Gene Symbol: Hsp90aa1
Description: heat shock protein 90, alpha (cytosolic), class A member 1
Alias: 86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4, heat shock protein HSP 90-alpha, HSP 86, HSP86, TSTA, heat shock 86 kDa, heat shock protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein, 1, heat shock protein, 86 kDa 1, heat shock protein, 89 kDa, tumor-specific transplantation 86 kDa antigen
Species: mouse
Products:     Hsp90aa1

Top Publications

  1. Lang S, Moser C, Gaumann A, Klein D, Glockzin G, Popp F, et al. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces ort. Clin Cancer Res. 2007;13:6459-68 pubmed
    Inhibitors of heat-shock protein 90 (Hsp90) may interfere with oncogenic signaling pathways, including Erk, Akt, and hypoxia-inducible factor-1alpha (HIF-1alpha)...
  2. Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci. 2008;28:3384-91 pubmed publisher
    ..Here we show that LRRK2 forms a complex with heat shock protein 90 (Hsp90) in vivo and that inhibition of Hsp90 disrupts the association of Hsp90 with LRRK2 and leads to proteasomal ..
  3. Metchat A, Akerfelt M, Bierkamp C, Delsinne V, Sistonen L, Alexandre H, et al. Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression. J Biol Chem. 2009;284:9521-8 pubmed publisher
    ..We find that Hsp90alpha (Hspaa1) is the major HSF1-dependent chaperone inasmuch as Hsf1 knock-out resulted in Hsp90-depleted oocytes...
  4. Kajiwara C, Kondo S, Uda S, Dai L, Ichiyanagi T, Chiba T, et al. Spermatogenesis arrest caused by conditional deletion of Hsp90? in adult mice. Biol Open. 2012;1:977-82 pubmed publisher
    ..It was recently shown that many spermatocytes underwent apoptosis in the testes of Hsp90? KO mice. We had generated Hsp90? KO mice independently and confirmed this phenotype...
  5. Vanmuylder N, Werry Huet A, Rooze M, Louryan S. Heat shock protein HSP86 expression during mouse embryo development, especially in the germ-line. Anat Embryol (Berl). 2002;205:301-6 pubmed
    ..immunohistochemical expression and the distribution of the two mammalian cytosolic isoforms of HSP90 (HSP84 and HSP86) during mouse development between E6 and E16...
  6. Wang X, Song X, Zhuo W, Fu Y, Shi H, Liang Y, et al. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. Proc Natl Acad Sci U S A. 2009;106:21288-93 pubmed publisher
    ..In sum, our results reveal the regulatory mechanism of Hsp90alpha secretion, and its function in tumor invasiveness, indicating it can be a promising diagnostic marker for tumor malignancy in clinical application. ..
  7. Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, et al. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 2012;47:970-9 pubmed publisher
    ..Like other cochaperones, Fkbp6 associates with the molecular chaperone Hsp90 via its tetratricopeptide repeat (TPR) domain...
  8. Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T, et al. Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. J Immunol. 2010;185:2693-700 pubmed publisher
    Extracellular HSP90 associated with Ag peptides have been demonstrated to efficiently cross-prime T cells, following internalization by dendritic cells (DCs)...
  9. Imai T, Kato Y, Kajiwara C, Mizukami S, Ishige I, Ichiyanagi T, et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011;108:16363-8 pubmed publisher
    ..Here we demonstrate that heat shock protein 90 (HSP90) is critical for this step. Cross-presentation and -priming were decreased in both HSP90?-null DCs and mice...

More Information


  1. Voss A, Thomas T, Gruss P. Mice lacking HSP90beta fail to develop a placental labyrinth. Development. 2000;127:1-11 pubmed
    ..The allantois mesoderm is thought to induce trophoblast differentiation. Our results show that Hsp90beta is a necessary component of this induction process. ..
  2. Grad I, Cederroth C, Walicki J, Grey C, Barluenga S, Winssinger N, et al. The molecular chaperone Hsp90? is required for meiotic progression of spermatocytes beyond pachytene in the mouse. PLoS ONE. 2010;5:e15770 pubmed publisher
    The molecular chaperone Hsp90 has been found to be essential for viability in all tested eukaryotes, from the budding yeast to Drosophila...
  3. Binder R, Srivastava P. Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells. Nat Immunol. 2005;6:593-9 pubmed
  4. Murshid A, Gong J, Calderwood S. Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J Immunol. 2010;185:2903-17 pubmed publisher
    ..We have investigated mechanisms involved in heat shock protein 90 (Hsp90) chaperone-mediated cross presentation of OVA-derived Ags...
  5. Hong T, Kim S, Wi A, Lee P, Kang M, Jeong J, et al. Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1. J Biol Chem. 2013;288:215-22 pubmed publisher
    Mammals have two cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones, Chp-1 and melusin, which are homologs of plant Rar1...
  6. BRADLEY E, Bieberich E, Mivechi N, Tangpisuthipongsa D, Wang G. Regulation of embryonic stem cell pluripotency by heat shock protein 90. Stem Cells. 2012;30:1624-33 pubmed publisher
    ..We report here that the molecular chaperone heat shock protein 90 (Hsp90) is essential for mouse embryonic stem cell (ESC) pluripotency through regulating multiple pluripotency factors, ..
  7. Prodromou N, Thompson C, Osborn D, Cogger K, Ashworth R, Knight M, et al. Heat shock induces rapid resorption of primary cilia. J Cell Sci. 2012;125:4297-305 pubmed publisher
    ..This implies a role for molecular chaperones in the maintenance of primary cilia. The cytosolic chaperone Hsp90 localises to the ciliary axoneme and its inhibition resulted in cilia loss...
  8. Delgoffe G, Kole T, Cotter R, Powell J. Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. Mol Immunol. 2009;46:2694-8 pubmed publisher
    ..Using this approach we have identified Hsp90 as an activation-induced binding partner of raptor in T cells...
  9. Yoshinari K, Kobayashi K, Moore R, Kawamoto T, Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett. 2003;548:17-20 pubmed
    ..In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex...
  10. Xu W, Yuan X, Beebe K, Xiang Z, Neckers L. Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity. Mol Cell Biol. 2007;27:220-8 pubmed
    ..We showed previously that the molecular chaperone Hsp90 protects ErbB2 from proteasome-mediated degradation by binding to a short loop structure in the N-lobe of the ..
  11. Hoel A, Yu P, Nguyen K, Sui X, Plescia J, Altieri D, et al. Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo. Am J Pathol. 2012;181:1151-7 pubmed publisher
    ..have highlighted the role of mitochondrial proteins, such as the molecular chaperone heat shock protein-90 (Hsp90), in promoting cancer cell survival, which leads to new candidate chemotherapeutic agents for neoplastic disease...
  12. Bardag Gorce F, van Leeuwen F, Nguyen V, French B, Li J, Riley N, et al. The role of the ubiquitin-proteasome pathway in the formation of mallory bodies. Exp Mol Pathol. 2002;73:75-83 pubmed
    ..In conclusion, the results support the concept that Mallory bodies are aggresomes which form as the result of the failure of the ubiquitin-proteasome complex to adequately eliminate cytokeratins destined for proteolysis. ..
  13. Schneider R, Linka R, Reinke H. HSP90 affects the stability of BMAL1 and circadian gene expression. J Biol Rhythms. 2014;29:87-96 pubmed publisher
    ..Furthermore, the HSP90 isoforms HSP90AA1 and HSP90AB1, and not HSP90B1-GRP94 or TRAP1, are responsible for maintaining proper cellular levels of BMAL1 ..
  14. Woodford M, Sager R, Marris E, Dunn D, Blanden A, Murphy R, et al. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. EMBO J. 2017;36:3650-3665 pubmed publisher
    ..The molecular chaperone heat-shock protein 90 (Hsp90) is an essential component of the cellular homeostatic machinery in eukaryotes...
  15. Ryu H, Won H, Lee D, Kwon S. HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery. Cell Stress Chaperones. 2017;22:253-261 pubmed publisher
    ..However, HDAC6 depletion had no effect on cell death in response to heat shock or ionizing radiation. Overall, our data suggest that HDAC6 may serve as a critical stress regulator in response to different cellular stresses. ..
  16. Hoffmann T, Hovemann B. Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens. Gene. 1988;74:491-501 pubmed
    ..Using these mouse hsp gene clones as hybridization probes we also isolated the corresponding pair of human cDNA clones. Comparison of the respective sequences reveals a strong evolutionary constraint on these two genes in mouse and man. ..
  17. Kuo C, Liang C, Lai C, Liang S. Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide. J Immunol. 2007;178:6100-8 pubmed
    ..This study thus reveals the involvement of Hsp90beta but not Hsp90alpha in CpG-B ODN-mediated antiapoptotic response and that Hsp90beta is distinct from Hsp90alpha in regulation of the cellular function of immune cells. ..
  18. Voelkel T, Andresen C, Unger A, Just S, Rottbauer W, Linke W. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochim Biophys Acta. 2013;1833:812-22 pubmed publisher
    ..Smyd2 has an intriguing function in the cytoplasm of skeletal myocytes, where it methylates the chaperone Hsp90, thus promoting the interaction of a Smyd2-methyl-Hsp90 complex with the N2A-domain of titin...
  19. Nichols R, Dzamko N, Morrice N, Campbell D, Deak M, Ordureau A, et al. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010;430:393-404 pubmed publisher
    ..These results provide the first evidence suggesting that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease...
  20. Langer T, Rosmus S, Fasold H. Intracellular localization of the 90 kDA heat shock protein (HSP90alpha) determined by expression of a EGFP-HSP90alpha-fusion protein in unstressed and heat stressed 3T3 cells. Cell Biol Int. 2003;27:47-52 pubmed
    Heat shock protein 90 (Hsp90) is an abundant protein and essential for all eukaryotic cells. The expression of Hsp90 is further enhanced after exposure to stress factors, e.g. a heat shock...
  21. Habib G, Shi Z, Lieberman M. Glutathione protects cells against arsenite-induced toxicity. Free Radic Biol Med. 2007;42:191-201 pubmed
    ..Arsenite treatment increased lipid peroxidation and induced ubiquitination of molecular chaperone Hsp90 and impaired its ability to bind cochaperone p50(Cdc-37) and client proteins Plk-1 and Cdk-4 in GCS-2 cells...
  22. Yano A, Tsutsumi S, Soga S, Lee M, Trepel J, Osada H, et al. Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. Proc Natl Acad Sci U S A. 2008;105:15541-6 pubmed publisher
    b>Hsp90 inhibitors are being evaluated extensively in patients with advanced cancers...
  23. Galigniana M, Erlejman A, Monte M, Gomez Sanchez C, Piwien Pilipuk G. The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events. Mol Cell Biol. 2010;30:1285-98 pubmed publisher
    ..The high-molecular-weight immunophilin (IMM) FKBP52 links the MR-hsp90 complex to dynein/dynactin motors favoring the cytoplasmic transport of MR to the nucleus...
  24. Lees Miller S, Anderson C. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. J Biol Chem. 1989;264:17275-80 pubmed
    ..Mouse hsp86 and rabbit hsp90 alpha are homologous to human hsp90 alpha; both heterologous proteins are phosphorylated at the ..
  25. Teng S, Chen Y, Su Y, Chou P, Chiang Y, Tseng S, et al. Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation. J Biol Chem. 2004;279:14649-55 pubmed
    ..Heat shock protein 90 (HSP90) is involved in the folding of proteins such as signal transduction molecules (Src, Raf1, cdk4) and steroid ..
  26. Callahan M, Garg M, Srivastava P. Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation. Proc Natl Acad Sci U S A. 2008;105:1662-7 pubmed publisher
    ..We report here that treatment of cells with hsp90 inhibitors leads to generation of "empty" MHC I caused by inhibited loading of MHC I with peptides...
  27. Liu Y, Liu M, Liu J, Zhang H, Tu Z, Xiao X. KLF4 is a novel regulator of the constitutively expressed HSP90. Cell Stress Chaperones. 2010;15:211-7 pubmed publisher
    ..But little is known about the regulation of KLF4 on the expression of HSP90 (HSP84 and HSP86)...
  28. Ayrault O, Godeny M, Dillon C, Zindy F, Fitzgerald P, Roussel M, et al. Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A. 2009;106:17037-42 pubmed publisher
    Elevated expression of HSP90 is observed in many tumor types and is associated with a limited clinical response...
  29. Evrard L, Vanmuylder N, Dourov N, Glineur R, Louryan S. Cytochemical identification of HSP110 during early mouse facial development. J Craniofac Genet Dev Biol. 1999;19:24-32 pubmed
  30. Srikakulam R, Liu L, Winkelmann D. Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS ONE. 2008;3:e2137 pubmed publisher
    Myosin folding and assembly in striated muscle is mediated by the general chaperones Hsc70 and Hsp90 and a myosin specific co-chaperone, UNC45. Two UNC45 genes are found in vertebrates, including a striated muscle specific form, Unc45b...
  31. Legagneux V, Mezger V, Quelard C, Barnier J, Bensaude O, Morange M. High constitutive transcription of HSP86 gene in murine embryonal carcinoma cells. Differentiation. 1989;41:42-8 pubmed
    In order to investigate HSP86 heat-shock gene expression in embryonal carcinoma cell lines (EC), a partial mouse HSP86 cDNA clone was isolated and characterized...
  32. Moore S, Appella E, Villar C, Kozak C. Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11. Genomics. 1991;10:1019-29 pubmed
    The HSP86 gene family in BALB/c, AKR/J, C58/J, and NFS/N inbred mice comprises an intron-containing expressed gene and, depending on the strain, two to four other HSP86-related members that are apparently processed pseudogenes...
  33. Li Y, Li S, Hoshino M, Ishikawa R, Kajiwara C, Gao X, et al. HSP90? deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation. Int Immunol. 2012;24:751-8 pubmed publisher
    Heat shock protein 90 (HSP90) is a molecular chaperone required for efficient antigen presentation and cross-presentation...
  34. Yamaza H, Matsuo K, Kiyoshima T, Shigemura N, Kobayashi I, Wada H, et al. Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Int J Dev Biol. 2001;45:675-80 pubmed
    ..search and semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), we thus found Pgk-1, Ccte, Hsp86, Nucleolin, Hsc73, Frg1, N-ras, Set alpha and Hsj2 from the E10...
  35. Shi Y, Chen Y, Dackour R, Potters L, Wang S, Ding Q, et al. Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha. Am J Pathol. 2010;177:964-73 pubmed publisher
  36. Lowe D, Fulford W, Moran L. Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983;3:1540-3 pubmed
    ..This result suggests that the sequence of the hsp70 gene(s) is highly conserved. ..
  37. Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi Miyagawa S, Nakano T, Chuma S, et al. HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Nucleic Acids Res. 2014;42:11903-11 pubmed publisher
    b>HSP90, found in all kingdoms of life, is a major chaperone protein regulating many client proteins...
  38. Choudhury A, Khole V. Immune-mediated destruction of ovarian follicles associated with the presence of HSP90 antibodies. Mol Reprod Dev. 2015;82:81-9 pubmed publisher
    We previously established that the presence of autoantibodies to heat-shock protein 90 (HSP90) is one common causes of female infertility, and demonstrated that its presence leads to detrimental effects on ovarian and reproductive ..
  39. Wang G, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003;36:48-61 pubmed
    ..These findings suggest that hsf2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production. ..
  40. Wesche J, Małecki J, Wiedłocha A, Skjerpen C, Claus P, Olsnes S. FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. J Biol Chem. 2006;281:11405-12 pubmed
    ..It was recently found that certain toxins are dependent on cytosolic Hsp90 for efficient translocation across the endosomal membrane...
  41. Merlet J, Racine C, Moreau E, Moreno S, Habert R. Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc Natl Acad Sci U S A. 2007;104:3615-20 pubmed
    ..Finally, our results focus on a new pathway in the fetal testis during the embryonic period, which is the most sensitive to antiandrogenic endocrine disruptors. ..
  42. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  43. Tucker D, Gijón M, Spencer D, Qiu Z, Gelb M, Leslie C. Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. J Leukoc Biol. 2008;84:798-806 pubmed publisher
    ..Inhibitors of heat shock protein 90 (hsp90), geldanamycin, and herbimycin blocked AA release in response to OA but not to A23187, PMA, or zymosan...
  44. Yamano T, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H. Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing. J Biol Chem. 2008;283:28060-5 pubmed publisher
    Heat shock protein 90 (hsp90) and the proteasome activator PA28 stimulate major histocompatibility complex (MHC) class I antigen processing...
  45. Bhatia A, O Brien K, Guo J, Lincoln V, Kajiwara C, Chen M, et al. Extracellular and Non-Chaperone Function of Heat Shock Protein-90α Is Required for Skin Wound Healing. J Invest Dermatol. 2018;138:423-433 pubmed publisher
    ..The precise role for these Hsp90α proteins, however, was unclear...
  46. Elaimy A, Ahsan A, Marsh K, Pratt W, Ray D, Lawrence T, et al. ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation. Oncotarget. 2016;7:82450-82457 pubmed publisher
    ..An Hsp90 isoform (Hsp90α) has been shown to be selectively phosphorylated on two N-terminal threonine residues (..
  47. Oda T, Hayano T, Miyaso H, Takahashi N, Yamashita T. Hsp90 regulates the Fanconi anemia DNA damage response pathway. Blood. 2007;109:5016-26 pubmed
    Heat shock protein 90 (Hsp90) regulates diverse signaling pathways...
  48. Mohamed B, Barakat A, Held T, Elkenani M, Mühlfeld C, Männer J, et al. Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014;50:817-24 pubmed publisher
    ..Our study demonstrates that HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth. ..
  49. Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J. Messenger RNA expression of heat shock proteins (HSPs) during ocular development. Curr Eye Res. 1995;14:1125-33 pubmed
    ..Expression of HSP32, HSP60, HSP70, HSP84, HSP86 and heat shock cognate protein (HSC)70 mRNAs was examined by in situ hybridization...
  50. Probst M, Fan C, Tessier Lavigne M, Hankinson O. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem. 1997;272:4451-7 pubmed
    ..Thus mouse SIM1 and SIM2 are novel heterodimerization partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism. ..
  51. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997;94:2392-7 pubmed
    ..This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches. ..
  52. Sarkar A, Zohn I. Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme. J Cell Biol. 2012;196:789-800 pubmed publisher
    ..We demonstrate that Hectd1 is a functional ubiquitin ligase and that one of its substrates is Hsp90, a chaperone protein with both intra- and extracellular clients...
  53. Luo S, Wang T, Qin H, Lei H, Xia Y. Obligatory role of heat shock protein 90 in iNOS induction. Am J Physiol Cell Physiol. 2011;301:C227-33 pubmed publisher
    ..Our previous studies found that heat shock protein 90 (Hsp90) associates with iNOS, and this association enhances iNOS activity...
  54. Papaconstantinou A, Fisher B, Umbreit T, Goering P, Lappas N, Brown K. Effects of beta-estradiol and bisphenol A on heat shock protein levels and localization in the mouse uterus are antagonized by the antiestrogen ICI 182,780. Toxicol Sci. 2001;63:173-80 pubmed
    ..These results suggest an involvement of the ER in BPA- and E2-induced increases in uterine levels of hsp90alpha, grp94, and hsp72, and localization of hsp90alpha. ..
  55. Shimamura T, Li D, Ji H, Haringsma H, Liniker E, Borgman C, et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 2008;68:5827-38 pubmed publisher
    ..In contrast, Hsp90 inhibition overcomes these limitations in vitro and depletes cells of EGFR, other RTKs, and phospho-Akt and ..
  56. Fiorenza M, Bevilacqua A, Canterini S, Torcia S, Pontecorvi M, Mangia F. Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol Reprod. 2004;70:1606-13 pubmed
    ..1, but not hsp70.3 and hsp90, heat shock genes...
  57. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008;27:1932-43 pubmed publisher
    ..Without TM site phosphorylation, Akt becomes protected by the molecular chaperone Hsp90 from ubiquitination-mediated proteasome degradation...
  58. Cheng A, Zhang M, Gentry M, Worby C, Dixon J, Saltiel A. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007;21:2399-409 pubmed
    ..Taken together, these results indicate that binding to glycogen crucially regulates the stability of AGL and, further, that its ubiquitination may play an important role in the pathophysiology of both Lafora and Cori's disease. ..
  59. Morales M, Watanabe R, Dacher M, Chafey P, Osorio y Fortéa J, Scott D, et al. Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage. Proc Natl Acad Sci U S A. 2010;107:8381-6 pubmed publisher
    ..Phosphorylation of the major Leishmania chaperones at the pathogenic stage suggests that these proteins may be promising drug targets via inhibition of their respective protein kinases. ..
  60. Wang H, Zou X, Wei Z, Wu Y, Li R, Zeng R, et al. Hsp90α forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling. J Cell Sci. 2015;128:100-8 pubmed publisher
    ..Here, through immunofluorescent staining and protein isolation, we identify the molecular chaperone Hsp90α clustered at the periciliary base...
  61. Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, et al. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010;239:2233-45 pubmed publisher
    ..Our findings indicate that Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER. ..
  62. Bird J, Takagi Y, Billington N, Strub M, Sellers J, Friedman T. Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Proc Natl Acad Sci U S A. 2014;111:12390-5 pubmed publisher
    ..coexpression of the muscle-myosin-specific chaperone UNC45B, in addition to the chaperone heat-shock protein 90 (HSP90) significantly increased the yield of functional protein...
  63. Levine R, LaRosa G, Gudas L. Isolation of cDNA clones for genes exhibiting reduced expression after differentiation of murine teratocarcinoma stem cells. Mol Cell Biol. 1984;4:2142-50 pubmed
  64. Bruns A, Yuldasheva N, Latham A, Bao L, Pellet Many C, Frankel P, et al. A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE. 2012;7:e48539 pubmed publisher
    ..Pharmacological inhibition of HSP90 stimulated VEGFR2 degradation in primary endothelial cells and blocked VEGF-A-stimulated intracellular signaling ..
  65. Nayernia K, Vauti F, Meinhardt A, Cadenas C, Schweyer S, Meyer B, et al. Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility. J Biol Chem. 2003;278:48377-85 pubmed
    ..These results provide evidence for an essential and hitherto uncharacterized role of the Lis1 protein in spermatogenesis, particularly in the differentiation of spermatids into spermatozoa. ..
  66. Wang H, Goode T, Iakova P, Albrecht J, Timchenko N. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. EMBO J. 2002;21:930-41 pubmed
    ..Gel filtration analysis of cdk4 complexes shows that a chaperone complex cdk4-cdc37-Hsp90, which protects cdk4 from degradation, is abundant in proliferating livers that lack C/EBPalpha, but this complex ..
  67. Yoshida M, Xia Y. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem. 2003;278:36953-8 pubmed
    ..Here we show that NO synthesis from iNOS can be profoundly modulated by heat shock protein 90 (hsp90) through protein-protein interaction...
  68. Fukuyama T, Doi M, Matsuo M, Nishinaga H, Miyake S, Okamura H. Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus. Biomed Res. 2008;29:93-8 pubmed
    ..Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins referred to HSP86 and HSP84 in the mouse suprachiasmatic nucleus, the circadian center...
  69. Wada H, Kobayashi I, Yamaza H, Matsuo K, Kiyoshima T, Akhtar M, et al. In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar. Histochem J. 2002;34:105-9 pubmed
    ..examined the detailed gene expression pattern of three different heat shock proteins (HSPs), Hsc73, Hsj2, and Hsp86, by means of an in situ hybridization method...
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