Gene Symbol: Hsp20
Description: heat shock protein, alpha-crystallin-related, B6
Alias: AA387366, Gm479, Hsp20, heat shock protein beta-6, cardiac heat shock protein p20, cardiac p20
Species: mouse
Products:     Hsp20

Top Publications

  1. Fan G, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, et al. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005;111:1792-9 pubmed
    ..from stress-induced injury; however, little is known about the role of another small heat-shock protein, Hsp20, which regulates activities of vasodilation and platelet aggregation, in cardioprotection against ischemia injury...
  2. Chu G, Egnaczyk G, Zhao W, Jo S, Fan G, Maggio J, et al. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circ Res. 2004;94:184-93 pubmed
    ..The mouse cardiac p20 contains the conserved domain sequences for heat shock proteins, and the RRAS consensus sequence for cAMP-PKA ..
  3. Fan G, Chu G, Mitton B, Song Q, Yuan Q, Kranias E. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circ Res. 2004;94:1474-82 pubmed
    ..is associated with transient increases in expression and phosphorylation of a small heat-shock protein, Hsp20. To determine the functional significance of Hsp20, we overexpressed this protein and its constitutively ..
  4. Fan G, Yuan Q, Song G, Wang Y, Chen G, Qian J, et al. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ Res. 2006;99:1233-42 pubmed
    ..pathway has been shown to result in transiently increased expression of a cardiac small heat-shock protein Hsp20. The present study shows that cardiac overexpression (10-fold) of Hsp20 may protect the heart against beta-agonist-..
  5. Huang L, Min J, Masters S, Mivechi N, Moskophidis D. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007;45:487-501 pubmed
  6. Fan G, Zhou X, Wang X, Song G, Qian J, Nicolaou P, et al. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circ Res. 2008;103:1270-9 pubmed publisher
    ..However, it is not clear whether Hsp20 would exert similar protective effects against DOX-induced cardiac injury...
  7. Bukach O, Glukhova A, Seit Nebi A, Gusev N. Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20). Biochim Biophys Acta. 2009;1794:486-95 pubmed publisher
    Formation of heterooligomeric complexes of human small heat shock proteins (sHsp) HspB6 (Hsp20) and HspB1 (Hsp27) was analyzed by means of native gel electrophoresis, analytical ultracentrifugation, chemical cross-linking and size-..
  8. Wang X, Zingarelli B, O Connor M, Zhang P, Adeyemo A, Kranias E, et al. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. J Mol Cell Cardiol. 2009;47:382-90 pubmed publisher
    ..Heat shock protein 20 (Hsp20) has been shown to enhance myocardial contractile function and protect against doxorubicin-induced cardiotoxicity...
  9. Zhu S, Xi L, Kukreja R. Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase ? and Echs1. J Cell Mol Med. 2012;16:950-8 pubmed publisher
    ..Such change was absent in the db/db heart. On the other hand, PostC reduced Hsp20 in the diabetic heart...

More Information


  1. Zeng L, Tan J, Lu W, Hu Z. Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax. Curr Neurovasc Res. 2013;10:208-15 pubmed
    ..b>Hsp20, one of the small heat shock proteins, has been implicated in multiple physiological and pathophysiological ..
  2. Quraishe S, Asuni A, Boelens W, O CONNOR V, Wyttenbach A. Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization. Neuroscience. 2008;153:483-91 pubmed publisher
    ..This biochemical signature is indicative of an association with synaptic and other neural specializations. This observation will help one understand the functional role played by sHsps during physiology and pathology in the CNS. ..
  3. Ren X, Wu J, Wang X, Sartor M, Jones K, Qian J, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation. 2009;119:2357-2366 pubmed publisher
    ..Using TargetScan software and proteomic analysis, we identified heat-shock protein 20 (Hsp20), a known cardioprotective protein, as an important candidate target for miR-320...
  4. Qian J, Ren X, Wang X, Zhang P, Jones W, Molkentin J, et al. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circ Res. 2009;105:1223-31 pubmed publisher
    ..small heat shock protein (Hsp)20 and its phosphorylation are increased on ischemic insults, and overexpression of Hsp20 protects the heart against ischemia/reperfusion injury...
  5. Qian J, Vafiadaki E, Florea S, Singh V, Song W, Lam C, et al. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circ Res. 2011;108:1429-38 pubmed publisher
    ..In the heart, the small Hsp20 has emerged as a key mediator of protection against apoptosis, remodeling, and ischemia/reperfusion injury...