Hsp90ab1

Summary

Gene Symbol: Hsp90ab1
Description: heat shock protein 90 alpha (cytosolic), class B member 1
Alias: 90kDa, AL022974, C81438, Hsp84, Hsp84-1, Hsp90, Hspcb, heat shock protein HSP 90-beta, HSP 84, TSTA, heat shock 84 kDa, heat shock 90kDa protein 1, beta, heat shock protein 1, beta, heat shock protein 90kDa alpha (cytosolic), class B member 1, heat shock protein, 84 kDa 1, retinal degeneration slow protein, tumor-specific transplantation 84 kDa antigen
Species: mouse
Products:     Hsp90ab1

Top Publications

  1. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007;21:2172-81 pubmed
    ..of major cellular chaperones by triggering the dissociation of a repressive HDAC6/HSF1 (heat-shock factor 1)/HSP90 (heat-shock protein 90) complex and a subsequent HSF1 activation...
  2. de Zoeten E, Wang L, Butler K, Beier U, Akimova T, Sai H, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011;31:2066-78 pubmed publisher
    ..effects of HDAC6 targeting are also achieved by inhibition of the HDAC6-regulated protein heat shock protein 90 (HSP90)...
  3. Voss A, Thomas T, Gruss P. Mice lacking HSP90beta fail to develop a placental labyrinth. Development. 2000;127:1-11 pubmed
    ..The allantois mesoderm is thought to induce trophoblast differentiation. Our results show that Hsp90beta is a necessary component of this induction process. ..
  4. Hummel B, Hansen E, Yoveva A, Aprile Garcia F, Hussong R, Sawarkar R. The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nat Struct Mol Biol. 2017;24:234-242 pubmed publisher
    ..The chaperone heat-shock protein 90 (HSP90) buffers genetic variation by stabilizing proteins with variant sequences, thereby uncoupling phenotypes from ..
  5. Dittmar K, Demady D, Stancato L, Krishna P, Pratt W. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem. 1997;272:21213-20 pubmed
    In cytosols from animal and plant cells, the abundant heat shock protein hsp90 is associated with several proteins that act together to assemble steroid receptors into receptor.hsp90 heterocomplexes...
  6. Reeves R, Gallahan D, O Hara B, Callahan R, Gearhart J. Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44:76-81 pubmed
    ..A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome. ..
  7. Hahn J. Regulation of Nod1 by Hsp90 chaperone complex. FEBS Lett. 2005;579:4513-9 pubmed
    ..It has been demonstrated that plant Hsp90 and its co-chaperone RAR1 are implicated in R-mediated disease resistance...
  8. Romano J, Seldin M, Appella E. Linkage of the mouse Hsp84 heat shock protein structural gene to the H-2 complex. Immunogenetics. 1989;29:142-4 pubmed
  9. Kitam V, Maksymchuk O, Chashchyn M. The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them. BMC Struct Biol. 2012;12:33 pubmed publisher
    ..The efficiency of such degradation depends on the presence of molecular chaperones (HSP90) as was shown from in vitro experiments...

More Information

Publications89

  1. Kovacs J, Murphy P, Gaillard S, Zhao X, Wu J, Nicchitta C, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005;18:601-7 pubmed
    The molecular chaperone heat shock protein 90 (Hsp90) and its accessory cochaperones function by facilitating the structural maturation and complex assembly of client proteins, including steroid hormone receptors and selected kinases...
  2. Piatelli M, Doughty C, Chiles T. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. J Biol Chem. 2002;277:12144-50 pubmed
    ..Disruption of endogenous heat shock protein 90 (hsp90) function with geldanamycin abrogated BCR-induced cyclin D2 expression and proliferation...
  3. Parekh V, McEwen A, Barbour V, Takahashi Y, Rehg J, Jane S, et al. Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Mol Cell Biol. 2004;24:7113-29 pubmed
    ..Collectively, these results demonstrate that LBP-1a plays a critical role in the regulation of extraembryonic angiogenesis. ..
  4. Yang K, Shi H, Qi R, Sun S, Tang Y, Zhang B, et al. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006;17:1461-71 pubmed
    ..by yeast two-hybrid approach a specific interaction between IRF3 and chaperone heat-shock protein of 90 kDa (Hsp90). The C-terminal truncation mutant of Hsp90 is a strong dominant-negative inhibitor of IRF3 activation...
  5. Bell D, Poland A. Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90. J Biol Chem. 2000;275:36407-14 pubmed
    ..The binding of AIP to AhR in reticulocyte lysate shows several of the characteristics of an hsp90-dependent process, including sensitivity to geldanamycin and temperature and a requirement for ATP or ..
  6. Ma Q, Whitlock J. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997;272:8878-84 pubmed
    ..in mouse hepatoma cells reveal that AIP is cytoplasmic and associates with unliganded Ah receptor and with hsp90; 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment disrupts the AhR-AIP-hsp90 interaction...
  7. Sarge K, Cullen K. Regulation of hsp expression during rodent spermatogenesis. Cell Mol Life Sci. 1997;53:191-7 pubmed
    ..we will review studies showing that the expression of several different members of both the hsp70 as well as hsp90 families of heat shock proteins is regulated during the differentiation of these cells...
  8. Metchat A, Akerfelt M, Bierkamp C, Delsinne V, Sistonen L, Alexandre H, et al. Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression. J Biol Chem. 2009;284:9521-8 pubmed publisher
    ..We find that Hsp90alpha (Hspaa1) is the major HSF1-dependent chaperone inasmuch as Hsf1 knock-out resulted in Hsp90-depleted oocytes...
  9. Simet S, Pavlik J, Sisson J. Proteomic analysis of bovine axonemes exposed to acute alcohol: role of endothelial nitric oxide synthase and heat shock protein 90 in cilia stimulation. Alcohol Clin Exp Res. 2013;37:609-15 pubmed publisher
    ..One of the proteins identified was heat shock protein 90 (HSP90), which undergoes increased threonine phosphorylation after brief alcohol exposure...
  10. Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
    ..expression inference and signaling pathway prediction analysis of P2RX7 signaling mediators pointed to HSPA2 and HSP90 proteins...
  11. Zhao Y, Shen H, Chen X, Xiong R, Li P, Liu P, et al. Genetic variations of heat shock protein 84 in mice mediate cellular glucocorticoid response. Cell Physiol Biochem. 2010;25:359-66 pubmed publisher
    Heat shock protein 90 (Hsp90), encoded by hsp84 and hsp86 in mice, has been confirmed to modulate glucocorticoid receptor (GR) function; however, the contribution of Hsp90 in glucocorticoid (GC) sensibility/resistance has received less ..
  12. Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett. 2003;548:17-20 pubmed
    ..In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex...
  13. Rao R, Balusu R, Fiskus W, Mudunuru U, Venkannagari S, Chauhan L, et al. Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther. 2012;11:973-83 pubmed publisher
    ..Treatment of MB-231 and SUM159PT cells with panobinostat disrupted the hsp90/histone deacetylase 6/HSF1/p97 complex, resulting in the upregulation of hsp...
  14. Pongratz I, Mason G, Poellinger L. Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activi. J Biol Chem. 1992;267:13728-34 pubmed
    ..The latent receptor form is associated with an inhibitory protein (the 90-kDa heat shock protein, hsp90), the release of which is necessary to unmask the DNA binding activity of the receptor...
  15. Kueh A, Dixon M, Voss A, Thomas T. HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011;31:845-60 pubmed publisher
    ..In conclusion, the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development. ..
  16. Prodromou N, Thompson C, Osborn D, Cogger K, Ashworth R, Knight M, et al. Heat shock induces rapid resorption of primary cilia. J Cell Sci. 2012;125:4297-305 pubmed publisher
    ..This implies a role for molecular chaperones in the maintenance of primary cilia. The cytosolic chaperone Hsp90 localises to the ciliary axoneme and its inhibition resulted in cilia loss...
  17. Schneider R, Linka R, Reinke H. HSP90 affects the stability of BMAL1 and circadian gene expression. J Biol Rhythms. 2014;29:87-96 pubmed publisher
    ..Furthermore, the HSP90 isoforms HSP90AA1 and HSP90AB1, and not HSP90B1-GRP94 or TRAP1, are responsible for maintaining proper cellular levels of BMAL1 protein...
  18. Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa W, et al. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. 2005;24:3954-63 pubmed
    b>Hsp90 client protein Akt has been shown to inhibit cell apoptosis in part by inhibiting proapoptotic kinase ASK1 (apoptosis signal-regulating kinase 1) activity...
  19. Delgoffe G, Kole T, Cotter R, Powell J. Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. Mol Immunol. 2009;46:2694-8 pubmed publisher
    ..Using this approach we have identified Hsp90 as an activation-induced binding partner of raptor in T cells...
  20. BRADLEY E, Bieberich E, Mivechi N, Tangpisuthipongsa D, Wang G. Regulation of embryonic stem cell pluripotency by heat shock protein 90. Stem Cells. 2012;30:1624-33 pubmed publisher
    ..We report here that the molecular chaperone heat shock protein 90 (Hsp90) is essential for mouse embryonic stem cell (ESC) pluripotency through regulating multiple pluripotency factors, ..
  21. Hoel A, Yu P, Nguyen K, Sui X, Plescia J, Altieri D, et al. Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo. Am J Pathol. 2012;181:1151-7 pubmed publisher
    ..have highlighted the role of mitochondrial proteins, such as the molecular chaperone heat shock protein-90 (Hsp90), in promoting cancer cell survival, which leads to new candidate chemotherapeutic agents for neoplastic disease...
  22. Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, et al. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007;104:9511-6 pubmed
    ..In malignant cells, the capacity to buffer transformation has been attributed to heat-shock protein 90 (Hsp90)...
  23. Ghosh A, Chawla Sarkar M, Stuehr D. Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J. 2011;25:2049-60 pubmed publisher
    ..We investigated a role for chaperone heat shock protein 90 (hsp90) in enabling heme insertion into the cytokine-inducible mouse NOS. We used macrophage cell line RAW 264...
  24. Kuo C, Liang C, Lai C, Liang S. Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide. J Immunol. 2007;178:6100-8 pubmed
    ..This study thus reveals the involvement of Hsp90beta but not Hsp90alpha in CpG-B ODN-mediated antiapoptotic response and that Hsp90beta is distinct from Hsp90alpha in regulation of the cellular function of immune cells. ..
  25. Graham L. Tumour rejection antigens of the hsp90 family (gp96) closely resemble tumour-associated heparanase enzymes. Biochem J. 1994;301 ( Pt 3):917-8 pubmed
  26. Dao Phan H, Formstecher P, Lefebvre P. Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid. Mol Endocrinol. 1997;11:962-72 pubmed
    ..GR) and progesterone (PR) receptors with a set of molecular chaperones, including the 90-kDa heat shock protein (hsp90), is a dynamic process required for proper folding and maintaining these nuclear receptors under a ..
  27. Joo J, Dorsey F, Joshi A, Hennessy Walters K, Rose K, McCastlain K, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell. 2011;43:572-85 pubmed publisher
    ..The Hsp90-Cdc37 chaperone complex coordinately regulates the activity of select kinases to orchestrate many facets of the ..
  28. Jochems J, Teegarden S, Chen Y, Boulden J, Challis C, Ben Dor G, et al. Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics. Biol Psychiatry. 2015;77:345-55 pubmed publisher
    Acetylation of heat shock protein 90 (Hsp90) regulates downstream hormone signaling via the glucocorticoid receptor (GR), but the role of this molecular mechanism in stress homeostasis is poorly understood...
  29. Kaucsár T, Bodor C, Godo M, Szalay C, Révész C, Nemeth Z, et al. LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney. PLoS ONE. 2014;9:e92004 pubmed publisher
    ..Here, by using the pharmacological Hsp90 inhibitor novobiocin (NB), we investigated the role of Hsp90 and the heat shock response in LPS-induced delayed ..
  30. Carlomagno Y, Zhang Y, Davis M, Lin W, Cook C, Dunmore J, et al. Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. PLoS ONE. 2014;9:e90452 pubmed publisher
    ..These findings demonstrate CKII induces polymerization of soluble TDP-43 into filaments and Hsp90 promotes TDP-43 filament depolymerization...
  31. Radovanac K, Morgner J, Schulz J, Blumbach K, Patterson C, Geiger T, et al. Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBO J. 2013;32:1409-24 pubmed publisher
    ..Here we report that the E3 ligase CHIP-heat shock protein 90 (Hsp90) axis regulates ILK turnover in fibroblasts...
  32. Moore S, Kozak C, Robinson E, Ullrich S, Appella E. Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences. Gene. 1987;56:29-40 pubmed
    ..Gene hsp84 codes for an acidic polypeptide of 724 amino acid (aa) residues...
  33. Hoffmann T, Hovemann B. Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens. Gene. 1988;74:491-501 pubmed
    ..Northern blot hybridization experiments reveal a 2.6-kb poly(A)+RNA when probed with the hsp84 clone and a 2.85-kb signal with the hsp84-related cDNA...
  34. Espallergues J, Teegarden S, Veerakumar A, Boulden J, Challis C, Jochems J, et al. HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. J Neurosci. 2012;32:4400-16 pubmed publisher
    ..of glucocorticoid hormones on socioaffective behaviors are critically regulated via reversible acetylation of Hsp90, a key component of the GR chaperone complex...
  35. Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J. Messenger RNA expression of heat shock proteins (HSPs) during ocular development. Curr Eye Res. 1995;14:1125-33 pubmed
    ..Expression of HSP32, HSP60, HSP70, HSP84, HSP86 and heat shock cognate protein (HSC)70 mRNAs was examined by in situ hybridization...
  36. Waheed A, Jones T. Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts. J Biol Chem. 2002;277:32409-12 pubmed
    ..Geldanamycin treatment, which specifically inhibits Hsp90, caused a partial loss of wild-type Galpha(12) and a complete loss of the Cys-11 mutant from the lipid rafts and ..
  37. Moore S, Rijli F, Appella E. Characterization of the mouse 84-kD heat shock protein gene family. DNA Cell Biol. 1990;9:387-400 pubmed
    The nucleotide sequence of a 6-kb region containing the gene for mouse 84-kD heat shock protein, HSP84, was determined...
  38. El Ghazi I, Martin B, Armitage I. Metallothionein-3 is a component of a multiprotein complex in the mouse brain. Exp Biol Med (Maywood). 2006;231:1500-6 pubmed
    ..The proteins identified were: heat shock protein 84 (HSP84), heat shock protein 70 (HSP70), dihydropyrimidinase-like protein-2 (DRP-2), creatine kinase (CK) and beta-actin...
  39. Le B, Powers G, Tam Y, Schumacher N, Malinowski R, Steinke L, et al. Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer. PLoS ONE. 2017;12:e0174658 pubmed publisher
    ..Specifically antimitotic agent docetaxel, mTOR inhibitor rapamycin, and HSP90 inhibitor 17-N-allylamino-17-demethoxygeldanamycin were incorporated into the micelle system (DR17) and tested for ..
  40. Mazzarella R, Green M. ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94). J Biol Chem. 1987;262:8875-83 pubmed
    ..revealed that ERp99 has extensive homology with the 90-kDa heat shock protein of Saccharomyces cerevisiae (hsp90) and the 83-kDa heat shock protein of Drosophila melanogaster...
  41. Jakob U, Buchner J. Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones. Trends Biochem Sci. 1994;19:205-11 pubmed
    b>Hsp90 and small Hsps are two abundant types of eukaryotic stress protein whose function has remained largely enigmatic...
  42. Sawarkar R, Sievers C, Paro R. Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli. Cell. 2012;149:807-18 pubmed publisher
    The molecular chaperone Heat shock protein 90 (Hsp90) promotes the maturation of several important proteins and plays a key role in development, cancer progression, and evolutionary diversification...
  43. Huang Q, He S, Tian Y, Gu Y, Chen P, Li C, et al. Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice. Blood. 2017;129:2737-2748 pubmed publisher
    ..In contrast, destabilizing T-cell Ezh2 protein by inhibiting Hsp90 using its specific inhibitor AUY922 reduced GVHD in mice undergoing allogeneic HSCT...
  44. Nguyen M, Csermely P, Soti C. Hsp90 chaperones PPAR? and regulates differentiation and survival of 3T3-L1 adipocytes. Cell Death Differ. 2013;20:1654-63 pubmed publisher
    ..The Hsp90 chaperone stabilizes a diverse set of signaling 'client' proteins, thereby regulates various biological processes...
  45. Collins C, Aherne C, Yeckes A, Pound K, Eltzschig H, Jedlicka P, et al. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013;6:960-71 pubmed publisher
    ..Inflammatory stress drives upregulation of heat-shock proteins (HSPs), including the pro-inflammatory chaperone, HSP90. This protein sequesters the transcription factor, heat-shock factor 1 (HSF1) in the cytoplasm preventing ..
  46. Odunewu Aderibigbe A, Fliegel L. Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase. Cell Signal. 2017;36:145-153 pubmed publisher
    ..the C-terminus of NHE1 yielded a number of NHE1 binding proteins including 14-3-3 protein, heat shock proteins (Hsp90 and Hsp70) and Na+/K+ ATPase...
  47. Tucker D, Gijón M, Spencer D, Qiu Z, Gelb M, Leslie C. Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. J Leukoc Biol. 2008;84:798-806 pubmed publisher
    ..Inhibitors of heat shock protein 90 (hsp90), geldanamycin, and herbimycin blocked AA release in response to OA but not to A23187, PMA, or zymosan...
  48. Ayrault O, Godeny M, Dillon C, Zindy F, Fitzgerald P, Roussel M, et al. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A. 2009;106:17037-42 pubmed publisher
    Elevated expression of HSP90 is observed in many tumor types and is associated with a limited clinical response...
  49. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches. ..
  50. Shi C, Huang X, Zhang B, Zhu D, Luo H, Lu Q, et al. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS ONE. 2015;10:e0138936 pubmed publisher
    ..In this study, we show that PABPN1 interacts with and is stabilized by heat shock protein 90 (HSP90)...
  51. Voss A, Thomas T, Gruss P. Efficiency assessment of the gene trap approach. Dev Dyn. 1998;212:171-80 pubmed
    ..Evidently, gene trapping does not always provide all three of the features mentioned above. In this paper, we discuss the efficiency of gene trapping and ways in which some problems may be overcome. ..
  52. Stecca B, Nait Oumesmar B, Kelley K, Voss A, Thomas T, Lazzarini R. Gcm1 expression defines three stages of chorio-allantoic interaction during placental development. Mech Dev. 2002;115:27-34 pubmed
    ..In the third phase, the labyrinth formation, cells expressing Gcm1 proliferate, involute in the chorionic plate and branched villi formation begins. ..
  53. Chakraborty A, Koldobskiy M, Sixt K, Juluri K, Mustafa A, Snowman A, et al. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A. 2008;105:1134-9 pubmed publisher
    ..Some HSPs, especially HSP90, can be antiapoptotic and the targets of anticancer drugs...
  54. Shen H, Zhao Y, Chen X, Xiong R, Lu J, Chen J, et al. Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma. J Neurotrauma. 2010;27:373-81 pubmed publisher
    Heat shock protein 90 (Hsp90), encoded by the murine hsp84 and hsp86 genes in mice, is a pivotal regulator of glucocorticoid receptor (GR) function in the hypothalamus-pituitary-adrenal axis and affords stress protection...
  55. Voss A, Vanyai H, Collin C, Dixon M, McLennan T, Sheikh B, et al. MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012;23:652-63 pubmed publisher
    ..Our data reveal a molecular mechanism for a specific chromatin modification of the Tbx1 locus intersecting with an environmental determinant, modeling variability in DiGeorge syndrome. ..
  56. Chan C, Reeves R, Geller R, Yaghoubi S, Hoehne A, Solow Cordero D, et al. Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proc Natl Acad Sci U S A. 2012;109:E2476-85 pubmed publisher
    Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (? and ?) play different roles in response to chemotherapy...
  57. Faulds G, Isenberg D, Latchman D. The tissue specific elevation in synthesis of the 90 kDa heat shock protein precedes the onset of disease in lupus prone MRL/lpr mice. J Rheumatol. 1994;21:234-8 pubmed
    ..MRL/lpr mice show an age independent and tissue specific increase in HSP 90 levels which, as in human patients with SLE, is specific for this HSP. ..
  58. Taylor D, Tradewell M, Minotti S, Durham H. Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1. Cell Stress Chaperones. 2007;12:151-62 pubmed
    ..regulated by a series of inhibitory checkpoints that include sequestration in multichaperone complexes governed by Hsp90. This study examined the role of multichaperone complexes in governing the heat shock response in motor neurons...
  59. Labbadia J, Novoselov S, Bett J, Weiss A, Paganetti P, Bates G, et al. Suppression of protein aggregation by chaperone modification of high molecular weight complexes. Brain. 2012;135:1180-96 pubmed publisher
    ..Furthermore, our findings represent an important proof of principle that DNAJ manipulation is a valid therapeutic approach for intervention in Huntington's disease. ..
  60. Zhang G, Liu Z, Ding H, Zhou Y, Doan H, Sin K, et al. Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nat Commun. 2017;8:589 pubmed publisher
    ..Here, we show that tumor-released extracellular Hsp70 and Hsp90 are responsible for tumor's capacity to induce muscle wasting...
  61. Faulds G, Conroy S, Madaio M, Isenberg D, Latchman D. Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-lpr/lpr mice. Br J Rheumatol. 1995;34:610-5 pubmed
    ..systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90)...
  62. Wagatsuma A, Shiozuka M, Kotake N, Takayuki K, Yusuke H, Mabuchi K, et al. Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells. Mol Cell Biochem. 2011;358:265-80 pubmed publisher
    Heat-shock protein90 (HSP90) plays an essential role in maintaining stability and activity of its clients. HSP90 is involved in cell differentiation and survival in a variety of cell types...
  63. Bruns A, Yuldasheva N, Latham A, Bao L, Pellet Many C, Frankel P, et al. A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE. 2012;7:e48539 pubmed publisher
    ..Pharmacological inhibition of HSP90 stimulated VEGFR2 degradation in primary endothelial cells and blocked VEGF-A-stimulated intracellular signaling ..
  64. Girola N, Matsuo A, Figueiredo C, Massaoka M, Farias C, Arruda D, et al. The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor. Peptides. 2016;85:1-15 pubmed publisher
    ..We found that Rb9 binds to and interferes with Hsp90 chaperone activity causing attenuation of FAK-Src signaling and downregulation of active Rac1 in B16F10-Nex2 ..
  65. Minami Y, Kawasaki H, Miyata Y, Suzuki K, Yahara I. Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90. J Biol Chem. 1991;266:10099-103 pubmed
    The 90-kDa heat shock protein, HSP90, of the mouse has two isoforms, alpha and beta, which are electrophoretically separable...
  66. Okumura F, Okumura A, Matsumoto M, Nakayama K, Hatakeyama S. TRIM8 regulates Nanog via Hsp90?-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta. 2011;1813:1784-92 pubmed publisher
    ..Here, we show that TRIM8 interacts with Hsp90?, which interacts with STAT3 and selectively downregulates transcription of Nanog in embryonic stem cells...
  67. Mayer P, Harjung A, Breinig M, Fischer L, Ehemann V, Malz M, et al. Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors. Endocr Relat Cancer. 2012;19:217-32 pubmed publisher
    ..analyses, and in 15 snap-frozen PET and in three healthy pancreatic tissues, we investigated the expression of HSP90 isoforms by means of semiquantitative RT-PCR...
  68. Braun S, Losel R, Wehling M, Boldyreff B. Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84. FEBS Lett. 2004;570:69-72 pubmed
    ..Src kinase activation was blocked by spironolactone. Aldosterone led to increased association of Src with HSP84. Furthermore, rapamycin blocked aldosterone-induced Src activation...
  69. Shaknovich R, Shue G, Kohtz D. Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84). Mol Cell Biol. 1992;12:5059-68 pubmed
    ..screened with an amphipathic helix antibody, and a recombinant representing the C-terminal 194 residues of murine HSP90 (HSP84) was cloned...
  70. Garcia R, Merino D, Gómez J, Nistal J, Hurlé M, Cortajarena A, et al. Extracellular heat shock protein 90 binding to TGF? receptor I participates in TGF?-mediated collagen production in myocardial fibroblasts. Cell Signal. 2016;28:1563-79 pubmed publisher
    ..Both, Hsp90aa1 and Hsp90ab1 isoforms participate in TGF?RI complex...
  71. Chen Y, Youn P, Pysher T, Scaife C, Furgeson D. Tumour eradication using synchronous thermal ablation and Hsp90 chemotherapy with protein engineered triblock biopolymer-geldanamycin conjugates. Int J Hyperthermia. 2014;30:550-64 pubmed publisher
    Hepatocellular carcinoma (HCC) suffers high tumour recurrence rate after thermal ablation. Heat shock protein 90 (Hsp90) induced post-ablation is critical for tumour survival and progression...
  72. Benitez M, Sanchez Ponce D, Garrido J, Wandosell F. Hsp90 activity is necessary to acquire a proper neuronal polarization. Biochim Biophys Acta. 2014;1843:245-52 pubmed publisher
    ..Heat Shock Proteins (Hsps) are the most representative group of chaperones. Hsp90 represents up to 1-2% of soluble protein...
  73. Chen F, Yu Y, Qian J, Wang Y, Cheng B, Dimitropoulou C, et al. Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production. Arterioscler Thromb Vasc Biol. 2012;32:2989-99 pubmed publisher
    ..We have previously shown that heat shock protein (Hsp90) inhibitors potently suppress Nox 1 to 3 and 5, and the goals of this study were to identify how molecular ..
  74. Cheng A, Zhang M, Gentry M, Worby C, Dixon J, Saltiel A. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007;21:2399-409 pubmed
    ..Taken together, these results indicate that binding to glycogen crucially regulates the stability of AGL and, further, that its ubiquitination may play an important role in the pathophysiology of both Lafora and Cori's disease. ..
  75. Hernández M, Chadli A, Toft D. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem. 2002;277:11873-81 pubmed
    ..However, an in vitro chaperoning system consisting of five proteins (HSP40, HSP70, HOP, HSP90, and p23) with ATP is capable of restoring this function...
  76. Stephanou A, Conroy S, Isenberg D, Maione D, Poli V, Ciliberto G, et al. Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies. J Autoimmun. 1998;11:249-53 pubmed
    ..PBL) in vitro with the cytokine interleukin-6 (IL-6) induces increased levels of the 90 kDa heat shock protein (hsp90)...
  77. Fukuyama T, Doi M, Matsuo M, Nishinaga H, Miyake S, Okamura H. Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus. Biomed Res. 2008;29:93-8 pubmed
    ..Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins referred to HSP86 and HSP84 in the mouse suprachiasmatic nucleus, the circadian center...
  78. Piwien Pilipuk G, Ayala A, Machado A, Galigniana M. Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongating factor 2 in kidney cells. J Biol Chem. 2002;277:11896-903 pubmed
    ..Although the oligomeric structure of the MR-hsp90 heterocomplex was always unaffected, a decreased amount of MR protein was evidenced after the long term treatment...
  79. Davies T, Ning Y, SANCHEZ E. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-600 pubmed
    ..FKBP51) for another (FKBP52), and concomitant recruitment of the transport protein dynein while leaving Hsp90 unchanged...
  80. Dale E, Yang X, Moore S, Shyamala G. Cloning and characterization of the promoter for murine 84-kDa heat-shock protein. Gene. 1996;172:279-84 pubmed
    ..understanding the basis for hsp90 regulation, we have cloned and characterized the 5' flanking region of murine hsp84, one of two genes which code for HSP90 proteins...