Hsf1

Summary

Gene Symbol: Hsf1
Description: heat shock factor 1
Alias: AA960185, HSTF, HSTF 1, Hsf1alpha, Hsf1beta, heat shock factor protein 1
Species: mouse
Products:     Hsf1

Top Publications

  1. Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, et al. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res. 2006;99:1411-8 pubmed
    ..Here, we showed a critical role of heat shock transcription factor 1 (HSF1), an important transcription factor for heat shock proteins, in the adaptive mechanism of cardiac hypertrophy...
  2. Bierkamp C, Luxey M, Metchat A, Audouard C, Dumollard R, Christians E. Lack of maternal Heat Shock Factor 1 results in multiple cellular and developmental defects, including mitochondrial damage and altered redox homeostasis, and leads to reduced survival of mammalian oocytes and embryos. Dev Biol. 2010;339:338-53 pubmed publisher
    Heat Shock Factor 1 (HSF1) is a transcription factor whose loss of function results in the inability of Hsf1(-/-) females to produce viable embryos, as a consequence of early developmental arrest...
  3. Hayashida N, Fujimoto M, Tan K, Prakasam R, Shinkawa T, Li L, et al. Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. EMBO J. 2010;29:3459-69 pubmed publisher
    Heat shock transcription factor 1 (HSF1) is an important regulator of protein homeostasis (proteostasis) by controlling the expression of major heat shock proteins (Hsps) that facilitate protein folding...
  4. Salmand P, Jungas T, Fernandez M, Conter A, Christians E. Mouse heat-shock factor 1 (HSF1) is involved in testicular response to genotoxic stress induced by doxorubicin. Biol Reprod. 2008;79:1092-101 pubmed publisher
    Heat-shock factor 1 (HSF1) protects cells and organisms against various types of stress, either by triggering a complex response that promotes cell survival or by triggering cell death when stress-induced alterations cannot be rescued...
  5. McMillan D, Xiao X, Shao L, Graves K, Benjamin I. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem. 1998;273:7523-8 pubmed
    Heat shock transcription factor 1 (HSF1) is a member of the vertebrate HSF family that regulates stress-inducible synthesis of heat shock proteins (HSPs)...
  6. Fujimoto M, Oshima K, Shinkawa T, Wang B, Inouye S, Hayashida N, et al. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J Biol Chem. 2008;283:29961-70 pubmed publisher
    ..In mammals, HSF1 is required for heat-mediated induction of classic heat shock genes; however, we do not know the molecular ..
  7. Lecomte S, Reverdy L, Le Quement C, Le Masson F, Amon A, Le Goff P, et al. Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms. PLoS ONE. 2013;8:e56085 pubmed publisher
    ..The two main factors in this family, HSF1 and HSF2, are co-expressed in numerous tissues where they can interact and form heterotrimers in response to ..
  8. Inouye S, Katsuki K, Izu H, Fujimoto M, Sugahara K, Yamada S, et al. Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures. Mol Cell Biol. 2003;23:5882-95 pubmed
    ..Curiously, HSF1 is essential for heat shock response in mammals, whereas in avian HSF3, an avian-specific factor is required for ..
  9. Santagata S, Hu R, Lin N, Mendillo M, Collins L, Hankinson S, et al. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A. 2011;108:18378-83 pubmed publisher
    Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells...

More Information

Publications78

  1. Fujimoto M, Takaki E, Hayashi T, Kitaura Y, Tanaka Y, Inouye S, et al. Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J Biol Chem. 2005;280:34908-16 pubmed
    ..Here, we examined the impact of active forms of heat shock transcription factor 1 (HSF1), which induces a set of Hsps, on polyglutamine inclusion formation and disease progression...
  2. Reinke H, Saini C, Fleury Olela F, Dibner C, Benjamin I, Schibler U. Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev. 2008;22:331-45 pubmed publisher
    ..In addition to several established circadian transcription factors, we found DNA binding of heat-shock factor 1 (HSF1) to be highly rhythmic...
  3. Le Masson F, Christians E. HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models. Cell Stress Chaperones. 2011;16:275-85 pubmed publisher
    ..Our studies confirm that, even in absence of any stress, HSF1 regulates Hsp70.1 in oocytes and early embryos...
  4. Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
    ..b>HSF1 and HSF2 are required for some developmental processes, but it is unclear how they regulate these processes...
  5. Inouye S, Izu H, Takaki E, Suzuki H, Shirai M, Yokota Y, et al. Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem. 2004;279:38701-9 pubmed
    Heat shock factor 1 (HSF1) is a major transactivator of heat shock proteins in response to heat shock, and it is also involved in oogenesis, spermatogenesis, and placental development...
  6. Izu H, Inouye S, Fujimoto M, Shiraishi K, Naito K, Nakai A. Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells. Biol Reprod. 2004;70:18-24 pubmed
    ..are not induced in male germ cells in response to thermal stress, although heat shock transcription factor 1 (HSF1) is activated...
  7. Vihervaara A, Sistonen L. HSF1 at a glance. J Cell Sci. 2014;127:261-6 pubmed publisher
    Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes...
  8. Xiao X, Zuo X, Davis A, McMillan D, Curry B, Richardson J, et al. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 1999;18:5943-52 pubmed
    b>HSF1 is the major heat shock transcriptional factor that binds heat shock element (HSE) in the promoter of heat shock proteins (Hsps) and controls rapid Hsp induction in cells subjected to various environmental stresses...
  9. Christians E, Davis A, Thomas S, Benjamin I. Maternal effect of Hsf1 on reproductive success. Nature. 2000;407:693-4 pubmed
  10. Sarge K, Zimarino V, Holm K, Wu C, Morimoto R. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev. 1991;5:1902-11 pubmed
    ..Both mHSF1 and mHSF2 are encoded by single-copy genes, and neither is transcriptionally regulated by heat shock. However, there is a striking difference in the levels of mHSF1 mRNA in different tissues of the mouse. ..
  11. Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, et al. Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun. 2013;4:1405 pubmed publisher
    ..These results suggest that heat shock factor-1 influences the pathological lesion selectivity in spinal and bulbar muscular atrophy. ..
  12. Steele A, Hutter G, Jackson W, Heppner F, Borkowski A, King O, et al. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. 2008;105:13626-31 pubmed publisher
    ..We hypothesized that the transcriptional regulator of the stress response, heat shock factor 1 (HSF1), would play an important role in prion disease...
  13. Zhang Y, Huang L, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones. J Cell Biochem. 2002;86:376-93 pubmed
    ..proteins (Hsps) in cells subjected to environmental challenge is controlled by heat shock transcription factor-1 (Hsf1). Regulation of Hsps by Hsf1 is highly complex and, in the whole organism, remains largely unexplored...
  14. Hayashida N, Inouye S, Fujimoto M, Tanaka Y, Izu H, Takaki E, et al. A novel HSF1-mediated death pathway that is suppressed by heat shock proteins. EMBO J. 2006;25:4773-83 pubmed
    Heat shock response is an adoptive response to proteotoxic stress, and a major heat shock transcription factor 1 (HSF1) has been believed to protect cells from cell death by inducing heat shock proteins (Hsps) that assist protein folding ..
  15. Fritah S, Col E, Boyault C, Govin J, Sadoul K, Chiocca S, et al. Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. Mol Biol Cell. 2009;20:4976-84 pubmed publisher
    A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome...
  16. Min J, Huang L, Zimonjic D, Moskophidis D, Mivechi N. Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene. 2007;26:5086-97 pubmed
    ..Heat shock transcription factor 1 (Hsf1) is a major transactivator of Hsp induction and has been proposed to affect tumor initiation and progression, ..
  17. Widlak W, Vydra N, Malusecka E, Dudaladava V, Winiarski B, Scieglinska D, et al. Heat shock transcription factor 1 down-regulates spermatocyte-specific 70 kDa heat shock protein expression prior to the induction of apoptosis in mouse testes. Genes Cells. 2007;12:487-99 pubmed
    Expression of constitutively active heat shock transcription factor 1 (HSF1) in mouse spermatocytes induces apoptosis and leads to male infertility...
  18. Lecomte S, Desmots F, Le Masson F, Le Goff P, Michel D, Christians E, et al. Roles of heat shock factor 1 and 2 in response to proteasome inhibition: consequence on p53 stability. Oncogene. 2010;29:4216-24 pubmed publisher
    ..the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ubiquitously expressed...
  19. Akerfelt M, Vihervaara A, Laiho A, Conter A, Christians E, Sistonen L, et al. Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression. J Biol Chem. 2010;285:34469-76 pubmed publisher
    Heat shock factor 1 (HSF1) is an important transcription factor in cellular stress responses, cancer, aging, and developmental processes including gametogenesis...
  20. Metchat A, Akerfelt M, Bierkamp C, Delsinne V, Sistonen L, Alexandre H, et al. Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression. J Biol Chem. 2009;284:9521-8 pubmed publisher
    Heat shock transcription factor 1 (HSF1) is the main regulator of the stress response that triggers the transcription of several genes encoding heat shock proteins (Hsps)...
  21. Takii R, Inouye S, Fujimoto M, Nakamura T, Shinkawa T, Prakasam R, et al. Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3. J Immunol. 2010;184:1041-8 pubmed publisher
    ..Heat shock transcription factor 1 (HSF1) activated by heat shock induced the expression of activating transcription factor (ATF) 3, a negative regulator of ..
  22. Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, et al. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012;122:3742-54 pubmed publisher
    ..A striking example is heat shock factor 1 (HSF1), master transcriptional regulator of the heat shock response...
  23. Santos S, Lambertsen K, Clausen B, Akinc A, Alvarez R, Finsen B, et al. CSF transthyretin neuroprotection in a mouse model of brain ischemia. J Neurochem. 2010;115:1434-44 pubmed publisher
    ..However, TTR null mice, heterozygous for the heat-shock transcription factor 1 (TTR(-/-) HSF1(+/-) mice), which compromised the stress response, showed a significant increase in cortical infarction, cerebral ..
  24. Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, et al. Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci. 2011;31:5225-34 pubmed publisher
    ..This study provides the first in vivo evidence confirming the potential therapeutic benefit of HSP70 for the prevention or treatment of AD. ..
  25. Goodson M, Sarge K. Regulated expression of heat shock factor 1 isoforms with distinct leucine zipper arrays via tissue-dependent alternative splicing. Biochem Biophys Res Commun. 1995;211:943-9 pubmed
    b>HSF1 mediates the stress induced expression of heat shock proteins, referred to as the cellular stress response...
  26. Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, et al. Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Mol Cell Biol. 2011;31:3410-23 pubmed publisher
    Heat shock factor 1 (HSF1), while recognized as the major regulator of the heat shock transcriptional response, also exerts important functions during mammalian embryonic development and gametogenesis...
  27. Jin X, Moskophidis D, Mivechi N. Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome. Cell Metab. 2011;14:91-103 pubmed publisher
    ..Heat shock transcription factor 1 (HSF1), a major transactivator of stress proteins, increases survival by protecting cells against environmental stressors...
  28. Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, et al. Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis. 2004;38:66-80 pubmed
    ..In contrast to hsf1(-/-) mice, which exhibit normal spermatogenesis, targeted disruption of hsf2 results in reduced testicular size but ..
  29. Vydra N, Malusecka E, Jarzab M, Lisowska K, Glowala Kosinska M, Benedyk K, et al. Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells. Cell Death Differ. 2006;13:212-22 pubmed
    ..Such HSF1 expression did not lead to transcription of inducible Hsp70 genes, but instead induced caspase-dependent apoptosis ..
  30. Dai C, Whitesell L, Rogers A, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 2007;130:1005-18 pubmed
    Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function increases survival under a great many pathophysiological conditions...
  31. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007;21:2172-81 pubmed
    ..induces the expression of major cellular chaperones by triggering the dissociation of a repressive HDAC6/HSF1 (heat-shock factor 1)/HSP90 (heat-shock protein 90) complex and a subsequent HSF1 activation...
  32. Inouye S, Fujimoto M, Nakamura T, Takaki E, Hayashida N, Hai T, et al. Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. J Biol Chem. 2007;282:33210-7 pubmed
    Heat shock transcription factor 1 (HSF1) not only regulates expression of heat shock genes in response to elevated temperature, but is also involved in developmental processes by regulating genes such as cytokine genes...
  33. Nakai A, Suzuki M, Tanabe M. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J. 2000;19:1545-54 pubmed
    ..We report here that male mice expressing an active form of heat shock transcription factor 1 (HSF1) in the testis are infertile due to a block in spermatogenesis...
  34. Dai Q, Zhang C, Wu Y, McDonough H, Whaley R, Godfrey V, et al. CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 2003;22:5446-58 pubmed
    ..to environmental stress, and is regulated by a transcriptional program that depends on heat shock factor 1 (HSF1), which is normally under negative regulatory control by molecular chaperones Hsp70 and Hsp90...
  35. Yasuhara K, Ohno Y, Kojima A, Uehara K, Beppu M, Sugiura T, et al. Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice. J Appl Physiol (1985). 2011;111:1142-9 pubmed publisher
    Effects of heat shock transcription factor 1 (HSF1) gene on the regrowth of atrophied mouse soleus muscles were studied...
  36. Ciocca D, Cuello Carrión F, Natoli A, Restall C, Anderson R. Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression. Histochem Cell Biol. 2012;137:187-94 pubmed publisher
    ..No significant changes in these proteins were found in the stroma surrounding these tumors. These results demonstrate that the disruption of the Cav-1 gene can cause alterations of specific Hsps as well as tumor development. ..
  37. Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, et al. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice. Acta Physiol (Oxf). 2015;215:191-203 pubmed publisher
    Effects of heat shock transcription factor 1 (HSF1) deficiency on heat stress-associated increase in slow soleus muscle mass of mice were investigated...
  38. Das S, Bhattacharyya N. Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin. Microrna. 2015;4:185-93 pubmed
    Heat shock factor 1 (HSF1) is the master regulator of chaperone network in mammalian cells and can protect cells from adverse effects of misfolded proteins by rapidly inducing expression of multiple heat shock proteins (HSPs) and other ..
  39. Murapa P, Ward M, Gandhapudi S, Woodward J, D Orazio S. Heat shock factor 1 protects mice from rapid death during Listeria monocytogenes infection by regulating expression of tumor necrosis factor alpha during fever. Infect Immun. 2011;79:177-84 pubmed publisher
    Heat shock factor 1 (HSF1) is a stress-induced transcription factor that promotes expression of genes that protect mammalian cells from the lethal effects of severely elevated temperatures (>42°C)...
  40. Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, et al. Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-?B/mitogen-activated protein kinase. Carcinogenesis. 2014;35:272-81 pubmed publisher
    Heat shock factor 1 (HSF1), a major transactivator of stress responses, has been implicated in carcinogenesis in various organs...
  41. Shamovsky I, Ivannikov M, Kandel E, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006;440:556-60 pubmed
    The heat-shock transcription factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expression of heat-shock proteins (HSPs) and other cytoprotective proteins...
  42. Ghemrawi R, Pooya S, Lorentz S, Gauchotte G, Arnold C, Gueant J, et al. Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. Cell Death Dis. 2013;4:e553 pubmed publisher
    ..caspase 3, through reduced SIRT1 expression and consequently greater acetylation of heat-shock factor protein 1 (HSF1)...
  43. Chang Z, Lu M, Park S, Park H, Kang H, Pak Y, et al. Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest. Mol Cells. 2012;33:465-70 pubmed publisher
    The present study highlighted the aromatic-participant interactions in in vivo trimerization of HSF1 and got an insight into the process of HSF1 protecting against apoptosis...
  44. Neueder A, Achilli F, Moussaoui S, Bates G. Novel isoforms of heat shock transcription factor 1, HSF1?? and HSF1??, regulate chaperone protein gene transcription. J Biol Chem. 2014;289:19894-906 pubmed publisher
    ..Its master regulator is heat shock transcription factor 1 (HSF1). Heat shock factors generally exist in multiple isoforms...
  45. Neef D, Jaeger A, Gómez Pastor R, Willmund F, Frydman J, Thiele D. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014;9:955-66 pubmed publisher
    Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis...
  46. Gomes J, Nogueira R, Vieira M, Santos S, Ferraz Nogueira J, Relvas J, et al. Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death Differ. 2016;23:1749-1764 pubmed publisher
    ..Our results indicate that TTR might be regarded as a neurotrophic factor, because it stimulates neurite outgrowth under physiological conditions, and promotes neuroprotection in ischemic conditions. ..
  47. Koya T, Nishizawa S, Ohno Y, Goto A, Ikuta A, Suzuki M, et al. Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. PLoS ONE. 2013;8:e77788 pubmed publisher
    ..mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles...
  48. Santos S, Fernandes R, Saraiva M. The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems. Neurobiol Aging. 2010;31:280-9 pubmed publisher
    ..characterized a new mouse model expressing the human transthyretin V30M in a heat shock transcription factor 1 (Hsf1) null background...
  49. Yang L, Wang Y, Zhang Q, Lai Y, Li C, Zhang Q, et al. Identification of Hsf1 as a novel androgen receptor-regulated gene in mouse Sertoli cells. Mol Reprod Dev. 2014;81:514-23 pubmed publisher
    ..In the current study, we found that the expression of heat-shock transcription factor 1 (Hsf1) was increased in the testes of Sertoli cell-selective androgen receptor knockout (S-AR(-/y) ) mice compared with ..
  50. Krishnamurthy K, Vedam K, Kanagasabai R, Druhan L, Ilangovan G. Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart. Proc Natl Acad Sci U S A. 2012;109:9023-8 pubmed publisher
  51. Fiorenza M, Bevilacqua A, Canterini S, Torcia S, Pontecorvi M, Mangia F. Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol Reprod. 2004;70:1606-13 pubmed
    ..We found that one-cell mouse embryos respond to the osmotic shock of in vitro isolation with migration of HSF1, the canonical stress activator of mammalian heat shock genes, to pronuclei and by transient transcription of the ..
  52. Davies A, Kortright K, Kaplan K. Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics. Oncotarget. 2015;6:25202-16 pubmed publisher
    ..Inhibition of microtubule dynamics is sufficient to activate an Hsf1-dependent increase in gene transcription and protein levels...
  53. Takii R, Fujimoto M, Tan K, Takaki E, Hayashida N, Nakato R, et al. ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol. 2015;35:11-25 pubmed publisher
    ..However, the regulation of target genes by the stress-inducible HSF1 transcription complex has not yet been examined in detail in mammalian cells...
  54. Cui X, Xie P, Jia P, Lou Q, Dun G, Li S, et al. Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro. Biochim Biophys Acta. 2015;1853:746-55 pubmed publisher
    The interplay between Hsf4 and Hsf1 plays an important role in the regulation of lens homeostasis. However, the mechanism of the intermolecular association involved is still unclear...
  55. Mandrekar P, Catalano D, Jeliazkova V, Kodys K. Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation. J Leukoc Biol. 2008;84:1335-45 pubmed publisher
    ..These results suggest that alcohol exposure differentially regulates hsp70 and hsp90 via HSF-1 activation. Further, hsp90 regulates TNF-alpha production in macrophages contributing to alcohol-induced inflammation. ..
  56. Wang X, Grammatikakis N, Siganou A, Stevenson M, Calderwood S. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem. 2004;279:49460-9 pubmed
    ..have examined the interaction of two key molecular components in the response, heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK)...
  57. Gwag T, Park K, Kim E, Son C, Park J, Nikawa T, et al. Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. Arch Biochem Biophys. 2013;537:21-30 pubmed publisher
    ..CEL treatment also increased expression of HSP72 and phosphorylation of heat shock transcription factor 1 (p-HSF1) 11-fold and 3.4-fold, respectively, as well as accumulation of p-HSF1 in the nucleus...
  58. Batulan Z, Shinder G, Minotti S, He B, Doroudchi M, Nalbantoglu J, et al. High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci. 2003;23:5789-98 pubmed
    ..These results indicate that the high threshold for induction of the stress response in motor neurons stems from an impaired ability to activate the main heat shock-stress sensor, HSF1.
  59. Tanaka K, Tsutsumi S, Arai Y, Hoshino T, Suzuki K, Takaki E, et al. Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions. Mol Pharmacol. 2007;71:985-93 pubmed
    ..In this study, we compared gastric ulcerogenic response in wild-type mice and in those lacking heat shock factor 1 (HSF1), a transcription factor for hsp genes...
  60. Gong T, Fairfield D, Fullarton L, Dolan D, Altschuler R, Kohrman D, et al. Induction of heat shock proteins by hyperthermia and noise overstimulation in hsf1 -/- mice. J Assoc Res Otolaryngol. 2012;13:29-37 pubmed publisher
    ..Stressors activate heat shock transcription factor 1 (HSF1), which binds to heat shock elements in the genes for heat shock proteins, leading to rapid induction of these ..
  61. Kim H, Wang X, Zhang J, Suh G, Benjamin I, Ryter S, et al. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. J Immunol. 2005;175:2622-9 pubmed
    ..These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies. ..
  62. Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, et al. Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein. Endocrinology. 2017;158:2648-2658 pubmed publisher
    ..We examined the relationship between the heat stress response and heat shock factor 1 (HSF1), which protects cells from proteotoxic stress by inducing heat shock protein as a molecular chaperone...
  63. Ogasawara S, Hashizume K, Okuno T, Imaizumi T, Inomata Y, Tezuka Y, et al. Effect of Geranylgeranylacetone on Ultraviolet Radiation Type B-Induced Cataract in Heat-Shock Transcription Factor 1 Heterozygous Mouse. Curr Eye Res. 2017;42:732-737 pubmed publisher
    We investigated whether heat-shock transcription factor 1 (HSF1) was involved in ultraviolet radiation type B (UVR-B)-induced lens opacity (cataract) using HSF1 heterozygous mice...
  64. Wang P, Wander C, Yuan C, Bereman M, Cohen T. Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program. Nat Commun. 2017;8:82 pubmed publisher
    ..We demonstrate that TDP-43 acetylation-mimic pathology is potently suppressed by an HSF1-dependent mechanism that disaggregates TDP-43...
  65. Zhang Y, Koushik S, Dai R, Mivechi N. Structural organization and promoter analysis of murine heat shock transcription factor-1 gene. J Biol Chem. 1998;273:32514-21 pubmed
  66. Dai B, Gong A, Jing Z, Aldape K, Kang S, Sawaya R, et al. Forkhead box M1 is regulated by heat shock factor 1 and promotes glioma cells survival under heat shock stress. J Biol Chem. 2013;288:1634-42 pubmed publisher
    ..In this study we found that FoxM1 was up-regulated by heat shock factor 1 (HSF1) under heat shock stress condition in multiple cell lines...
  67. Mimoto T, Morimoto N, Miyazaki K, Kurata T, Sato K, Ikeda Y, et al. Expression of heat shock transcription factor 1 and its downstream target protein T-cell death associated gene 51 in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Brain Res. 2012;1488:123-31 pubmed publisher
    Heat shock transcription factor 1 (HSF1) modulates the expression of the cell survival heat shock protein 70 (HSP70) and the cell death T-cell death associated gene 51 (TDAG51) in response to heat shock and various other cell stressors...
  68. Taylor D, Tradewell M, Minotti S, Durham H. Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1. Cell Stress Chaperones. 2007;12:151-62 pubmed
    ..of the major transcription factor mediating stress-induced Hsp upregulation, heat shock transcription factor 1 (Hsf1)...
  69. Zhu X, Cheng M, Peng M, Xiao X, Yao S, Zhang X. Basal behavioral characterization of hsf1 deficient mice and its cellular and behavioral abnormalities underlying chronic unpredictable stressors. Behav Brain Res. 2008;193:225-9 pubmed publisher
    The heat shock factor 1 (HSF1) is a major transcriptional factor that controls the rapid induction of heat shock proteins in response to various environmental stressors...