Hsd17b11

Summary

Gene Symbol: Hsd17b11
Description: hydroxysteroid (17-beta) dehydrogenase 11
Alias: Dhrs8, Pan1b, SDR2, retSDR2, estradiol 17-beta-dehydrogenase 11, 17-beta-HSD 11, 17-beta-HSD XI, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase XI, 17bHSD11, 17beta-HSD11, 17betaHSD11, 17betaHSDXI, dehydrogenase/reductase (SDR family) member 8, retinal short-chain dehydrogenase/reductase 2, retinal short-chain dehydrogenase/reductase SDR2
Species: mouse
Products:     Hsd17b11

Top Publications

  1. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, et al. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001;171:111-7 pubmed
    We describe a new member of the 17beta-hydroxysteroid dehydrogenase group of enzymes. Human Pan1b displays greatest activity with 5alpha-androstan-3alpha,17beta-diol (3alpha-Diol) as substrate, suggesting that it may be important in ..
  2. Yokoi Y, Horiguchi Y, Araki M, Motojima K. Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver. FEBS J. 2007;274:4837-47 pubmed
  3. Sewell W, Sparrow D, Smith A, Gonzalez D, Rappaport E, Dunwoodie S, et al. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009;329:400-9 pubmed publisher
    ..Towards identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important regulator that requires Dll3 but not Lfng for normal function...
  4. Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, et al. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Endocrinology. 2003;144:2084-91 pubmed
    ..17 beta HSDXI is colinear with human retinal short-chain dehydrogenase/reductase retSDR2, a protein with no known biological activity (accession no. AAF06939)...
  5. Horiguchi Y, Araki M, Motojima K. Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11. Arch Biochem Biophys. 2008;479:121-30 pubmed publisher
    17beta-Hydroxysteroid dehydrogenase type 11 (17betaHSD11) is mostly localized on the endoplasmic reticulum (ER) membrane under normal conditions and redistributes to lipid droplets (LDs) when the formation of LDs is induced...