Genomes and Genes
Gene Symbol: Hrg
Description: histidine-rich glycoprotein
Alias: AI265597, AW413091, D16jh2, D18020, Hprg, Hrgp, histidine-rich glycoprotein, histidine-proline-rich glycoprotein
- Tugues S, Roche F, Noguer O, Orlova A, Bhoi S, Padhan N, et al. Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes. PLoS ONE. 2014;9:e107483 pubmed publisherHistidine-rich glycoprotein (HRG) is implicated in tumor growth and metastasis by regulation of angiogenesis and inflammation. HRG is produced by hepatocytes and carried to tissues via the circulation...
- Claesson Welsh L. Blood vessels as targets in tumor therapy. Ups J Med Sci. 2012;117:178-86 pubmed publisher..This review describes the hallmarks of tumor vessels, how different angiogenic growth factors exert their function, and the perspectives for future development of anti-angiogenic therapy...
- Brunacci C, Piobbico D, Bartoli D, Castelli M, Pieroni S, Bellet M, et al. Identification and characterization of a novel peptide interacting with cAMP-responsive elements binding and cAMP-responsive elements modulator in mouse liver. Liver Int. 2010;30:388-95 pubmed publisher..The characterization of molecules capable of interfering in the liver with an important pathway such as CREB could be significant in designing and/or developing new therapeutic approaches to the control of liver cell proliferation. ..
- Hale J, Li M, Sinyuk M, Jahnen Dechent W, LATHIA J, Silverstein R. Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS ONE. 2012;7:e40033 pubmed publisher..Recent studies revealed that circulating Histidine Rich Glycoprotein (HRG) inhibits the anti-angiogenic potential of the CD36-TSR pathway by functioning as a decoy receptor ..
- White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher..Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism. ..
- Cedervall J, Zhang Y, Ringvall M, Thulin A, Moustakas A, Jahnen Dechent W, et al. HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. Angiogenesis. 2013;16:889-902 pubmed publisherMice lacking histidine-rich glycoprotein (HRG) display an accelerated angiogenic switch and larger tumors-a phenotype caused by enhanced platelet activation in the HRG-deficient mice...
- Hsu S, Nagase H, Balmain A. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. Genome. 2004;47:931-46 pubmed..a bacterial artificial chromosome (BAC) library, leading to the identification of the histidine-rich glycoprotein (Hrg) and Fetuin-B as the most tightly linked genes...
- Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, PeroviÄ‡ Ottstadt S, et al. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. Int J Cancer. 2015;136:2693-704 pubmed publisher..Histidine-rich glycoprotein (HRG) is an abundant plasma protein produced by the liver with the proposed function as a pattern recognition molecule ..
- Vu T, Zhou J, Leslie B, Stafford A, Fredenburgh J, Ni R, et al. Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein. Blood. 2015;125:2712-9 pubmed publisher..Previously, we showed that histidine-rich glycoprotein (HRG) binds FXIIa and attenuates its capacity to trigger coagulation...
- Jones A, Hulett M, Altin J, Hogg P, Parish C. Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. J Biol Chem. 2004;279:38267-76 pubmed..Previous studies have reported that the plasma protein, histidine-rich glycoprotein (HRG), interacts with plasminogen and cell surfaces, raising the possibility that HRG may immobilize plasminogen/plasmin ..