Gene Symbol: Hspa1a
Description: heat shock protein 1A
Alias: Hsp70-3, Hsp70.3, Hsp72, hsp68, hsp70A1, heat shock 70 kDa protein 1A, 68 kDa heat shock protein, heat shock 70 kDa protein 3, heat shock 70kDa protein 1A, heat shock protein, 70 kDa 3, inducible heat shock protein 70
Species: mouse
Products:     Hspa1a

Top Publications

  1. Singleton K, Wischmeyer P. Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. Am J Physiol Lung Cell Mol Physiol. 2006;290:L956-61 pubmed
    ..The specific absence of HSP70 gene expression also leads to increased mortality after septic insult. ..
  2. Ohno M, Kitabatake N, Tani F. Functional region of mouse heat shock protein 72 for its binding to lymphoid neoplastic P388D1 cells. Mol Immunol. 2007;44:2344-54 pubmed
    ..We have found that recombinant mouse inducible heat shock protein 72 (Hsp72) bound to lymphoid neoplastic P388D1 cells...
  3. Singleton K, Wischmeyer P. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1839-45 pubmed
    ..These results confirm our hypothesis that HSP70 expression is required for GLN's effects on survival, tissue injury, and the inflammatory response after global inflammatory injury. ..
  4. Mashukova A, Wald F, SALAS P. Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mol Cell Biol. 2011;31:756-65 pubmed publisher
    ..These effects, including ZO-1 downregulation, were rescued by overexpression of constitutively active aPKC. We conclude that this novel mechanism is a complementary effector pathway for TNF-? signaling. ..
  5. Tang D, Kang R, Xiao W, Wang H, Calderwood S, Xiao X. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol. 2007;179:1236-44 pubmed
    ..In this study, we demonstrate that increases in levels of a major stress-inducible protein, heat shock protein 72 (Hsp72) by gene transfection attenuated LPS- or TNF-alpha-induced HMGB1 cytoplasmic translocation and release...
  6. Tao Y, Hart J, Lichtenstein L, Joseph L, Ciancio M, Hu S, et al. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009;30:175-82 pubmed publisher
    ..This model will be useful to dissect the role of Hsp70 in inflammatory bowel disease colon cancer. ..
  7. Chase M, Wheeler D, Lierl K, Hughes V, Wong H, Page K. Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism. J Immunol. 2007;179:6318-24 pubmed
    Heat shock proteins are generally regarded as intracellular proteins acting as molecular chaperones; however, Hsp72 is also detected in the extracellular compartment...
  8. Hunt C, Dix D, Sharma G, Pandita R, Gupta A, Funk M, et al. Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol. 2004;24:899-911 pubmed
    ..1/3(-/-) cells in comparison to Hsp70.1/3(+/+) cells. Both in vivo and in vitro studies demonstrate for the first time that Hsp70.1 and Hsp70.3 have an essential role in maintaining genomic stability under stress conditions. ..
  9. Murakami N, Kühnel A, Schmid T, Ilicic K, Stangl S, Braun I, et al. Role of membrane Hsp70 in radiation sensitivity of tumor cells. Radiat Oncol. 2015;10:149 pubmed publisher
    The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage...

More Information


  1. Mohamed B, Barakat A, Held T, Elkenani M, Mühlfeld C, Männer J, et al. Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014;50:817-24 pubmed publisher
    ..Our study demonstrates that HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth. ..
  2. Kraynik S, Gabanic A, Anthony S, Kelley M, Paulding W, Roessler A, et al. The stress-induced heat shock protein 70.3 expression is regulated by a dual-component mechanism involving alternative polyadenylation and HuR. Biochim Biophys Acta. 2015;1849:688-96 pubmed publisher
    ..These results not only provide important insight to the regulation of stress response genes following heat shock, but also contribute an enhanced understanding of how alternative polyadenylation contributes to gene regulation. ..
  3. Wilhide M, Tranter M, Ren X, Chen J, Sartor M, Medvedovic M, et al. Identification of a NF-?B cardioprotective gene program: NF-?B regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion. J Mol Cell Cardiol. 2011;51:82-9 pubmed publisher
    ..The genes encoding heat shock protein 70.3 (hspa1a) and heat shock protein 70...
  4. Kim Y, Suarez J, Hu Y, McDonough P, Boer C, Dix D, et al. Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy. Circulation. 2006;113:2589-97 pubmed
    b>Hspa1a and Hspa1b genes encode stress-inducible 70-kDa heat shock proteins (Hsp70) that protect cells from insults such as ischemia. Mice with null mutations of both genes (KO) were generated, and their cardiac phenotype was explored...
  5. Garoby Salom S, Rouahi M, Mucher E, Auge N, Salvayre R, Negre Salvayre A. Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL. Redox Biol. 2015;4:118-26 pubmed publisher
    ..The protective mechanism of HAS2 involves an increased expression of the heat-shock protein Hsp72, a chaperone with antiapoptotic activity...
  6. Meng L, Hunt C, Yaglom J, Gabai V, Sherman M. Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene. 2011;30:2836-45 pubmed publisher
    The major heat shock protein Hsp72 is expressed at elevated levels in many human cancers and its expression correlates with tumor progression...
  7. Fijneman R, Oomen L, Snoek M, Demant P. A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex. Immunogenetics. 1995;41:106-9 pubmed
    ..A(1R) (P < 0.001). For papillary tumors no significant differences were observed. We conclude that the alveolar lung tumor load is influenced by an LTS gene located within the Hsp70.3-G7 interval. ..
  8. McCallister C, Kdeiss B, Oliverio R, Nikolaidis N. Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides. Biochem Biophys Res Commun. 2016;472:270-5 pubmed publisher
    b>HspA1A, a seventy-kilodalton heat shock protein, binds to specific anionic lipids and this interaction regulates important physiological phenomena like apoptosis, tumor growth, and lysosomal rescue...
  9. Hampton C, Shimamoto A, Rothnie C, Griscavage Ennis J, Chong A, Dix D, et al. HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts. Am J Physiol Heart Circ Physiol. 2003;285:H866-74 pubmed
    ..1/3(-/-) mice. We conclude that inducible HSP70.1 and HSP70.3 are required for late-phase protection against infarction following IP in mice. ..
  10. Hunt C, Gasser D, Chaplin D, Pierce J, Kozak C. Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78. Genomics. 1993;16:193-8 pubmed
  11. Hu S, Zhu X, Triggs J, Tao Y, Wang Y, Lichtenstein L, et al. Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1003-11 pubmed publisher
    Although the inducible heat shock protein 70 (Hsp70) is essential for maintaining intestinal homeostasis in colitis, it is translationally downregulated in inflamed colonic mucosa, paradoxically rendering the gut more susceptible to ..
  12. Eriksson M, Jokinen E, Sistonen L, Leppa S. Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000;44:471-7 pubmed
    ..Taken together, our results indicate that HSF2 activation is associated with specific stages of heart formation but is not involved in the regulation of inducible heat shock gene expression. ..
  13. Welc S, Phillips N, Oca Cossio J, Wallet S, Chen D, Clanton T. Hyperthermia increases interleukin-6 in mouse skeletal muscle. Am J Physiol Cell Physiol. 2012;303:C455-66 pubmed publisher
    ..2-fold) in the soleus taken from intact mice exposed, in vivo, to hyperthermia. Muscle HSP72 mRNA increased as a function of the level of hyperthermia, and IL-6 mRNA responses increased proportionally with ..
  14. Fujimoto M, Oshima K, Shinkawa T, Wang B, Inouye S, Hayashida N, et al. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J Biol Chem. 2008;283:29961-70 pubmed publisher
    ..These results suggest novel mechanisms of gene regulation controlled by HSF4 in non-classic heat shock response and in lens development. ..
  15. Subramanian S, Yim Y, Liu K, Tus K, Zhou X, Wakeland E. Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J Immunol. 2005;175:1062-72 pubmed
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene. ..
  16. Wang Z, Gall J, Bonegio R, Havasi A, Hunt C, Sherman M, et al. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011;79:861-70 pubmed publisher
    ..Thus, increasing Hsp70 either before or after ischemic injury preserves renal function by attenuating acute kidney injury. ..
  17. Ngalame N, Micciche A, Feil M, States J. Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure. Toxicol Sci. 2013;131:225-33 pubmed publisher
    ..Earlier microarray analyses showed prenatal arsenic exposure increased Hsc70 (HspA8) and Hsp70 (HspA1a) mRNAs in livers of 10-week-old mice...
  18. Manaenko A, Fathali N, CHEN H, Suzuki H, Williams S, Zhang J, et al. Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage. Neurochem Int. 2010;57:844-50 pubmed publisher
    ..Geldanamycin administration results in reduction of inflammation, preservation of blood-brain-barrier and amelioration of neurobehavioral deficits after an insult possibly by upregulation of heat shock protein 72. ..
  19. Gasser D, Sternberg N, Pierce J, Goldner Sauve A, Feng H, Haq A, et al. P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci. Immunogenetics. 1994;39:48-55 pubmed
    ..1 and BAT6 (valyl-tRNA synthetase). This refines the location of the Cps-1 locus to a 45 kb region contained in the H2-124 P1 insert...
  20. Borowiec A, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, et al. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016;30:3155-70 pubmed publisher
    ..Dewailly, E., Slomianny, C., Mauduit, C., Benahmed, M., Roudbaraki, M., Jégou, B., Prevarskaya, N., Bidaux, G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. ..
  21. Carles M, Wagener B, Lafargue M, Roux J, Iles K, Liu D, et al. Heat-shock response increases lung injury caused by Pseudomonas aeruginosa via an interleukin-10-dependent mechanism in mice. Anesthesiology. 2014;120:1450-62 pubmed publisher
    ..aeruginosa pneumonia in mice via heat-shock protein-72- and interleukin-10-dependent mechanisms. These results provide a novel mechanism for the immunosuppression observed after severe trauma that is known to activate HSR in humans. ..
  22. Dix D, Garges J, Hong R. Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol Reprod Dev. 1998;51:373-80 pubmed
    ..However, these results clearly indicate that some minimal amount of Hsp70-1 and/or Hsp70-3 is required for preimplantation embryogenesis, and that increasing the demand for Hsp70s by arsenic exposure heightens this requirement. ..
  23. de Buhr M, Mahler M, Geffers R, Hansen W, Westendorf A, Lauber J, et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006;25:426-34 pubmed
    ..Strain differences for them are already known or are shown in this study. ..
  24. Jinwal U, Akoury E, Abisambra J, O Leary J, Thompson A, Blair L, et al. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 2013;27:1450-9 pubmed publisher
    ..in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively...
  25. Yoshino M, Sagai T, Lindahl K, Toyoda Y, Shirayoshi Y, Matsumoto K, et al. Recombination in the class III region of the mouse major histocompatibility complex. Immunogenetics. 1994;40:280-6 pubmed
    ..The result demonstrated that an unequal distribution of recombination is a general feature of the mouse MHC, suggesting the presence of a recombinational hotspot within the Int3:Tnx interval. ..
  26. Wacker J, Huang S, Steele A, Aron R, Lotz G, Nguyen Q, et al. Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. J Neurosci. 2009;29:9104-14 pubmed publisher
    ..Thus, endogenous Hsp70s are a critical component of the cellular defense against the toxic effects of misfolded htt protein in neurons, but buffer toxicity by mechanisms independent of the deposition of fibrillar aggregates. ..
  27. Liu Y, Zhao J, Liu J, Zhang H, Liu M, Xiao X. Upregulation of the constitutively expressed HSC70 by KLF4. Cell Stress Chaperones. 2008;13:337-45 pubmed publisher
    ..However, the regulation of the expression of inducible heat shock protein 70 (HSP72) and heat shock cognate 70 (HSP73) by KLF4 is not defined...
  28. Tranter M, Ren X, Forde T, Wilhide M, Chen J, Sartor M, et al. NF-kappaB driven cardioprotective gene programs; Hsp70.3 and cardioprotection after late ischemic preconditioning. J Mol Cell Cardiol. 2010;49:664-72 pubmed publisher
    ..The results of infarct studies confirm that Hsp70.3 is protective after IPC. However, though Hsp70.1 and Hsp70.3 are coordinately regulated, their functions are opposing after I/R injury. ..
  29. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  30. Snoek M, Teuscher C, van Vugt H. Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. J Immunol. 1998;160:266-72 pubmed
    ..The exact localization of crossovers in recombinants that have been used in functional studies is important for mapping susceptibility genes and limits the number of candidate genes. ..
  31. Zaprjanova S, Rashev P, Zasheva D, Martinova Y, Mollova M. Electrophoretic and immunocytochemical analysis of Hsp72 and Hsp73 expression in heat-stressed mouse testis and epididymis. Eur J Obstet Gynecol Reprod Biol. 2013;168:54-9 pubmed publisher
    ..Expression of the main isoforms of the Hsp70 family (constitutive Hsp73 and stress-inducible Hsp72) was determined in normal and heat-stressed mouse testes and epididymis from sexually mature (60-day-old) mice ..
  32. Zhang Y, Zhang X, Shan P, Hunt C, Pandita T, Lee P. A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. J Immunol. 2013;191:1393-403 pubmed publisher
    ..To our knowledge, our studies are the first to define an Hsp70-TLR4-Trif cytoprotective axis in the lung and endothelial cells. This pathway is a potential therapeutic target against a range of oxidant-induced lung injuries. ..
  33. Snoek M, Jansen M, Olavesen M, Campbell R, Teuscher C, van Vugt H. Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus. Genomics. 1993;15:350-6 pubmed
    ..Heat shock proteins play an important role in a large number of physiological processes and it is tempting to speculate that Hsc70t, which exhibits testis-specific expression, may be identical to Orch-1...
  34. Tranter M, Helsley R, Paulding W, McGuinness M, Brokamp C, Haar L, et al. Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation. J Biol Chem. 2011;286:29828-37 pubmed publisher
    ..3 in parallel with ischemic or heat shock-induced up-regulation of mRNA levels and implicate the importance of this process in post-transcriptional control of Hsp70.3 expression. ..
  35. Perry M, Aujame L, Shtang S, Moran L. Structure and expression of an inducible HSP70-encoding gene from Mus musculus. Gene. 1994;146:273-8 pubmed
    We have determined the nucleotide sequence of a stress-inducible mouse Hsp70-encoding gene named hsp70A1. The gene encodes a 641-amino-acid protein whose deduced sequence is similar to those of other members of the HSP70 family...
  36. Kim J, Kim J, Yu Y, Jeong S, Kim K. Protective effect of heat shock proteins 70.1 and 70.3 on retinal photic injury after systemic hyperthermia. Korean J Ophthalmol. 2005;19:116-21 pubmed
    ..Histology and immunohistochemistry for the inducible heat shock protein 70 (hsp70), the constitutive heat shock protein 70 (hsc70), and westem blot analysis, reverse ..
  37. Huang L, Mivechi N, Moskophidis D. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Mol Cell Biol. 2001;21:8575-91 pubmed
    ..The additive or synergistic effects exhibited by coexpression of both hsp70 genes, and the evolutionary significance of the presence of both hsp70 genes, is hence underlined. ..
  38. Kim J, Kim N, Zheng Z, Lee J, Yenari M. The 70 kDa heat shock protein protects against experimental traumatic brain injury. Neurobiol Dis. 2013;58:289-95 pubmed publisher
    ..Our data demonstrate a new mechanism linking TBI-induced hemorrhage and neuronal injury to the suppression of MMPs by Hsp70, and support the development of Hsp70 enhancing strategies for the treatment of TBI. ..
  39. Drew B, Ribas V, Le J, Henstridge D, Phun J, Zhou Z, et al. HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes. 2014;63:1488-505 pubmed publisher
    ..Herein we show that HSP72 is a critical regulator of stress-induced mitochondrial triage signaling since Parkin, an E3 ubiquitin ligase ..
  40. Geng J, Li H, Huang C, Chai J, Zheng R, Li F, et al. Functional analysis of HSPA1A and HSPA8 in parturition. Biochem Biophys Res Commun. 2017;483:371-379 pubmed publisher
    ..HSP70 for regulating parturition, we overexpressed and knocked down two representative members of HSP70 (HSPA1A and HSPA8) through transfection of their recombinant plasmid and si-RNA separately in WISH (human amniotic ..
  41. Xu L, Emery J, Ouyang Y, Voloboueva L, Giffard R. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. 2010;58:1042-9 pubmed publisher
    ..Two well-studied protective proteins, heat shock protein 72 (Hsp72) or superoxide dismutase 2 (SOD2), were genetically targeted for expression in astrocytes using the astrocyte-..
  42. Papaconstantinou A, Fisher B, Umbreit T, Goering P, Lappas N, Brown K. Effects of beta-estradiol and bisphenol A on heat shock protein levels and localization in the mouse uterus are antagonized by the antiestrogen ICI 182,780. Toxicol Sci. 2001;63:173-80 pubmed
    ..E2, increased hsp90alpha and grp94 to similar levels, but was much less effective than E2 in increasing levels of hsp72. Treatment with 100 mg BPA/kg/day or 2 microg E2/kg/day increased hsp90alpha to 300% of control levels and altered ..
  43. Matsumori Y, Northington F, Hong S, Kayama T, Sheldon R, Vexler Z, et al. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Stroke. 2006;37:507-12 pubmed
  44. Goto K, Kojima A, Morioka S, Naito T, Akema T, Matsuba Y, et al. Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells. Biochem Biophys Res Commun. 2007;358:331-5 pubmed
    Effects of an antiulcer drug, geranylgeranylaceton (GGA), and/or heat-stress on 72 kDa heat shock protein (HSP72) expression and protein content in cultured skeletal muscle cells were studied...
  45. Ohno M, Kitabatake N, Tani F. Role of the C-terminal region of mouse inducible Hsp72 in the recognition of peptide substrate for chaperone activity. FEBS Lett. 2004;576:381-6 pubmed
    Here, we produced the C-terminal truncation variants of mouse inducible heat shock protein 72 (Hsp72) to elucidate the regulatory role of the C-terminal helical lid of Hsp70 for substrate recognition...
  46. Ganter M, Ware L, Howard M, Roux J, Gartland B, Matthay M, et al. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006;291:L354-61 pubmed
    Previous studies have shown that heat shock protein 72 (Hsp72) is found in the extracellular space (eHsp72) and that eHsp72 has potent immunomodulatory effects...
  47. Kothary R, Perry M, Moran L, Rossant J. Cell-lineage-specific expression of the mouse hsp68 gene during embryogenesis. Dev Biol. 1987;121:342-8 pubmed
    Transcription of the mouse hsp68 and hsc70 genes in embryonal carcinoma cells, various embryonic and extraembryonic tissues, and some adult tissues has been assessed using cloned probes to the mouse hsp68 gene...
  48. Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M. hsp72, a host determinant of measles virus neurovirulence. J Virol. 2006;80:11031-9 pubmed
    ..as that experienced during febrile episodes increases expression of the major inducible 70-kDa heat shock protein (hsp72)...
  49. Ohtsuka Y, Brunson K, Jedlicka A, Mitzner W, Clarke R, Zhang L, et al. Genetic linkage analysis of susceptibility to particle exposure in mice. Am J Respir Cell Mol Biol. 2000;22:574-81 pubmed
  50. Lee J, Beebe K, Nangle L, Jang J, Longo Guess C, Cook S, et al. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443:50-5 pubmed
    ..These findings demonstrate that disruption of translational fidelity in terminally differentiated neurons leads to the accumulation of misfolded proteins and cell death, and provide a novel mechanism underlying neurodegeneration. ..
  51. Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
    ..This work rigorously demonstrates the unique location of two highly similar DSPs on opposing sides of the mitochondrial inner membrane...
  52. Eroglu B, Moskophidis D, Mivechi N. Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol. 2010;30:4626-43 pubmed publisher
  53. Snoek M, van Vugt H, Groot P. New microsatellite size variants as markers for a cross-over hotspot in the C4-H-2D region. Mamm Genome. 1994;5:174-6 pubmed
  54. Tani F, Ohno M, Furukawa Y, Sakamoto M, Masuda S, Kitabatake N. Surface expression of a C-terminal alpha-helix region in heat shock protein 72 on murine LL/2 lung carcinoma can be recognized by innate immune sentinels. Mol Immunol. 2009;46:1326-39 pubmed publisher
    ..Here we examined how the inducible mouse Hsp72 can be expressed on the surface of two types of murine tumor cell lines in response to non-lethal heat shock...
  55. Haraguchi S, Tsuda M, Kitajima S, Sasaoka Y, Nomura Kitabayashid A, Kurokawa K, et al. nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Mech Dev. 2003;120:721-31 pubmed
    ..The nanos1 -deficient mice develop to term without any detectable abnormality and they are fertile. No significant neural defect is observed in terms of their behavior to date. ..
  56. Ammirante M, Rosati A, Arra C, Basile A, Falco A, Festa M, et al. IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. Proc Natl Acad Sci U S A. 2010;107:7497-502 pubmed publisher
    ..As a proof of principle, we show that treatment of a mouse xenograft tumor model with bag3siRNA-adenovirus that down-regulates bag3 results in reduced tumor growth and increased animal survival. ..
  57. Matsuda M, Hoshino T, Yamashita Y, Tanaka K, Maji D, Sato K, et al. Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem. 2010;285:5848-58 pubmed publisher
    ..The findings here also suggest that the protective action of HSP70 is mediated by anti-apoptotic, anti-inflammatory, and anti-DNA damage effects. ..
  58. Ambrosini M, Mariucci G, Tantucci M, Van Hooijdonk L, Ammassari Teule M. Hippocampal 72-kDa heat shock protein expression varies according to mice learning performance independently from chronic exposure to stress. Hippocampus. 2005;15:413-7 pubmed
    The possibility that the inducible 72-kDa heat shock protein (hsp72) is involved in learning-related plasticity mechanisms was investigated in two inbred strains of mice that show spontaneous differences in spatial learning performance ..
  59. Egawa T, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, et al. AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells. Am J Physiol Endocrinol Metab. 2014;306:E344-54 pubmed publisher
    ..The treatment with AICAR, a potent stimulator of AMPK, decreased 72-kDa HSP (HSP72) expression, whereas there were no changes in the expressions of 25-kDa HSP, 70-kDa heat shock cognate, and heat ..
  60. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges N, Hagiwara H, et al. Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature. 2008;456:611-6 pubmed publisher
    ..Biochemical and immunohistochemical studies show that Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. ..
  61. Zietara N, Łyszkiewicz M, Gekara N, Puchałka J, dos Santos V, Hunt C, et al. Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol. 2009;183:1099-109 pubmed publisher
    ..Thus, constitutive IFN-beta expression regulates Hsp70 levels to help maintain dendritic cells in a competent state for efficient priming of effector T cells in vivo. ..
  62. Tang D, Kang R, Xiao W, Jiang L, Liu M, Shi Y, et al. Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J Immunol. 2007;178:7376-84 pubmed
    ..In response to oxidative stress, cytoplasmic Hsp72 translocated to the nucleus, where it interacted with nuclear proteins including HMGB1...
  63. Hashimoto Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, et al. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014;82:560-72 pubmed publisher
    ..We propose that HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be a key component in the pathogenesis of late-onset neuropsychiatric disorders. ..
  64. Okamoto Y, Pehlivan D, Wiszniewski W, Beck C, Snipes G, Lupski J, et al. Curcumin facilitates a transitory cellular stress response in Trembler-J mice. Hum Mol Genet. 2013;22:4698-705 pubmed publisher
  65. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches. ..
  66. Barrier M, Dix D, Mirkes P. Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice. Birth Defects Res A Clin Mol Teratol. 2009;85:732-40 pubmed publisher
    ..Previously, our laboratory has shown that embryos overexpressing the 70-Da heat shock proteins (HSPs) Hspa1a and Hspa1b were partially protected from the deleterious effects of exposure to hyperthermia in vitro...
  67. Henstridge D, Estevez E, Allen T, Heywood S, Gardner T, Yang C, et al. Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance. Cell Stress Chaperones. 2015;20:461-72 pubmed publisher
    Heat shock protein 72 (Hsp72) protects cells against a variety of stressors, and multiple studies have suggested that Hsp72 plays a cardioprotective role...
  68. Ito Y, Ando A, Ando H, Ando J, Saijoh Y, Inoko H, et al. Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. J Biochem. 1998;124:347-53 pubmed
    ..1 and Hsp70.3, located in the MHC class III region. The syntenic region of human chromosome 6 contains the HSPA1B, HSPA1A, and HSPA1L genes. Here, we have isolated a HSPA1L cDNA clone from human testicular cells...
  69. McConnell K, Fox A, Clark A, Chang N, Dominguez J, Farris A, et al. The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol. 2011;186:3718-25 pubmed publisher
    ..HSP70 may play a protective role in an age-dependent response to sepsis by preventing excessive gut apoptosis and both pulmonary and systemic inflammation. ..
  70. Henstridge D, Bruce C, Drew B, Tory K, Kolonics A, Estevez E, et al. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 2014;63:1881-94 pubmed publisher
    ..Here, we show that HSP72 plays a pivotal role in increasing skeletal muscle mitochondrial number and oxidative metabolism...
  71. Gunther E, Walter L. Genetic aspects of the hsp70 multigene family in vertebrates. Experientia. 1994;50:987-1001 pubmed
    ..After a detailed description of the various hsp70 genes more general characteristics of the organization and evolution of the multigene family are discussed. ..
  72. Hurwitz M, Kaur P, Nagaraja G, Bausero M, Manola J, Asea A. Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer. Radiother Oncol. 2010;95:350-8 pubmed publisher
    b>Hsp72 found in the extracellular milieu has been shown to play an important role in immune regulation. The impact of common cancer therapies on extracellular release of Hsp72 however, has been to date undefined...
  73. Allende M, Molina E, Guruceaga E, Tamayo I, González Porras J, Gonzalez López T, et al. Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. Cardiovasc Res. 2016;110:309-18 pubmed publisher
    ..Hsp70 induction is a novel approach to delay thrombus formation with minimal bleeding risk, and is especially promising for treating AF patients and in other situations where there is also a major bleeding hazard. ..
  74. Steel R, Doherty J, Buzzard K, Clemons N, Hawkins C, Anderson R. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. J Biol Chem. 2004;279:51490-9 pubmed
    b>Hsp72 protects cells against apoptosis in response to various stresses...
  75. Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy Martin J, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010;120:457-71 pubmed publisher
    ..isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and MDSCs determines the suppressive activity of the MDSCs via activation of Stat3...
  76. Tao Y, Drabik K, Waypa T, Musch M, Alverdy J, Schneewind O, et al. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006;290:C1018-30 pubmed
    ..LGG-CM induces both Hsp25 and Hsp72 in a time- and concentration-dependent manner...
  77. Kazemi Z, Chang H, Haserodt S, McKen C, Zachara N. O-linked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner. J Biol Chem. 2010;285:39096-107 pubmed publisher
    ..In OGT null cells the stress-induced expression of 18 molecular chaperones, including HSP72, were reduced...
  78. Hirsh M, Hashiguchi N, Chen Y, Yip L, Junger W. Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing. Eur J Immunol. 2006;36:712-21 pubmed
    ..Inhibitors of transcription, protein synthesis, and intracellular protein transport blocked HSP72 expression, indicating that de novo synthesis is required...
  79. Xu L, Xiong X, Ouyang Y, Barreto G, Giffard R. Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice. Neurosci Lett. 2011;488:279-82 pubmed publisher
    ..The inducible member of the Heat shock protein 70 (Hsp70) family, Heat shock protein 72 (Hsp72), has been widely found to reduce ischemic injury...
  80. Barreto G, White R, Xu L, Palm C, Giffard R. Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse. Exp Neurol. 2012;238:284-96 pubmed publisher
    ..Heat shock protein 72 (Hsp72) protects from cerebral ischemia, and although several protective mechanisms have been investigated, effects on ..