Hsd3b7

Summary

Gene Symbol: Hsd3b7
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Alias: AI195443, BB098564, 3 beta-hydroxysteroid dehydrogenase type 7, 3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-HSD VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, c(27) 3-beta-HSD, cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
Species: mouse
Products:     Hsd3b7

Top Publications

  1. Shea H, Head D, Setchell K, Russell D. Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function. Proc Natl Acad Sci U S A. 2007;104:11526-33 pubmed
    ..We conclude that the correct stereochemistry of a single hydroxyl group at carbon 3 in bile acids is required to maintain their physiologic and regulatory functions in mammals. ..
  2. Yi T, Wang X, Kelly L, An J, Xu Y, Sailer A, et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012;37:535-48 pubmed publisher
    ..cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7. We showed that all three enzymes control EBI2 ligand concentration in lymphoid tissues...
  3. Schwarz M, Wright A, Davis D, Nazer H, Bjorkhem I, Russell D. The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. J Clin Invest. 2000;106:1175-84 pubmed
  4. Li J, Lu E, Yi T, Cyster J. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110-4 pubmed publisher
  5. Yi T, Cyster J. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. elife. 2013;2:e00757 pubmed publisher
    ..These findings establish an essential role for EBI2 in CD4(+) DC positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens. DOI:http://dx.doi.org/10.7554/eLife.00757.001. ..