Hrh1

Summary

Gene Symbol: Hrh1
Description: histamine receptor H1
Alias: Bphs, Bordetella pertussis induced histamine sensitization, H1R, HH1R, histamine H1 receptor
Species: mouse

Publications

  1. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    Yo Oishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 105:19992-7
  2. The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders
    R Parmentier
    INSERM U628, Department of Experimental Medicine, Faculty of Medicine, Claude Bernard University, 69373 Lyon, France
    Biochem Pharmacol 73:1157-71
  3. Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Neurosci Res 57:306-13
  4. Contribution of histamine type-1 receptor to metabolic and behavioral control of ventilation
    Takashi Ishiguro
    Department of 2nd Physiology, Showa University School of Medicine, Tokyo, 142 8555, Japan
    J Physiol Sci 56:287-95
  5. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata
    Fu Wen Zhou
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis, TN 38163, USA
    J Neurophysiol 96:1581-91
  6. Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model
    Kenichi Miyamoto
    Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 140:215-22
  7. The H1 histamine receptor regulates allergic lung responses
    Paul J Bryce
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 116:1624-32
  8. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase
    Kosuke Aritake
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 281:15277-86
  9. Impaired ventilation and metabolism response to hypoxia in histamine H1 receptor-knockout mice
    Takashi Ishiguro
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Respir Physiol Neurobiol 154:331-41
  10. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92

Scientific Experts

  • Takayuki Masaki
  • Shinobu Sakurada
  • Paul J Bryce
  • Fu-Ming Zhou
  • R A McIndoe
  • Jung Han Kim
  • K Yanai
  • Cory Teuscher
  • Jun-ichi Suto
  • Takeshi Watanabe
  • Yasuyoshi Ohshima
  • Michiko Iwase
  • Ikuo Homma
  • T Watanabe
  • Takashi Ishiguro
  • Rajkumar Noubade
  • Masahiko Izumizaki
  • Mitsuko Kanamaru
  • Hongmei Dai
  • Kenichi Miyamoto
  • A Zlomuzica
  • E Dere
  • Yoshihiro Urade
  • Zhi Li Huang
  • Ryoji Kayasuga
  • Elizabeth P Blankenhorn
  • Hiroshi Ohtsu
  • Eiko Sakurai
  • U Greferath
  • Chiaki Kamei
  • L A Ruocco
  • D Viggiano
  • M A De Souza Silva
  • Charles N Rudick
  • J P Huston
  • A G Sadile
  • Walid Beghdadi
  • Yo Oishi
  • Graeme Milligan
  • Mercedes Rincon
  • Roxana del Rio
  • R Lever
  • Jacqueline P McGlade
  • Sangwon F Kim
  • Osamu Hayaishi
  • R Parmentier
  • Kosuke Aritake
  • Atsuo Kuramasu
  • Motohisa Kato
  • Tiina Kaisa Kukko Lukjanov
  • Hiroshi Kimura
  • James F Zachary
  • Kousaku Ohinata
  • Kazuie Iinuma
  • Tadashi Hirai
  • Z Wiener
  • Rosetta Pedotti
  • Zhong Chen
  • Jian Feng Gao
  • Parley D Fillmore
  • Nathan D Meeker
  • I Inoue
  • Runlin Z Ma
  • Yukio Sugimoto
  • A Mollet
  • M Jutel
  • N D Meeker
  • J I Mobarakeh
  • M Izumizaki
  • X Zhao
  • C Barth
  • M Murphy
  • E L Fletcher
  • M Kambourakis
  • Bradley S Schneider
  • Laura A Guichelaar
  • Theodoros Kantidakis
  • David J Klumpp
  • Michel Huerre
  • Naresha Saligrama
  • David Dubayle
  • U A Gironi Carnevale
  • Roger Peronet
  • Ruth E Berry
  • Adeline Porcherie
  • Bertil B Fredholm
  • Jacques Louis
  • Y Banu
  • Karen Spach
  • T Ishizuka

Detail Information

Publications59

  1. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    Yo Oishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 105:19992-7
    ..These results indicate that endogenous adenosine in the TMN suppresses the histaminergic system via A(1)R to promote NREM sleep...
  2. The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders
    R Parmentier
    INSERM U628, Department of Experimental Medicine, Faculty of Medicine, Claude Bernard University, 69373 Lyon, France
    Biochem Pharmacol 73:1157-71
    ....
  3. Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Neurosci Res 57:306-13
    ..In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact...
  4. Contribution of histamine type-1 receptor to metabolic and behavioral control of ventilation
    Takashi Ishiguro
    Department of 2nd Physiology, Showa University School of Medicine, Tokyo, 142 8555, Japan
    J Physiol Sci 56:287-95
    ..We concluded that histamine modulates ventilation by affecting metabolism and arousal state via H1 receptors...
  5. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata
    Fu Wen Zhou
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis, TN 38163, USA
    J Neurophysiol 96:1581-91
    ..Functional balance of these different histamine receptors may contribute to the proper intensity and pattern of basal ganglia output and, as a consequence, exert important effects on motor control...
  6. Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model
    Kenichi Miyamoto
    Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 140:215-22
    ..histamine H1 receptors in airway allergic inflammation by comparing the development of bronchial asthma in histamine H1 receptor gene knockout (H1RKO) and wild-type mice...
  7. The H1 histamine receptor regulates allergic lung responses
    Paul J Bryce
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 116:1624-32
    Histamine, signaling via the type 1 receptor (H1R), has been shown to suppress Th2 cytokine production by in vitro cultured T cells. We examined the role of H1R in allergic inflammation in vivo using a murine asthma model...
  8. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase
    Kosuke Aritake
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 281:15277-86
    ....
  9. Impaired ventilation and metabolism response to hypoxia in histamine H1 receptor-knockout mice
    Takashi Ishiguro
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Respir Physiol Neurobiol 154:331-41
    ..Peripheral chemoreceptor sensitivity did not differ between genotypes. We conclude that central histamine contributes via the H1 receptor to changes in metabolic rate during hypoxia to increase HVD in conscious mice...
  10. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92
    ....
  11. Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system
    Tiina Kaisa Kukko Lukjanov
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    J Neurosci 26:1088-97
    ..Our results suggest that histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 and H3 receptors...
  12. Blockage of histamine H1 receptor attenuates social isolation-induced disruption of prepulse inhibition: a study in H1 receptor gene knockout mice
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Psychopharmacology (Berl) 183:285-93
    ....
  13. Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen
    Jacqueline P McGlade
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA, Australia
    J Immunol 178:2794-802
    ....
  14. From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
    Sangwon F Kim
    The Solomon H Snyder Department of Neuroscience, Departments of Pharmacology and Molecular Sciences and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3456-9
    ..These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake...
  15. Characterization of histamine projections and their potential cellular targets in the mouse retina
    U Greferath
    Department of Anatomy and Cell Biology, University of Melbourne, Grattan Street, Melbourne, Victoria 3010, Australia
    Neuroscience 158:932-44
    ..This distribution of histamine and its receptors is consistent with a brain-derived source of histamine acting on diverse populations of cells in the retina, including both neurons and glia...
  16. Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum
    E Dere
    Institute of Physiological Psychology, Center for Biological and Medical Research, Heinrich Heine University of Düsseldorf, Universitätsstr 1, D 40225 Düsseldorf, Germany
    Neuroscience 157:532-41
    We investigated episodic-like (ELM) and procedural memory (PM) in histamine H1 receptor knockout (H1R-KO) mice...
  17. Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 180:7471-9
    ..M313V, and S331P) in the third intracellular loop of the murine histamine receptor H(1) (H(1)R) are candidates for Bphs, a shared autoimmune disease locus in experimental allergic encephalomyelitis and experimental allergic orchitis...
  18. Mast cell-derived histamine mediates cystitis pain
    Charles N Rudick
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 3:e2096
    ..Conversely, genetic or pharmacologic disruption of histamine receptor H1R or H2R attenuated pelvic pain without altering pathophysiology...
  19. Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice
    Yasuyoshi Ohshima
    Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    J Physiol Sci 58:147-50
    ..Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase...
  20. The roles of histamine H1 receptors on cognition
    K Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980-8575, Japan
    Inflamm Res 57:S39-40
  21. The histamine H1-receptor mediates the motivational effects of novelty
    A Zlomuzica
    Institute of Physiological Psychology, Center for Biological and Medical Research, Heinrich Heine University of Düsseldorf, Universitätsstr 1, D 40225 Düsseldorf, Germany
    Eur J Neurosci 27:1461-74
    ..Histamine and histamine-1-receptor (H1R) agonists induced arousal and wakefulness in humans and rodents, e.g...
  22. Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice
    Jun ichi Suto
    Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Med Sci Monit 14:CR65-74
    ..A genetic relationship among glucosuria, body weight, and fasting glucose levels was confirmed. Allelism between glucosuria QTL and body weight QTL was strongly suggested...
  23. Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease
    Walid Beghdadi
    Unité des Réponses Précoces aux Parasites et Immunopathologie, Institut Pasteur, Paris 75015, France
    J Exp Med 205:395-408
    ..Combined genetic and pharmacologic approaches demonstrated that histamine binding to H1R and H2R but not H3R and H4R increases the susceptibility of mice to infection with Plasmodium...
  24. Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    J Clin Invest 117:3507-18
    Histamine receptor H1 (H1R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell-mediated models of organ-specific autoimmune disease...
  25. Hypoxic ventilatory response during light and dark periods and the involvement of histamine H1 receptor in mice
    Yasuyoshi Ohshima
    2nd Dept of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Am J Physiol Regul Integr Comp Physiol 293:R1350-6
    ..periods and that histamine H1 receptors are required for the circadian variation, using wild-type (WT) and histamine H1 receptor knockout (H1RKO) mice...
  26. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses
    R Lever
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, UK
    Clin Exp Allergy 37:909-17
    ..Furthermore, our data suggest an important potential steroid-sparing role for such drugs in the treatment of allergic inflammatory conditions...
  27. The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury
    Takayuki Masaki
    Department of Internal Medicine, School of Medicine, Oita University, Hasama, Oita, Japan
    FASEB J 19:1245-52
    ..LPS)-induced liver injury, a combination of D-galactosamine and LPS (GalN/LPS) was administered to histamine H1 receptor knockout (H1-R KO) and H2 receptor knockout (H2-R KO) mice...
  28. Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity
    Jung Han Kim
    Department of Nutrition, The University of Tennessee, Knoxville 37996 1920, USA
    Physiol Genomics 22:171-81
    ..In summary, tabw2 congenic mice are a new animal model for diet-induced obesity that will be valuable for the study of gene-diet interactions...
  29. The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice
    Kousaku Ohinata
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611 0011, Japan
    Peptides 25:2135-8
    ..The NT-induced anorectic effect was partially ameliorated in H1 knockout mice. The findings suggest that the H1 receptor in part mediates the NT-induced suppression of food intake...
  30. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
    M Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Nature 413:420-5
    ..Here we report that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas both TH1- and TH2-type responses are negatively regulated by H2R through the activation of different ..
  31. Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice
    T Masaki
    Department of Internal Medicine, School of Medicine, Oita Medical University, Hasama, Japan
    Diabetes 50:385-91
    Histamine neurons are widely distributed in the brain and suppress food intake through the histamine H1 receptor (H1-R) in the hypothalamus...
  32. Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse
    X Zhao
    Departments of Molecular and Integrative Physiology, Obstetrics and Gynecology and Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Development 127:2643-51
    ..Using multiple approaches, we demonstrate herein that uterine-derived histamine interacts with embryonic H(2) receptors in a paracrine fashion to initiate the process of implantation...
  33. Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice
    M Izumizaki
    Department of Physiology, School of Medicine, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Neurosci Lett 284:139-42
    ..These results indicate that central histamine contributes to an increase in respiratory frequency due to a reduction in expiratory time through histamine H1 receptors when body temperature is raised...
  34. Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice
    J I Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai, Japan
    Eur J Pharmacol 391:81-9
    ..The difference in the effect of histamine H(1) receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H(1) receptors on pain threshold...
  35. Physical mapping of the autoimmune disease susceptibility locus, Bphs: co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6
    N D Meeker
    Department of Veterinary Pathobiology, 2001 South Lincoln Ave, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
    Mamm Genome 10:858-63
    ..This subphenotype is controlled by a single locus, Bphs, previously mapped to a 33 cM region on mouse Chromosome (Chr) 6...
  36. Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice
    R A McIndoe
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:2210-4
    ..This locus (Cia4) was located on chromosome 2 and was linked to the same region as Cia2. Determining the identity of these loci may provide insights into the etiology of human rheumatoid arthritis...
  37. Augmentation of antigen receptor-mediated responses by histamine H1 receptor signaling
    Y Banu
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Exp Med 189:673-82
    ..In studies of histamine H1R knockout mice, H1R-deficient T cells had low proliferative responses to anti-CD3epsilon cross-linking or antigen ..
  38. Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors
    K Yanai
    Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan
    Neuroscience 87:479-87
    ....
  39. Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization
    K Yanai
    Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan
    Life Sci 62:1607-10
    ..In correlation to the behavioral changes in the mutant mice, 5-hydroxytryptamine release was significantly increased in the brains of mutant mice...
  40. Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
    I Inoue
    Department of Molecular Immunology, Kyushu University, Fukuoka, Japan
    Proc Natl Acad Sci U S A 93:13316-20
    ..To define the contribution of the histamine H1 receptors (H1R) to behavior, mutant mice lacking the H1R were generated by homologous recombination...
  41. Characteristics of the mouse genomic histamine H1 receptor gene
    I Inoue
    Department of Molecular Immunology, Kyushu University 3 1 1, Higashi ku, Fukuoka, 812, Japan
    Genomics 36:178-81
    We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors...
  42. Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin
    A Mollet
    Institute of Veterinary Physiology, University of Zurich, 8057 Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 281:R1442-8
    ..The same applies to leptin but not to CCK. H1Rko mice showed significantly increased body weight gain compared with WT mice, supporting the role of endogenous histamine in the regulation of feeding and body weight...
  43. Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice
    Ryoji Kayasuga
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Int Immunopharmacol 2:745-50
    ..role of histamine H1 receptors in nasal allergic symptoms (sneezing and nasal rubbing) were studied using histamine H1 receptor-deficient mice...
  44. Identification of Bphs, an autoimmune disease locus, as histamine receptor H1
    Runlin Z Ma
    Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101
    Science 297:620-3
    ..We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice...
  45. Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice
    Kenichi Miyamoto
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Respir Physiol Neurobiol 144:25-33
    ..We conclude that alterations of inspiratory off-switch and respiratory rhythm generation change breathing pattern without affecting central chemosensitivity in H1RKO. Histamine might affect breathing pattern centrally via H1 receptors...
  46. Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord
    Shinobu Sakurada
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pain 112:171-82
    ..H1 receptor knockout (H1R-KO) mice did not show the nociceptin-induced nociceptive behavior, which was observed in wild-type mice...
  47. Confirmation and characterization of murine body weight QTLs, Bwq1 and Bwq2, identified in C57BL/6J x KK-Ay/a F2-Ay/a mice
    Jun ichi Suto
    Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 66:1039-45
    ..There are two candidate genes, Pparg and Hrh1, which are located near the 95% confidence interval of Bwq2, and which are expressed in the adipose tissue; however,..
  48. Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity
    Takayuki Masaki
    Department of Internal Medicine, School of Medicine Oita University, Hasama, Oita, 879 5593 Japan
    Diabetes 53:2250-60
    ..In addition, centrally acting histamine H(1)-R may be a novel therapeutic target for the treatment of obesity and related metabolic disorders...
  49. Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient mice
    Tadashi Hirai
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Epilepsia 45:309-13
    ..receptors in the development of amygdaloid kindling by using histidine decarboxylase (HDC)-deficient and histamine H1 receptor (H1R)-deficient mice...
  50. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells
    Cory Teuscher
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 164:883-92
    ..CD4+ T-cells from histamine H1 receptor (H1R)-deficient (H1RKO) mice produce significantly less interferon-gamma and more interleukin (IL)-4 in in ..
  51. Mouse embryonic stem cells express histidine decarboxylase and histamine H1 receptors
    Z Wiener
    Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary
    Inflamm Res 52:S53-4
  52. Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obese mice
    Takayuki Masaki
    Department of Internal Medicine, School of Medicine, Oita Medical University, Oita 879 5593, Japan
    Endocrinology 144:2741-8
    ..In addition, it appears that the histamine H(1)-R signaling pathway may be independent or downstream of the POMC/MC-4R signaling...
  53. Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice
    Zhong Chen
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, 980 8575, Sendai, Japan
    Brain Res 968:162-6
    ..The present study indicates that histamine plays a suppressive role in seizure development through H(1)-receptors...
  54. Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin
    Jian Feng Gao
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Infect Immun 71:1281-7
    ..We recently identified Bphs, the locus controlling PTX-induced hypersensitivity to the vasoactive amine histamine, as the histamine H(1) ..
  55. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
    Rosetta Pedotti
    Department of Neurology and Neurological Science, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:1867-72
    ..traditionally associated with allergic responses, including prostaglandin D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc epsilon receptor 1 (Fc epsilon RI), and tryptase...
  56. Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors
    Ryoji Kayasuga
    Department of Pharmacology, Faculty of Pharmaceutical Science, Okayama University, Okayama 700 8530, Okayama, Japan
    Eur J Pharmacol 449:287-91
    ....
  57. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6
    J D Sudweeks
    Department of Microbiology, Brigham Young University, Provo, UT 84602
    Proc Natl Acad Sci U S A 90:3700-4
    ..to PTX, as measured by hypersensitivity following vasoactive amine challenge, is genetically controlled by the Bphs locus...