Gene Symbol: Hrg
Description: histidine-rich glycoprotein
Alias: AI265597, AW413091, D16jh2, D18020, Hprg, Hrgp, histidine-rich glycoprotein, histidine-proline-rich glycoprotein
Species: mouse
Products:     Hrg

Top Publications

  1. Tsuchida Straeten N, Ensslen S, Schafer C, Wöltje M, Denecke B, Moser M, et al. Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). J Thromb Haemost. 2005;3:865-72 pubmed
    Histidine-rich glycoprotein (HRG) is a serum protein belonging to the cystatin superfamily. HRG may play a regulatory role in hemostasis and innate immunity...
  2. Simantov R, Febbraio M, Silverstein R. The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. Matrix Biol. 2005;24:27-34 pubmed, is homologous to domains on other TSP binding proteins, such as LIMP-2 and histidine-rich glycoprotein (HRGP)...
  3. Rydengård V, Shannon O, Lundqvist K, Kacprzyk L, Chalupka A, Olsson A, et al. Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathog. 2008;4:e1000116 pubmed publisher
    ..further by the present investigation, demonstrating a novel antifungal role of histidine-rich glycoprotein (HRG), an abundant and multimodular plasma protein...
  4. Shannon O, Rydengård V, Schmidtchen A, Morgelin M, Alm P, Sørensen O, et al. Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis. Blood. 2010;116:2365-72 pubmed publisher
    Streptococcus pyogenes is a significant bacterial pathogen in humans. In this study, histidine-rich glycoprotein (HRG), an abundant plasma protein, was found to kill S pyogenes...
  5. Hulett M, Parish C. Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. Immunol Cell Biol. 2000;78:280-7 pubmed
    Histidine-rich glycoprotein (HRG) is a plasma protein of vertebrates that has been implicated in the regulation of several important biological functions, including the immune response and blood clotting...
  6. Thulin A, Ringvall M, Dimberg A, Kårehed K, Väisänen T, Väisänen M, et al. Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. Mol Cancer Res. 2009;7:1792-802 pubmed publisher
    The angiogenesis inhibitor histidine-rich glycoprotein (HRG) constitutes one of several examples of molecules regulating both angiogenesis and hemostasis...
  7. Tugues S, Honjo S, König C, Noguer O, Hedlund M, Botling J, et al. Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization. Cancer Res. 2012;72:1953-63 pubmed publisher
    Histidine-rich glycoprotein (HRG) is a 75-kDa heparin-binding plasma protein implicated in the regulation of tumor growth and vascularization...
  8. Ringvall M, Thulin A, Zhang L, Cedervall J, Tsuchida Straeten N, Jahnen Dechent W, et al. Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein. PLoS ONE. 2011;6:e14526 pubmed publisher
    The heparin-binding plasma protein histidine-rich glycoprotein (HRG; alternatively, HRGP/HPRG) can suppress tumor angiogenesis and growth in vitro and in vivo...
  9. Roche F, Sipilä K, Honjo S, Johansson S, Tugues S, Heino J, et al. Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin. Matrix Biol. 2015;48:89-99 pubmed publisher
    The plasma protein histidine-rich glycoprotein (HRG) affects the morphology and function of both endothelial cells (ECs) and monocytes/macrophages in cancer. Here, we examined the mechanism of action of HRG's effect on ECs...

More Information


  1. Tugues S, Roche F, Noguer O, Orlova A, Bhoi S, Padhan N, et al. Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes. PLoS ONE. 2014;9:e107483 pubmed publisher
    Histidine-rich glycoprotein (HRG) is implicated in tumor growth and metastasis by regulation of angiogenesis and inflammation. HRG is produced by hepatocytes and carried to tissues via the circulation...
  2. Claesson Welsh L. Blood vessels as targets in tumor therapy. Ups J Med Sci. 2012;117:178-86 pubmed publisher
    ..This review describes the hallmarks of tumor vessels, how different angiogenic growth factors exert their function, and the perspectives for future development of anti-angiogenic therapy...
  3. Brunacci C, Piobbico D, Bartoli D, Castelli M, Pieroni S, Bellet M, et al. Identification and characterization of a novel peptide interacting with cAMP-responsive elements binding and cAMP-responsive elements modulator in mouse liver. Liver Int. 2010;30:388-95 pubmed publisher
    ..The characterization of molecules capable of interfering in the liver with an important pathway such as CREB could be significant in designing and/or developing new therapeutic approaches to the control of liver cell proliferation. ..
  4. Hale J, Li M, Sinyuk M, Jahnen Dechent W, LATHIA J, Silverstein R. Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS ONE. 2012;7:e40033 pubmed publisher
    ..Recent studies revealed that circulating Histidine Rich Glycoprotein (HRG) inhibits the anti-angiogenic potential of the CD36-TSR pathway by functioning as a decoy receptor ..
  5. White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher
    ..Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism. ..
  6. Cedervall J, Zhang Y, Ringvall M, Thulin A, Moustakas A, Jahnen Dechent W, et al. HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. Angiogenesis. 2013;16:889-902 pubmed publisher
    Mice lacking histidine-rich glycoprotein (HRG) display an accelerated angiogenic switch and larger tumors-a phenotype caused by enhanced platelet activation in the HRG-deficient mice...
  7. Hsu S, Nagase H, Balmain A. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. Genome. 2004;47:931-46 pubmed
    ..a bacterial artificial chromosome (BAC) library, leading to the identification of the histidine-rich glycoprotein (Hrg) and Fetuin-B as the most tightly linked genes...
  8. Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović Ottstadt S, et al. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. Int J Cancer. 2015;136:2693-704 pubmed publisher
    ..Histidine-rich glycoprotein (HRG) is an abundant plasma protein produced by the liver with the proposed function as a pattern recognition molecule ..
  9. Vu T, Zhou J, Leslie B, Stafford A, Fredenburgh J, Ni R, et al. Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein. Blood. 2015;125:2712-9 pubmed publisher
    ..Previously, we showed that histidine-rich glycoprotein (HRG) binds FXIIa and attenuates its capacity to trigger coagulation...
  10. Jones A, Hulett M, Altin J, Hogg P, Parish C. Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. J Biol Chem. 2004;279:38267-76 pubmed
    ..Previous studies have reported that the plasma protein, histidine-rich glycoprotein (HRG), interacts with plasminogen and cell surfaces, raising the possibility that HRG may immobilize plasminogen/plasmin ..