by heat and other stress stimuli. hsp70.1 and hsp70...
  62. Tanaka T, Kunath T, Kimber W, Jaradat S, Stagg C, Usuda M, et al. Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res. 2002;12:1921-8 pubmed
    ..We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage...
  63. Dai Y, Xu J, Molkentin J. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005;25:9936-48 pubmed
    ..Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj. ..
  64. Widlak W, Winiarski B, Krawczyk A, Vydra N, Malusecka E, Krawczyk Z. Inducible 70 kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism. Int J Androl. 2007;30:80-7 pubmed
    ..Despite constitutive expression of testis-specific Hsp70 proteins, spermatocytes are very sensitive to damage at elevated temperatures...
  65. Son Y, Lee J, Kim D. Modulation of RAG/DNA complex by HSP70 in V(D)J recombination. Biochem Biophys Res Commun. 2008;365:113-7 pubmed
    ..It was also co-immunoprecipitated with RAG2 in pro-B cells. Purified HSP70 protein disrupted RAG/DNA complexes assembled in vitro and also inhibited the V(D)J cleavage (both nick and ..
  66. Denman C, McCracken J, Hariharan V, Klarquist J, Oyarbide Valencia K, Guevara Patino J, et al. HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. J Invest Dermatol. 2008;128:2041-8 pubmed publisher
    ..Intracellular HSP70 can act as a cytoprotectant, preventing apoptosis in cells under stress...
  67. Tao Y, Hart J, Lichtenstein L, Joseph L, Ciancio M, Hu S, et al. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009;30:175-82 pubmed publisher
    Heat shock protein 70 (Hsp70) regulates protein biosynthesis and refolding of denatured proteins...
  68. Kim M, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, et al. hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain. J Virol. 2013;87:998-1009 pubmed publisher
    The major inducible 70-kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection...
  69. Dodd K, Nance S, Quezada M, Janke L, Morrison J, Williams R, et al. Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity. Oncogene. 2015;34:1312-22 pubmed publisher
    The anti-apoptotic function and tumor-associated expression of heat-shock protein 70 (HSP70) is consistent with HSP70 functioning as a survival factor to promote tumorigenesis...
  70. Lowe D, Fulford W, Moran L. Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983;3:1540-3 pubmed
    We used a cloned Drosophila melanogaster hsp70 gene to hybrid-select heat shock-induced mouse mRNA and showed that this mRNA encodes the major mouse heat shock protein...
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    In rat cells hyperthermia induces two hsp70 transcripts of 2.5 kb and 2.7 kb. We have cloned and determined the nucleotide sequence of a gene (named hsp70.1) encoding the 2...
  72. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..The detailed analysis of the activity of a luciferase reporter gene under the control of the hsp70.1 promoter, as well as the description of the protein expression patterns of the major heat shock proteins in the ..
  73. Eriksson M, Jokinen E, Sistonen L, Leppa S. Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000;44:471-7 pubmed
    ..Taken together, our results indicate that HSF2 activation is associated with specific stages of heart formation but is not involved in the regulation of inducible heat shock gene expression. ..
  74. Boulard O, Fluteau G, Eloy L, Damotte D, Bedossa P, Garchon H. Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1. J Immunol. 2002;168:4192-201 pubmed
    ..1 in females and on chr.7 in males, probably because of the latent autoimmune predisposition of the NZW strain. Altogether these findings reflect the complexity and heterogeneity of human SS. ..
  75. Chung J, Li M. Biochemical characterization of the native Kv2.1 potassium channel. FEBS J. 2005;272:3743-55 pubmed
    ..1 subunits but not homologous Kv2.2 subunits. The proteins precipitated by anti-Kv2.1 and their physiological relevance are of interest for further investigation. ..
  76. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
    ..level and under stress conditions (heat challenge), HSPB1 act synergistically with the stress-induced HSPA1 (HSP70) in thermotolerance development, protecting cells from apoptosis...
  77. Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, et al. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol. 2009;11:123-32 pubmed publisher
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO. ..
  78. Ozaydin T, Sur E, Oznurlu Y, Celik I, Uluışık D. Immunohistochemical distribution of heat shock protein 70 and proliferating cell nuclear antigen in mouse placenta at different gestational stages. Microsc Res Tech. 2016;79:251-7 pubmed publisher
    The aim of the present study was to investigate immunohistochemical distribution of heat shock protein 70 (Hsp70) and proliferating cell nuclear antigen (PCNA) in the mouse placenta at different gestational stages...
  79. Allende M, Molina E, Guruceaga E, Tamayo I, González Porras J, Gonzalez López T, et al. Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. Cardiovasc Res. 2016;110:309-18 pubmed publisher
    ..b>HSPA1B, which encodes for heat-shock protein 70 kDa (Hsp70), was the most differentially expressed gene...
  80. Hjerpe R, Bett J, Keuss M, Solovyova A, McWilliams T, Johnson C, et al. UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell. 2016;166:935-949 pubmed publisher
    ..We aimed to determine why these parallel delivery mechanisms exist and found that UBQLN2 acts with the HSP70-HSP110 disaggregase machinery to clear protein aggregates via the 26S proteasome...
  81. Rosario M, Perkins S, O Brien D, Allen R, Eddy E. Identification of the gene for the developmentally expressed 70 kDa heat-shock protein (P70) of mouse spermatogenic cells. Dev Biol. 1992;150:1-11 pubmed
    Mouse spermatogenic cells synthesize a 70-kDa protein (P70) closely related to the major heat-shock protein (hsp70) of mammalian cells (R. L. Allen, D. A. O'Brien, and E. M. Eddy, Mol. Cell. Biol. 8, 828-832, 1988)...
  82. Matz J, Blake M, Tatelman H, Lavoi K, Holbrook N. Characterization and regulation of cold-induced heat shock protein expression in mouse brown adipose tissue. Am J Physiol. 1995;269:R38-47 pubmed
    ..Adrenergic receptor antagonists were found to block cold-induced HSP70 expression in BAT, whereas adrenergic agonists induced BAT HSP expression in the absence of cold exposure...
  83. Christians E, Michel E, Adenot P, Mezger V, Rallu M, Morange M, et al. Evidence for the involvement of mouse heat shock factor 1 in the atypical expression of the HSP70.1 heat shock gene during mouse zygotic genome activation. Mol Cell Biol. 1997;17:778-88 pubmed
    The mouse HSP70.1 gene, which codes for a heat shock protein (hsp70), is highly transcribed at the onset of zygotic genome activation (ZGA). This expression, which occurs in the absence of stress, is then repressed...
  84. Galazka G, Stasiolek M, Walczak A, Jurewicz A, Zylicz A, Brosnan C, et al. Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis. J Immunol. 2006;176:1588-99 pubmed
    ..In this study, we show that Hsp70-peptide complexes (pc) isolated from brains of mice with EAE prevented the development of EAE clinically and ..
  85. Ren Z, Ye X, Fang C, Lu Q, Zhao Y, Liu F, et al. Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response. Cancer Biol Ther. 2008;7:191-95 pubmed
    ..These results indicated that the recombinant oncolytic adenovirus over-expressing HSPs possessed powerful in vivo anti-tumor efficacy and might be a valuable approach for cancer immune gene therapy. ..
  86. Zhao L, Shen X, Cao Y, Wang L, Deng H, Zhang H. Effects of laser irradiation on arthritic histopathology and heat shock protein 70 expression in C57 black mice with osteoarthritis. Zhong Xi Yi Jie He Xue Bao. 2011;9:761-7 pubmed
    ..01). Compared with the normal control group, there was a significant induction of HSP70 in the arthritic chondrocytes of the combined laser group...
  87. Song S, Zhou F, Chen W, Xing D. PDT-induced HSP70 externalization up-regulates NO production via TLR2 signal pathway in macrophages. FEBS Lett. 2013;587:128-35 pubmed publisher
    ..We demonstrate that NO production is initially induced by HSP70 on the apoptotic cell surface, and is further enhanced by macrophage phagocytosis...
  88. Hashimoto Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, et al. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014;82:560-72 pubmed publisher
    ..We propose that HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be a key component in the pathogenesis of late-onset neuropsychiatric disorders. ..
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    Mouse spermatogenic cells are known to express HSP70-2, a member of the HSP70 family of heat-shock proteins...
  91. Li H, Niki T, Taira T, Iguchi Ariga S, Ariga H. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res. 2005;39:1091-9 pubmed
    ..The results showed that DJ-1 and its mutants were associated with Hsp70, CHIP and mtHsp70/Grp75, a mitochondria-resident Hsp70, and that L166P and M26I mutants found in PD patients were ..
  92. Singleton K, Wischmeyer P. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1839-45 pubmed
    ..trial data have indicated a relationship between GLN-mediated protection and enhanced heat shock protein 70 (HSP70) expression...