Gene Symbol: Hsd17b3
Description: hydroxysteroid (17-beta) dehydrogenase 3
Alias: testosterone 17-beta-dehydrogenase 3, 17(beta)HSD type 3, 17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, testicular 17-beta-hydroxysteroid dehydrogenase
Species: mouse
Products:     Hsd17b3

Top Publications

  1. Sha J, Dudley K, Rajapaksha W, O Shaughnessy P. Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs. J Steroid Biochem Mol Biol. 1997;60:19-24 pubmed
    ..All other tissues tested contained mRNA encoding both isoforms of the enzyme although levels were markedly lower than in the gonads. ..
  2. Sha J, Baker P, O Shaughnessy P. Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis. Biochem Biophys Res Commun. 1996;222:90-4 pubmed
    ..The presence of the type 1 17 beta HSD enzyme in fetal testes may explain the virilization of the mesonephric (Wolffian) duct which occurs in pseudohermaphrodite individuals lacking the type 3 isoform. ..
  3. Mustonen M, Poutanen M, Isomaa V, Vihko P, Vihko R. Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem J. 1997;325 ( Pt 1):199-205 pubmed
    ..The data therefore suggest that there is transient oestradiol production in the early days of embryonic development, after which inactivation of sex steroids predominates in the fetus and placenta. ..
  4. Provost P, Simard M, Tremblay Y. A link between lung androgen metabolism and the emergence of mature epithelial type II cells. Am J Respir Crit Care Med. 2004;170:296-305 pubmed
    ..The production of androgens after the emergence of mature PTII cells should negatively regulate PTII cell maturation and, thus, a role for androgens in cell reprogramming is suggested. ..
  5. Dang W, Wang S, Tian S, Chen B, Sun F, Li W, et al. [Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007;25:91-5 pubmed
    ..To explore the biological effects of infrasound on the polygonal cells in adrenal cortex zona fasciculation in mice...
  6. Howerton C, Bale T. Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2014;111:9639-44 pubmed publisher
    ..ChIP-Seq for the O-GlcNAc mark identified the 17 beta hydroxysteroid dehydrogenase-3 (Hsd17b3) locus in male EPS placentas, which correlated with a reduction in Hsd17b3 expression and concordant reduced ..
  7. Umehara T, Kawashima I, Kawai T, Hoshino Y, Morohashi K, Shima Y, et al. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice. Endocrinology. 2016;157:4899-4913 pubmed
  8. Baker P, Sha J, O Shaughnessy P. Localisation and regulation of 17beta-hydroxysteroid dehydrogenase type 3 mRNA during development in the mouse testis. Mol Cell Endocrinol. 1997;133:127-33 pubmed
  9. Vainio S, Heikkilä M, Kispert A, Chin N, McMahon A. Female development in mammals is regulated by Wnt-4 signalling. Nature. 1999;397:405-9 pubmed
    ..Wnt-4 may also be required for maintenance of the female germ line. Thus, the establishment of sexual dimorphism is under the control of both local and systemic signals. ..

More Information


  1. Marshall K, Godden E, Yang F, Burgers S, Buck K, Sikela J. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol. 2002;3:RESEARCH0078 pubmed
    ..As a test of this approach we focused on two QTLs on mouse chromosomes 1 and 13 that are involved in physical dependence on alcohol...
  2. Chassot A, Ranc F, Gregoire E, Roepers Gajadien H, Taketo M, Camerino G, et al. Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008;17:1264-77 pubmed publisher
    ..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development. ..
  3. Ji Y, Wang H, Liu P, Wang Q, Zhao X, Meng X, et al. Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reprod Toxicol. 2010;29:176-83 pubmed publisher
    ..Taken together, these results suggest that the decreased testicular T synthesis might partially contribute to pubertal Cd-induced impairment on testicular development and spermatogenesis in mice. ..
  4. Kotula Balak M, Pochec E, Hejmej A, Duda M, Bilinska B. Octylphenol affects morphology and steroidogenesis in mouse tumor Leydig cells. Toxicol In Vitro. 2011;25:1018-26 pubmed publisher
    ..It seems likely that OP besides acting via ER may mediate its action through AR modulating Leydig cell function. ..
  5. Kaftanovskaya E, Lopez C, Ferguson L, Myhr C, Agoulnik A. Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015;29:2327-37 pubmed publisher
    ..We propose that the antiandrogenic exposure during early development may similarly result in an increase of FLC in adult testis, leading to abnormal LC differentiation. ..
  6. Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, et al. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015;112:4003-8 pubmed publisher
    ..This study thus provides a novel concept for somatic cell fate determination in testis development that may also represent an etiology of male infertility in human patients. ..
  7. Miyado M, Nakamura M, Miyado K, Morohashi K, Sano S, Nagata E, et al. Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012;153:6033-40 pubmed publisher
    ..The contrastive phenotypic findings between Mamld1 KO male mice and MAMLD1 mutation positive patients would primarily be ascribed to species difference in the fetal sex development. ..